Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 152 (26 Feb 2020)
Sequence version 1 (01 Dec 2001)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Zinc finger protein 521

Gene

ZNF521

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri47 – 67C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri118 – 140C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri146 – 168C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri174 – 196C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri202 – 224C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri246 – 269C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri281 – 304C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri310 – 332C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri405 – 429C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri437 – 460C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri477 – 500C2H2-type 11PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri513 – 536C2H2-type 12PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri560 – 585C2H2-type 13; atypicalPROSITE-ProRule annotationAdd BLAST26
Zinc fingeri634 – 656C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri664 – 686C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri694 – 717C2H2-type 16PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri722 – 745C2H2-type 17PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri752 – 775C2H2-type 18PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri783 – 805C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri809 – 832C2H2-type 20PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri886 – 908C2H2-type 21; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri930 – 952C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri959 – 981C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1020 – 1042C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1065 – 1083C2H2-type 25; degeneratePROSITE-ProRule annotationAdd BLAST19
Zinc fingeri1138 – 1161C2H2-type 26PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1195 – 1217C2H2-type 27PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1225 – 1247C2H2-type 28PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1256 – 1279C2H2-type 29PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1286 – 1309C2H2-type 30PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding, Repressor
Biological processDifferentiation, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8940973 RUNX2 regulates osteoblast differentiation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q96K83

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 521
Alternative name(s):
Early hematopoietic zinc finger protein
LYST-interacting protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF521
Synonyms:EHZF, LIP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24605 ZNF521

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610974 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96K83

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving ZNF521 is found in acute lymphoblastic leukemia. Translocation t(9;18)(p13;q11.2) with PAX5. The translocation generates the PAX5-ZNF521 oncogene consisting of the N-terminus part of PAX5 and the C-terminus part of ZNF521.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei72 – 73Breakpoint for translocation to form PAX5-ZNF5212

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
25925

Open Targets

More...
OpenTargetsi
ENSG00000198795

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134956321

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96K83 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF521

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74760909

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003068711 – 1311Zinc finger protein 521Add BLAST1311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei546PhosphoserineCombined sources1
Modified residuei605PhosphoserineCombined sources1
Modified residuei608PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1146Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96K83

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96K83

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96K83

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96K83

PeptideAtlas

More...
PeptideAtlasi
Q96K83

PRoteomics IDEntifications database

More...
PRIDEi
Q96K83

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
77052

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96K83

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96K83

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in hematopoietic cells. Present in organs and tissues that contain stem and progenitor cells, myeloid and/or lymphoid: placenta, spleen, lymph nodes, thymus, bone marrow and fetal liver. Within the hematopoietic system, it is abundant in CD34+ cells but undetectable in mature peripheral blood leukocytes, and its levels rapidly decrease during the differentiation of CD34+ cells in response to hemopoietins.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198795 Expressed in cerebellar vermis and 192 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96K83 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96K83 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA023056
HPA023849

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with EBF1.

Interacts with SMAD1 and SMAD4.

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117425, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q96K83, 11 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000354794

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96K83 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96K83

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Uses different DNA- and protein-binding zinc fingers to regulate the distinct BMP-Smad and hematopoietic system.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri47 – 67C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri118 – 140C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri146 – 168C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri174 – 196C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri202 – 224C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri246 – 269C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri281 – 304C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri310 – 332C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri405 – 429C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri437 – 460C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri477 – 500C2H2-type 11PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri513 – 536C2H2-type 12PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri560 – 585C2H2-type 13; atypicalPROSITE-ProRule annotationAdd BLAST26
Zinc fingeri634 – 656C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri664 – 686C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri694 – 717C2H2-type 16PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri722 – 745C2H2-type 17PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri752 – 775C2H2-type 18PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri783 – 805C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri809 – 832C2H2-type 20PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri886 – 908C2H2-type 21; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri930 – 952C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri959 – 981C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1020 – 1042C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1065 – 1083C2H2-type 25; degeneratePROSITE-ProRule annotationAdd BLAST19
Zinc fingeri1138 – 1161C2H2-type 26PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1195 – 1217C2H2-type 27PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1225 – 1247C2H2-type 28PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1256 – 1279C2H2-type 29PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1286 – 1309C2H2-type 30PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159287

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004018_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96K83

Identification of Orthologs from Complete Genome Data

More...
OMAi
SENFHTV

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96K83

TreeFam database of animal gene trees

More...
TreeFami
TF331504

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 30 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 10 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 27 hits
PS50157 ZINC_FINGER_C2H2_2, 24 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q96K83-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRRKQAKPR SLKDPNCKLE DKTEDGEALD CKKRPEDGEE LEDEAVHSCD
60 70 80 90 100
SCLQVFESLS DITEHKINQC QLTDGVDVED DPTCSWPASS PSSKDQTSPS
110 120 130 140 150
HGEGCDFGEE EGGPGLPYPC QFCDKSFSRL SYLKHHEQSH SDKLPFKCTY
160 170 180 190 200
CSRLFKHKRS RDRHIKLHTG DKKYHCSECD AAFSRSDHLK IHLKTHTSNK
210 220 230 240 250
PYKCAICRRG FLSSSSLHGH MQVHERNKDG SQSGSRMEDW KMKDTQKCSQ
260 270 280 290 300
CEEGFDFPED LQKHIAECHP ECSPNEDRAA LQCVYCHELF VEETSLMNHM
310 320 330 340 350
EQVHSGEKKN SCSICSESFH TVEELYSHMD SHQQPESCNH SNSPSLVTVG
360 370 380 390 400
YTSVSSTTPD SNLSVDSSTM VEAAPPIPKS RGRKRAAQQT PDMTGPSSKQ
410 420 430 440 450
AKVTYSCIYC NKQLFSSLAV LQIHLKTMHL DKPEQAHICQ YCLEVLPSLY
460 470 480 490 500
NLNEHLKQVH EAQDPGLIVS AMPAIVYQCN FCSEVVNDLN TLQEHIRCSH
510 520 530 540 550
GFANPAAKDS NAFFCPHCYM GFLTDSSLEE HIRQVHCDLS GSRFGSPVLG
560 570 580 590 600
TPKEPVVEVY SCSYCTNSPI FNSVLKLNKH IKENHKNIPL ALNYIHNGKK
610 620 630 640 650
SRALSPLSPV AIEQTSLKMM QAVGGAPARP TGEYICNQCG AKYTSLDSFQ
660 670 680 690 700
THLKTHLDTV LPKLTCPQCN KEFPNQESLL KHVTIHFMIT STYYICESCD
710 720 730 740 750
KQFTSVDDLQ KHLLDMHTFV FFRCTLCQEV FDSKVSIQLH LAVKHSNEKK
760 770 780 790 800
VYRCTSCNWD FRNETDLQLH VKHNHLENQG KVHKCIFCGE SFGTEVELQC
810 820 830 840 850
HITTHSKKYN CKFCSKAFHA IILLEKHLRE KHCVFETKTP NCGTNGASEQ
860 870 880 890 900
VQKEEVELQT LLTNSQESHN SHDGSEEDVD TSEPMYGCDI CGAAYTMETL
910 920 930 940 950
LQNHQLRDHN IRPGESAIVK KKAELIKGNY KCNVCSRTFF SENGLREHMQ
960 970 980 990 1000
THLGPVKHYM CPICGERFPS LLTLTEHKVT HSKSLDTGNC RICKMPLQSE
1010 1020 1030 1040 1050
EEFLEHCQMH PDLRNSLTGF RCVVCMQTVT STLELKIHGT FHMQKTGNGS
1060 1070 1080 1090 1100
AVQTTGRGQH VQKLYKCASC LKEFRSKQDL VKLDINGLPY GLCAGCVNLS
1110 1120 1130 1140 1150
KSASPGINVP PGTNRPGLGQ NENLSAIEGK GKVGGLKTRC SSCNVKFESE
1160 1170 1180 1190 1200
SELQNHIQTI HRELVPDSNS TQLKTPQVSP MPRISPSQSD EKKTYQCIKC
1210 1220 1230 1240 1250
QMVFYNEWDI QVHVANHMID EGLNHECKLC SQTFDSPAKL QCHLIEHSFE
1260 1270 1280 1290 1300
GMGGTFKCPV CFTVFVQANK LQQHIFSAHG QEDKIYDCTQ CPQKFFFQTE
1310
LQNHTMTQHS S
Length:1,311
Mass (Da):147,866
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC52DCC71C2B16C8F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KTI4J3KTI4_HUMAN
Zinc finger protein 521
ZNF521
1,091Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BYU6H7BYU6_HUMAN
Zinc finger protein 521
ZNF521
1,244Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSZ4J3KSZ4_HUMAN
Zinc finger protein 521
ZNF521
224Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRW6J3QRW6_HUMAN
Zinc finger protein 521
ZNF521
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KT07J3KT07_HUMAN
Zinc finger protein 521
ZNF521
30Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QQI2J3QQI2_HUMAN
Zinc finger protein 521
ZNF521
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence ABI33104 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB13829 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti203K → E in CAD57322 (PubMed:14630787).Curated1
Sequence conflicti301E → K in ABI33104 (PubMed:17344859).Curated1
Sequence conflicti599K → Q in BAB13829 (PubMed:14702039).Curated1
Sequence conflicti649F → L in CAD57322 (PubMed:14630787).Curated1
Sequence conflicti701K → E in CAD57322 (PubMed:14630787).Curated1
Sequence conflicti933N → S in CAD57322 (PubMed:14630787).Curated1
Sequence conflicti933N → S in CAB56016 (PubMed:17344859).Curated1
Sequence conflicti1019G → A in CAD57322 (PubMed:14630787).Curated1
Sequence conflicti1019G → A in CAB56016 (PubMed:17344859).Curated1
Sequence conflicti1173L → M in AAG49442 (PubMed:17974005).Curated1
Sequence conflicti1176P → T in AAG49442 (PubMed:17974005).Curated1
Sequence conflicti1204F → L in AAG49442 (PubMed:17974005).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ518106 mRNA Translation: CAD57322.1
AK021452 mRNA Translation: BAB13829.1 Different initiation.
AK027354 mRNA Translation: BAB55056.1
AK074046 mRNA Translation: BAB84872.1
EF445043 Genomic DNA Translation: ACA06095.1
CH471088 Genomic DNA Translation: EAX01201.1
BC113622 mRNA Translation: AAI13623.1
BC113648 mRNA Translation: AAI13649.1
DQ845345 mRNA Translation: ABI33104.1 Different initiation.
AL117615 mRNA Translation: CAB56016.1
AF141339 mRNA Translation: AAG49442.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32806.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T17326

NCBI Reference Sequences

More...
RefSeqi
NP_001295154.1, NM_001308225.1
NP_056276.1, NM_015461.2
XP_011524213.1, XM_011525911.1
XP_016881187.1, XM_017025698.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000361524; ENSP00000354794; ENSG00000198795
ENST00000538137; ENSP00000440768; ENSG00000198795

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25925

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:25925

UCSC genome browser

More...
UCSCi
uc002kvk.3 human

Keywords - Coding sequence diversityi

Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ518106 mRNA Translation: CAD57322.1
AK021452 mRNA Translation: BAB13829.1 Different initiation.
AK027354 mRNA Translation: BAB55056.1
AK074046 mRNA Translation: BAB84872.1
EF445043 Genomic DNA Translation: ACA06095.1
CH471088 Genomic DNA Translation: EAX01201.1
BC113622 mRNA Translation: AAI13623.1
BC113648 mRNA Translation: AAI13649.1
DQ845345 mRNA Translation: ABI33104.1 Different initiation.
AL117615 mRNA Translation: CAB56016.1
AF141339 mRNA Translation: AAG49442.1
CCDSiCCDS32806.1
PIRiT17326
RefSeqiNP_001295154.1, NM_001308225.1
NP_056276.1, NM_015461.2
XP_011524213.1, XM_011525911.1
XP_016881187.1, XM_017025698.1

3D structure databases

SMRiQ96K83
ModBaseiSearch...

Protein-protein interaction databases

BioGridi117425, 12 interactors
IntActiQ96K83, 11 interactors
STRINGi9606.ENSP00000354794

PTM databases

iPTMnetiQ96K83
PhosphoSitePlusiQ96K83

Polymorphism and mutation databases

BioMutaiZNF521
DMDMi74760909

Proteomic databases

EPDiQ96K83
jPOSTiQ96K83
MassIVEiQ96K83
PaxDbiQ96K83
PeptideAtlasiQ96K83
PRIDEiQ96K83
ProteomicsDBi77052

Genome annotation databases

EnsembliENST00000361524; ENSP00000354794; ENSG00000198795
ENST00000538137; ENSP00000440768; ENSG00000198795
GeneIDi25925
KEGGihsa:25925
UCSCiuc002kvk.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25925
DisGeNETi25925

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZNF521
HGNCiHGNC:24605 ZNF521
HPAiHPA023056
HPA023849
MIMi610974 gene
neXtProtiNX_Q96K83
OpenTargetsiENSG00000198795
PharmGKBiPA134956321

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000159287
HOGENOMiCLU_004018_0_0_1
InParanoidiQ96K83
OMAiSENFHTV
OrthoDBi1318335at2759
PhylomeDBiQ96K83
TreeFamiTF331504

Enzyme and pathway databases

ReactomeiR-HSA-8940973 RUNX2 regulates osteoblast differentiation
SIGNORiQ96K83

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZNF521 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
25925
PharosiQ96K83 Tbio

Protein Ontology

More...
PROi
PR:Q96K83
RNActiQ96K83 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000198795 Expressed in cerebellar vermis and 192 other tissues
ExpressionAtlasiQ96K83 baseline and differential
GenevisibleiQ96K83 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 30 hits
SUPFAMiSSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 27 hits
PS50157 ZINC_FINGER_C2H2_2, 24 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN521_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96K83
Secondary accession number(s): A3QVP7
, B0YJB7, Q8IXI0, Q8TES6, Q9C065, Q9HAL5, Q9UFK4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 1, 2001
Last modified: February 26, 2020
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again