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Protein

Olfactory receptor 10C1

Gene

OR10C1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10C1
Alternative name(s):
Hs6M1-17
Olfactory receptor 10C2
Gene namesi
Name:OR10C1
Synonyms:OR10C2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000206474.7
HostDB:ENSG00000279941.1
HGNCiHGNC:8165 OR10C1
neXtProtiNX_Q96KK4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24ExtracellularSequence analysisAdd BLAST24
Transmembranei25 – 45Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini46 – 53CytoplasmicSequence analysis8
Transmembranei54 – 74Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini75 – 98ExtracellularSequence analysisAdd BLAST24
Transmembranei99 – 119Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini120 – 138CytoplasmicSequence analysisAdd BLAST19
Transmembranei139 – 159Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini160 – 196ExtracellularSequence analysisAdd BLAST37
Transmembranei197 – 216Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini217 – 236CytoplasmicSequence analysisAdd BLAST20
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 270ExtracellularSequence analysisAdd BLAST13
Transmembranei271 – 291Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini292 – 312CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiOR10C1
DMDMi296439284

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506931 – 312Olfactory receptor 10C1Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96KK4
PeptideAtlasiQ96KK4
PRIDEiQ96KK4
ProteomicsDBi77081

PTM databases

iPTMnetiQ96KK4
PhosphoSitePlusiQ96KK4

Expressioni

Gene expression databases

BgeeiENSG00000206474 Expressed in 1 organ(s), highest expression level in blood
CleanExiHS_OR10C1
ExpressionAtlasiQ96KK4 baseline and differential
GenevisibleiQ96KK4 HS

Organism-specific databases

HPAiHPA049336

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000419119

Structurei

3D structure databases

ProteinModelPortaliQ96KK4
SMRiQ96KK4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITUP Eukaryota
ENOG4111574 LUCA
GeneTreeiENSGT00760000119002
HOVERGENiHBG017625
InParanoidiQ96KK4
KOiK04257
PhylomeDBiQ96KK4
TreeFamiTF337350

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q96KK4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSANTSMVTE FLLLGFSHLA DLQGLLFSVF LTIYLLTVAG NFLIVVLVST
60 70 80 90 100
DAALQSPMYF FLRTLSALEI GYTSVTVPLL LHHLLTGRRH ISRSGCALQM
110 120 130 140 150
FFFLFFGATE CCLLAAMAYD RYAAICEPLR YPLLLSHRVC LQLAGSAWAC
160 170 180 190 200
GVLVGLGHTP FIFSLPFCGP NTIPQFFCEI QPVLQLVCGD TSLNELQIIL
210 220 230 240 250
ATALLILCPF GLILGSYGRI LVTIFRIPSV AGRRKAFSTC SSHLIMVSLF
260 270 280 290 300
YGTALFIYIR PKASYDPATD PLVSLFYAVV TPILNPIIYS LRNTEVKAAL
310
KRTIQKTVPM EI
Length:312
Mass (Da):34,384
Last modified:May 18, 2010 - v3
Checksum:iB6FD7A4A2018F69C
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WY02A0A087WY02_HUMAN
Olfactory receptor
OR10C1
314Annotation score:
Q6IFQ5Q6IFQ5_HUMAN
Olfactory receptor
OR10C1 hCG_1645045
312Annotation score:
A0A140T9J0A0A140T9J0_HUMAN
Olfactory receptor
OR10C1
312Annotation score:
A0A0G2JL13A0A0G2JL13_HUMAN
Olfactory receptor
OR10C1
314Annotation score:
A0A140TA55A0A140TA55_HUMAN
Olfactory receptor
OR10C1
314Annotation score:

Sequence cautioni

The sequence CAB44507 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Polymorphismi

A stop codon at position Gln-55 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in African-Americans than in non-Africans.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03782257P → S. Corresponds to variant dbSNP:rs17184016Ensembl.1
Natural variantiVAR_03782360F → L. Corresponds to variant dbSNP:rs2074469Ensembl.1
Natural variantiVAR_03782489R → S. Corresponds to variant dbSNP:rs11755182Ensembl.1
Natural variantiVAR_037825100M → V. Corresponds to variant dbSNP:rs17177632Ensembl.1
Natural variantiVAR_037826121R → C. Corresponds to variant dbSNP:rs17177639Ensembl.1
Natural variantiVAR_037827138R → W. Corresponds to variant dbSNP:rs17177646Ensembl.1
Natural variantiVAR_037828160P → S. Corresponds to variant dbSNP:rs2074468Ensembl.1
Natural variantiVAR_037829161F → L. Corresponds to variant dbSNP:rs2074467Ensembl.1
Natural variantiVAR_037830174P → Q. Corresponds to variant dbSNP:rs2074466Ensembl.1
Natural variantiVAR_037831246M → V2 PublicationsCorresponds to variant dbSNP:rs2074464Ensembl.1
Natural variantiVAR_037832255L → I. Corresponds to variant dbSNP:rs17177674Ensembl.1
Natural variantiVAR_037833310M → R. Corresponds to variant dbSNP:rs11968123Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035542 Genomic DNA Translation: CAB44507.1 Different initiation.
AL645927 Genomic DNA No translation available.
CR759768 Genomic DNA No translation available.
CR388393 Genomic DNA No translation available.
BC136996 mRNA Translation: AAI36997.1
BC136997 mRNA Translation: AAI36998.1
AF399627 Genomic DNA Translation: AAK95112.1
CCDSiCCDS34364.1
RefSeqiNP_039229.3, NM_013941.3
UniGeneiHs.631997

Genome annotation databases

EnsembliENST00000377138; ENSP00000366343; ENSG00000229412
ENST00000391549; ENSP00000375393; ENSG00000204689
ENST00000437403; ENSP00000408961; ENSG00000224234
ENST00000444197; ENSP00000419119; ENSG00000206474
ENST00000455234; ENSP00000402486; ENSG00000230505
ENST00000457403; ENSP00000412512; ENSG00000232397
GeneIDi442194
KEGGihsa:442194
UCSCiuc011dlp.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035542 Genomic DNA Translation: CAB44507.1 Different initiation.
AL645927 Genomic DNA No translation available.
CR759768 Genomic DNA No translation available.
CR388393 Genomic DNA No translation available.
BC136996 mRNA Translation: AAI36997.1
BC136997 mRNA Translation: AAI36998.1
AF399627 Genomic DNA Translation: AAK95112.1
CCDSiCCDS34364.1
RefSeqiNP_039229.3, NM_013941.3
UniGeneiHs.631997

3D structure databases

ProteinModelPortaliQ96KK4
SMRiQ96KK4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000419119

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ96KK4
PhosphoSitePlusiQ96KK4

Polymorphism and mutation databases

BioMutaiOR10C1
DMDMi296439284

Proteomic databases

PaxDbiQ96KK4
PeptideAtlasiQ96KK4
PRIDEiQ96KK4
ProteomicsDBi77081

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377138; ENSP00000366343; ENSG00000229412
ENST00000391549; ENSP00000375393; ENSG00000204689
ENST00000437403; ENSP00000408961; ENSG00000224234
ENST00000444197; ENSP00000419119; ENSG00000206474
ENST00000455234; ENSP00000402486; ENSG00000230505
ENST00000457403; ENSP00000412512; ENSG00000232397
GeneIDi442194
KEGGihsa:442194
UCSCiuc011dlp.3 human

Organism-specific databases

CTDi442194
EuPathDBiHostDB:ENSG00000206474.7
HostDB:ENSG00000279941.1
GeneCardsiOR10C1
HGNCiHGNC:8165 OR10C1
HPAiHPA049336
neXtProtiNX_Q96KK4
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITUP Eukaryota
ENOG4111574 LUCA
GeneTreeiENSGT00760000119002
HOVERGENiHBG017625
InParanoidiQ96KK4
KOiK04257
PhylomeDBiQ96KK4
TreeFamiTF337350

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR10C1
GenomeRNAii442194
PROiPR:Q96KK4

Gene expression databases

BgeeiENSG00000206474 Expressed in 1 organ(s), highest expression level in blood
CleanExiHS_OR10C1
ExpressionAtlasiQ96KK4 baseline and differential
GenevisibleiQ96KK4 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO10C1_HUMAN
AccessioniPrimary (citable) accession number: Q96KK4
Secondary accession number(s): Q5SUN7, Q96R18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 153 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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