Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cleft lip and palate transmembrane protein 1-like protein

Gene

CLPTM1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enhances cisplatin-mediated apoptosis, when overexpressed.1 Publication

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Cleft lip and palate transmembrane protein 1-like protein
Short name:
CLPTM1-like protein
Alternative name(s):
Cisplatin resistance-related protein 9
Short name:
CRR9p
Gene namesi
Name:CLPTM1L
Synonyms:CRR9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000049656.13
HGNCiHGNC:24308 CLPTM1L
MIMi612585 gene
neXtProtiNX_Q96KA5

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 284ExtracellularSequence analysisAdd BLAST253
Transmembranei285 – 305HelicalSequence analysisAdd BLAST21
Topological domaini306 – 324CytoplasmicSequence analysisAdd BLAST19
Transmembranei325 – 342HelicalSequence analysisAdd BLAST18
Topological domaini343 – 346ExtracellularSequence analysis4
Transmembranei347 – 364HelicalSequence analysisAdd BLAST18
Topological domaini365 – 402CytoplasmicSequence analysisAdd BLAST38
Transmembranei403 – 423HelicalSequence analysisAdd BLAST21
Topological domaini424 – 428ExtracellularSequence analysis5
Transmembranei429 – 449HelicalSequence analysisAdd BLAST21
Topological domaini450 – 538CytoplasmicSequence analysisAdd BLAST89

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi81037
OpenTargetsiENSG00000049656
PharmGKBiPA147358156

Polymorphism and mutation databases

BioMutaiCLPTM1L
DMDMi74732209

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003313001 – 538Cleft lip and palate transmembrane protein 1-like proteinAdd BLAST538

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi229N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ96KA5
MaxQBiQ96KA5
PaxDbiQ96KA5
PeptideAtlasiQ96KA5
PRIDEiQ96KA5
ProteomicsDBi77054
77055 [Q96KA5-2]

PTM databases

GlyConnecti1117
iPTMnetiQ96KA5
PhosphoSitePlusiQ96KA5
SwissPalmiQ96KA5

Expressioni

Inductioni

Up-regulated by cisplatin.1 Publication

Gene expression databases

BgeeiENSG00000049656 Expressed in 196 organ(s), highest expression level in kidney epithelium
CleanExiHS_CLPTM1L
ExpressionAtlasiQ96KA5 baseline and differential
GenevisibleiQ96KA5 HS

Organism-specific databases

HPAiHPA014791

Interactioni

Protein-protein interaction databases

BioGridi123354, 25 interactors
IntActiQ96KA5, 21 interactors
STRINGi9606.ENSP00000313854

Structurei

3D structure databases

ProteinModelPortaliQ96KA5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CLPTM1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2489 Eukaryota
ENOG410XPEV LUCA
GeneTreeiENSGT00530000063461
HOGENOMiHOG000201405
HOVERGENiHBG057146
InParanoidiQ96KA5
OMAiHMLFDFL
OrthoDBiEOG091G05EF
PhylomeDBiQ96KA5
TreeFamiTF318501

Family and domain databases

InterProiView protein in InterPro
IPR008429 CLPTM1
IPR030434 CLPTM1L
PANTHERiPTHR21347 PTHR21347, 1 hit
PTHR21347:SF0 PTHR21347:SF0, 1 hit
PfamiView protein in Pfam
PF05602 CLPTM1, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96KA5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWSGRSSFTS LVVGVFVVYV VHTCWVMYGI VYTRPCSGDA NCIQPYLARR
60 70 80 90 100
PKLQLSVYTT TRSHLGAENN IDLVLNVEDF DVESKFERTV NVSVPKKTRN
110 120 130 140 150
NGTLYAYIFL HHAGVLPWHD GKQVHLVSPL TTYMVPKPEE INLLTGESDT
160 170 180 190 200
QQIEAEKKPT SALDEPVSHW RPRLALNVMA DNFVFDGSSL PADVHRYMKM
210 220 230 240 250
IQLGKTVHYL PILFIDQLSN RVKDLMVINR STTELPLTVS YDKVSLGRLR
260 270 280 290 300
FWIHMQDAVY SLQQFGFSEK DADEVKGIFV DTNLYFLALT FFVAAFHLLF
310 320 330 340 350
DFLAFKNDIS FWKKKKSMIG MSTKAVLWRC FSTVVIFLFL LDEQTSLLVL
360 370 380 390 400
VPAGVGAAIE LWKVKKALKM TIFWRGLMPE FQFGTYSESE RKTEEYDTQA
410 420 430 440 450
MKYLSYLLYP LCVGGAVYSL LNIKYKSWYS WLINSFVNGV YAFGFLFMLP
460 470 480 490 500
QLFVNYKLKS VAHLPWKAFT YKAFNTFIDD VFAFIITMPT SHRLACFRDD
510 520 530
VVFLVYLYQR WLYPVDKRRV NEFGESYEEK ATRAPHTD
Length:538
Mass (Da):62,229
Last modified:December 1, 2001 - v1
Checksum:iA83FF068AED01FC7
GO
Isoform 2 (identifier: Q96KA5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     325-360: Missing.

Show »
Length:502
Mass (Da):58,356
Checksum:iF336609A093D72AB
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E9Z2G5E9Z2_HUMAN
Cisplatin resistance related protei...
CLPTM1L CRR9, hCG_1810932
369Annotation score:

Sequence cautioni

The sequence BAB20083 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042754313K → N in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_042755537T → M. Corresponds to variant dbSNP:rs33955038Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_033157325 – 360Missing in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027306 mRNA Translation: BAB55030.1
CH471102 Genomic DNA Translation: EAX08162.1
CH471102 Genomic DNA Translation: EAX08163.1
BC016399 mRNA Translation: AAH16399.1
BC025305 mRNA Translation: AAH25305.1
AB045223 mRNA Translation: BAB20083.1 Different initiation.
AL832953 mRNA Translation: CAH56333.1
CCDSiCCDS3862.1 [Q96KA5-1]
PIRiJC7599
RefSeqiNP_110409.2, NM_030782.4 [Q96KA5-1]
UniGeneiHs.444673

Genome annotation databases

EnsembliENST00000320895; ENSP00000313854; ENSG00000049656 [Q96KA5-1]
ENST00000620010; ENSP00000480372; ENSG00000274811 [Q96KA5-1]
GeneIDi81037
KEGGihsa:81037
UCSCiuc003jch.4 human [Q96KA5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027306 mRNA Translation: BAB55030.1
CH471102 Genomic DNA Translation: EAX08162.1
CH471102 Genomic DNA Translation: EAX08163.1
BC016399 mRNA Translation: AAH16399.1
BC025305 mRNA Translation: AAH25305.1
AB045223 mRNA Translation: BAB20083.1 Different initiation.
AL832953 mRNA Translation: CAH56333.1
CCDSiCCDS3862.1 [Q96KA5-1]
PIRiJC7599
RefSeqiNP_110409.2, NM_030782.4 [Q96KA5-1]
UniGeneiHs.444673

3D structure databases

ProteinModelPortaliQ96KA5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123354, 25 interactors
IntActiQ96KA5, 21 interactors
STRINGi9606.ENSP00000313854

PTM databases

GlyConnecti1117
iPTMnetiQ96KA5
PhosphoSitePlusiQ96KA5
SwissPalmiQ96KA5

Polymorphism and mutation databases

BioMutaiCLPTM1L
DMDMi74732209

Proteomic databases

EPDiQ96KA5
MaxQBiQ96KA5
PaxDbiQ96KA5
PeptideAtlasiQ96KA5
PRIDEiQ96KA5
ProteomicsDBi77054
77055 [Q96KA5-2]

Protocols and materials databases

DNASUi81037
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320895; ENSP00000313854; ENSG00000049656 [Q96KA5-1]
ENST00000620010; ENSP00000480372; ENSG00000274811 [Q96KA5-1]
GeneIDi81037
KEGGihsa:81037
UCSCiuc003jch.4 human [Q96KA5-1]

Organism-specific databases

CTDi81037
DisGeNETi81037
EuPathDBiHostDB:ENSG00000049656.13
GeneCardsiCLPTM1L
HGNCiHGNC:24308 CLPTM1L
HPAiHPA014791
MIMi612585 gene
neXtProtiNX_Q96KA5
OpenTargetsiENSG00000049656
PharmGKBiPA147358156
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2489 Eukaryota
ENOG410XPEV LUCA
GeneTreeiENSGT00530000063461
HOGENOMiHOG000201405
HOVERGENiHBG057146
InParanoidiQ96KA5
OMAiHMLFDFL
OrthoDBiEOG091G05EF
PhylomeDBiQ96KA5
TreeFamiTF318501

Miscellaneous databases

ChiTaRSiCLPTM1L human
GeneWikiiCLPTM1L
GenomeRNAii81037
PROiPR:Q96KA5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000049656 Expressed in 196 organ(s), highest expression level in kidney epithelium
CleanExiHS_CLPTM1L
ExpressionAtlasiQ96KA5 baseline and differential
GenevisibleiQ96KA5 HS

Family and domain databases

InterProiView protein in InterPro
IPR008429 CLPTM1
IPR030434 CLPTM1L
PANTHERiPTHR21347 PTHR21347, 1 hit
PTHR21347:SF0 PTHR21347:SF0, 1 hit
PfamiView protein in Pfam
PF05602 CLPTM1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLP1L_HUMAN
AccessioniPrimary (citable) accession number: Q96KA5
Secondary accession number(s): D3DTC1
, Q658W6, Q7LG29, Q96AZ0, Q9H3N4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again