ADGRG7

Protein namesⁱ	Recommended name: Adhesion G-protein coupled receptor G71 Publication Alternative name(s): G-protein coupled receptor 128
Gene namesⁱ	Name:ADGRG7 Synonyms:GPR128
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000144820.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19241 ADGRG7
MIMⁱ	612307 gene
neXtProtⁱ	NX_Q96K78

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	27 – 438	ExtracellularSequence analysisAdd BLAST	412
Transmembraneⁱ	439 – 459	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	460 – 468	CytoplasmicSequence analysis	9
Transmembraneⁱ	469 – 489	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	490 – 528	ExtracellularSequence analysisAdd BLAST	39
Transmembraneⁱ	529 – 549	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	550 – 565	CytoplasmicSequence analysisAdd BLAST	16
Transmembraneⁱ	566 – 586	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	587 – 623	ExtracellularSequence analysisAdd BLAST	37
Transmembraneⁱ	624 – 644	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	645 – 669	CytoplasmicSequence analysisAdd BLAST	25
Transmembraneⁱ	670 – 690	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	691 – 698	ExtracellularSequence analysis	8
Transmembraneⁱ	699 – 719	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	720 – 797	CytoplasmicSequence analysisAdd BLAST	78

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	84873
Open Targets More...OpenTargetsⁱ	ENSG00000144820
PharmGKBⁱ	PA134982718

Polymorphism and mutation databases

BioMutaⁱ	GPR128
DMDMⁱ	229462926

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 26	Sequence analysisAdd BLAST		26
ChainⁱPRO_0000012903	27 – 797	Adhesion G-protein coupled receptor G7Add BLAST		771

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	82	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	159	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	178	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	191	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	247	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	261	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	312	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	316	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	387	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	413	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q96K78
PeptideAtlas More...PeptideAtlasⁱ	Q96K78
PRIDEⁱ	Q96K78
ProteomicsDBⁱ	77050

PTM databases

iPTMnetⁱ	Q96K78
PhosphoSitePlusⁱ	Q96K78

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000144820 Expressed in 74 organ(s), highest expression level in intestine
CleanExⁱ	HS_GPR128
ExpressionAtlasⁱ	Q96K78 baseline and differential
Genevisibleⁱ	Q96K78 HS

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
	A8KA83	3	EBI-10290200,EBI-10174961
LDLRAD1	Q5T700	5	EBI-10290200,EBI-10173166

Protein-protein interaction databases

BioGridⁱ	124318, 3 interactors
IntActⁱ	Q96K78, 4 interactors
STRINGⁱ	9606.ENSP00000273352

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96K78
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	380 – 427	GPSPROSITE-ProRule annotationAdd BLAST		48

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4193 Eukaryota ENOG410XSD2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148984
HOGENOMⁱ	HOG000236310
HOVERGENⁱ	HBG063831
InParanoidⁱ	Q96K78
KEGG Orthology (KO) More...KOⁱ	K08464
OMAⁱ	LWKNNQN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03DK
PhylomeDBⁱ	Q96K78
TreeFamⁱ	TF351485

Family and domain databases

InterProⁱ	View protein in InterPro IPR017981 GPCR_2-like IPR000832 GPCR_2_secretin-like IPR000203 GPS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00002 7tm_2, 1 hit PF01825 GPS, 1 hit
PRINTSⁱ	PR00249 GPCRSECRETIN
SMARTⁱ	View protein in SMART SM00303 GPS, 1 hit
PROSITEⁱ	View protein in PROSITE PS50261 G_PROTEIN_RECEP_F2_4, 1 hit PS50221 GPS, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.ⁱShow all

Q96K78-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASCRAWNLR VLVAVVCGLL TGIILGLGIW RIVIRIQRGK STSSSSTPTE 
        60         70         80         90        100
FCRNGGTWEN GRCICTEEWK GLRCTIANFC ENSTYMGFTF ARIPVGRYGP 
       110        120        130        140        150
SLQTCGKDTP NAGNPMAVRL CSLSLYGEIE LQKVTIGNCN ENLETLEKQV 
       160        170        180        190        200
KDVTAPLNNI SSEVQILTSD ANKLTAENIT SATRVVGQIF NTSRNASPEA 
       210        220        230        240        250
KKVAIVTVSQ LLDASEDAFQ RVAATANDDA LTTLIEQMET YSLSLGNQSV 
       260        270        280        290        300
VEPNIAIQSA NFSSENAVGP SNVRFSVQKG ASSSLVSSST FIHTNVDGLN 
       310        320        330        340        350
PDAQTELQVL LNMTKNYTKT CGFVVYQNDK LFQSKTFTAK SDFSQKIISS 
       360        370        380        390        400
KTDENEQDQS ASVDMVFSPK YNQKEFQLYS YACVYWNLSA KDWDTYGCQK 
       410        420        430        440        450
DKGTDGFLRC RCNHTTNFAV LMTFKKDYQY PKSLDILSNV GCALSVTGLA 
       460        470        480        490        500
LTVIFQIVTR KVRKTSVTWV LVNLCISMLI FNLLFVFGIE NSNKNLQTSD 
       510        520        530        540        550
GDINNIDFDN NDIPRTDTIN IPNPMCTAIA ALLHYFLLVT FTWNALSAAQ 
       560        570        580        590        600
LYYLLIRTMK PLPRHFILFI SLIGWGVPAI VVAITVGVIY SQNGNNPQWE 
       610        620        630        640        650
LDYRQEKICW LAIPEPNGVI KSPLLWSFIV PVTIILISNV VMFITISIKV 
       660        670        680        690        700
LWKNNQNLTS TKKVSSMKKI VSTLSVAVVF GITWILAYLM LVNDDSIRIV 
       710        720        730        740        750
FSYIFCLFNT TQGLQIFILY TVRTKVFQSE ASKVLMLLSS IGRRKSLPSV 
       760        770        780        790 
TRPRLRVKMY NFLRSLPTLH ERFRLLETSP STEEITLSES DNAKESI

Length:797

Mass (Da):88,909

Last modified:May 5, 2009 - v2

Checksum:ⁱD6CAAA78AC0E4679

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	E9PHI0	E9PHI0_HUMAN		Adhesion G-protein-coupled receptor... Adhesion G-protein-coupled receptor G7	ADGRG7	502	Annotation score:

Sequence cautionⁱ

The sequence AAO27358 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_055138	151	K → E1 PublicationCorresponds to variant dbSNP:rs1144122Ensembl.	1
Natural variantⁱVAR_049459	645	T → S. Corresponds to variant dbSNP:rs16842529Ensembl.	1
Natural variantⁱVAR_049460	756	R → H. Corresponds to variant dbSNP:rs9872512Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY181246 mRNA Translation: AAO27358.1 Different initiation. AK027360 mRNA Translation: BAB55061.1 CH471052 Genomic DNA Translation: EAW79818.1 BC113451 mRNA Translation: AAI13452.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2938.1
NCBI Reference Sequences More...RefSeqⁱ	NP_116176.2, NM_032787.2
UniGeneⁱ	Hs.334511

Genome annotation databases

Ensemblⁱ	ENST00000273352; ENSP00000273352; ENSG00000144820
GeneIDⁱ	84873
KEGGⁱ	hsa:84873
UCSC genome browser More...UCSCⁱ	uc003duc.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96K78	cDNA FLJ23935 fis, clone COLF0858		HUMAN		433	UniRef100_Q96K78

Protein	Similar proteins		Species	Score	Length	Source
Q96K78	cDNA FLJ23935 fis, clone COLF0858		HUMAN		433	UniRef90_Q96K78
ADGRG7 isoform 1		PANTR		797
ADGRG7 isoform 1		PONAB		797
Adhesion G protein-coupled receptor G7		CERAT		797
Adhesion G protein-coupled receptor G7		RHIRO		797
+33

Protein	Similar proteins		Species	Score	Length	Source
Q96K78	cDNA FLJ23935 fis, clone COLF0858		HUMAN		433	UniRef50_Q96K78
Adhesion G protein-coupled receptor G7		CERAT		797
ADGRG7 isoform 1		PONAB		797
Adhesion G protein-coupled receptor G7		NOMLE		797
Adhesion G protein-coupled receptor G7		MANLE		797
+45

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY181246 mRNA Translation: AAO27358.1 Different initiation. AK027360 mRNA Translation: BAB55061.1 CH471052 Genomic DNA Translation: EAW79818.1 BC113451 mRNA Translation: AAI13452.1
CCDSⁱ	CCDS2938.1
RefSeqⁱ	NP_116176.2, NM_032787.2
UniGeneⁱ	Hs.334511

3D structure databases

ProteinModelPortalⁱ	Q96K78
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	124318, 3 interactors
IntActⁱ	Q96K78, 4 interactors
STRINGⁱ	9606.ENSP00000273352

Protein family/group databases

MEROPSⁱ	P02.020
GPCRDBⁱ	Search...

PTM databases

iPTMnetⁱ	Q96K78
PhosphoSitePlusⁱ	Q96K78

Polymorphism and mutation databases

BioMutaⁱ	GPR128
DMDMⁱ	229462926

Proteomic databases

PaxDbⁱ	Q96K78
PeptideAtlasⁱ	Q96K78
PRIDEⁱ	Q96K78
ProteomicsDBⁱ	77050

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	84873
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000273352; ENSP00000273352; ENSG00000144820
GeneIDⁱ	84873
KEGGⁱ	hsa:84873
UCSCⁱ	uc003duc.5 human

Organism-specific databases

CTDⁱ	84873
DisGeNETⁱ	84873
EuPathDBⁱ	HostDB:ENSG00000144820.7
GeneCardsⁱ	ADGRG7
HGNCⁱ	HGNC:19241 ADGRG7
MIMⁱ	612307 gene
neXtProtⁱ	NX_Q96K78
OpenTargetsⁱ	ENSG00000144820
PharmGKBⁱ	PA134982718
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4193 Eukaryota ENOG410XSD2 LUCA
GeneTreeⁱ	ENSGT00920000148984
HOGENOMⁱ	HOG000236310
HOVERGENⁱ	HBG063831
InParanoidⁱ	Q96K78
KOⁱ	K08464
OMAⁱ	LWKNNQN
OrthoDBⁱ	EOG091G03DK
PhylomeDBⁱ	Q96K78
TreeFamⁱ	TF351485

Miscellaneous databases

ChiTaRSⁱ	ADGRG7 human
GenomeRNAiⁱ	84873
Protein Ontology More...PROⁱ	PR:Q96K78
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000144820 Expressed in 74 organ(s), highest expression level in intestine
CleanExⁱ	HS_GPR128
ExpressionAtlasⁱ	Q96K78 baseline and differential
Genevisibleⁱ	Q96K78 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR017981 GPCR_2-like IPR000832 GPCR_2_secretin-like IPR000203 GPS
Pfamⁱ	View protein in Pfam PF00002 7tm_2, 1 hit PF01825 GPS, 1 hit
PRINTSⁱ	PR00249 GPCRSECRETIN
SMARTⁱ	View protein in SMART SM00303 GPS, 1 hit
PROSITEⁱ	View protein in PROSITE PS50261 G_PROTEIN_RECEP_F2_4, 1 hit PS50221 GPS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AGRG7_HUMAN
Accessionⁱ	Q96K78Primary (citable) accession number: Q96K78 Secondary accession number(s): Q14D94, Q86SQ2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 29, 2004
	Last sequence update:	May 5, 2009
	Last modified:	September 12, 2018
	This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96K78 (AGRG7_HUMAN)

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Adhesion G-protein coupled receptor G7

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ