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Entry version 117 (16 Oct 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Transmembrane protein 87B

Gene

TMEM87B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 87BCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM87BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25913 TMEM87B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617203 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96K49

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini43 – 214LumenalCuratedAdd BLAST172
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei215 – 235Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini236 – 247CytoplasmicCuratedAdd BLAST12
Transmembranei248 – 268Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini269 – 299LumenalCuratedAdd BLAST31
Transmembranei300 – 320Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini321 – 322CytoplasmicCurated2
Transmembranei323 – 343Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini344 – 350LumenalCurated7
Transmembranei351 – 371Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini372 – 396CytoplasmicCuratedAdd BLAST25
Transmembranei397 – 417Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini418 – 429LumenalCuratedAdd BLAST12
Transmembranei430 – 450Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini451 – 555CytoplasmicCuratedAdd BLAST105

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

TMEM87B mutations may be involved in restrictive cardiomyopathy (RCM), a rare non-ischemic myocardial disease. RCM is characterized by restrictive ventricular-filling physiology in the presence of normal or reduced diastolic and/or systolic volumes (of 1 or both ventricles), biatrial enlargement, and normal ventricular wall thickness.1 Publication

Organism-specific databases

DisGeNET

More...
DisGeNETi
84910

Open Targets

More...
OpenTargetsi
ENSG00000153214

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670740

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96K49

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM87B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74732185

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 42Sequence analysisAdd BLAST42
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000029175343 – 555Transmembrane protein 87BAdd BLAST513

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi197N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi272N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei469PhosphoserineCombined sources1
Modified residuei494PhosphoserineCombined sources1
Modified residuei496PhosphoserineCombined sources1
Modified residuei534PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96K49

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96K49

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96K49

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96K49

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96K49

PeptideAtlas

More...
PeptideAtlasi
Q96K49

PRoteomics IDEntifications database

More...
PRIDEi
Q96K49

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
77041 [Q96K49-1]
77042 [Q96K49-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1855

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96K49

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96K49

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q96K49

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000153214 Expressed in 194 organ(s), highest expression level in corpus epididymis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96K49 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96K49 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA035183

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124347, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q96K49, 4 interactors

Molecular INTeraction database

More...
MINTi
Q96K49

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000283206

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LU7TM family. TMEM87 subfamily.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2568 Eukaryota
ENOG410XS1Q LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156844

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231789

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96K49

Identification of Orthologs from Complete Genome Data

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OMAi
PCIFDDR

Database of Orthologous Groups

More...
OrthoDBi
1448608at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96K49

TreeFam database of animal gene trees

More...
TreeFami
TF314452

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009637 GPR107/GPR108-like

The PANTHER Classification System

More...
PANTHERi
PTHR21229 PTHR21229, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06814 Lung_7-TM_R, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96K49-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVAACRSVAG LLPRRRRCFP ARAPLLRVAL CLLCWTPAAV RAVPELGLWL
60 70 80 90 100
ETVNDKSGPL IFRKTMFNST DIKLSVKSFH CSGPVKFTIV WHLKYHTCHN
110 120 130 140 150
EHSNLEELFQ KHKLSVDEDF CHYLKNDNCW TTKNENLDCN SDSQVFPSLN
160 170 180 190 200
NKELINIRNV SNQERSMDVV ARTQKDGFHI FIVSIKTENT DASWNLNVSL
210 220 230 240 250
SMIGPHGYIS ASDWPLMIFY MVMCIVYILY GILWLTWSAC YWKDILRIQF
260 270 280 290 300
WIAAVIFLGM LEKAVFYSEY QNISNTGLST QGLLIFAELI SAIKRTLARL
310 320 330 340 350
LVIIVSLGYG IVKPRLGTVM HRVIGLGLLY LIFAAVEGVM RVIGGSNHLA
360 370 380 390 400
VVLDDIILAV IDSIFVWFIF ISLAQTMKTL RLRKNTVKFS LYRHFKNTLI
410 420 430 440 450
FAVLASIVFM GWTTKTFRIA KCQSDWMERW VDDAFWSFLF SLILIVIMFL
460 470 480 490 500
WRPSANNQRY AFMPLIDDSD DEIEEFMVTS ENLTEGIKLR ASKSVSNGTA
510 520 530 540 550
KPATSENFDE DLKWVEENIP SSFTDVALPV LVDSDEEIMT RSEMAEKMFS

SEKIM
Length:555
Mass (Da):63,536
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7D9B61E5AADF0AA3
GO
Isoform 2 (identifier: Q96K49-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     167-167: Missing.

Show »
Length:554
Mass (Da):63,405
Checksum:iF4C617CBF68BEDD9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A494BZZ8A0A494BZZ8_HUMAN
Transmembrane protein 87B
TMEM87B
547Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0B3H7C0B3_HUMAN
Transmembrane protein 87B
TMEM87B
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IU29A0A3B3IU29_HUMAN
Transmembrane protein 87B
TMEM87B
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1G1H7C1G1_HUMAN
Transmembrane protein 87B
TMEM87B
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_078997456N → D Found in restrictive cardiomyopathy; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs369634007EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_026219167Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK027587 mRNA Translation: BAB55214.1
AK290294 mRNA Translation: BAF82983.1
AC092645 Genomic DNA No translation available.
AC093675 Genomic DNA Translation: AAY24214.1
BC115373 mRNA Translation: AAI15374.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33275.1 [Q96K49-1]

NCBI Reference Sequences

More...
RefSeqi
NP_116213.1, NM_032824.2 [Q96K49-1]
XP_005263884.1, XM_005263827.2 [Q96K49-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000283206; ENSP00000283206; ENSG00000153214 [Q96K49-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84910

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84910

UCSC genome browser

More...
UCSCi
uc002thm.2 human [Q96K49-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027587 mRNA Translation: BAB55214.1
AK290294 mRNA Translation: BAF82983.1
AC092645 Genomic DNA No translation available.
AC093675 Genomic DNA Translation: AAY24214.1
BC115373 mRNA Translation: AAI15374.1
CCDSiCCDS33275.1 [Q96K49-1]
RefSeqiNP_116213.1, NM_032824.2 [Q96K49-1]
XP_005263884.1, XM_005263827.2 [Q96K49-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi124347, 7 interactors
IntActiQ96K49, 4 interactors
MINTiQ96K49
STRINGi9606.ENSP00000283206

PTM databases

GlyConnecti1855
iPTMnetiQ96K49
PhosphoSitePlusiQ96K49
SwissPalmiQ96K49

Polymorphism and mutation databases

BioMutaiTMEM87B
DMDMi74732185

Proteomic databases

EPDiQ96K49
jPOSTiQ96K49
MassIVEiQ96K49
MaxQBiQ96K49
PaxDbiQ96K49
PeptideAtlasiQ96K49
PRIDEiQ96K49
ProteomicsDBi77041 [Q96K49-1]
77042 [Q96K49-2]

Genome annotation databases

EnsembliENST00000283206; ENSP00000283206; ENSG00000153214 [Q96K49-1]
GeneIDi84910
KEGGihsa:84910
UCSCiuc002thm.2 human [Q96K49-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84910
DisGeNETi84910

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TMEM87B
HGNCiHGNC:25913 TMEM87B
HPAiHPA035183
MIMi617203 gene
neXtProtiNX_Q96K49
OpenTargetsiENSG00000153214
PharmGKBiPA142670740

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2568 Eukaryota
ENOG410XS1Q LUCA
GeneTreeiENSGT00940000156844
HOGENOMiHOG000231789
InParanoidiQ96K49
OMAiPCIFDDR
OrthoDBi1448608at2759
PhylomeDBiQ96K49
TreeFamiTF314452

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TMEM87B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84910
PharosiQ96K49

Protein Ontology

More...
PROi
PR:Q96K49

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000153214 Expressed in 194 organ(s), highest expression level in corpus epididymis
ExpressionAtlasiQ96K49 baseline and differential
GenevisibleiQ96K49 HS

Family and domain databases

InterProiView protein in InterPro
IPR009637 GPR107/GPR108-like
PANTHERiPTHR21229 PTHR21229, 1 hit
PfamiView protein in Pfam
PF06814 Lung_7-TM_R, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM87B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96K49
Secondary accession number(s): A8K2M9, Q1RLN2, Q53R54
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: December 1, 2001
Last modified: October 16, 2019
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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