Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger and BTB domain-containing protein 45

Gene

ZBTB45

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation (Probable). In the central nervous system, may play a role in glial cell differentiation (By similarity).By similarityCurated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri403 – 425C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri486 – 508C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processNeurogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 45
Alternative name(s):
Zinc finger protein 499
Gene namesi
Name:ZBTB45
Synonyms:ZNF499
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000119574.12
HGNCiHGNC:23715 ZBTB45
neXtProtiNX_Q96K62

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000119574
PharmGKBiPA162409464

Polymorphism and mutation databases

BioMutaiZBTB45
DMDMi45477325

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476191 – 511Zinc finger and BTB domain-containing protein 45Add BLAST511

Proteomic databases

EPDiQ96K62
PaxDbiQ96K62
PeptideAtlasiQ96K62
PRIDEiQ96K62
ProteomicsDBi77044

PTM databases

iPTMnetiQ96K62
PhosphoSitePlusiQ96K62

Expressioni

Gene expression databases

BgeeiENSG00000119574 Expressed in 158 organ(s), highest expression level in quadriceps femoris
CleanExiHS_ZBTB45
ExpressionAtlasiQ96K62 baseline and differential
GenevisibleiQ96K62 HS

Organism-specific databases

HPAiHPA035754

Interactioni

Protein-protein interaction databases

BioGridi124322, 2 interactors
DIPiDIP-62048N
IntActiQ96K62, 4 interactors
STRINGi9606.ENSP00000346603

Structurei

3D structure databases

ProteinModelPortaliQ96K62
SMRiQ96K62
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 96BTBPROSITE-ProRule annotationAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi128 – 197Pro-richAdd BLAST70
Compositional biasi299 – 401Pro-richAdd BLAST103

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri403 – 425C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri486 – 508C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119063
HOGENOMiHOG000136747
HOVERGENiHBG060183
InParanoidiQ96K62
KOiK10516
OMAiPDCALAG
OrthoDBiEOG091G0EMJ
PhylomeDBiQ96K62
TreeFamiTF335684

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q96K62-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAEAVHHI HLQNFSRSLL ETLNGQRLGG HFCDVTVRIR EASLRAHRCV
60 70 80 90 100
LAAGSPFFQD KLLLGHSEIR VPPVVPAQTV RQLVEFLYSG SLVVAQGEAL
110 120 130 140 150
QVLTAASVLR IQTVIDECTQ IIARARAPGT SAPTPLPTPV PPPLAPAQLR
160 170 180 190 200
HRLRHLLAAR PPGHPGAAHS RKQRQPARLQ LPAPPTPAKA EGPDADPSLS
210 220 230 240 250
AAPDDRGDED DEESDDETDG EDGEGGGPGE GQAPPSFPDC AAGFLTAAAD
260 270 280 290 300
SACEEPPAPT GLADYSGAGR DFLRGAGSAE DVFPDSYVST WHDEDGAVPE
310 320 330 340 350
GCPTETPVQP DCILSGSRPP GVKTPGPPVA LFPFHLGAPG PPAPPPSAPS
360 370 380 390 400
GPAPAPPPAF YPTLQPEAAP STQLGEVPAP SAAPTTAPSG TPARTPGAEP
410 420 430 440 450
PTYECSHCRK TFSSRKNYTK HMFIHSGEKP HQCAVCWRSF SLRDYLLKHM
460 470 480 490 500
VTHTGVRAFQ CAVCAKRFTQ KSSLNVHMRT HRPERAPCPA CGKVFSHRAL
510
LERHLAAHPA P
Length:511
Mass (Da):54,008
Last modified:December 1, 2001 - v1
Checksum:i6E691746C51CB988
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QZ57M0QZ57_HUMAN
Zinc finger and BTB domain-containi...
ZBTB45
121Annotation score:
M0R1I4M0R1I4_HUMAN
Zinc finger and BTB domain-containi...
ZBTB45
17Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052924293D → E. Corresponds to variant dbSNP:rs35430780Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027392 mRNA Translation: BAB55079.1
BC024738 mRNA Translation: AAH24738.1
CCDSiCCDS12984.1
RefSeqiNP_001303907.1, NM_001316978.1
NP_001303908.1, NM_001316979.1
NP_001303909.1, NM_001316980.1
NP_001303910.1, NM_001316981.1
NP_001303911.1, NM_001316982.1
NP_116181.1, NM_032792.3
XP_006723508.1, XM_006723445.3
UniGeneiHs.515662

Genome annotation databases

EnsembliENST00000354590; ENSP00000346603; ENSG00000119574
ENST00000594051; ENSP00000469089; ENSG00000119574
ENST00000600990; ENSP00000473072; ENSG00000119574
GeneIDi84878
KEGGihsa:84878
UCSCiuc002qtd.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027392 mRNA Translation: BAB55079.1
BC024738 mRNA Translation: AAH24738.1
CCDSiCCDS12984.1
RefSeqiNP_001303907.1, NM_001316978.1
NP_001303908.1, NM_001316979.1
NP_001303909.1, NM_001316980.1
NP_001303910.1, NM_001316981.1
NP_001303911.1, NM_001316982.1
NP_116181.1, NM_032792.3
XP_006723508.1, XM_006723445.3
UniGeneiHs.515662

3D structure databases

ProteinModelPortaliQ96K62
SMRiQ96K62
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124322, 2 interactors
DIPiDIP-62048N
IntActiQ96K62, 4 interactors
STRINGi9606.ENSP00000346603

PTM databases

iPTMnetiQ96K62
PhosphoSitePlusiQ96K62

Polymorphism and mutation databases

BioMutaiZBTB45
DMDMi45477325

Proteomic databases

EPDiQ96K62
PaxDbiQ96K62
PeptideAtlasiQ96K62
PRIDEiQ96K62
ProteomicsDBi77044

Protocols and materials databases

DNASUi84878
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354590; ENSP00000346603; ENSG00000119574
ENST00000594051; ENSP00000469089; ENSG00000119574
ENST00000600990; ENSP00000473072; ENSG00000119574
GeneIDi84878
KEGGihsa:84878
UCSCiuc002qtd.3 human

Organism-specific databases

CTDi84878
EuPathDBiHostDB:ENSG00000119574.12
GeneCardsiZBTB45
HGNCiHGNC:23715 ZBTB45
HPAiHPA035754
neXtProtiNX_Q96K62
OpenTargetsiENSG00000119574
PharmGKBiPA162409464
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119063
HOGENOMiHOG000136747
HOVERGENiHBG060183
InParanoidiQ96K62
KOiK10516
OMAiPDCALAG
OrthoDBiEOG091G0EMJ
PhylomeDBiQ96K62
TreeFamiTF335684

Miscellaneous databases

ChiTaRSiZBTB45 human
GenomeRNAii84878
PROiPR:Q96K62

Gene expression databases

BgeeiENSG00000119574 Expressed in 158 organ(s), highest expression level in quadriceps femoris
CleanExiHS_ZBTB45
ExpressionAtlasiQ96K62 baseline and differential
GenevisibleiQ96K62 HS

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZBT45_HUMAN
AccessioniPrimary (citable) accession number: Q96K62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again