Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Solute carrier family 35 member E1

Gene

SLC35E1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative transporter.By similarity

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.7.9.9 the drug/metabolite transporter (dmt) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member E1
Gene namesi
Name:SLC35E1
ORF Names:PSEC0038
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000127526.13
HGNCiHGNC:20803 SLC35E1
neXtProtiNX_Q96K37

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Transmembranei133 – 153HelicalSequence analysisAdd BLAST21
Transmembranei165 – 184HelicalSequence analysisAdd BLAST20
Transmembranei188 – 207HelicalSequence analysisAdd BLAST20
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Transmembranei252 – 274HelicalSequence analysisAdd BLAST23
Transmembranei282 – 303HelicalSequence analysisAdd BLAST22
Transmembranei312 – 332HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000127526
PharmGKBiPA134916810

Polymorphism and mutation databases

BioMutaiSLC35E1
DMDMi172045863

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000719411 – 410Solute carrier family 35 member E1Add BLAST410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei363PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96K37
MaxQBiQ96K37
PaxDbiQ96K37
PeptideAtlasiQ96K37
PRIDEiQ96K37
ProteomicsDBi77038
77039 [Q96K37-2]
77040 [Q96K37-3]

PTM databases

iPTMnetiQ96K37
PhosphoSitePlusiQ96K37
SwissPalmiQ96K37

Expressioni

Gene expression databases

BgeeiENSG00000127526 Expressed in 243 organ(s), highest expression level in cerebellum
CleanExiHS_SLC35E1
ExpressionAtlasiQ96K37 baseline and differential
GenevisibleiQ96K37 HS

Organism-specific databases

HPAiHPA016570
HPA062214

Interactioni

Protein-protein interaction databases

BioGridi123013, 26 interactors
IntActiQ96K37, 33 interactors
MINTiQ96K37
STRINGi9606.ENSP00000470652

Structurei

3D structure databases

ProteinModelPortaliQ96K37
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1441 Eukaryota
ENOG410XP1S LUCA
GeneTreeiENSGT00530000063705
HOGENOMiHOG000241297
HOVERGENiHBG067079
InParanoidiQ96K37
KOiK15283
OMAiGFPYPVT
OrthoDBiEOG091G0C5E
PhylomeDBiQ96K37
TreeFamiTF324822

Family and domain databases

InterProiView protein in InterPro
IPR004853 Sugar_P_trans_dom
PfamiView protein in Pfam
PF03151 TPT, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96K37-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAAVGAGH GAGGPGAASS SGGAREGARV AALCLLWYAL SAGGNVVNKV
60 70 80 90 100
ILSAFPFPVT VSLCHILALC AGLPPLLRAW RVPPAPPVSG PGPSPHPSSG
110 120 130 140 150
PLLPPRFYPR YVLPLAFGKY FASVSAHVSI WKVPVSYAHT VKATMPIWVV
160 170 180 190 200
LLSRIIMKEK QSTKVYLSLI PIISGVLLAT VTELSFDMWG LVSALAATLC
210 220 230 240 250
FSLQNIFSKK VLRDSRIHHL RLLNILGCHA VFFMIPTWVL VDLSAFLVSS
260 270 280 290 300
DLTYVYQWPW TLLLLAVSGF CNFAQNVIAF SILNLVSPLS YSVANATKRI
310 320 330 340 350
MVITVSLIML RNPVTSTNVL GMMTAILGVF LYNKTKYDAN QQARKHLLPV
360 370 380 390 400
TTADLSSKER HRSPLEKPHN GLLFPQHGDY QYGRNNILTD HFQYSRQSYP
410
NSYSLNRYDV
Length:410
Mass (Da):44,773
Last modified:February 26, 2008 - v2
Checksum:i691D67A89A1D2114
GO
Isoform 2 (identifier: Q96K37-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-300: Missing.

Note: No experimental confirmation available.
Show »
Length:110
Mass (Da):12,701
Checksum:i76B981790DC73E2B
GO
Isoform 3 (identifier: Q96K37-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-156: Missing.
     253-260: TYVYQWPW → GLPSENVL
     261-410: Missing.

Note: No experimental confirmation available.
Show »
Length:104
Mass (Da):11,547
Checksum:i41E9411E9FC514ED
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C1I0H7C1I0_HUMAN
Solute carrier family 35 member E1
SLC35E1
344Annotation score:
C9JK45C9JK45_HUMAN
Solute carrier family 35 member E1
SLC35E1
116Annotation score:
A0A0A0MSG4A0A0A0MSG4_HUMAN
Solute carrier family 35 member E1
SLC35E1
105Annotation score:

Sequence cautioni

The sequence AAH14557 differs from that shown. Reason: Frameshift at positions 372 and 384.Curated
The sequence AAH62562 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55306 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55410 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC11565 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti242D → V in CAE45863 (PubMed:17974005).Curated1
Sequence conflicti318N → I in BAC11565 (PubMed:16303743).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0101391 – 300Missing in isoform 2. 1 PublicationAdd BLAST300
Alternative sequenceiVSP_0313511 – 156Missing in isoform 3. 1 PublicationAdd BLAST156
Alternative sequenceiVSP_010140253 – 260TYVYQWPW → GLPSENVL in isoform 3. 1 Publication8
Alternative sequenceiVSP_010141261 – 410Missing in isoform 3. 1 PublicationAdd BLAST150

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640756 mRNA Translation: CAE45863.1
BC062562 mRNA Translation: AAH62562.1 Different initiation.
BC014557 mRNA Translation: AAH14557.1 Frameshift.
AK027699 mRNA Translation: BAB55306.1 Different initiation.
AK027850 mRNA Translation: BAB55410.1 Different initiation.
AK075355 mRNA Translation: BAC11565.1 Different initiation.
CCDSiCCDS12346.2 [Q96K37-1]
RefSeqiNP_079157.3, NM_024881.4 [Q96K37-1]
UniGeneiHs.620596

Genome annotation databases

EnsembliENST00000595753; ENSP00000470652; ENSG00000127526 [Q96K37-1]
GeneIDi79939
KEGGihsa:79939
UCSCiuc010xph.3 human [Q96K37-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640756 mRNA Translation: CAE45863.1
BC062562 mRNA Translation: AAH62562.1 Different initiation.
BC014557 mRNA Translation: AAH14557.1 Frameshift.
AK027699 mRNA Translation: BAB55306.1 Different initiation.
AK027850 mRNA Translation: BAB55410.1 Different initiation.
AK075355 mRNA Translation: BAC11565.1 Different initiation.
CCDSiCCDS12346.2 [Q96K37-1]
RefSeqiNP_079157.3, NM_024881.4 [Q96K37-1]
UniGeneiHs.620596

3D structure databases

ProteinModelPortaliQ96K37
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123013, 26 interactors
IntActiQ96K37, 33 interactors
MINTiQ96K37
STRINGi9606.ENSP00000470652

Protein family/group databases

TCDBi2.A.7.9.9 the drug/metabolite transporter (dmt) superfamily

PTM databases

iPTMnetiQ96K37
PhosphoSitePlusiQ96K37
SwissPalmiQ96K37

Polymorphism and mutation databases

BioMutaiSLC35E1
DMDMi172045863

Proteomic databases

EPDiQ96K37
MaxQBiQ96K37
PaxDbiQ96K37
PeptideAtlasiQ96K37
PRIDEiQ96K37
ProteomicsDBi77038
77039 [Q96K37-2]
77040 [Q96K37-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000595753; ENSP00000470652; ENSG00000127526 [Q96K37-1]
GeneIDi79939
KEGGihsa:79939
UCSCiuc010xph.3 human [Q96K37-1]

Organism-specific databases

CTDi79939
EuPathDBiHostDB:ENSG00000127526.13
GeneCardsiSLC35E1
H-InvDBiHIX0027455
HGNCiHGNC:20803 SLC35E1
HPAiHPA016570
HPA062214
neXtProtiNX_Q96K37
OpenTargetsiENSG00000127526
PharmGKBiPA134916810
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1441 Eukaryota
ENOG410XP1S LUCA
GeneTreeiENSGT00530000063705
HOGENOMiHOG000241297
HOVERGENiHBG067079
InParanoidiQ96K37
KOiK15283
OMAiGFPYPVT
OrthoDBiEOG091G0C5E
PhylomeDBiQ96K37
TreeFamiTF324822

Miscellaneous databases

GenomeRNAii79939
PROiPR:Q96K37

Gene expression databases

BgeeiENSG00000127526 Expressed in 243 organ(s), highest expression level in cerebellum
CleanExiHS_SLC35E1
ExpressionAtlasiQ96K37 baseline and differential
GenevisibleiQ96K37 HS

Family and domain databases

InterProiView protein in InterPro
IPR004853 Sugar_P_trans_dom
PfamiView protein in Pfam
PF03151 TPT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS35E1_HUMAN
AccessioniPrimary (citable) accession number: Q96K37
Secondary accession number(s): Q8NBQ2, Q96JV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: February 26, 2008
Last modified: November 7, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again