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Protein

Adhesion G-protein coupled receptor G7

Gene

ADGRG7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: GDB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPSiP02.020

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G-protein coupled receptor G71 Publication
Alternative name(s):
G-protein coupled receptor 128
Gene namesi
Name:ADGRG7
Synonyms:GPR128
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000144820.7
HGNCiHGNC:19241 ADGRG7
MIMi612307 gene
neXtProtiNX_Q96K78

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 438ExtracellularSequence analysisAdd BLAST412
Transmembranei439 – 459Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini460 – 468CytoplasmicSequence analysis9
Transmembranei469 – 489Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini490 – 528ExtracellularSequence analysisAdd BLAST39
Transmembranei529 – 549Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini550 – 565CytoplasmicSequence analysisAdd BLAST16
Transmembranei566 – 586Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini587 – 623ExtracellularSequence analysisAdd BLAST37
Transmembranei624 – 644Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini645 – 669CytoplasmicSequence analysisAdd BLAST25
Transmembranei670 – 690Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini691 – 698ExtracellularSequence analysis8
Transmembranei699 – 719Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini720 – 797CytoplasmicSequence analysisAdd BLAST78

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi84873
OpenTargetsiENSG00000144820
PharmGKBiPA134982718

Polymorphism and mutation databases

BioMutaiGPR128
DMDMi229462926

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001290327 – 797Adhesion G-protein coupled receptor G7Add BLAST771

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi191N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi247N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi261N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi312N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi316N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi387N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi413N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96K78
PeptideAtlasiQ96K78
PRIDEiQ96K78
ProteomicsDBi77050

PTM databases

iPTMnetiQ96K78
PhosphoSitePlusiQ96K78

Expressioni

Gene expression databases

BgeeiENSG00000144820 Expressed in 74 organ(s), highest expression level in intestine
CleanExiHS_GPR128
ExpressionAtlasiQ96K78 baseline and differential
GenevisibleiQ96K78 HS

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi124318, 3 interactors
IntActiQ96K78, 4 interactors
STRINGi9606.ENSP00000273352

Structurei

3D structure databases

ProteinModelPortaliQ96K78
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini380 – 427GPSPROSITE-ProRule annotationAdd BLAST48

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4193 Eukaryota
ENOG410XSD2 LUCA
GeneTreeiENSGT00920000148984
HOGENOMiHOG000236310
HOVERGENiHBG063831
InParanoidiQ96K78
KOiK08464
OMAiLWKNNQN
OrthoDBiEOG091G03DK
PhylomeDBiQ96K78
TreeFamiTF351485

Family and domain databases

InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR000832 GPCR_2_secretin-like
IPR000203 GPS
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF01825 GPS, 1 hit
PRINTSiPR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00303 GPS, 1 hit
PROSITEiView protein in PROSITE
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q96K78-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASCRAWNLR VLVAVVCGLL TGIILGLGIW RIVIRIQRGK STSSSSTPTE
60 70 80 90 100
FCRNGGTWEN GRCICTEEWK GLRCTIANFC ENSTYMGFTF ARIPVGRYGP
110 120 130 140 150
SLQTCGKDTP NAGNPMAVRL CSLSLYGEIE LQKVTIGNCN ENLETLEKQV
160 170 180 190 200
KDVTAPLNNI SSEVQILTSD ANKLTAENIT SATRVVGQIF NTSRNASPEA
210 220 230 240 250
KKVAIVTVSQ LLDASEDAFQ RVAATANDDA LTTLIEQMET YSLSLGNQSV
260 270 280 290 300
VEPNIAIQSA NFSSENAVGP SNVRFSVQKG ASSSLVSSST FIHTNVDGLN
310 320 330 340 350
PDAQTELQVL LNMTKNYTKT CGFVVYQNDK LFQSKTFTAK SDFSQKIISS
360 370 380 390 400
KTDENEQDQS ASVDMVFSPK YNQKEFQLYS YACVYWNLSA KDWDTYGCQK
410 420 430 440 450
DKGTDGFLRC RCNHTTNFAV LMTFKKDYQY PKSLDILSNV GCALSVTGLA
460 470 480 490 500
LTVIFQIVTR KVRKTSVTWV LVNLCISMLI FNLLFVFGIE NSNKNLQTSD
510 520 530 540 550
GDINNIDFDN NDIPRTDTIN IPNPMCTAIA ALLHYFLLVT FTWNALSAAQ
560 570 580 590 600
LYYLLIRTMK PLPRHFILFI SLIGWGVPAI VVAITVGVIY SQNGNNPQWE
610 620 630 640 650
LDYRQEKICW LAIPEPNGVI KSPLLWSFIV PVTIILISNV VMFITISIKV
660 670 680 690 700
LWKNNQNLTS TKKVSSMKKI VSTLSVAVVF GITWILAYLM LVNDDSIRIV
710 720 730 740 750
FSYIFCLFNT TQGLQIFILY TVRTKVFQSE ASKVLMLLSS IGRRKSLPSV
760 770 780 790
TRPRLRVKMY NFLRSLPTLH ERFRLLETSP STEEITLSES DNAKESI
Length:797
Mass (Da):88,909
Last modified:May 5, 2009 - v2
Checksum:iD6CAAA78AC0E4679
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PHI0E9PHI0_HUMAN
Adhesion G-protein-coupled receptor...
ADGRG7
502Annotation score:

Sequence cautioni

The sequence AAO27358 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055138151K → E1 PublicationCorresponds to variant dbSNP:rs1144122Ensembl.1
Natural variantiVAR_049459645T → S. Corresponds to variant dbSNP:rs16842529Ensembl.1
Natural variantiVAR_049460756R → H. Corresponds to variant dbSNP:rs9872512Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY181246 mRNA Translation: AAO27358.1 Different initiation.
AK027360 mRNA Translation: BAB55061.1
CH471052 Genomic DNA Translation: EAW79818.1
BC113451 mRNA Translation: AAI13452.1
CCDSiCCDS2938.1
RefSeqiNP_116176.2, NM_032787.2
UniGeneiHs.334511

Genome annotation databases

EnsembliENST00000273352; ENSP00000273352; ENSG00000144820
GeneIDi84873
KEGGihsa:84873
UCSCiuc003duc.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY181246 mRNA Translation: AAO27358.1 Different initiation.
AK027360 mRNA Translation: BAB55061.1
CH471052 Genomic DNA Translation: EAW79818.1
BC113451 mRNA Translation: AAI13452.1
CCDSiCCDS2938.1
RefSeqiNP_116176.2, NM_032787.2
UniGeneiHs.334511

3D structure databases

ProteinModelPortaliQ96K78
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124318, 3 interactors
IntActiQ96K78, 4 interactors
STRINGi9606.ENSP00000273352

Protein family/group databases

MEROPSiP02.020
GPCRDBiSearch...

PTM databases

iPTMnetiQ96K78
PhosphoSitePlusiQ96K78

Polymorphism and mutation databases

BioMutaiGPR128
DMDMi229462926

Proteomic databases

PaxDbiQ96K78
PeptideAtlasiQ96K78
PRIDEiQ96K78
ProteomicsDBi77050

Protocols and materials databases

DNASUi84873
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273352; ENSP00000273352; ENSG00000144820
GeneIDi84873
KEGGihsa:84873
UCSCiuc003duc.5 human

Organism-specific databases

CTDi84873
DisGeNETi84873
EuPathDBiHostDB:ENSG00000144820.7
GeneCardsiADGRG7
HGNCiHGNC:19241 ADGRG7
MIMi612307 gene
neXtProtiNX_Q96K78
OpenTargetsiENSG00000144820
PharmGKBiPA134982718
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4193 Eukaryota
ENOG410XSD2 LUCA
GeneTreeiENSGT00920000148984
HOGENOMiHOG000236310
HOVERGENiHBG063831
InParanoidiQ96K78
KOiK08464
OMAiLWKNNQN
OrthoDBiEOG091G03DK
PhylomeDBiQ96K78
TreeFamiTF351485

Miscellaneous databases

ChiTaRSiADGRG7 human
GenomeRNAii84873
PROiPR:Q96K78
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144820 Expressed in 74 organ(s), highest expression level in intestine
CleanExiHS_GPR128
ExpressionAtlasiQ96K78 baseline and differential
GenevisibleiQ96K78 HS

Family and domain databases

InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR000832 GPCR_2_secretin-like
IPR000203 GPS
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF01825 GPS, 1 hit
PRINTSiPR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00303 GPS, 1 hit
PROSITEiView protein in PROSITE
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAGRG7_HUMAN
AccessioniPrimary (citable) accession number: Q96K78
Secondary accession number(s): Q14D94, Q86SQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: May 5, 2009
Last modified: September 12, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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