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Protein

DnaJ homolog subfamily C member 1

Gene

DNAJC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May modulate protein synthesis.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 1
Alternative name(s):
DnaJ protein homolog MTJ1
Gene namesi
Name:DNAJC1
Synonyms:HTJ1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000136770.10
HGNCiHGNC:20090 DNAJC1
MIMi611207 gene
neXtProtiNX_Q96KC8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini48 – 153LumenalBy similarityAdd BLAST106
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Topological domaini175 – 554CytoplasmicBy similarityAdd BLAST380

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi64215
OpenTargetsiENSG00000136770
PharmGKBiPA128394706

Polymorphism and mutation databases

BioMutaiDNAJC1
DMDMi27805464

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 47Sequence analysisAdd BLAST47
ChainiPRO_000007104248 – 554DnaJ homolog subfamily C member 1Add BLAST507

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei381PhosphoserineCombined sources1
Modified residuei430PhosphoserineCombined sources1
Modified residuei479PhosphoserineCombined sources1
Modified residuei480PhosphoserineCombined sources1
Modified residuei484PhosphoserineCombined sources1
Modified residuei492PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96KC8
MaxQBiQ96KC8
PaxDbiQ96KC8
PeptideAtlasiQ96KC8
PRIDEiQ96KC8
ProteomicsDBi77059

PTM databases

iPTMnetiQ96KC8
PhosphoSitePlusiQ96KC8

Expressioni

Gene expression databases

BgeeiENSG00000136770 Expressed in 228 organ(s), highest expression level in secondary oocyte
CleanExiHS_DNAJC1
ExpressionAtlasiQ96KC8 baseline and differential
GenevisibleiQ96KC8 HS

Organism-specific databases

HPAiHPA013432

Interactioni

Subunit structurei

Interacts (via J domain) with HSPA5. Interacts (via cytosolic domain) with ribosomes (By similarity). Interacts (via SANT 2 domain) with SERPINA3; the interaction delays the formation of the covalent inhibitory complex SERPINA3-chymotrypsin, but does not alter the catalytic activity of SERPINA3. Interacts (via SANT 2 domain) with ITIH4 (via C-terminus); the interaction protects ITIH4 against in vitro cleavage by kallikrein.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SERPINA3P010113EBI-296550,EBI-296557

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122105, 29 interactors
IntActiQ96KC8, 14 interactors
MINTiQ96KC8
STRINGi9606.ENSP00000366179

Structurei

Secondary structure

1554
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ96KC8
SMRiQ96KC8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96KC8

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 129JPROSITE-ProRule annotationAdd BLAST65
Domaini325 – 379SANT 1PROSITE-ProRule annotationAdd BLAST55
Domaini492 – 547SANT 2PROSITE-ProRule annotationAdd BLAST56

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410INV7 Eukaryota
COG2214 LUCA
GeneTreeiENSGT00530000063419
HOGENOMiHOG000231867
HOVERGENiHBG051374
InParanoidiQ96KC8
KOiK09521
OMAiPNWRSAV
OrthoDBiEOG091G0I6J
PhylomeDBiQ96KC8
TreeFamiTF105161

Family and domain databases

CDDicd06257 DnaJ, 1 hit
cd00167 SANT, 2 hits
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR018253 DnaJ_domain_CS
IPR009057 Homeobox-like_sf
IPR036869 J_dom_sf
IPR001005 SANT/Myb
IPR017884 SANT_dom
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF00249 Myb_DNA-binding, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SM00717 SANT, 2 hits
SUPFAMiSSF46565 SSF46565, 1 hit
SSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS00636 DNAJ_1, 1 hit
PS50076 DNAJ_2, 1 hit
PS51293 SANT, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q96KC8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTAPCSQPAQ LPGRRQLGLV PFPPPPPRTP LLWLLLLLLA AVAPARGWES
60 70 80 90 100
GDLELFDLVE EVQLNFYQFL GVQQDASSAD IRKAYRKLSL TLHPDKNKDE
110 120 130 140 150
NAETQFRQLV AIYEVLKDDE RRQRYDDILI NGLPDWRQPV FYYRRVRKMS
160 170 180 190 200
NAELALLLFI ILTVGHYAVV WSIYLEKQLD ELLSRKKREK KKKTGSKSVD
210 220 230 240 250
VSKLGASEKN ERLLMKPQWH DLLPCKLGIW FCLTLKALPH LIQDAGQFYA
260 270 280 290 300
KYKETRLKEK EDALTRTELE TLQKQKKVKK PKPEFPVYTP LETTYIQSYD
310 320 330 340 350
HGTSIEEIEE QMDDWLENRN RTQKKQAPEW TEEDLSQLTR SMVKFPGGTP
360 370 380 390 400
GRWEKIAHEL GRSVTDVTTK AKQLKDSVTC SPGMVRLSEL KSTVQNSRPI
410 420 430 440 450
KTATTLPDDM ITQREDAEGV AAEEEQEGDS GEQETGATDA RPRRRKPARL
460 470 480 490 500
LEATAKPEPE EKSRAKRQKD FDIAEQNESS DEESLRKERA RSAEEPWTQN
510 520 530 540 550
QQKLLELALQ QYPRGSSDRW DKIARCVPSK SKEDCIARYK LLVELVQKKK

QAKS
Length:554
Mass (Da):63,883
Last modified:December 1, 2001 - v1
Checksum:i65EAAB16C65E2B46
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T1X2Q5T1X2_HUMAN
DnaJ homolog subfamily C member 1 v...
DNAJC1
109Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY225122 mRNA Translation: AAP50497.1
AK026062 mRNA Translation: BAB15343.1
AK027263 mRNA Translation: BAB55004.1
EF444973 Genomic DNA Translation: ACA05978.1
EF444973 Genomic DNA Translation: ACA05979.1
AL445431 Genomic DNA No translation available.
AL359697 Genomic DNA No translation available.
BC110894 mRNA Translation: AAI10895.1
CCDSiCCDS7136.1
RefSeqiNP_071760.2, NM_022365.3
UniGeneiHs.499000

Genome annotation databases

EnsembliENST00000376980; ENSP00000366179; ENSG00000136770
GeneIDi64215
KEGGihsa:64215
UCSCiuc001irc.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY225122 mRNA Translation: AAP50497.1
AK026062 mRNA Translation: BAB15343.1
AK027263 mRNA Translation: BAB55004.1
EF444973 Genomic DNA Translation: ACA05978.1
EF444973 Genomic DNA Translation: ACA05979.1
AL445431 Genomic DNA No translation available.
AL359697 Genomic DNA No translation available.
BC110894 mRNA Translation: AAI10895.1
CCDSiCCDS7136.1
RefSeqiNP_071760.2, NM_022365.3
UniGeneiHs.499000

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CQQNMR-A327-385[»]
2CQRNMR-A484-543[»]
ProteinModelPortaliQ96KC8
SMRiQ96KC8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122105, 29 interactors
IntActiQ96KC8, 14 interactors
MINTiQ96KC8
STRINGi9606.ENSP00000366179

PTM databases

iPTMnetiQ96KC8
PhosphoSitePlusiQ96KC8

Polymorphism and mutation databases

BioMutaiDNAJC1
DMDMi27805464

Proteomic databases

EPDiQ96KC8
MaxQBiQ96KC8
PaxDbiQ96KC8
PeptideAtlasiQ96KC8
PRIDEiQ96KC8
ProteomicsDBi77059

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376980; ENSP00000366179; ENSG00000136770
GeneIDi64215
KEGGihsa:64215
UCSCiuc001irc.4 human

Organism-specific databases

CTDi64215
DisGeNETi64215
EuPathDBiHostDB:ENSG00000136770.10
GeneCardsiDNAJC1
HGNCiHGNC:20090 DNAJC1
HPAiHPA013432
MIMi611207 gene
neXtProtiNX_Q96KC8
OpenTargetsiENSG00000136770
PharmGKBiPA128394706
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INV7 Eukaryota
COG2214 LUCA
GeneTreeiENSGT00530000063419
HOGENOMiHOG000231867
HOVERGENiHBG051374
InParanoidiQ96KC8
KOiK09521
OMAiPNWRSAV
OrthoDBiEOG091G0I6J
PhylomeDBiQ96KC8
TreeFamiTF105161

Miscellaneous databases

ChiTaRSiDNAJC1 human
EvolutionaryTraceiQ96KC8
GeneWikiiDNAJC1
GenomeRNAii64215
PROiPR:Q96KC8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136770 Expressed in 228 organ(s), highest expression level in secondary oocyte
CleanExiHS_DNAJC1
ExpressionAtlasiQ96KC8 baseline and differential
GenevisibleiQ96KC8 HS

Family and domain databases

CDDicd06257 DnaJ, 1 hit
cd00167 SANT, 2 hits
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR018253 DnaJ_domain_CS
IPR009057 Homeobox-like_sf
IPR036869 J_dom_sf
IPR001005 SANT/Myb
IPR017884 SANT_dom
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF00249 Myb_DNA-binding, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SM00717 SANT, 2 hits
SUPFAMiSSF46565 SSF46565, 1 hit
SSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS00636 DNAJ_1, 1 hit
PS50076 DNAJ_2, 1 hit
PS51293 SANT, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiDNJC1_HUMAN
AccessioniPrimary (citable) accession number: Q96KC8
Secondary accession number(s): B0YIZ8, Q5VX89, Q9H6B8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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