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Entry version 101 (31 Jul 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Protein FAM71F1

Gene

FAM71F1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM71F1
Alternative name(s):
Protein FAM137A
Testis development protein NYD-SP18
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM71F1
Synonyms:FAM137A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30704 FAM71F1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96KD3

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84691

Open Targets

More...
OpenTargetsi
ENSG00000135248

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162387797

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM71F1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74716898

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003116911 – 344Protein FAM71F1Add BLAST344

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96KD3

PRoteomics IDEntifications database

More...
PRIDEi
Q96KD3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
72637
77061 [Q96KD3-1]
77062 [Q96KD3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96KD3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96KD3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000135248 Expressed in 77 organ(s), highest expression level in right testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96KD3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96KD3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA020636

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124206, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q96KD3, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000326652

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM71 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IJY2 Eukaryota
ENOG410YRY8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161477

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000148766

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96KD3

Identification of Orthologs from Complete Genome Data

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OMAi
CLVPKNS

Database of Orthologous Groups

More...
OrthoDBi
1360447at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96KD3

TreeFam database of animal gene trees

More...
TreeFami
TF336050

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR022168 DUF3699

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12480 DUF3699, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96KD3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSSFPHRKT WRKSKKTVKV TRSYPTFPSL NAWEEFRGLL PVDGEPNPGA
60 70 80 90 100
GLGVEEGLLC RVVHSPEFNL FLDSVVFESN FIQVKRGRNW RDVYKASNTM
110 120 130 140 150
ALGVTSSVPC LPLPNILLMA SVKWHQGQNQ TWNRPSIAPN IFLKRILPLR
160 170 180 190 200
FVELQVCDHY QRILQLRTVT EKIYYLKLHP DHPETVFHFW IRLVQILQKG
210 220 230 240 250
LSITTKDPRI LVTHCLVPKN CSSPSGDSKL VQKKLQASQP SESLIQLMTK
260 270 280 290 300
GESEALSQIF ADLHQQNQLS FRSSRKVETN KNSSGKDSSR EDSIPCTCDL
310 320 330 340
RWRASFTYGE WERENPSGLQ PLSLLSTLAA STGPQLAPPI GNSI
Length:344
Mass (Da):38,946
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i94CCE9753A43058A
GO
Isoform 2 (identifier: Q96KD3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     270-271: Missing.

Show »
Length:342
Mass (Da):38,712
Checksum:i3CD677E67B2A2D4B
GO
Isoform 3 (identifier: Q96KD3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: MLSSFPHRKT...GLLCRVVHSP → MELDGQKGQE...IHSPQHLPEE
     67-165: Missing.
     270-271: Missing.

Note: No experimental confirmation available.
Show »
Length:243
Mass (Da):27,034
Checksum:i2AC1CE10D0A8AB8C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WC62F8WC62_HUMAN
Protein FAM71F1
FAM71F1
286Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4R1H7C4R1_HUMAN
Protein FAM71F1
FAM71F1
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WC78F8WC78_HUMAN
Protein FAM71F1
FAM71F1
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037271228S → L. Corresponds to variant dbSNP:rs6949056Ensembl.1
Natural variantiVAR_037272242E → K. Corresponds to variant dbSNP:rs6971091Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0552701 – 66MLSSF…VVHSP → MELDGQKGQELERRLQSFQH HGPGGDLLGTLPAPPQHPTH GQCQMAPGAEPDMEQTIHSP QHLPEE in isoform 3. 1 PublicationAdd BLAST66
Alternative sequenceiVSP_05527167 – 165Missing in isoform 3. 1 PublicationAdd BLAST99
Alternative sequenceiVSP_029580270 – 271Missing in isoform 2 and isoform 3. 2 Publications2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF367470 mRNA Translation: AAK53406.1
AK093161 mRNA Translation: BAC04080.1
AC018638 Genomic DNA No translation available.
AC024952 Genomic DNA No translation available.
CH471070 Genomic DNA Translation: EAW83668.1
CH471070 Genomic DNA Translation: EAW83670.1
CH471070 Genomic DNA Translation: EAW83672.1
BC037248 mRNA Translation: AAH37248.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5804.1 [Q96KD3-1]
CCDS64763.1 [Q96KD3-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001269717.1, NM_001282788.1 [Q96KD3-2]
NP_001269718.1, NM_001282789.1 [Q96KD3-3]
NP_115988.1, NM_032599.3 [Q96KD3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000315184; ENSP00000326652; ENSG00000135248 [Q96KD3-1]
ENST00000485070; ENSP00000418192; ENSG00000135248 [Q96KD3-3]
ENST00000621392; ENSP00000477573; ENSG00000135248 [Q96KD3-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84691

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84691

UCSC genome browser

More...
UCSCi
uc003vnn.2 human [Q96KD3-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF367470 mRNA Translation: AAK53406.1
AK093161 mRNA Translation: BAC04080.1
AC018638 Genomic DNA No translation available.
AC024952 Genomic DNA No translation available.
CH471070 Genomic DNA Translation: EAW83668.1
CH471070 Genomic DNA Translation: EAW83670.1
CH471070 Genomic DNA Translation: EAW83672.1
BC037248 mRNA Translation: AAH37248.1
CCDSiCCDS5804.1 [Q96KD3-1]
CCDS64763.1 [Q96KD3-3]
RefSeqiNP_001269717.1, NM_001282788.1 [Q96KD3-2]
NP_001269718.1, NM_001282789.1 [Q96KD3-3]
NP_115988.1, NM_032599.3 [Q96KD3-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi124206, 2 interactors
IntActiQ96KD3, 2 interactors
STRINGi9606.ENSP00000326652

PTM databases

iPTMnetiQ96KD3
PhosphoSitePlusiQ96KD3

Polymorphism and mutation databases

BioMutaiFAM71F1
DMDMi74716898

Proteomic databases

PaxDbiQ96KD3
PRIDEiQ96KD3
ProteomicsDBi72637
77061 [Q96KD3-1]
77062 [Q96KD3-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
84691
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315184; ENSP00000326652; ENSG00000135248 [Q96KD3-1]
ENST00000485070; ENSP00000418192; ENSG00000135248 [Q96KD3-3]
ENST00000621392; ENSP00000477573; ENSG00000135248 [Q96KD3-3]
GeneIDi84691
KEGGihsa:84691
UCSCiuc003vnn.2 human [Q96KD3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84691
DisGeNETi84691

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAM71F1
HGNCiHGNC:30704 FAM71F1
HPAiHPA020636
neXtProtiNX_Q96KD3
OpenTargetsiENSG00000135248
PharmGKBiPA162387797

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJY2 Eukaryota
ENOG410YRY8 LUCA
GeneTreeiENSGT00940000161477
HOGENOMiHOG000148766
InParanoidiQ96KD3
OMAiCLVPKNS
OrthoDBi1360447at2759
PhylomeDBiQ96KD3
TreeFamiTF336050

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84691

Protein Ontology

More...
PROi
PR:Q96KD3

Gene expression databases

BgeeiENSG00000135248 Expressed in 77 organ(s), highest expression level in right testis
ExpressionAtlasiQ96KD3 baseline and differential
GenevisibleiQ96KD3 HS

Family and domain databases

InterProiView protein in InterPro
IPR022168 DUF3699
PfamiView protein in Pfam
PF12480 DUF3699, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF71F1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96KD3
Secondary accession number(s): Q8IY75, Q8NA48
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 1, 2001
Last modified: July 31, 2019
This is version 101 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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