UniProtKB - Q96K78 (AGRG7_HUMAN)
Protein
Adhesion G-protein coupled receptor G7
Gene
ADGRG7
Organism
Homo sapiens (Human)
Status
Functioni
Orphan receptor.
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central
- cell surface receptor signaling pathway Source: InterPro
- G protein-coupled receptor signaling pathway Source: GDB
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q96K78 |
Protein family/group databases
MEROPSi | P02.020 |
Names & Taxonomyi
Protein namesi | Recommended name: Adhesion G-protein coupled receptor G71 PublicationAlternative name(s): G-protein coupled receptor 128 |
Gene namesi | Name:ADGRG7 Synonyms:GPR128 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000144820.7 |
HGNCi | HGNC:19241, ADGRG7 |
MIMi | 612307, gene |
neXtProti | NX_Q96K78 |
Subcellular locationi
Other locations
- Membrane Sequence analysis; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: GDB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 27 – 438 | ExtracellularSequence analysisAdd BLAST | 412 | |
Transmembranei | 439 – 459 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 460 – 468 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 469 – 489 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 490 – 528 | ExtracellularSequence analysisAdd BLAST | 39 | |
Transmembranei | 529 – 549 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 550 – 565 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 566 – 586 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 587 – 623 | ExtracellularSequence analysisAdd BLAST | 37 | |
Transmembranei | 624 – 644 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 645 – 669 | CytoplasmicSequence analysisAdd BLAST | 25 | |
Transmembranei | 670 – 690 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 691 – 698 | ExtracellularSequence analysis | 8 | |
Transmembranei | 699 – 719 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 720 – 797 | CytoplasmicSequence analysisAdd BLAST | 78 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 84873 |
OpenTargetsi | ENSG00000144820 |
PharmGKBi | PA134982718 |
Miscellaneous databases
Pharosi | Q96K78, Tdark |
Polymorphism and mutation databases
BioMutai | ADGRG7 |
DMDMi | 229462926 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_0000012903 | 27 – 797 | Adhesion G-protein coupled receptor G7Add BLAST | 771 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 82 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 159 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 178 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 191 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 247 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 261 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 312 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 316 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 387 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 413 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MassIVEi | Q96K78 |
PaxDbi | Q96K78 |
PeptideAtlasi | Q96K78 |
PRIDEi | Q96K78 |
ProteomicsDBi | 77050 |
PTM databases
GlyGeni | Q96K78, 10 sites |
iPTMneti | Q96K78 |
PhosphoSitePlusi | Q96K78 |
Expressioni
Gene expression databases
Bgeei | ENSG00000144820, Expressed in intestine and 98 other tissues |
ExpressionAtlasi | Q96K78, baseline and differential |
Genevisiblei | Q96K78, HS |
Organism-specific databases
HPAi | ENSG00000144820, Group enriched (intestine, liver) |
Interactioni
Binary interactionsi
Hide detailsQ96K78
With | #Exp. | IntAct |
---|---|---|
LDLRAD1 [Q5T700] | 7 | EBI-10290200,EBI-10173166 |
SORT1 [Q99523] | 3 | EBI-10290200,EBI-1057058 |
VAPA [Q9P0L0] | 3 | EBI-10290200,EBI-1059156 |
A8KA83 | 3 | EBI-10290200,EBI-10174961 |
Protein-protein interaction databases
BioGRIDi | 124318, 4 interactors |
IntActi | Q96K78, 4 interactors |
STRINGi | 9606.ENSP00000273352 |
Miscellaneous databases
RNActi | Q96K78, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 380 – 427 | GPSPROSITE-ProRule annotationAdd BLAST | 48 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4193, Eukaryota |
GeneTreei | ENSGT00940000159169 |
HOGENOMi | CLU_370321_0_0_1 |
InParanoidi | Q96K78 |
OMAi | DYRQEEI |
OrthoDBi | 349194at2759 |
PhylomeDBi | Q96K78 |
TreeFami | TF351485 |
Family and domain databases
InterProi | View protein in InterPro IPR017981, GPCR_2-like IPR000832, GPCR_2_secretin-like IPR000203, GPS |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF01825, GPS, 1 hit |
PRINTSi | PR00249, GPCRSECRETIN |
SMARTi | View protein in SMART SM00303, GPS, 1 hit |
PROSITEi | View protein in PROSITE PS50261, G_PROTEIN_RECEP_F2_4, 1 hit PS50221, GPS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q96K78-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASCRAWNLR VLVAVVCGLL TGIILGLGIW RIVIRIQRGK STSSSSTPTE
60 70 80 90 100
FCRNGGTWEN GRCICTEEWK GLRCTIANFC ENSTYMGFTF ARIPVGRYGP
110 120 130 140 150
SLQTCGKDTP NAGNPMAVRL CSLSLYGEIE LQKVTIGNCN ENLETLEKQV
160 170 180 190 200
KDVTAPLNNI SSEVQILTSD ANKLTAENIT SATRVVGQIF NTSRNASPEA
210 220 230 240 250
KKVAIVTVSQ LLDASEDAFQ RVAATANDDA LTTLIEQMET YSLSLGNQSV
260 270 280 290 300
VEPNIAIQSA NFSSENAVGP SNVRFSVQKG ASSSLVSSST FIHTNVDGLN
310 320 330 340 350
PDAQTELQVL LNMTKNYTKT CGFVVYQNDK LFQSKTFTAK SDFSQKIISS
360 370 380 390 400
KTDENEQDQS ASVDMVFSPK YNQKEFQLYS YACVYWNLSA KDWDTYGCQK
410 420 430 440 450
DKGTDGFLRC RCNHTTNFAV LMTFKKDYQY PKSLDILSNV GCALSVTGLA
460 470 480 490 500
LTVIFQIVTR KVRKTSVTWV LVNLCISMLI FNLLFVFGIE NSNKNLQTSD
510 520 530 540 550
GDINNIDFDN NDIPRTDTIN IPNPMCTAIA ALLHYFLLVT FTWNALSAAQ
560 570 580 590 600
LYYLLIRTMK PLPRHFILFI SLIGWGVPAI VVAITVGVIY SQNGNNPQWE
610 620 630 640 650
LDYRQEKICW LAIPEPNGVI KSPLLWSFIV PVTIILISNV VMFITISIKV
660 670 680 690 700
LWKNNQNLTS TKKVSSMKKI VSTLSVAVVF GITWILAYLM LVNDDSIRIV
710 720 730 740 750
FSYIFCLFNT TQGLQIFILY TVRTKVFQSE ASKVLMLLSS IGRRKSLPSV
760 770 780 790
TRPRLRVKMY NFLRSLPTLH ERFRLLETSP STEEITLSES DNAKESI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9PHI0 | E9PHI0_HUMAN | Adhesion G-protein-coupled receptor... | ADGRG7 | 502 | Annotation score: |
Sequence cautioni
The sequence AAO27358 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055138 | 151 | K → E1 PublicationCorresponds to variant dbSNP:rs1144122Ensembl. | 1 | |
Natural variantiVAR_049459 | 645 | T → S. Corresponds to variant dbSNP:rs16842529Ensembl. | 1 | |
Natural variantiVAR_049460 | 756 | R → H. Corresponds to variant dbSNP:rs9872512EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY181246 mRNA Translation: AAO27358.1 Different initiation. AK027360 mRNA Translation: BAB55061.1 CH471052 Genomic DNA Translation: EAW79818.1 BC113451 mRNA Translation: AAI13452.1 |
CCDSi | CCDS2938.1 |
RefSeqi | NP_116176.2, NM_032787.2 |
Genome annotation databases
Ensembli | ENST00000273352; ENSP00000273352; ENSG00000144820 |
GeneIDi | 84873 |
KEGGi | hsa:84873 |
UCSCi | uc003duc.5, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY181246 mRNA Translation: AAO27358.1 Different initiation. AK027360 mRNA Translation: BAB55061.1 CH471052 Genomic DNA Translation: EAW79818.1 BC113451 mRNA Translation: AAI13452.1 |
CCDSi | CCDS2938.1 |
RefSeqi | NP_116176.2, NM_032787.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 124318, 4 interactors |
IntActi | Q96K78, 4 interactors |
STRINGi | 9606.ENSP00000273352 |
Protein family/group databases
MEROPSi | P02.020 |
GPCRDBi | Search... |
PTM databases
GlyGeni | Q96K78, 10 sites |
iPTMneti | Q96K78 |
PhosphoSitePlusi | Q96K78 |
Polymorphism and mutation databases
BioMutai | ADGRG7 |
DMDMi | 229462926 |
Proteomic databases
MassIVEi | Q96K78 |
PaxDbi | Q96K78 |
PeptideAtlasi | Q96K78 |
PRIDEi | Q96K78 |
ProteomicsDBi | 77050 |
Protocols and materials databases
Antibodypediai | 15851, 103 antibodies |
DNASUi | 84873 |
Genome annotation databases
Ensembli | ENST00000273352; ENSP00000273352; ENSG00000144820 |
GeneIDi | 84873 |
KEGGi | hsa:84873 |
UCSCi | uc003duc.5, human |
Organism-specific databases
CTDi | 84873 |
DisGeNETi | 84873 |
EuPathDBi | HostDB:ENSG00000144820.7 |
GeneCardsi | ADGRG7 |
HGNCi | HGNC:19241, ADGRG7 |
HPAi | ENSG00000144820, Group enriched (intestine, liver) |
MIMi | 612307, gene |
neXtProti | NX_Q96K78 |
OpenTargetsi | ENSG00000144820 |
PharmGKBi | PA134982718 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4193, Eukaryota |
GeneTreei | ENSGT00940000159169 |
HOGENOMi | CLU_370321_0_0_1 |
InParanoidi | Q96K78 |
OMAi | DYRQEEI |
OrthoDBi | 349194at2759 |
PhylomeDBi | Q96K78 |
TreeFami | TF351485 |
Enzyme and pathway databases
PathwayCommonsi | Q96K78 |
Miscellaneous databases
BioGRID-ORCSi | 84873, 1 hit in 835 CRISPR screens |
ChiTaRSi | ADGRG7, human |
GenomeRNAii | 84873 |
Pharosi | Q96K78, Tdark |
PROi | PR:Q96K78 |
RNActi | Q96K78, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000144820, Expressed in intestine and 98 other tissues |
ExpressionAtlasi | Q96K78, baseline and differential |
Genevisiblei | Q96K78, HS |
Family and domain databases
InterProi | View protein in InterPro IPR017981, GPCR_2-like IPR000832, GPCR_2_secretin-like IPR000203, GPS |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF01825, GPS, 1 hit |
PRINTSi | PR00249, GPCRSECRETIN |
SMARTi | View protein in SMART SM00303, GPS, 1 hit |
PROSITEi | View protein in PROSITE PS50261, G_PROTEIN_RECEP_F2_4, 1 hit PS50221, GPS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AGRG7_HUMAN | |
Accessioni | Q96K78Primary (citable) accession number: Q96K78 Secondary accession number(s): Q14D94, Q86SQ2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 29, 2004 |
Last sequence update: | May 5, 2009 | |
Last modified: | December 2, 2020 | |
This is version 149 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries