UniProtKB - Q96K37 (S35E1_HUMAN)
Protein
Solute carrier family 35 member E1
Gene
SLC35E1
Organism
Homo sapiens (Human)
Status
Functioni
Putative transporter.By similarity
GO - Molecular functioni
- antiporter activity Source: GO_Central
- transmembrane transporter activity Source: GO_Central
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
PathwayCommonsi | Q96K37 |
Protein family/group databases
TCDBi | 2.A.7.9.9, the drug/metabolite transporter (dmt) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 35 member E1 |
Gene namesi | Name:SLC35E1 ORF Names:PSEC0038 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20803, SLC35E1 |
neXtProti | NX_Q96K37 |
VEuPathDBi | HostDB:ENSG00000127526.13 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Golgi apparatus
- Golgi apparatus Source: HPA
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 50 – 70 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 111 – 131 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 133 – 153 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 165 – 184 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 188 – 207 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 222 – 242 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 252 – 274 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 282 – 303 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 312 – 332 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 79939 |
OpenTargetsi | ENSG00000127526 |
PharmGKBi | PA134916810 |
Miscellaneous databases
Pharosi | Q96K37, Tdark |
Genetic variation databases
BioMutai | SLC35E1 |
DMDMi | 172045863 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000071941 | 1 – 410 | Solute carrier family 35 member E1Add BLAST | 410 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 363 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q96K37 |
jPOSTi | Q96K37 |
MassIVEi | Q96K37 |
MaxQBi | Q96K37 |
PaxDbi | Q96K37 |
PeptideAtlasi | Q96K37 |
PRIDEi | Q96K37 |
ProteomicsDBi | 77038 [Q96K37-1] 77039 [Q96K37-2] 77040 [Q96K37-3] |
PTM databases
iPTMneti | Q96K37 |
PhosphoSitePlusi | Q96K37 |
SwissPalmi | Q96K37 |
Expressioni
Gene expression databases
Bgeei | ENSG00000127526, Expressed in cerebellum and 256 other tissues |
ExpressionAtlasi | Q96K37, baseline and differential |
Genevisiblei | Q96K37, HS |
Organism-specific databases
HPAi | ENSG00000127526, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 123013, 46 interactors |
IntActi | Q96K37, 37 interactors |
MINTi | Q96K37 |
STRINGi | 9606.ENSP00000470652 |
Miscellaneous databases
RNActi | Q96K37, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1441, Eukaryota |
GeneTreei | ENSGT00940000159007 |
HOGENOMi | CLU_019048_1_0_1 |
InParanoidi | Q96K37 |
OMAi | DTRIHHL |
PhylomeDBi | Q96K37 |
TreeFami | TF324822 |
Family and domain databases
InterProi | View protein in InterPro IPR004853, Sugar_P_trans_dom |
Pfami | View protein in Pfam PF03151, TPT, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96K37-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAAAVGAGH GAGGPGAASS SGGAREGARV AALCLLWYAL SAGGNVVNKV
60 70 80 90 100
ILSAFPFPVT VSLCHILALC AGLPPLLRAW RVPPAPPVSG PGPSPHPSSG
110 120 130 140 150
PLLPPRFYPR YVLPLAFGKY FASVSAHVSI WKVPVSYAHT VKATMPIWVV
160 170 180 190 200
LLSRIIMKEK QSTKVYLSLI PIISGVLLAT VTELSFDMWG LVSALAATLC
210 220 230 240 250
FSLQNIFSKK VLRDSRIHHL RLLNILGCHA VFFMIPTWVL VDLSAFLVSS
260 270 280 290 300
DLTYVYQWPW TLLLLAVSGF CNFAQNVIAF SILNLVSPLS YSVANATKRI
310 320 330 340 350
MVITVSLIML RNPVTSTNVL GMMTAILGVF LYNKTKYDAN QQARKHLLPV
360 370 380 390 400
TTADLSSKER HRSPLEKPHN GLLFPQHGDY QYGRNNILTD HFQYSRQSYP
410
NSYSLNRYDV
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C1I0 | H7C1I0_HUMAN | Solute carrier family 35 member E1 | SLC35E1 | 344 | Annotation score: | ||
C9JK45 | C9JK45_HUMAN | Solute carrier family 35 member E1 | SLC35E1 | 116 | Annotation score: | ||
A0A0A0MSG4 | A0A0A0MSG4_HUMAN | Solute carrier family 35 member E1 | SLC35E1 | 105 | Annotation score: |
Sequence cautioni
The sequence AAH14557 differs from that shown. Reason: Frameshift.Curated
The sequence AAH62562 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55306 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55410 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC11565 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 242 | D → V in CAE45863 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 318 | N → I in BAC11565 (PubMed:16303743).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010139 | 1 – 300 | Missing in isoform 2. 1 PublicationAdd BLAST | 300 | |
Alternative sequenceiVSP_031351 | 1 – 156 | Missing in isoform 3. 1 PublicationAdd BLAST | 156 | |
Alternative sequenceiVSP_010140 | 253 – 260 | TYVYQWPW → GLPSENVL in isoform 3. 1 Publication | 8 | |
Alternative sequenceiVSP_010141 | 261 – 410 | Missing in isoform 3. 1 PublicationAdd BLAST | 150 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX640756 mRNA Translation: CAE45863.1 BC062562 mRNA Translation: AAH62562.1 Different initiation. BC014557 mRNA Translation: AAH14557.1 Frameshift. AK027699 mRNA Translation: BAB55306.1 Different initiation. AK027850 mRNA Translation: BAB55410.1 Different initiation. AK075355 mRNA Translation: BAC11565.1 Different initiation. |
CCDSi | CCDS12346.2 [Q96K37-1] |
RefSeqi | NP_079157.3, NM_024881.4 [Q96K37-1] |
Genome annotation databases
Ensembli | ENST00000595753; ENSP00000470652; ENSG00000127526 [Q96K37-1] |
GeneIDi | 79939 |
KEGGi | hsa:79939 |
UCSCi | uc010xph.3, human [Q96K37-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX640756 mRNA Translation: CAE45863.1 BC062562 mRNA Translation: AAH62562.1 Different initiation. BC014557 mRNA Translation: AAH14557.1 Frameshift. AK027699 mRNA Translation: BAB55306.1 Different initiation. AK027850 mRNA Translation: BAB55410.1 Different initiation. AK075355 mRNA Translation: BAC11565.1 Different initiation. |
CCDSi | CCDS12346.2 [Q96K37-1] |
RefSeqi | NP_079157.3, NM_024881.4 [Q96K37-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 123013, 46 interactors |
IntActi | Q96K37, 37 interactors |
MINTi | Q96K37 |
STRINGi | 9606.ENSP00000470652 |
Protein family/group databases
TCDBi | 2.A.7.9.9, the drug/metabolite transporter (dmt) superfamily |
PTM databases
iPTMneti | Q96K37 |
PhosphoSitePlusi | Q96K37 |
SwissPalmi | Q96K37 |
Genetic variation databases
BioMutai | SLC35E1 |
DMDMi | 172045863 |
Proteomic databases
EPDi | Q96K37 |
jPOSTi | Q96K37 |
MassIVEi | Q96K37 |
MaxQBi | Q96K37 |
PaxDbi | Q96K37 |
PeptideAtlasi | Q96K37 |
PRIDEi | Q96K37 |
ProteomicsDBi | 77038 [Q96K37-1] 77039 [Q96K37-2] 77040 [Q96K37-3] |
Protocols and materials databases
Antibodypediai | 3098, 41 antibodies |
Genome annotation databases
Ensembli | ENST00000595753; ENSP00000470652; ENSG00000127526 [Q96K37-1] |
GeneIDi | 79939 |
KEGGi | hsa:79939 |
UCSCi | uc010xph.3, human [Q96K37-1] |
Organism-specific databases
CTDi | 79939 |
DisGeNETi | 79939 |
GeneCardsi | SLC35E1 |
HGNCi | HGNC:20803, SLC35E1 |
HPAi | ENSG00000127526, Low tissue specificity |
neXtProti | NX_Q96K37 |
OpenTargetsi | ENSG00000127526 |
PharmGKBi | PA134916810 |
VEuPathDBi | HostDB:ENSG00000127526.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1441, Eukaryota |
GeneTreei | ENSGT00940000159007 |
HOGENOMi | CLU_019048_1_0_1 |
InParanoidi | Q96K37 |
OMAi | DTRIHHL |
PhylomeDBi | Q96K37 |
TreeFami | TF324822 |
Enzyme and pathway databases
PathwayCommonsi | Q96K37 |
Miscellaneous databases
BioGRID-ORCSi | 79939, 15 hits in 878 CRISPR screens |
ChiTaRSi | SLC35E1, human |
GenomeRNAii | 79939 |
Pharosi | Q96K37, Tdark |
PROi | PR:Q96K37 |
RNActi | Q96K37, protein |
Gene expression databases
Bgeei | ENSG00000127526, Expressed in cerebellum and 256 other tissues |
ExpressionAtlasi | Q96K37, baseline and differential |
Genevisiblei | Q96K37, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004853, Sugar_P_trans_dom |
Pfami | View protein in Pfam PF03151, TPT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S35E1_HUMAN | |
Accessioni | Q96K37Primary (citable) accession number: Q96K37 Secondary accession number(s): Q8NBQ2, Q96JV7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2004 |
Last sequence update: | February 26, 2008 | |
Last modified: | February 10, 2021 | |
This is version 148 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM