UniProtKB - Q96KC8 (DNJC1_HUMAN)
DnaJ homolog subfamily C member 1
DNAJC1
Functioni
May modulate protein synthesis.
By similarityGO - Molecular functioni
- ATPase activator activity Source: UniProtKB
- chaperone binding Source: Ensembl
- DNA binding Source: UniProtKB-KW
GO - Biological processi
- negative regulation of proteolysis Source: UniProtKB
- protein folding Source: Ensembl
- regulation of protein secretion Source: UniProtKB
- regulation of translation Source: Ensembl
Keywordsi
Molecular function | Chaperone, DNA-binding |
Enzyme and pathway databases
PathwayCommonsi | Q96KC8 |
SignaLinki | Q96KC8 |
Names & Taxonomyi
Protein namesi | Recommended name: DnaJ homolog subfamily C member 1Alternative name(s): DnaJ protein homolog MTJ1 |
Gene namesi | Name:DNAJC1 Synonyms:HTJ1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20090, DNAJC1 |
MIMi | 611207, gene |
neXtProti | NX_Q96KC8 |
VEuPathDBi | HostDB:ENSG00000136770 |
Subcellular locationi
Nucleus
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity
- Microsome membrane By similarity; Single-pass type I membrane protein By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Nucleus
- nuclear membrane Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: Ensembl
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 48 – 153 | LumenalBy similarityAdd BLAST | 106 | |
Transmembranei | 154 – 174 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 175 – 554 | CytoplasmicBy similarityAdd BLAST | 380 |
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, Microsome, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 64215 |
OpenTargetsi | ENSG00000136770 |
PharmGKBi | PA128394706 |
Miscellaneous databases
Pharosi | Q96KC8, Tbio |
Genetic variation databases
BioMutai | DNAJC1 |
DMDMi | 27805464 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 47 | Sequence analysisAdd BLAST | 47 | |
ChainiPRO_0000071042 | 48 – 554 | DnaJ homolog subfamily C member 1Add BLAST | 507 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 381 | PhosphoserineCombined sources | 1 | |
Modified residuei | 430 | PhosphoserineCombined sources | 1 | |
Modified residuei | 479 | PhosphoserineCombined sources | 1 | |
Modified residuei | 480 | PhosphoserineCombined sources | 1 | |
Modified residuei | 484 | PhosphoserineCombined sources | 1 | |
Modified residuei | 492 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q96KC8 |
jPOSTi | Q96KC8 |
MassIVEi | Q96KC8 |
MaxQBi | Q96KC8 |
PaxDbi | Q96KC8 |
PeptideAtlasi | Q96KC8 |
PRIDEi | Q96KC8 |
ProteomicsDBi | 77059 |
PTM databases
iPTMneti | Q96KC8 |
MetOSitei | Q96KC8 |
PhosphoSitePlusi | Q96KC8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000136770, Expressed in secondary oocyte and 241 other tissues |
ExpressionAtlasi | Q96KC8, baseline and differential |
Genevisiblei | Q96KC8, HS |
Organism-specific databases
HPAi | ENSG00000136770, Low tissue specificity |
Interactioni
Subunit structurei
Interacts (via J domain) with HSPA5.
Interacts (via cytosolic domain) with ribosomes (By similarity).
Interacts (via SANT 2 domain) with SERPINA3; the interaction delays the formation of the covalent inhibitory complex SERPINA3-chymotrypsin, but does not alter the catalytic activity of SERPINA3.
Interacts (via SANT 2 domain) with ITIH4 (via C-terminus); the interaction protects ITIH4 against in vitro cleavage by kallikrein.
By similarity1 PublicationBinary interactionsi
Q96KC8
GO - Molecular functioni
- chaperone binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 122105, 359 interactors |
IntActi | Q96KC8, 36 interactors |
MINTi | Q96KC8 |
STRINGi | 9606.ENSP00000366179 |
Miscellaneous databases
RNActi | Q96KC8, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q96KC8 |
SMRi | Q96KC8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q96KC8 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 65 – 129 | JPROSITE-ProRule annotationAdd BLAST | 65 | |
Domaini | 325 – 379 | SANT 1PROSITE-ProRule annotationAdd BLAST | 55 | |
Domaini | 492 – 547 | SANT 2PROSITE-ProRule annotationAdd BLAST | 56 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 392 – 500 | DisorderedSequence analysisAdd BLAST | 109 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 392 – 409 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 434 – 494 | Basic and acidic residuesSequence analysisAdd BLAST | 61 |
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0724, Eukaryota |
GeneTreei | ENSGT00940000156678 |
HOGENOMi | CLU_036945_2_0_1 |
InParanoidi | Q96KC8 |
OMAi | KEECVAR |
OrthoDBi | 972481at2759 |
PhylomeDBi | Q96KC8 |
TreeFami | TF105161 |
Family and domain databases
CDDi | cd06257, DnaJ, 1 hit cd00167, SANT, 2 hits |
Gene3Di | 1.10.287.110, 1 hit |
InterProi | View protein in InterPro IPR001623, DnaJ_domain IPR018253, DnaJ_domain_CS IPR009057, Homeobox-like_sf IPR036869, J_dom_sf IPR017930, Myb_dom IPR001005, SANT/Myb IPR017884, SANT_dom |
Pfami | View protein in Pfam PF00226, DnaJ, 1 hit PF00249, Myb_DNA-binding, 1 hit |
PRINTSi | PR00625, JDOMAIN |
SMARTi | View protein in SMART SM00271, DnaJ, 1 hit SM00717, SANT, 2 hits |
SUPFAMi | SSF46565, SSF46565, 1 hit SSF46689, SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS00636, DNAJ_1, 1 hit PS50076, DNAJ_2, 1 hit PS51293, SANT, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MTAPCSQPAQ LPGRRQLGLV PFPPPPPRTP LLWLLLLLLA AVAPARGWES
60 70 80 90 100
GDLELFDLVE EVQLNFYQFL GVQQDASSAD IRKAYRKLSL TLHPDKNKDE
110 120 130 140 150
NAETQFRQLV AIYEVLKDDE RRQRYDDILI NGLPDWRQPV FYYRRVRKMS
160 170 180 190 200
NAELALLLFI ILTVGHYAVV WSIYLEKQLD ELLSRKKREK KKKTGSKSVD
210 220 230 240 250
VSKLGASEKN ERLLMKPQWH DLLPCKLGIW FCLTLKALPH LIQDAGQFYA
260 270 280 290 300
KYKETRLKEK EDALTRTELE TLQKQKKVKK PKPEFPVYTP LETTYIQSYD
310 320 330 340 350
HGTSIEEIEE QMDDWLENRN RTQKKQAPEW TEEDLSQLTR SMVKFPGGTP
360 370 380 390 400
GRWEKIAHEL GRSVTDVTTK AKQLKDSVTC SPGMVRLSEL KSTVQNSRPI
410 420 430 440 450
KTATTLPDDM ITQREDAEGV AAEEEQEGDS GEQETGATDA RPRRRKPARL
460 470 480 490 500
LEATAKPEPE EKSRAKRQKD FDIAEQNESS DEESLRKERA RSAEEPWTQN
510 520 530 540 550
QQKLLELALQ QYPRGSSDRW DKIARCVPSK SKEDCIARYK LLVELVQKKK
QAKS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ5T1X2 | Q5T1X2_HUMAN | DnaJ homolog subfamily C member 1 | DNAJC1 | 109 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY225122 mRNA Translation: AAP50497.1 AK026062 mRNA Translation: BAB15343.1 AK027263 mRNA Translation: BAB55004.1 EF444973 Genomic DNA Translation: ACA05978.1 EF444973 Genomic DNA Translation: ACA05979.1 AL445431 Genomic DNA No translation available. AL359697 Genomic DNA No translation available. BC110894 mRNA Translation: AAI10895.1 |
CCDSi | CCDS7136.1 |
RefSeqi | NP_071760.2, NM_022365.3 |
Genome annotation databases
Ensembli | ENST00000376980.8; ENSP00000366179.3; ENSG00000136770.11 |
GeneIDi | 64215 |
KEGGi | hsa:64215 |
MANE-Selecti | ENST00000376980.8; ENSP00000366179.3; NM_022365.4; NP_071760.2 |
UCSCi | uc001irc.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY225122 mRNA Translation: AAP50497.1 AK026062 mRNA Translation: BAB15343.1 AK027263 mRNA Translation: BAB55004.1 EF444973 Genomic DNA Translation: ACA05978.1 EF444973 Genomic DNA Translation: ACA05979.1 AL445431 Genomic DNA No translation available. AL359697 Genomic DNA No translation available. BC110894 mRNA Translation: AAI10895.1 |
CCDSi | CCDS7136.1 |
RefSeqi | NP_071760.2, NM_022365.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CQQ | NMR | - | A | 327-385 | [»] | |
2CQR | NMR | - | A | 484-543 | [»] | |
AlphaFoldDBi | Q96KC8 | |||||
SMRi | Q96KC8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 122105, 359 interactors |
IntActi | Q96KC8, 36 interactors |
MINTi | Q96KC8 |
STRINGi | 9606.ENSP00000366179 |
PTM databases
iPTMneti | Q96KC8 |
MetOSitei | Q96KC8 |
PhosphoSitePlusi | Q96KC8 |
Genetic variation databases
BioMutai | DNAJC1 |
DMDMi | 27805464 |
Proteomic databases
EPDi | Q96KC8 |
jPOSTi | Q96KC8 |
MassIVEi | Q96KC8 |
MaxQBi | Q96KC8 |
PaxDbi | Q96KC8 |
PeptideAtlasi | Q96KC8 |
PRIDEi | Q96KC8 |
ProteomicsDBi | 77059 |
Protocols and materials databases
Antibodypediai | 2466, 87 antibodies from 24 providers |
DNASUi | 64215 |
Genome annotation databases
Ensembli | ENST00000376980.8; ENSP00000366179.3; ENSG00000136770.11 |
GeneIDi | 64215 |
KEGGi | hsa:64215 |
MANE-Selecti | ENST00000376980.8; ENSP00000366179.3; NM_022365.4; NP_071760.2 |
UCSCi | uc001irc.4, human |
Organism-specific databases
CTDi | 64215 |
DisGeNETi | 64215 |
GeneCardsi | DNAJC1 |
HGNCi | HGNC:20090, DNAJC1 |
HPAi | ENSG00000136770, Low tissue specificity |
MIMi | 611207, gene |
neXtProti | NX_Q96KC8 |
OpenTargetsi | ENSG00000136770 |
PharmGKBi | PA128394706 |
VEuPathDBi | HostDB:ENSG00000136770 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0724, Eukaryota |
GeneTreei | ENSGT00940000156678 |
HOGENOMi | CLU_036945_2_0_1 |
InParanoidi | Q96KC8 |
OMAi | KEECVAR |
OrthoDBi | 972481at2759 |
PhylomeDBi | Q96KC8 |
TreeFami | TF105161 |
Enzyme and pathway databases
PathwayCommonsi | Q96KC8 |
SignaLinki | Q96KC8 |
Miscellaneous databases
BioGRID-ORCSi | 64215, 5 hits in 1098 CRISPR screens |
ChiTaRSi | DNAJC1, human |
EvolutionaryTracei | Q96KC8 |
GeneWikii | DNAJC1 |
GenomeRNAii | 64215 |
Pharosi | Q96KC8, Tbio |
PROi | PR:Q96KC8 |
RNActi | Q96KC8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000136770, Expressed in secondary oocyte and 241 other tissues |
ExpressionAtlasi | Q96KC8, baseline and differential |
Genevisiblei | Q96KC8, HS |
Family and domain databases
CDDi | cd06257, DnaJ, 1 hit cd00167, SANT, 2 hits |
Gene3Di | 1.10.287.110, 1 hit |
InterProi | View protein in InterPro IPR001623, DnaJ_domain IPR018253, DnaJ_domain_CS IPR009057, Homeobox-like_sf IPR036869, J_dom_sf IPR017930, Myb_dom IPR001005, SANT/Myb IPR017884, SANT_dom |
Pfami | View protein in Pfam PF00226, DnaJ, 1 hit PF00249, Myb_DNA-binding, 1 hit |
PRINTSi | PR00625, JDOMAIN |
SMARTi | View protein in SMART SM00271, DnaJ, 1 hit SM00717, SANT, 2 hits |
SUPFAMi | SSF46565, SSF46565, 1 hit SSF46689, SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS00636, DNAJ_1, 1 hit PS50076, DNAJ_2, 1 hit PS51293, SANT, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | DNJC1_HUMAN | |
Accessioni | Q96KC8Primary (citable) accession number: Q96KC8 Secondary accession number(s): B0YIZ8, Q5VX89, Q9H6B8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 17, 2003 |
Last sequence update: | December 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 176 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references