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Entry version 171 (07 Apr 2021)
Sequence version 3 (30 Nov 2010)
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Protein

Ubiquitin carboxyl-terminal hydrolase 47

Gene

USP47

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level.2 Publications

Caution

Was initially thought to catalytically inactive (PubMed:14715245). However, it was later shown that it is active (PubMed:21362556).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei197NucleophilePROSITE-ProRule annotation1
Active sitei503Proton acceptorPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processDNA damage, DNA repair, Ubl conjugation pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96K76

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5689880, Ub-specific processing proteases

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C19.055

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 47 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 47
Ubiquitin thioesterase 47
Ubiquitin-specific-processing protease 47
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:USP47
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20076, USP47

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614460, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96K76

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000170242.17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55031

Open Targets

More...
OpenTargetsi
ENSG00000170242

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134880952

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96K76, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2157851

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
USP47

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104266

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000806761 – 1375Ubiquitin carboxyl-terminal hydrolase 47Add BLAST1375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei122N6-acetyllysineCombined sources1
Modified residuei832PhosphoserineCombined sources1
Modified residuei910PhosphoserineCombined sources1
Modified residuei933PhosphoserineCombined sources1
Modified residuei1013PhosphoserineCombined sources1
Modified residuei1015PhosphothreonineCombined sources1
Modified residuei1017PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96K76

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96K76

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96K76

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96K76

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96K76

PeptideAtlas

More...
PeptideAtlasi
Q96K76

PRoteomics IDEntifications database

More...
PRIDEi
Q96K76

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
21996
77047 [Q96K76-1]
77048 [Q96K76-2]
77049 [Q96K76-3]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q96K76

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96K76

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q96K76

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96K76

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in skeletal muscle, heart and testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000170242, Expressed in epithelium of mammary gland and 245 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96K76, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000170242, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with BTRC and FBXW11.

Interacts with POLB.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120360, 126 interactors

Database of interacting proteins

More...
DIPi
DIP-53629N

Protein interaction database and analysis system

More...
IntActi
Q96K76, 75 interactors

Molecular INTeraction database

More...
MINTi
Q96K76

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000433146

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q96K76

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96K76, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96K76

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini188 – 564USPAdd BLAST377

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4598, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157223

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002928_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96K76

Identification of Orthologs from Complete Genome Data

More...
OMAi
FLCEWIV

Database of Orthologous Groups

More...
OrthoDBi
77113at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96K76

TreeFam database of animal gene trees

More...
TreeFami
TF314142

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR001394, Peptidase_C19_UCH
IPR029071, Ubiquitin-like_domsf
IPR018200, USP_CS
IPR028889, USP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00443, UCH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001, SSF54001, 1 hit
SSF54236, SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00972, USP_1, 1 hit
PS00973, USP_2, 1 hit
PS50235, USP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96K76-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVPGEENQLV PKEDVFWRCR QNIFDEMKKK FLQIENAAEE PRVLCIIQDT
60 70 80 90 100
TNSKTVNERI TLNLPASTPV RKLFEDVANK VGYINGTFDL VWGNGINTAD
110 120 130 140 150
MAPLDHTSDK SLLDANFEPG KKNFLHLTDK DGEQPQILLE DSSAGEDSVH
160 170 180 190 200
DRFIGPLPRE GSGGSTSDYV SQSYSYSSIL NKSETGYVGL VNQAMTCYLN
210 220 230 240 250
SLLQTLFMTP EFRNALYKWE FEESEEDPVT SIPYQLQRLF VLLQTSKKRA
260 270 280 290 300
IETTDVTRSF GWDSSEAWQQ HDVQELCRVM FDALEQKWKQ TEQADLINEL
310 320 330 340 350
YQGKLKDYVR CLECGYEGWR IDTYLDIPLV IRPYGSSQAF ASVEEALHAF
360 370 380 390 400
IQPEILDGPN QYFCERCKKK CDARKGLRFL HFPYLLTLQL KRFDFDYTTM
410 420 430 440 450
HRIKLNDRMT FPEELDMSTF IDVEDEKSPQ TESCTDSGAE NEGSCHSDQM
460 470 480 490 500
SNDFSNDDGV DEGICLETNS GTEKISKSGL EKNSLIYELF SVMVHSGSAA
510 520 530 540 550
GGHYYACIKS FSDEQWYSFN DQHVSRITQE DIKKTHGGSS GSRGYYSSAF
560 570 580 590 600
ASSTNAYMLI YRLKDPARNA KFLEVDEYPE HIKNLVQKER ELEEQEKRQR
610 620 630 640 650
EIERNTCKIK LFCLHPTKQV MMENKLEVHK DKTLKEAVEM AYKMMDLEEV
660 670 680 690 700
IPLDCCRLVK YDEFHDYLER SYEGEEDTPM GLLLGGVKST YMFDLLLETR
710 720 730 740 750
KPDQVFQSYK PGEVMVKVHV VDLKAESVAA PITVRAYLNQ TVTEFKQLIS
760 770 780 790 800
KAIHLPAETM RIVLERCYND LRLLSVSSKT LKAEGFFRSN KVFVESSETL
810 820 830 840 850
DYQMAFADSH LWKLLDRHAN TIRLFVLLPE QSPVSYSKRT AYQKAGGDSG
860 870 880 890 900
NVDDDCERVK GPVGSLKSVE AILEESTEKL KSLSLQQQQD GDNGDSSKST
910 920 930 940 950
ETSDFENIES PLNERDSSAS VDNRELEQHI QTSDPENFQS EERSDSDVNN
960 970 980 990 1000
DRSTSSVDSD ILSSSHSSDT LCNADNAQIP LANGLDSHSI TSSRRTKANE
1010 1020 1030 1040 1050
GKKETWDTAE EDSGTDSEYD ESGKSRGEMQ YMYFKAEPYA ADEGSGEGHK
1060 1070 1080 1090 1100
WLMVHVDKRI TLAAFKQHLE PFVGVLSSHF KVFRVYASNQ EFESVRLNET
1110 1120 1130 1140 1150
LSSFSDDNKI TIRLGRALKK GEYRVKVYQL LVNEQEPCKF LLDAVFAKGM
1160 1170 1180 1190 1200
TVRQSKEELI PQLREQCGLE LSIDRFRLRK KTWKNPGTVF LDYHIYEEDI
1210 1220 1230 1240 1250
NISSNWEVFL EVLDGVEKMK SMSQLAVLSR RWKPSEMKLD PFQEVVLESS
1260 1270 1280 1290 1300
SVDELREKLS EISGIPLDDI EFAKGRGTFP CDISVLDIHQ DLDWNPKVST
1310 1320 1330 1340 1350
LNVWPLYICD DGAVIFYRDK TEELMELTDE QRNELMKKES SRLQKTGHRV
1360 1370
TYSPRKEKAL KIYLDGAPNK DLTQD
Length:1,375
Mass (Da):157,311
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1EDEAA9B5AFC97FE
GO
Isoform 2 (identifier: Q96K76-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-101: Missing.

Show »
Length:1,287
Mass (Da):147,223
Checksum:i2A332C63E843B074
GO
Isoform 3 (identifier: Q96K76-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1218: Missing.

Show »
Length:157
Mass (Da):18,150
Checksum:i95A4D6BB8090CD30
GO
Isoform 4 (identifier: Q96K76-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-33: Missing.

Show »
Length:1,355
Mass (Da):154,697
Checksum:i1AE6E4E9054F921A
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91348 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BC071559 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti340F → L in BAG54467 (PubMed:14702039).Curated1
Sequence conflicti494V → A in BAB55063 (PubMed:14702039).Curated1
Sequence conflicti494V → A in BAG54467 (PubMed:14702039).Curated1
Sequence conflicti494V → A in BC071559 (PubMed:15489334).Curated1
Sequence conflicti520N → D in BAB55063 (PubMed:14702039).Curated1
Sequence conflicti576D → G in BAB55063 (PubMed:14702039).Curated1
Sequence conflicti604R → G in BAB84902 (Ref. 4) Curated1
Sequence conflicti911P → S in BAG54467 (PubMed:14702039).Curated1
Sequence conflicti1157E → G in BAA91348 (PubMed:14702039).Curated1
Sequence conflicti1313A → G in BAA91348 (PubMed:14702039).Curated1
Sequence conflicti1368P → Q in BC071559 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_022787163G → VCombined sources2 PublicationsCorresponds to variant dbSNP:rs11022079Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0144141 – 1218Missing in isoform 3. 1 PublicationAdd BLAST1218
Alternative sequenceiVSP_01441514 – 101Missing in isoform 2. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_05565014 – 33Missing in isoform 4. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK000734 mRNA Translation: BAA91348.1 Different initiation.
AK027362 mRNA Translation: BAB55063.1
AK092290 mRNA No translation available.
AK127264 mRNA Translation: BAG54467.1
AC104383 Genomic DNA No translation available.
AC124276 Genomic DNA No translation available.
BC000226 mRNA Translation: AAH00226.2
BC047044 mRNA Translation: AAH47044.2
BC071559 mRNA No translation available.
AK074076 mRNA Translation: BAB84902.1
AL832991 mRNA Translation: CAH56337.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS41619.1 [Q96K76-2]
CCDS60725.1 [Q96K76-4]
CCDS81554.1 [Q96K76-1]

NCBI Reference Sequences

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RefSeqi
NP_001269588.1, NM_001282659.1 [Q96K76-4]
NP_001317137.1, NM_001330208.1 [Q96K76-1]
NP_060414.3, NM_017944.3 [Q96K76-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000339865; ENSP00000339957; ENSG00000170242 [Q96K76-2]
ENST00000399455; ENSP00000382382; ENSG00000170242 [Q96K76-1]
ENST00000527733; ENSP00000433146; ENSG00000170242 [Q96K76-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55031

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55031

UCSC genome browser

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UCSCi
uc001mjr.4, human [Q96K76-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000734 mRNA Translation: BAA91348.1 Different initiation.
AK027362 mRNA Translation: BAB55063.1
AK092290 mRNA No translation available.
AK127264 mRNA Translation: BAG54467.1
AC104383 Genomic DNA No translation available.
AC124276 Genomic DNA No translation available.
BC000226 mRNA Translation: AAH00226.2
BC047044 mRNA Translation: AAH47044.2
BC071559 mRNA No translation available.
AK074076 mRNA Translation: BAB84902.1
AL832991 mRNA Translation: CAH56337.1
CCDSiCCDS41619.1 [Q96K76-2]
CCDS60725.1 [Q96K76-4]
CCDS81554.1 [Q96K76-1]
RefSeqiNP_001269588.1, NM_001282659.1 [Q96K76-4]
NP_001317137.1, NM_001330208.1 [Q96K76-1]
NP_060414.3, NM_017944.3 [Q96K76-2]

3D structure databases

SMRiQ96K76
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120360, 126 interactors
DIPiDIP-53629N
IntActiQ96K76, 75 interactors
MINTiQ96K76
STRINGi9606.ENSP00000433146

Chemistry databases

BindingDBiQ96K76
ChEMBLiCHEMBL2157851

Protein family/group databases

MEROPSiC19.055

PTM databases

CarbonylDBiQ96K76
iPTMnetiQ96K76
MetOSiteiQ96K76
PhosphoSitePlusiQ96K76

Genetic variation databases

BioMutaiUSP47
DMDMi313104266

Proteomic databases

EPDiQ96K76
jPOSTiQ96K76
MassIVEiQ96K76
MaxQBiQ96K76
PaxDbiQ96K76
PeptideAtlasiQ96K76
PRIDEiQ96K76
ProteomicsDBi21996
77047 [Q96K76-1]
77048 [Q96K76-2]
77049 [Q96K76-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
24483, 145 antibodies

Genome annotation databases

EnsembliENST00000339865; ENSP00000339957; ENSG00000170242 [Q96K76-2]
ENST00000399455; ENSP00000382382; ENSG00000170242 [Q96K76-1]
ENST00000527733; ENSP00000433146; ENSG00000170242 [Q96K76-4]
GeneIDi55031
KEGGihsa:55031
UCSCiuc001mjr.4, human [Q96K76-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55031
DisGeNETi55031

GeneCards: human genes, protein and diseases

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GeneCardsi
USP47
HGNCiHGNC:20076, USP47
HPAiENSG00000170242, Low tissue specificity
MIMi614460, gene
neXtProtiNX_Q96K76
OpenTargetsiENSG00000170242
PharmGKBiPA134880952
VEuPathDBiHostDB:ENSG00000170242.17

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4598, Eukaryota
GeneTreeiENSGT00940000157223
HOGENOMiCLU_002928_0_0_1
InParanoidiQ96K76
OMAiFLCEWIV
OrthoDBi77113at2759
PhylomeDBiQ96K76
TreeFamiTF314142

Enzyme and pathway databases

PathwayCommonsiQ96K76
ReactomeiR-HSA-5689880, Ub-specific processing proteases

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
55031, 8 hits in 995 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
USP47, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
USP47

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55031
PharosiQ96K76, Tchem

Protein Ontology

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PROi
PR:Q96K76
RNActiQ96K76, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000170242, Expressed in epithelium of mammary gland and 245 other tissues
GenevisibleiQ96K76, HS

Family and domain databases

InterProiView protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR001394, Peptidase_C19_UCH
IPR029071, Ubiquitin-like_domsf
IPR018200, USP_CS
IPR028889, USP_dom
PfamiView protein in Pfam
PF00443, UCH, 1 hit
SUPFAMiSSF54001, SSF54001, 1 hit
SSF54236, SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00972, USP_1, 1 hit
PS00973, USP_2, 1 hit
PS50235, USP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBP47_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96K76
Secondary accession number(s): B3KXF5
, E9PM46, Q658U0, Q86Y73, Q8TEP6, Q9BWI0, Q9NWN1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: November 30, 2010
Last modified: April 7, 2021
This is version 171 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
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