PBK

Functionⁱ

Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.2 Publications

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Activity regulationⁱ

Activated by phosphorylation.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	64	ATPPROSITE-ProRule annotation		1
Active siteⁱ	167	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	38 – 46	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
protein serine/threonine kinase activity
Source: UniProtKB
Traceable author statementⁱ
- 10779557

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to UV Source: Ensembl
mitotic cell cycle
Source: UniProtKB
Non-traceable author statementⁱ
- 10779557
negative regulation of inflammatory response Source: Ensembl
negative regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
negative regulation of stress-activated MAPK cascade Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkⁱ	Q96KB5
SIGNORⁱ	Q96KB5

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Lymphokine-activated killer T-cell-originated protein kinase (EC:2.7.12.2) Alternative name(s): Cancer/testis antigen 84 Short name: CT84 MAPKK-like protein kinase Nori-3 PDZ-binding kinase Spermatogenesis-related protein kinase Short name: SPK T-LAK cell-originated protein kinase
Gene namesⁱ	Name:PBK Synonyms:TOPK
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000168078.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18282 PBK
MIMⁱ	611210 gene
neXtProtⁱ	NX_Q96KB5

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	9	T → E: TP53-binding. 1 Publication	1
Mutagenesisⁱ	64 – 65	KK → AA: Loss of activity. 1 Publication	2
Mutagenesisⁱ	320	T → A: Decrease in the binding to DLG1. 1 Publication	1
Mutagenesisⁱ	322	V → A: Decrease in the binding to DLG1. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	55872
Open Targets More...OpenTargetsⁱ	ENSG00000168078
PharmGKBⁱ	PA134925802

Chemistry databases

ChEMBLⁱ	CHEMBL4896
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2140

Polymorphism and mutation databases

BioMutaⁱ	PBK
DMDMⁱ	83305809

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000086763	1 – 322	Lymphokine-activated killer T-cell-originated protein kinaseAdd BLAST		322

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	9	PhosphothreonineCombined sources	1
Modified residueⁱ	24	PhosphothreonineCombined sources	1
Modified residueⁱ	32	PhosphoserineCombined sources	1
Modified residueⁱ	59	PhosphoserineCombined sources	1
Cross-linkⁱ	169	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationⁱ

Phosphorylated; in a cell-cycle dependent manner at mitosis.2 Publications

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q96KB5
PaxDbⁱ	Q96KB5
PeptideAtlas More...PeptideAtlasⁱ	Q96KB5
PRIDEⁱ	Q96KB5
ProteomicsDBⁱ	77056

PTM databases

iPTMnetⁱ	Q96KB5
PhosphoSitePlusⁱ	Q96KB5

Expressionⁱ

Tissue specificityⁱ

Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000168078 Expressed in 128 organ(s), highest expression level in sperm
CleanExⁱ	HS_PBK
ExpressionAtlasⁱ	Q96KB5 baseline and differential
Genevisibleⁱ	Q96KB5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA005753 HPA050656

HPAⁱ

HPA005753
HPA050656

Interactionⁱ

Subunit structureⁱ

Interacts with DLG1 and TP53.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ARAF	P10398	3	EBI-536853,EBI-365961
TP53	P04637	7	EBI-536853,EBI-366083

Protein-protein interaction databases

BioGridⁱ	120971, 31 interactors
IntActⁱ	Q96KB5, 12 interactors
Molecular INTeraction database More...MINTⁱ	Q96KB5
STRINGⁱ	9606.ENSP00000301905

Chemistry databases

BindingDBⁱ

Q96KB5

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	26 – 29	Combined sources	4
Helixⁱ	34 – 37	Combined sources	4
Beta strandⁱ	44 – 48	Combined sources	5
Helixⁱ	54 – 57	Combined sources	4
Helixⁱ	60 – 65	Combined sources	6
Helixⁱ	69 – 71	Combined sources	3
Helixⁱ	73 – 77	Combined sources	5
Beta strandⁱ	78 – 82	Combined sources	5
Helixⁱ	83 – 91	Combined sources	9
Beta strandⁱ	100 – 105	Combined sources	6
Beta strandⁱ	108 – 115	Combined sources	8
Beta strandⁱ	120 – 122	Combined sources	3
Helixⁱ	123 – 131	Combined sources	9
Turnⁱ	132 – 134	Combined sources	3
Helixⁱ	140 – 159	Combined sources	20
Helixⁱ	170 – 172	Combined sources	3
Beta strandⁱ	173 – 176	Combined sources	4
Turnⁱ	177 – 180	Combined sources	4
Beta strandⁱ	181 – 184	Combined sources	4
Beta strandⁱ	189 – 192	Combined sources	4
Helixⁱ	210 – 212	Combined sources	3
Helixⁱ	215 – 217	Combined sources	3
Beta strandⁱ	219 – 221	Combined sources	3
Helixⁱ	227 – 242	Combined sources	16
Beta strandⁱ	250 – 252	Combined sources	3
Turnⁱ	254 – 256	Combined sources	3
Helixⁱ	263 – 265	Combined sources	3
Helixⁱ	268 – 274	Combined sources	7
Turnⁱ	283 – 285	Combined sources	3
Helixⁱ	291 – 300	Combined sources	10
Helixⁱ	305 – 307	Combined sources	3
Helixⁱ	311 – 319	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	Q96KB5
SMRⁱ	Q96KB5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	32 – 322	Protein kinasePROSITE-ProRule annotationAdd BLAST		291

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	320 – 322	PDZ-interaction		3

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0192 Eukaryota COG0515 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00720000108839
HOGENOMⁱ	HOG000294208
HOVERGENⁱ	HBG056011
InParanoidⁱ	Q96KB5
KEGG Orthology (KO) More...KOⁱ	K08865
OMAⁱ	SMCLAME
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05V7
PhylomeDBⁱ	Q96KB5
TreeFamⁱ	TF329763

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR008271 Ser/Thr_kinase_AS IPR034368 TOPK
PANTHERⁱ	PTHR43289:SF3 PTHR43289:SF3, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q96KB5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGISNFKTP SKLSEKKKSV LCSTPTINIP ASPFMQKLGF GTGVNVYLMK 
        60         70         80         90        100
RSPRGLSHSP WAVKKINPIC NDHYRSVYQK RLMDEAKILK SLHHPNIVGY 
       110        120        130        140        150
RAFTEANDGS LCLAMEYGGE KSLNDLIEER YKASQDPFPA AIILKVALNM 
       160        170        180        190        200
ARGLKYLHQE KKLLHGDIKS SNVVIKGDFE TIKICDVGVS LPLDENMTVT 
       210        220        230        240        250
DPEACYIGTE PWKPKEAVEE NGVITDKADI FAFGLTLWEM MTLSIPHINL 
       260        270        280        290        300
SNDDDDEDKT FDESDFDDEA YYAALGTRPP INMEELDESY QKVIELFSVC 
       310        320 
TNEDPKDRPS AAHIVEALET DV

Length:322

Mass (Da):36,085

Last modified:December 6, 2005 - v3

Checksum:ⁱ6BF55789BC204ABE

GO

Isoform 2 (identifier: Q96KB5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
198-198: T → TAPAFITILLVS

« Hide

        10         20         30         40         50
MEGISNFKTP SKLSEKKKSV LCSTPTINIP ASPFMQKLGF GTGVNVYLMK 
        60         70         80         90        100
RSPRGLSHSP WAVKKINPIC NDHYRSVYQK RLMDEAKILK SLHHPNIVGY 
       110        120        130        140        150
RAFTEANDGS LCLAMEYGGE KSLNDLIEER YKASQDPFPA AIILKVALNM 
       160        170        180        190        200
ARGLKYLHQE KKLLHGDIKS SNVVIKGDFE TIKICDVGVS LPLDENMTAP 
       210        220        230        240        250
AFITILLVSV TDPEACYIGT EPWKPKEAVE ENGVITDKAD IFAFGLTLWE 
       260        270        280        290        300
MMTLSIPHIN LSNDDDDEDK TFDESDFDDE AYYAALGTRP PINMEELDES 
       310        320        330 
YQKVIELFSV CTNEDPKDRP SAAHIVEALE TDV

Note: No experimental confirmation available.

Show »

Length:333

Mass (Da):37,211

Checksum:ⁱ05A472E8DD4D9928

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E5RFX4	E5RFX4_HUMAN	Lymphokine-activated killer T-cell-... Lymphokine-activated killer T-cell-originated protein kinase	PBK	151	Annotation score:
E5RIE1	E5RIE1_HUMAN	Lymphokine-activated killer T-cell-... Lymphokine-activated killer T-cell-originated protein kinase	PBK	63	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	34	F → I in AAF71521 (PubMed:11378444).Curated	1
Sequence conflictⁱ	169	K → E in BAB55019 (PubMed:14702039).Curated	1
Sequence conflictⁱ	254	D → N in BAB55019 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_021162	107	N → S4 PublicationsCorresponds to variant dbSNP:rs3779620Ensembl.	1
Natural variantⁱVAR_051676	220	E → D. Corresponds to variant dbSNP:rs17057901Ensembl.	1
Natural variantⁱVAR_041234	241	M → L1 PublicationCorresponds to variant dbSNP:rs36086402Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_055269	198	T → TAPAFITILLVS in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB027249 mRNA Translation: BAA99576.1 AB027250 mRNA Translation: BAA99577.1 AF189722 mRNA Translation: AAF69107.1 AF237709 mRNA Translation: AAF71521.1 AK027291 mRNA Translation: BAB55019.1 AK301836 mRNA Translation: BAG63280.1 AC104997 Genomic DNA No translation available. CH471080 Genomic DNA Translation: EAW63536.1 CH471080 Genomic DNA Translation: EAW63537.1 BC015191 mRNA Translation: AAH15191.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6063.1 [Q96KB5-1] CCDS64858.1 [Q96KB5-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001265874.1, NM_001278945.1 [Q96KB5-2] NP_060962.2, NM_018492.3 [Q96KB5-1] XP_006716431.1, XM_006716368.2
UniGeneⁱ	Hs.104741

Genome annotation databases

Ensemblⁱ	ENST00000301905; ENSP00000301905; ENSG00000168078 [Q96KB5-1] ENST00000522944; ENSP00000428489; ENSG00000168078 [Q96KB5-2]
GeneIDⁱ	55872
KEGGⁱ	hsa:55872
UCSC genome browser More...UCSCⁱ	uc011lap.4 human [Q96KB5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q96KB5	Epididymis luminal protein 164		HUMAN		322	UniRef100_Q96KB5
Q96KB5-2	Lymphokine-activated killer T-cell-originated protein kinase (Fragment)		HUMAN		151	UniRef100_Q96KB5-2

Protein	Similar proteins		Species	Score	Length	Source
Q96KB5	Epididymis luminal protein 164		HUMAN		322	UniRef90_Q96KB5
PDZ binding kinase		HORSE		324
lymphokine-activated killer T-cell-originated protein kinase		URSMA		324
Uncharacterized protein		FELCA		324
Uncharacterized protein		CANLF		323
+54
Q96KB5-2	Lymphokine-activated killer T-cell-originated protein kinase (Fragment)		HUMAN		151	UniRef90_Q96KB5-2
Uncharacterized protein		RHIRO		338
Uncharacterized protein		COLAP		335
PBK isoform 4 (Fragment)		PONAB		151
Uncharacterized protein		PAPAN		335
+72

Protein	Similar proteins		Species	Score	Length	Source
Q96KB5	Lymphokine-activated killer T-cell-originated protein kinase		MOUSE		330	UniRef50_Q96KB5
Epididymis luminal protein 164		HUMAN		322
Uncharacterized protein		FELCA		324
PDZ binding kinase		HORSE		324
lymphokine-activated killer T-cell-originated protein kinase		URSMA		324
+258

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB027249 mRNA Translation: BAA99576.1 AB027250 mRNA Translation: BAA99577.1 AF189722 mRNA Translation: AAF69107.1 AF237709 mRNA Translation: AAF71521.1 AK027291 mRNA Translation: BAB55019.1 AK301836 mRNA Translation: BAG63280.1 AC104997 Genomic DNA No translation available. CH471080 Genomic DNA Translation: EAW63536.1 CH471080 Genomic DNA Translation: EAW63537.1 BC015191 mRNA Translation: AAH15191.1
CCDSⁱ	CCDS6063.1 [Q96KB5-1] CCDS64858.1 [Q96KB5-2]
RefSeqⁱ	NP_001265874.1, NM_001278945.1 [Q96KB5-2] NP_060962.2, NM_018492.3 [Q96KB5-1] XP_006716431.1, XM_006716368.2
UniGeneⁱ	Hs.104741

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5J0A	X-ray	2.74	A	23-320	[»]
				B	19-319	[»]
ProteinModelPortalⁱ	Q96KB5
SMRⁱ	Q96KB5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120971, 31 interactors
IntActⁱ	Q96KB5, 12 interactors
MINTⁱ	Q96KB5
STRINGⁱ	9606.ENSP00000301905

Chemistry databases

BindingDBⁱ	Q96KB5
ChEMBLⁱ	CHEMBL4896
GuidetoPHARMACOLOGYⁱ	2140

PTM databases

iPTMnetⁱ	Q96KB5
PhosphoSitePlusⁱ	Q96KB5

Polymorphism and mutation databases

BioMutaⁱ	PBK
DMDMⁱ	83305809

Proteomic databases

EPDⁱ	Q96KB5
PaxDbⁱ	Q96KB5
PeptideAtlasⁱ	Q96KB5
PRIDEⁱ	Q96KB5
ProteomicsDBⁱ	77056

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	55872
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000301905; ENSP00000301905; ENSG00000168078 [Q96KB5-1] ENST00000522944; ENSP00000428489; ENSG00000168078 [Q96KB5-2]
GeneIDⁱ	55872
KEGGⁱ	hsa:55872
UCSCⁱ	uc011lap.4 human [Q96KB5-1]

Organism-specific databases

CTDⁱ	55872
DisGeNETⁱ	55872
EuPathDBⁱ	HostDB:ENSG00000168078.9
GeneCardsⁱ	PBK
HGNCⁱ	HGNC:18282 PBK
HPAⁱ	HPA005753 HPA050656
MIMⁱ	611210 gene
neXtProtⁱ	NX_Q96KB5
OpenTargetsⁱ	ENSG00000168078
PharmGKBⁱ	PA134925802
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0192 Eukaryota COG0515 LUCA
GeneTreeⁱ	ENSGT00720000108839
HOGENOMⁱ	HOG000294208
HOVERGENⁱ	HBG056011
InParanoidⁱ	Q96KB5
KOⁱ	K08865
OMAⁱ	SMCLAME
OrthoDBⁱ	EOG091G05V7
PhylomeDBⁱ	Q96KB5
TreeFamⁱ	TF329763

Enzyme and pathway databases

SignaLinkⁱ	Q96KB5
SIGNORⁱ	Q96KB5

Miscellaneous databases

ChiTaRSⁱ	PBK human
GeneWikiⁱ	PBK_(gene)
GenomeRNAiⁱ	55872
Protein Ontology More...PROⁱ	PR:Q96KB5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000168078 Expressed in 128 organ(s), highest expression level in sperm
CleanExⁱ	HS_PBK
ExpressionAtlasⁱ	Q96KB5 baseline and differential
Genevisibleⁱ	Q96KB5 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR008271 Ser/Thr_kinase_AS IPR034368 TOPK
PANTHERⁱ	PTHR43289:SF3 PTHR43289:SF3, 1 hit
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TOPK_HUMAN
Accessionⁱ	Q96KB5Primary (citable) accession number: Q96KB5 Secondary accession number(s): B4DX68 , D3DST2, Q9NPD9, Q9NYL7, Q9NZK6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
	Last sequence update:	December 6, 2005
	Last modified:	November 7, 2018
	This is version 157 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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UniProtKB - Q96KB5 (TOPK_HUMAN)

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Lymphokine-activated killer T-cell-originated protein kinase

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ