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Protein

RBPJ-interacting and tubulin-associated protein 1

Gene

RITA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.1 Publication

GO - Molecular functioni

  • tubulin binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processNeurogenesis, Notch signaling pathway

Enzyme and pathway databases

SIGNORiQ96K30

Names & Taxonomyi

Protein namesi
Recommended name:
RBPJ-interacting and tubulin-associated protein 1
Alternative name(s):
RBPJ-interacting and tubulin-associated protein
Gene namesi
Name:RITA1
Synonyms:C12orf52, RITA
ORF Names:PSEC0043
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139405.15
HGNCiHGNC:25925 RITA1
neXtProtiNX_Q96K30

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi7L → A: Results in nuclear accumulation; when associated with A-12 and A-15. 1 Publication1
Mutagenesisi12M → A: Results in nuclear accumulation; when associated with A-7 and A-15. 1 Publication1
Mutagenesisi15L → A: Results in nuclear accumulation; when associated with A-7 and A-12. 1 Publication1
Mutagenesisi95 – 97RKK → AAA: Abolishes nuclear localization. 1 Publication3

Organism-specific databases

DisGeNETi84934
OpenTargetsiENSG00000139405
PharmGKBiPA143485381

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002944291 – 269RBPJ-interacting and tubulin-associated protein 1Add BLAST269

Proteomic databases

PaxDbiQ96K30
PeptideAtlasiQ96K30
PRIDEiQ96K30
ProteomicsDBi77035
77036 [Q96K30-2]

PTM databases

iPTMnetiQ96K30
PhosphoSitePlusiQ96K30

Expressioni

Gene expression databases

BgeeiENSG00000139405 Expressed in 192 organ(s), highest expression level in muscle of leg
CleanExiHS_C12orf52
ExpressionAtlasiQ96K30 baseline and differential
GenevisibleiQ96K30 HS

Organism-specific databases

HPAiHPA039094
HPA039095
HPA061531

Interactioni

Subunit structurei

Interacts with RBPJ/RBPSUH.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124368, 5 interactors
IntActiQ96K30, 10 interactors
MINTiQ96K30
STRINGi9606.ENSP00000410395

Structurei

Secondary structure

1269
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ96K30
SMRiQ96K30
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni128 – 156Interaction with RBPJ/RBPSUH1 PublicationAdd BLAST29
Regioni156 – 269Interaction with tubulinAdd BLAST114

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi5 – 17Nuclear export signalAdd BLAST13
Motifi92 – 108Nuclear localization signalAdd BLAST17

Sequence similaritiesi

Belongs to the RITA family.Curated

Phylogenomic databases

eggNOGiENOG410IKKU Eukaryota
ENOG411251C LUCA
GeneTreeiENSGT00390000013005
HOGENOMiHOG000111762
HOVERGENiHBG101945
InParanoidiQ96K30
OMAiKPKPPWK
OrthoDBiEOG091G0OOF
PhylomeDBiQ96K30
TreeFamiTF337291

Family and domain databases

InterProiView protein in InterPro
IPR031418 RITA1
PANTHERiPTHR34917 PTHR34917, 1 hit
PfamiView protein in Pfam
PF17066 RITA, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96K30-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKTPVELAVS GMQTLGLQHR CRGGYRVKAR TSYVDETLFG SPAGTRPTPP
60 70 80 90 100
DFDPPWVEKA NRTRGVGKEA SKALGAKGSC ETTPSRGSTP TLTPRKKNKY
110 120 130 140 150
RPISHTPSYC DESLFGSRSE GASFGAPRMA KGDAAKLRAL LWTPPPTPRG
160 170 180 190 200
SHSPRPREAP LRAIHPAGPS KTEPGPAADS QKLSMGGLHS SRPLKRGLSH
210 220 230 240 250
SLTHLNVPST GHPATSAPHT NGPQDLRPST SGVTFRSPLV TSRARSVSIS
260
VPSTPRRGGA TQKPKPPWK
Length:269
Mass (Da):28,619
Last modified:December 1, 2001 - v1
Checksum:i3F053E1454F60773
GO
Isoform 2 (identifier: Q96K30-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-177: LRAIHPAGPSKTEPGPA → VPPTQMGLRISGLPRQG
     178-269: Missing.

Note: No experimental confirmation available.
Show »
Length:177
Mass (Da):19,050
Checksum:i834FD0C7095AED0B
GO
Isoform 3 (identifier: Q96K30-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLREPRKQGLAGRAHLLSPGTTGSM

Note: No experimental confirmation available. Gene prediction based on partial EST data.
Show »
Length:293
Mass (Da):31,135
Checksum:i0CCC65D03B9B6825
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X1G3A0A087X1G3_HUMAN
RBPJ-interacting and tubulin-associ...
RITA1
38Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73A → S in BAG53956 (PubMed:14702039).Curated1
Sequence conflicti217A → V in BAD96628 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050865113S → W. Corresponds to variant dbSNP:rs16942601Ensembl.1
Natural variantiVAR_033175220T → K. Corresponds to variant dbSNP:rs34831139Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0556491M → MLREPRKQGLAGRAHLLSPG TTGSM in isoform 3. Curated1
Alternative sequenceiVSP_026636161 – 177LRAIH…EPGPA → VPPTQMGLRISGLPRQG in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_026637178 – 269Missing in isoform 2. 1 PublicationAdd BLAST92

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075358 mRNA Translation: BAC11568.1
AK027733 mRNA Translation: BAB55328.1
AK027741 mRNA Translation: BAB55333.1
AK123762 mRNA Translation: BAG53956.1
AK222908 mRNA Translation: BAD96628.1
AC089999 Genomic DNA No translation available.
BC022092 mRNA Translation: AAH22092.1
CCDSiCCDS66473.1 [Q96K30-3]
CCDS9166.1 [Q96K30-1]
RefSeqiNP_001273144.1, NM_001286215.1 [Q96K30-3]
NP_116237.1, NM_032848.2 [Q96K30-1]
XP_005254029.1, XM_005253972.2 [Q96K30-1]
UniGeneiHs.524762

Genome annotation databases

EnsembliENST00000548278; ENSP00000449841; ENSG00000139405 [Q96K30-1]
ENST00000549621; ENSP00000448289; ENSG00000139405 [Q96K30-1]
ENST00000552495; ENSP00000448680; ENSG00000139405 [Q96K30-3]
GeneIDi84934
KEGGihsa:84934
UCSCiuc001tur.2 human [Q96K30-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075358 mRNA Translation: BAC11568.1
AK027733 mRNA Translation: BAB55328.1
AK027741 mRNA Translation: BAB55333.1
AK123762 mRNA Translation: BAG53956.1
AK222908 mRNA Translation: BAD96628.1
AC089999 Genomic DNA No translation available.
BC022092 mRNA Translation: AAH22092.1
CCDSiCCDS66473.1 [Q96K30-3]
CCDS9166.1 [Q96K30-1]
RefSeqiNP_001273144.1, NM_001286215.1 [Q96K30-3]
NP_116237.1, NM_032848.2 [Q96K30-1]
XP_005254029.1, XM_005253972.2 [Q96K30-1]
UniGeneiHs.524762

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5EG6X-ray2.09R133-148[»]
ProteinModelPortaliQ96K30
SMRiQ96K30
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124368, 5 interactors
IntActiQ96K30, 10 interactors
MINTiQ96K30
STRINGi9606.ENSP00000410395

PTM databases

iPTMnetiQ96K30
PhosphoSitePlusiQ96K30

Proteomic databases

PaxDbiQ96K30
PeptideAtlasiQ96K30
PRIDEiQ96K30
ProteomicsDBi77035
77036 [Q96K30-2]

Protocols and materials databases

DNASUi84934
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000548278; ENSP00000449841; ENSG00000139405 [Q96K30-1]
ENST00000549621; ENSP00000448289; ENSG00000139405 [Q96K30-1]
ENST00000552495; ENSP00000448680; ENSG00000139405 [Q96K30-3]
GeneIDi84934
KEGGihsa:84934
UCSCiuc001tur.2 human [Q96K30-1]

Organism-specific databases

CTDi84934
DisGeNETi84934
EuPathDBiHostDB:ENSG00000139405.15
GeneCardsiRITA1
H-InvDBiHIX0011019
HGNCiHGNC:25925 RITA1
HPAiHPA039094
HPA039095
HPA061531
neXtProtiNX_Q96K30
OpenTargetsiENSG00000139405
PharmGKBiPA143485381
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKKU Eukaryota
ENOG411251C LUCA
GeneTreeiENSGT00390000013005
HOGENOMiHOG000111762
HOVERGENiHBG101945
InParanoidiQ96K30
OMAiKPKPPWK
OrthoDBiEOG091G0OOF
PhylomeDBiQ96K30
TreeFamiTF337291

Enzyme and pathway databases

SIGNORiQ96K30

Miscellaneous databases

GenomeRNAii84934
PROiPR:Q96K30

Gene expression databases

BgeeiENSG00000139405 Expressed in 192 organ(s), highest expression level in muscle of leg
CleanExiHS_C12orf52
ExpressionAtlasiQ96K30 baseline and differential
GenevisibleiQ96K30 HS

Family and domain databases

InterProiView protein in InterPro
IPR031418 RITA1
PANTHERiPTHR34917 PTHR34917, 1 hit
PfamiView protein in Pfam
PF17066 RITA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRITA1_HUMAN
AccessioniPrimary (citable) accession number: Q96K30
Secondary accession number(s): B3KVZ4
, C9JIN1, F8VRG5, Q53GM3, Q96K25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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