UniProtKB - Q96KF2 (PRAC1_HUMAN)
Protein
Small nuclear protein PRAC1
Gene
PRAC1
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Small nuclear protein PRAC1Alternative name(s): Prostate cancer susceptibility candidate protein 1 Prostate, rectum and colon expressed gene protein |
Gene namesi | Name:PRAC1 Synonyms:C17orf92, PRAC |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000159182.4 |
HGNCi | HGNC:30591, PRAC1 |
MIMi | 609819, gene |
neXtProti | NX_Q96KF2 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 84366 |
OpenTargetsi | ENSG00000159182 |
PharmGKBi | PA164725009 |
Miscellaneous databases
Pharosi | Q96KF2, Tbio |
Polymorphism and mutation databases
BioMutai | PRAC1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000312417 | 1 – 57 | Small nuclear protein PRAC1Add BLAST | 57 |
Proteomic databases
PaxDbi | Q96KF2 |
PRIDEi | Q96KF2 |
ProteomicsDBi | 77065 |
PTM databases
iPTMneti | Q96KF2 |
PhosphoSitePlusi | Q96KF2 |
Expressioni
Tissue specificityi
Highly expressed in prostate, rectum, and distal colon, and weakly expressed in bladder. Expressed in prostate cancer cell lines.1 Publication
Gene expression databases
Bgeei | ENSG00000159182, Expressed in rectum and 67 other tissues |
Genevisiblei | Q96KF2, HS |
Organism-specific databases
HPAi | ENSG00000159182, Group enriched (intestine, prostate) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000290294 |
Miscellaneous databases
RNActi | Q96KF2, protein |
Family & Domainsi
Phylogenomic databases
eggNOGi | ENOG502TEAX, Eukaryota |
GeneTreei | ENSGT00940000165611 |
HOGENOMi | CLU_2995884_0_0_1 |
InParanoidi | Q96KF2 |
OMAi | RDGSACN |
PhylomeDBi | Q96KF2 |
TreeFami | TF341666 |
i Sequence
Sequence statusi: Complete.
Q96KF2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLCAHFSDQG PAHLTTSKSA FLSNKKTSTL KHLLGETRSD GSACNSGISG
GRGRKIP
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051285 | 4 | A → V. Corresponds to variant dbSNP:rs34734055Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF331165 mRNA Translation: AAK38837.1 AC091179 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94717.1 BC030950 mRNA Translation: AAH30950.1 |
CCDSi | CCDS11535.1 |
RefSeqi | NP_115767.1, NM_032391.2 |
Genome annotation databases
Ensembli | ENST00000290294; ENSP00000290294; ENSG00000159182 |
GeneIDi | 84366 |
KEGGi | hsa:84366 |
UCSCi | uc002iny.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF331165 mRNA Translation: AAK38837.1 AC091179 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94717.1 BC030950 mRNA Translation: AAH30950.1 |
CCDSi | CCDS11535.1 |
RefSeqi | NP_115767.1, NM_032391.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000290294 |
PTM databases
iPTMneti | Q96KF2 |
PhosphoSitePlusi | Q96KF2 |
Polymorphism and mutation databases
BioMutai | PRAC1 |
Proteomic databases
PaxDbi | Q96KF2 |
PRIDEi | Q96KF2 |
ProteomicsDBi | 77065 |
Protocols and materials databases
Antibodypediai | 45201, 79 antibodies |
Genome annotation databases
Ensembli | ENST00000290294; ENSP00000290294; ENSG00000159182 |
GeneIDi | 84366 |
KEGGi | hsa:84366 |
UCSCi | uc002iny.4, human |
Organism-specific databases
CTDi | 84366 |
DisGeNETi | 84366 |
EuPathDBi | HostDB:ENSG00000159182.4 |
GeneCardsi | PRAC1 |
HGNCi | HGNC:30591, PRAC1 |
HPAi | ENSG00000159182, Group enriched (intestine, prostate) |
MIMi | 609819, gene |
neXtProti | NX_Q96KF2 |
OpenTargetsi | ENSG00000159182 |
PharmGKBi | PA164725009 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502TEAX, Eukaryota |
GeneTreei | ENSGT00940000165611 |
HOGENOMi | CLU_2995884_0_0_1 |
InParanoidi | Q96KF2 |
OMAi | RDGSACN |
PhylomeDBi | Q96KF2 |
TreeFami | TF341666 |
Enzyme and pathway databases
PathwayCommonsi | Q96KF2 |
Miscellaneous databases
BioGRID-ORCSi | 84366, 140 hits in 830 CRISPR screens |
ChiTaRSi | PRAC1, human |
GenomeRNAii | 84366 |
Pharosi | Q96KF2, Tbio |
PROi | PR:Q96KF2 |
RNActi | Q96KF2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000159182, Expressed in rectum and 67 other tissues |
Genevisiblei | Q96KF2, HS |
Family and domain databases
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PRAC1_HUMAN | |
Accessioni | Q96KF2Primary (citable) accession number: Q96KF2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 4, 2007 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations