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Entry version 155 (07 Oct 2020)
Sequence version 3 (05 Oct 2010)
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Protein

Zinc finger protein 668

Gene

ZNF668

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri22 – 44C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri84 – 106C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri112 – 134C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri140 – 162C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri168 – 190C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri516 – 538C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri544 – 566C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri572 – 594C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96K58

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 668
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF668
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000167394.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25821, ZNF668

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96K58

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
79759

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670515

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96K58, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF668

Domain mapping of disease mutations (DMDM)

More...
DMDMi
306526260

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002514781 – 619Zinc finger protein 668Add BLAST619

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei10PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki57Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki59Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki65Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki80Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki154Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei387PhosphoserineCombined sources1
Cross-linki512Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96K58

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96K58

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96K58

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96K58

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96K58

PeptideAtlas

More...
PeptideAtlasi
Q96K58

PRoteomics IDEntifications database

More...
PRIDEi
Q96K58

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
10221
77043 [Q96K58-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96K58

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96K58

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000167394, Expressed in blood and 135 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96K58, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96K58, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000167394, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
122868, 48 interactors

Protein interaction database and analysis system

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IntActi
Q96K58, 32 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000442573

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96K58, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96K58

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri22 – 44C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri84 – 106C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri112 – 134C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri140 – 162C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri168 – 190C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri516 – 538C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri544 – 566C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri572 – 594C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_44_10_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96K58

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96K58

TreeFam database of animal gene trees

More...
TreeFami
TF331849

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096, zf-C2H2, 13 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355, ZnF_C2H2, 16 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667, SSF57667, 8 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 16 hits
PS50157, ZINC_FINGER_C2H2_2, 16 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96K58-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEVEAAEARS PAPGYKRSGR RYKCVSCTKT FPNAPRAARH AATHGPADCS
60 70 80 90 100
EEVAEVKPKP ETEAKAEEAS GEKVSGSAAK PRPYACPLCP KAYKTAPELR
110 120 130 140 150
SHGRSHTGEK PFPCPECGRR FMQPVCLRVH LASHAGELPF RCAHCPKAYG
160 170 180 190 200
ALSKLKIHQR GHTGERPYAC ADCGKSFADP SVFRKHRRTH AGLRPYSCER
210 220 230 240 250
CGKAYAELKD LRNHERSHTG ERPFLCSECG KSFSRSSSLT CHQRIHAAQK
260 270 280 290 300
PYRCPACGKG FTQLSSYQSH ERTHSGEKPF LCPRCGRMFS DPSSFRRHQR
310 320 330 340 350
AHEGVKPYHC EKCGKDFRQP ADLAMHRRVH TGDRPFKCLQ CDKTFVASWD
360 370 380 390 400
LKRHALVHSG QRPFRCEECG RAFAERASLT KHSRVHSGER PFHCNACGKS
410 420 430 440 450
FVVSSSLRKH ERTHRSSEAA GVPPAQELVV GLALPVGVAG ESSAAPAAGA
460 470 480 490 500
GLGDPPAGLL GLPPESGGVM ATQWQVVGMT VEHVECQDAG VREAPGPLEG
510 520 530 540 550
AGEAGGEEAD EKPPQFVCRE CKETFSTMTL LRRHERSHPE LRPFPCTQCG
560 570 580 590 600
KSFSDRAGLR KHSRTHSSVR PYTCPHCPKA FLSASDLRKH ERTHPVPMGT
610
PTPLEPLVAL LGMPEEGPA
Length:619
Mass (Da):67,890
Last modified:October 5, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB86A2E15E9E7D7E8
GO
Isoform 2 (identifier: Q96K58-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSEPGMLGRKDVWVPRETPFTKAM

Show »
Length:642
Mass (Da):70,505
Checksum:i186431601BBF0075
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JCJ0C9JCJ0_HUMAN
Zinc finger protein 668
ZNF668
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JG35C9JG35_HUMAN
Zinc finger protein 668
ZNF668
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J092C9J092_HUMAN
Zinc finger protein 668
ZNF668
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14602 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAD92947 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti130H → R in BAB14602 (PubMed:14702039).Curated1
Sequence conflicti553F → I in BAB55084 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02768925V → L3 PublicationsCorresponds to variant dbSNP:rs2032917Ensembl.1
Natural variantiVAR_03559566A → T in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1429688220Ensembl.1
Natural variantiVAR_035596286G → S in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs553159663Ensembl.1
Natural variantiVAR_027690304G → E1 PublicationCorresponds to variant dbSNP:rs17851949Ensembl.1
Natural variantiVAR_035597331T → R in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_027691447A → V. Corresponds to variant dbSNP:rs8046978Ensembl.1
Natural variantiVAR_035598556R → Q in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs148738674Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0537861M → MSEPGMLGRKDVWVPRETPF TKAM in isoform 2. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK023541 mRNA Translation: BAB14602.1 Different initiation.
AK027398 mRNA Translation: BAB55084.1
AB209710 mRNA Translation: BAD92947.2 Different initiation.
AC135050 Genomic DNA No translation available.
BC021997 mRNA Translation: AAH21997.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10701.1 [Q96K58-1]
CCDS54003.1 [Q96K58-2]

NCBI Reference Sequences

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RefSeqi
NP_001166139.1, NM_001172668.1
NP_001166140.1, NM_001172669.1
NP_001166141.1, NM_001172670.1
NP_078982.3, NM_024706.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000300849; ENSP00000300849; ENSG00000167394
ENST00000394983; ENSP00000378434; ENSG00000167394
ENST00000426488; ENSP00000403975; ENSG00000167394
ENST00000535577; ENSP00000441349; ENSG00000167394
ENST00000538906; ENSP00000440149; ENSG00000167394
ENST00000539836; ENSP00000442573; ENSG00000167394

Database of genes from NCBI RefSeq genomes

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GeneIDi
79759

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:79759

UCSC genome browser

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UCSCi
uc002eao.4, human [Q96K58-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023541 mRNA Translation: BAB14602.1 Different initiation.
AK027398 mRNA Translation: BAB55084.1
AB209710 mRNA Translation: BAD92947.2 Different initiation.
AC135050 Genomic DNA No translation available.
BC021997 mRNA Translation: AAH21997.1
CCDSiCCDS10701.1 [Q96K58-1]
CCDS54003.1 [Q96K58-2]
RefSeqiNP_001166139.1, NM_001172668.1
NP_001166140.1, NM_001172669.1
NP_001166141.1, NM_001172670.1
NP_078982.3, NM_024706.4

3D structure databases

SMRiQ96K58
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122868, 48 interactors
IntActiQ96K58, 32 interactors
STRINGi9606.ENSP00000442573

PTM databases

iPTMnetiQ96K58
PhosphoSitePlusiQ96K58

Polymorphism and mutation databases

BioMutaiZNF668
DMDMi306526260

Proteomic databases

EPDiQ96K58
jPOSTiQ96K58
MassIVEiQ96K58
MaxQBiQ96K58
PaxDbiQ96K58
PeptideAtlasiQ96K58
PRIDEiQ96K58
ProteomicsDBi10221
77043 [Q96K58-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
13908, 108 antibodies

The DNASU plasmid repository

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DNASUi
79759

Genome annotation databases

EnsembliENST00000300849; ENSP00000300849; ENSG00000167394
ENST00000394983; ENSP00000378434; ENSG00000167394
ENST00000426488; ENSP00000403975; ENSG00000167394
ENST00000535577; ENSP00000441349; ENSG00000167394
ENST00000538906; ENSP00000440149; ENSG00000167394
ENST00000539836; ENSP00000442573; ENSG00000167394
GeneIDi79759
KEGGihsa:79759
UCSCiuc002eao.4, human [Q96K58-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
79759
DisGeNETi79759
EuPathDBiHostDB:ENSG00000167394.12

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF668
HGNCiHGNC:25821, ZNF668
HPAiENSG00000167394, Low tissue specificity
neXtProtiNX_Q96K58
PharmGKBiPA142670515

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721, Eukaryota
HOGENOMiCLU_002678_44_10_1
InParanoidiQ96K58
OrthoDBi1318335at2759
PhylomeDBiQ96K58
TreeFamiTF331849

Enzyme and pathway databases

PathwayCommonsiQ96K58
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
79759, 4 hits in 893 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF668, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79759
PharosiQ96K58, Tdark

Protein Ontology

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PROi
PR:Q96K58
RNActiQ96K58, protein

Gene expression databases

BgeeiENSG00000167394, Expressed in blood and 135 other tissues
ExpressionAtlasiQ96K58, baseline and differential
GenevisibleiQ96K58, HS

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 13 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 16 hits
SUPFAMiSSF57667, SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 16 hits
PS50157, ZINC_FINGER_C2H2_2, 16 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN668_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96K58
Secondary accession number(s): C9JHH8
, F5H7E7, Q59EV1, Q8N669, Q9H8L4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 5, 2010
Last modified: October 7, 2020
This is version 155 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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