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Entry version 159 (12 Aug 2020)
Sequence version 3 (18 May 2010)
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Protein

Abscission/NoCut checkpoint regulator

Gene

ZFYVE19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.1 Publication

Caution

Phosphorylated in vitro at Ser-22 by AURKB; however, phosphorylation at this site could not be confirmed in vivo.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri74 – 133FYVE-typePROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division
LigandLipid-binding, Metal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96K21

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Abscission/NoCut checkpoint regulator
Short name:
ANCHR
Alternative name(s):
MLL partner containing FYVE domain
Zinc finger FYVE domain-containing protein 19
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZFYVE19
Synonyms:ANCHR, MPFYVE
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000166140.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20758, ZFYVE19

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96K21

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving ZFYVE19 is associated with acute myeloblastic leukemia (AML). Translocation t(11;15)(q23;q14) with KMT2A/MLL1 (PubMed:12618766).1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi101R → A: Abolishes binding to phosphatidylinositol-3-phosphate (PtdIns(3)P) without affecting localization to the midbody. 1 Publication1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei145 – 146Breakpoint for translocation to form KMT2A/MLL1-ZFYVE192

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
84936

Open Targets

More...
OpenTargetsi
ENSG00000166140

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134906967

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96K21, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZFYVE19

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296453076

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000987181 – 471Abscission/NoCut checkpoint regulatorAdd BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei144PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki207Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei243PhosphothreonineCombined sources1
Modified residuei293PhosphoserineCombined sources1
Modified residuei354PhosphoserineCombined sources1
Modified residuei463PhosphoserineCombined sources1
Isoform 3 (identifier: Q96K21-3)
Modified residuei286PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96K21

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96K21

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96K21

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96K21

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96K21

PeptideAtlas

More...
PeptideAtlasi
Q96K21

PRoteomics IDEntifications database

More...
PRIDEi
Q96K21

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
42921
77031 [Q96K21-1]
77032 [Q96K21-2]
77033 [Q96K21-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q96K21, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96K21

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q96K21

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96K21

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain, heart, skeletal muscle, kidney and liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166140, Expressed in C1 segment of cervical spinal cord and 179 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96K21, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96K21, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000166140, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via MIM1-B) with VPS4A; interaction takes place at the midbody ring following cytokinesis checkpoint activation.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124370, 44 interactors

Database of interacting proteins

More...
DIPi
DIP-60854N

Protein interaction database and analysis system

More...
IntActi
Q96K21, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000347498

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96K21, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96K21

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili311 – 375Sequence analysisAdd BLAST65

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi174 – 187MIM1-AAdd BLAST14
Motifi326 – 339MIM1-BAdd BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi412 – 417Poly-Glu6
Compositional biasi421 – 444Cys-richAdd BLAST24

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The FYVE-type zinc finger mediates binding to phosphatidylinositol-3-phosphate (PtdIns3P).1 Publication
The MIM1-B motif mediates interaction with VPS4A.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri74 – 133FYVE-typePROSITE-ProRule annotationAdd BLAST60

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1818, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016108

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_043234_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96K21

Identification of Orthologs from Complete Genome Data

More...
OMAi
FKKECGC

Database of Orthologous Groups

More...
OrthoDBi
1355078at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96K21

TreeFam database of animal gene trees

More...
TreeFami
TF317652

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000306, Znf_FYVE
IPR017455, Znf_FYVE-rel
IPR011011, Znf_FYVE_PHD
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01363, FYVE, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00064, FYVE, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50178, ZF_FYVE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96K21-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNYDSQQPPL PPLPYAGCRR ASGFPALGRG GTVPVGVWGG AGQGREGRSW
60 70 80 90 100
GEGPRGPGLG RRDLSSADPA VLGATMESRC YGCAVKFTLF KKEYGCKNCG
110 120 130 140 150
RAFCSGCLSF SAAVPRTGNT QQKVCKQCHE VLTRGSSANA SKWSPPQNYK
160 170 180 190 200
KRVAALEAKQ KPSTSQSQGL TRQDQMIAER LARLRQENKP KLVPSQAEIE
210 220 230 240 250
ARLAALKDER QGSIPSTQEM EARLAALQGR VLPSQTPQPA HHTPDTRTQA
260 270 280 290 300
QQTQDLLTQL AAEVAIDESW KGGGPAASLQ NDLNQGGPGS TNSKRQANWS
310 320 330 340 350
LEEEKSRLLA EAALELREEN TRQERILALA KRLAMLRGQD PERVTLQDYR
360 370 380 390 400
LPDSDDDEDE ETAIQRVLQQ LTEEASLDEA SGFNIPAEQA SRPWTQPRGA
410 420 430 440 450
EPEAQDVDPR PEAEEEELPW CCICNEDATL RCAGCDGDLF CARCFREGHD
460 470
AFELKEHQTS AYSPPRAGQE H
Length:471
Mass (Da):51,546
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0F07D2DDFD19864D
GO
Isoform 2 (identifier: Q96K21-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-93: MNYDSQQPPL...AVKFTLFKKE → MPAVAEALGQ...DLPDSSGKLQ

Show »
Length:461
Mass (Da):50,534
Checksum:i0366891B7E766686
GO
Isoform 3 (identifier: Q96K21-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     276-343: Missing.

Show »
Length:403
Mass (Da):43,934
Checksum:iF2D8DF956362DABF
GO
Isoform 4 (identifier: Q96K21-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-175: Missing.

Show »
Length:296
Mass (Da):32,963
Checksum:i53D85D6E28C521A1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BN64H3BN64_HUMAN
Abscission/NoCut checkpoint regulat...
ZFYVE19
271Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BRF9H3BRF9_HUMAN
Abscission/NoCut checkpoint regulat...
ZFYVE19
448Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BRM1H3BRM1_HUMAN
Abscission/NoCut checkpoint regulat...
ZFYVE19
307Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BP54H3BP54_HUMAN
Abscission/NoCut checkpoint regulat...
ZFYVE19
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUW6H3BUW6_HUMAN
Abscission/NoCut checkpoint regulat...
ZFYVE19
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSF5H3BSF5_HUMAN
Abscission/NoCut checkpoint regulat...
ZFYVE19
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BVF5H3BVF5_HUMAN
Abscission/NoCut checkpoint regulat...
ZFYVE19
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BS07H3BS07_HUMAN
Abscission/NoCut checkpoint regulat...
ZFYVE19
21Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH21092 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAO73862 differs from that shown. Reason: Frameshift.Curated
The sequence BAB55338 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti104C → R in AAH21092 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057494210R → H. Corresponds to variant dbSNP:rs34819163Ensembl.1
Natural variantiVAR_060474376S → A2 PublicationsCorresponds to variant dbSNP:rs690347Ensembl.1
Natural variantiVAR_060475398R → C. Corresponds to variant dbSNP:rs72735636Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0460081 – 175Missing in isoform 4. 1 PublicationAdd BLAST175
Alternative sequenceiVSP_0137911 – 93MNYDS…LFKKE → MPAVAEALGQEGPPDLSRSA FLATVLTSLSAAFSSMPSSA YSLPFSRSLELDYHTSSCFR GTMVKADCPVPITDLPDSSG KLQ in isoform 2. 1 PublicationAdd BLAST93
Alternative sequenceiVSP_013792276 – 343Missing in isoform 3. 1 PublicationAdd BLAST68

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF445414 mRNA Translation: AAO73862.1 Frameshift.
AK027746 mRNA Translation: BAB55338.1 Different initiation.
AK122779 mRNA Translation: BAG53724.1
AC012476 Genomic DNA No translation available.
CH471125 Genomic DNA Translation: EAW92451.1
BC021092 mRNA Translation: AAH21092.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42025.1 [Q96K21-1]
CCDS58353.1 [Q96K21-2]
CCDS58354.1 [Q96K21-3]
CCDS58355.1 [Q96K21-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001070736.1, NM_001077268.1 [Q96K21-1]
NP_001245349.1, NM_001258420.1 [Q96K21-3]
NP_001245350.1, NM_001258421.1 [Q96K21-4]
NP_116239.3, NM_032850.4 [Q96K21-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000299173; ENSP00000299173; ENSG00000166140 [Q96K21-3]
ENST00000336455; ENSP00000337824; ENSG00000166140 [Q96K21-2]
ENST00000355341; ENSP00000347498; ENSG00000166140 [Q96K21-1]
ENST00000564258; ENSP00000457617; ENSG00000166140 [Q96K21-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84936

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84936

UCSC genome browser

More...
UCSCi
uc001zmt.2, human [Q96K21-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF445414 mRNA Translation: AAO73862.1 Frameshift.
AK027746 mRNA Translation: BAB55338.1 Different initiation.
AK122779 mRNA Translation: BAG53724.1
AC012476 Genomic DNA No translation available.
CH471125 Genomic DNA Translation: EAW92451.1
BC021092 mRNA Translation: AAH21092.1 Different initiation.
CCDSiCCDS42025.1 [Q96K21-1]
CCDS58353.1 [Q96K21-2]
CCDS58354.1 [Q96K21-3]
CCDS58355.1 [Q96K21-4]
RefSeqiNP_001070736.1, NM_001077268.1 [Q96K21-1]
NP_001245349.1, NM_001258420.1 [Q96K21-3]
NP_001245350.1, NM_001258421.1 [Q96K21-4]
NP_116239.3, NM_032850.4 [Q96K21-2]

3D structure databases

SMRiQ96K21
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124370, 44 interactors
DIPiDIP-60854N
IntActiQ96K21, 10 interactors
STRINGi9606.ENSP00000347498

PTM databases

GlyGeniQ96K21, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ96K21
MetOSiteiQ96K21
PhosphoSitePlusiQ96K21

Polymorphism and mutation databases

BioMutaiZFYVE19
DMDMi296453076

Proteomic databases

EPDiQ96K21
jPOSTiQ96K21
MassIVEiQ96K21
MaxQBiQ96K21
PaxDbiQ96K21
PeptideAtlasiQ96K21
PRIDEiQ96K21
ProteomicsDBi42921
77031 [Q96K21-1]
77032 [Q96K21-2]
77033 [Q96K21-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
23171, 189 antibodies

Genome annotation databases

EnsembliENST00000299173; ENSP00000299173; ENSG00000166140 [Q96K21-3]
ENST00000336455; ENSP00000337824; ENSG00000166140 [Q96K21-2]
ENST00000355341; ENSP00000347498; ENSG00000166140 [Q96K21-1]
ENST00000564258; ENSP00000457617; ENSG00000166140 [Q96K21-4]
GeneIDi84936
KEGGihsa:84936
UCSCiuc001zmt.2, human [Q96K21-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84936
DisGeNETi84936
EuPathDBiHostDB:ENSG00000166140.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZFYVE19
HGNCiHGNC:20758, ZFYVE19
HPAiENSG00000166140, Low tissue specificity
neXtProtiNX_Q96K21
OpenTargetsiENSG00000166140
PharmGKBiPA134906967

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1818, Eukaryota
GeneTreeiENSGT00390000016108
HOGENOMiCLU_043234_1_0_1
InParanoidiQ96K21
OMAiFKKECGC
OrthoDBi1355078at2759
PhylomeDBiQ96K21
TreeFamiTF317652

Enzyme and pathway databases

PathwayCommonsiQ96K21

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
84936, 9 hits in 878 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZFYVE19, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ZFYVE19

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84936
PharosiQ96K21, Tbio

Protein Ontology

More...
PROi
PR:Q96K21
RNActiQ96K21, protein

Gene expression databases

BgeeiENSG00000166140, Expressed in C1 segment of cervical spinal cord and 179 other tissues
ExpressionAtlasiQ96K21, baseline and differential
GenevisibleiQ96K21, HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR000306, Znf_FYVE
IPR017455, Znf_FYVE-rel
IPR011011, Znf_FYVE_PHD
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363, FYVE, 1 hit
SMARTiView protein in SMART
SM00064, FYVE, 1 hit
SUPFAMiSSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50178, ZF_FYVE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANCHR_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96K21
Secondary accession number(s): B3KVB2
, C9JNF4, H3BUF9, Q86WC2, Q8WU96
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: May 18, 2010
Last modified: August 12, 2020
This is version 159 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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