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Entry version 97 (18 Sep 2019)
Sequence version 3 (11 Jan 2011)
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Protein

Calcium-binding and spermatid-specific protein 1

Gene

CABS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • spermatogenesis Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcium-binding and spermatid-specific protein 1
Alternative name(s):
Testis development protein NYD-SP26
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CABS1
Synonyms:C4orf35
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:30710 CABS1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96KC9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Flagellum, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
85438

Open Targets

More...
OpenTargetsi
ENSG00000145309

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162379775

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CABS1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373451

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003391781 – 395Calcium-binding and spermatid-specific protein 1Add BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei273PhosphoserineBy similarity1
Modified residuei287Phosphothreonine; by CK2By similarity1
Modified residuei319PhosphoserineBy similarity1
Modified residuei376PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96KC9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96KC9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96KC9

PeptideAtlas

More...
PeptideAtlasi
Q96KC9

PRoteomics IDEntifications database

More...
PRIDEi
Q96KC9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
77060

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96KC9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000145309 Expressed in 21 organ(s), highest expression level in sperm

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96KC9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA044016
HPA055352

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124525, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q96KC9, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000273936

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96KC9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410INTR Eukaryota
ENOG4111EGF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015647

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96KC9

Identification of Orthologs from Complete Genome Data

More...
OMAi
KIYSHPP

Database of Orthologous Groups

More...
OrthoDBi
1176309at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96KC9

TreeFam database of animal gene trees

More...
TreeFami
TF338174

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026118 Ca-bd_spermatid

The PANTHER Classification System

More...
PANTHERi
PTHR22810 PTHR22810, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15367 CABS1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q96KC9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEDGLPKIY SHPPTESSKT PTAATIFFGA DNAIPKSETT ITSEGDHVTS
60 70 80 90 100
VNEYMLESDF STTTDNKLTA KKEKLKSEDD MGTDFIKSTT HLQKEITSLT
110 120 130 140 150
GTTNSITRDS ITEHFMPVKI GNISSPVTTV SLIDFSTDIA KEDILLATID
160 170 180 190 200
TGDAEISITS EVSGTLKDSS AGVADAPAFP RKKDEADMSN YNSSIKSNVP
210 220 230 240 250
ADEAVQVTDS TIPEAEIPPA PEESFTTIPD ITALEEEKIT EIDLSVLEDD
260 270 280 290 300
TSAVATLTDS DEKFITVFEL TTSAEKDKDK REDTLLTDEE TTEGASIWME
310 320 330 340 350
RDTANEAETH SVLLTAVESR YDFVVPASIA TNLVEESSTE EDLSETDNTE
360 370 380 390
TVPKITEPFS GTTSVLDTPD YKEDTSTTET DIFELLKEEP DEFMI
Length:395
Mass (Da):43,003
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i92165DC845F00BBB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04392476K → Q. Corresponds to variant dbSNP:rs3796706Ensembl.1
Natural variantiVAR_043925211T → I3 PublicationsCorresponds to variant dbSNP:rs1351419Ensembl.1
Natural variantiVAR_043926298W → G1 PublicationCorresponds to variant dbSNP:rs2291182Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF380838 mRNA Translation: AAK57455.1
AK057459 mRNA Translation: BAB71497.1
AK315022 mRNA Translation: BAG37512.1
AC106884 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05615.1
BC046111 mRNA Translation: AAH46111.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3539.1

NCBI Reference Sequences

More...
RefSeqi
NP_149113.3, NM_033122.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000273936; ENSP00000273936; ENSG00000145309

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
85438

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:85438

UCSC genome browser

More...
UCSCi
uc003hff.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380838 mRNA Translation: AAK57455.1
AK057459 mRNA Translation: BAB71497.1
AK315022 mRNA Translation: BAG37512.1
AC106884 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05615.1
BC046111 mRNA Translation: AAH46111.1
CCDSiCCDS3539.1
RefSeqiNP_149113.3, NM_033122.3

3D structure databases

SMRiQ96KC9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi124525, 9 interactors
IntActiQ96KC9, 7 interactors
STRINGi9606.ENSP00000273936

PTM databases

PhosphoSitePlusiQ96KC9

Polymorphism and mutation databases

BioMutaiCABS1
DMDMi317373451

Proteomic databases

jPOSTiQ96KC9
MassIVEiQ96KC9
PaxDbiQ96KC9
PeptideAtlasiQ96KC9
PRIDEiQ96KC9
ProteomicsDBi77060

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
85438
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273936; ENSP00000273936; ENSG00000145309
GeneIDi85438
KEGGihsa:85438
UCSCiuc003hff.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
85438
DisGeNETi85438

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CABS1
HGNCiHGNC:30710 CABS1
HPAiHPA044016
HPA055352
neXtProtiNX_Q96KC9
OpenTargetsiENSG00000145309
PharmGKBiPA162379775

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410INTR Eukaryota
ENOG4111EGF LUCA
GeneTreeiENSGT00390000015647
InParanoidiQ96KC9
OMAiKIYSHPP
OrthoDBi1176309at2759
PhylomeDBiQ96KC9
TreeFamiTF338174

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
85438

Pharos

More...
Pharosi
Q96KC9

Protein Ontology

More...
PROi
PR:Q96KC9

Gene expression databases

BgeeiENSG00000145309 Expressed in 21 organ(s), highest expression level in sperm
GenevisibleiQ96KC9 HS

Family and domain databases

InterProiView protein in InterPro
IPR026118 Ca-bd_spermatid
PANTHERiPTHR22810 PTHR22810, 3 hits
PfamiView protein in Pfam
PF15367 CABS1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCABS1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96KC9
Secondary accession number(s): B2RCB5, Q86UE0, Q96M17
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: January 11, 2011
Last modified: September 18, 2019
This is version 97 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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