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Entry version 126 (11 Dec 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Protein LRATD2

Gene

LRATD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein LRATD2Curated
Alternative name(s):
Breast cancer membrane protein 101
LRAT domain-containing 2Imported
Protein FAM84BCurated
Protein NSE2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRATD2Imported
Synonyms:BCMP101, FAM84BImported, NSE2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000168672.3

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24166 LRATD2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
609483 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96KN1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
157638

Open Targets

More...
OpenTargetsi
ENSG00000168672

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671855

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96KN1 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM84B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74732219

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002343481 – 310Protein LRATD2Add BLAST310

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96KN1

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96KN1

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96KN1

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96KN1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96KN1

PeptideAtlas

More...
PeptideAtlasi
Q96KN1

PRoteomics IDEntifications database

More...
PRIDEi
Q96KN1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
77084

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96KN1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96KN1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in esophageal squamous cell carcinomas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000168672 Expressed in 208 organ(s), highest expression level in pigmented layer of retina

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96KN1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA050782
HPA062115

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
127609, 20 interactors

Protein interaction database and analysis system

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IntActi
Q96KN1, 18 interactors

Molecular INTeraction database

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MINTi
Q96KN1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000302578

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q96KN1 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96KN1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi47 – 76Pro-richAdd BLAST30

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LRATD family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IGIG Eukaryota
ENOG410ZUU0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159198

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293400

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96KN1

KEGG Orthology (KO)

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KOi
K22810

Identification of Orthologs from Complete Genome Data

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OMAi
KDRELSW

Database of Orthologous Groups

More...
OrthoDBi
953643at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96KN1

TreeFam database of animal gene trees

More...
TreeFami
TF330836

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007053 LRAT_dom
IPR028815 LRATD2

The PANTHER Classification System

More...
PANTHERi
PTHR46341:SF2 PTHR46341:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04970 LRAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q96KN1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNQVEKLTH LSYKEVPTAD PTGVDRDDGP RIGVSYIFSN DDEDVEPQPP
60 70 80 90 100
PQGPDGGGLP DGGDGPPPPQ PQPYDPRLHE VECSVFYRDE CIYQKSFAPG
110 120 130 140 150
SAALSTYTPE NLLNKCKPGD LVEFVSQAQY PHWAVYVGNF QVVHLHRLEV
160 170 180 190 200
INSFLTDASQ GRRGRVVNDL YRYKPLSSSA VVRNALAHVG AKERELSWRN
210 220 230 240 250
SESFAAWCRY GKREFKIGGE LRIGKQPYRL QIQLSAQRSH TLEFQSLEDL
260 270 280 290 300
IMEKRRNDQI GRAAVLQELA THLHPAEPEE GDSNVARTTP PPGRPPAPSS
310
EEEDGEAVAH
Length:310
Mass (Da):34,474
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB587A33F9CB41938
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ417849 mRNA Translation: CAD10629.1
BC052957 mRNA Translation: AAH52957.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6358.1

NCBI Reference Sequences

More...
RefSeqi
NP_777571.1, NM_174911.4
XP_016868596.1, XM_017013107.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000304916; ENSP00000302578; ENSG00000168672
ENST00000652209; ENSP00000498944; ENSG00000168672

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
157638

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:157638

UCSC genome browser

More...
UCSCi
uc003yrz.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ417849 mRNA Translation: CAD10629.1
BC052957 mRNA Translation: AAH52957.1
CCDSiCCDS6358.1
RefSeqiNP_777571.1, NM_174911.4
XP_016868596.1, XM_017013107.1

3D structure databases

SMRiQ96KN1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi127609, 20 interactors
IntActiQ96KN1, 18 interactors
MINTiQ96KN1
STRINGi9606.ENSP00000302578

PTM databases

iPTMnetiQ96KN1
PhosphoSitePlusiQ96KN1

Polymorphism and mutation databases

BioMutaiFAM84B
DMDMi74732219

Proteomic databases

EPDiQ96KN1
jPOSTiQ96KN1
MassIVEiQ96KN1
MaxQBiQ96KN1
PaxDbiQ96KN1
PeptideAtlasiQ96KN1
PRIDEiQ96KN1
ProteomicsDBi77084

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
157638

Genome annotation databases

EnsembliENST00000304916; ENSP00000302578; ENSG00000168672
ENST00000652209; ENSP00000498944; ENSG00000168672
GeneIDi157638
KEGGihsa:157638
UCSCiuc003yrz.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
157638
DisGeNETi157638
EuPathDBiHostDB:ENSG00000168672.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LRATD2
HGNCiHGNC:24166 LRATD2
HPAiHPA050782
HPA062115
MIMi609483 gene
neXtProtiNX_Q96KN1
OpenTargetsiENSG00000168672
PharmGKBiPA142671855

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGIG Eukaryota
ENOG410ZUU0 LUCA
GeneTreeiENSGT00940000159198
HOGENOMiHOG000293400
InParanoidiQ96KN1
KOiK22810
OMAiKDRELSW
OrthoDBi953643at2759
PhylomeDBiQ96KN1
TreeFamiTF330836

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FAM84B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
157638
PharosiQ96KN1 Tbio

Protein Ontology

More...
PROi
PR:Q96KN1
RNActiQ96KN1 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000168672 Expressed in 208 organ(s), highest expression level in pigmented layer of retina
GenevisibleiQ96KN1 HS

Family and domain databases

InterProiView protein in InterPro
IPR007053 LRAT_dom
IPR028815 LRATD2
PANTHERiPTHR46341:SF2 PTHR46341:SF2, 1 hit
PfamiView protein in Pfam
PF04970 LRAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRAT2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96KN1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 1, 2001
Last modified: December 11, 2019
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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