UniProtKB - Q96JX3 (SRAC1_HUMAN)

BLAST

>sp|Q96JX3|SRAC1_HUMAN Protein SERAC1 OS=Homo sapiens OX=9606 GN=SERAC1 PE=1 SV=1
MSLAAYCVICCRRIGTSTSPPKSGTHWRDIRNIIKFTGSLILGGSLFLTYEVLALKKAVT
LDTQVVEREKMKSYIYVHTVSLDKGENHGIAWQARKELHKAVRKVLATSAKILRNPFADP
FSTVDIEDHECAVWLLLRKSKSDDKTTRLEAVREMSETHHWHDYQYRIIAQACDPKTLIG
LARSEESDLRFFLLPPPLPSLKEDSSTEEELRQLLASLPQTELDECIQYFTSLALSESSQ
SLAAQKGGLWCFGGNGLPYAESFGEVPSATVEMFCLEAIVKHSEISTHCDKIEANGGLQL
LQRLYRLHKDCPKVQRNIMRVIGNMALNEHLHSSIVRSGWVSIMAEAMKSPHIMESSHAA
RILANLDRETVQEKYQDGVYVLHPQYRTSQPIKADVLFIHGLMGAAFKTWRQQDSEQAVI
EKPMEDEDRYTTCWPKTWLAKDCPALRIISVEYDTSLSDWRARCPMERKSIAFRSNELLR
KLRAAGVGDRPVVWISHSMGGLLVKKMLLEASTKPEMSTVINNTRGIIFYSVPHHGSRLA
EYSVNIRYLLFPSLEVKELSKDSPALKTLQDDFLEFAKDKNFQVLNFVETLPTYIGSMIK
LHVVPVESADLGIGDLIPVDVNHLNICKPKKKDAFLYQRTLQFIREALAKDLEN

Align

Format
Add to basket Added to basket
History
Entry version 132 (07 Nov 2018)
Sequence version 1 (01 Dec 2001)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Protein SERAC1

Gene

SERAC1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. May catalyze the remodeling of phosphatidylglycerol and be involved in the transacylation-acylation reaction to produce phosphatidylglycerol-36:1. May be involved in bis(monoacylglycerol)phosphate biosynthetic pathway.1 Publication

GO - Biological processⁱ

extracellular matrix organization Source: Ensembl
intracellular cholesterol transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22683713
phosphatidylglycerol acyl-chain remodeling
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22683713
phospholipid biosynthetic process Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Biological process

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Protein family/group databases

ESTHERⁱ	human-SERAC1 PGAP1

ESTHERⁱ

human-SERAC1 PGAP1

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein SERAC1 Alternative name(s): Serine active site-containing protein 1
Gene namesⁱ	Name:SERAC1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000122335.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21061 SERAC1
MIMⁱ	614725 gene
neXtProtⁱ	NX_Q96JX3

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	32 – 54	HelicalSequence analysisAdd BLAST		23

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane, Mitochondrion

Pathology & Biotechⁱ

Involvement in diseaseⁱ

3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome (MEGDEL)3 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive disorder characterized by childhood onset of delayed psychomotor development or psychomotor regression, sensorineural deafness, spasticity or dystonia, and increased excretion of 3-methylglutaconic acid. Brain imaging shows cerebral and cerebellar atrophy as well as lesions in the basal ganglia reminiscent of Leigh syndrome. Laboratory studies show increased serum lactate and alanine, mitochondrial oxidative phosphorylation defects, abnormal mitochondria, abnormal phosphatidylglycerol and cardiolipin profiles in fibroblasts, and abnormal accumulation of unesterified cholesterol within cells.

Keywords - Diseaseⁱ

Deafness, Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	84947
MalaCards human disease database More...MalaCardsⁱ	SERAC1
MIMⁱ	614739 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000122335
Orphanetⁱ	352328 MEGDEL syndrome
PharmGKBⁱ	PA134951844

Polymorphism and mutation databases

BioMutaⁱ	SERAC1
DMDMⁱ	74751971

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000274671	1 – 654	Protein SERAC1Add BLAST		654

Proteomic databases

EPDⁱ	Q96JX3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96JX3
PaxDbⁱ	Q96JX3
PeptideAtlas More...PeptideAtlasⁱ	Q96JX3
PRIDEⁱ	Q96JX3
ProteomicsDBⁱ	77011 77012 [Q96JX3-2] 77013 [Q96JX3-3]

PTM databases

iPTMnetⁱ	Q96JX3
PhosphoSitePlusⁱ	Q96JX3

Expressionⁱ

Tissue specificityⁱ

Widely expressed, with predominant expression in fetal skeletal muscle and adult brain. In the brain, highest levels are found in the frontal and occipital cortices, cerebellum and hippocampus.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000122335 Expressed in 175 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_SERAC1
ExpressionAtlasⁱ	Q96JX3 baseline and differential
Genevisibleⁱ	Q96JX3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA025715 HPA025716

HPAⁱ

HPA025715
HPA025716

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	124380, 6 interactors
IntActⁱ	Q96JX3, 2 interactors
STRINGⁱ	9606.ENSP00000356071

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96JX3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the SERAC1 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG2029 Eukaryota ENOG410YIPC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003560
HOGENOMⁱ	HOG000154411
HOVERGENⁱ	HBG057428
InParanoidⁱ	Q96JX3
OMAⁱ	KTMANLD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G061M
PhylomeDBⁱ	Q96JX3
TreeFamⁱ	TF319689

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit 3.40.50.1820, 1 hit
InterProⁱ	View protein in InterPro IPR029058 AB_hydrolase IPR011989 ARM-like IPR016024 ARM-type_fold
SUPFAMⁱ	SSF48371 SSF48371, 1 hit SSF53474 SSF53474, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q96JX3-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLAAYCVIC CRRIGTSTSP PKSGTHWRDI RNIIKFTGSL ILGGSLFLTY 
        60         70         80         90        100
EVLALKKAVT LDTQVVEREK MKSYIYVHTV SLDKGENHGI AWQARKELHK 
       110        120        130        140        150
AVRKVLATSA KILRNPFADP FSTVDIEDHE CAVWLLLRKS KSDDKTTRLE 
       160        170        180        190        200
AVREMSETHH WHDYQYRIIA QACDPKTLIG LARSEESDLR FFLLPPPLPS 
       210        220        230        240        250
LKEDSSTEEE LRQLLASLPQ TELDECIQYF TSLALSESSQ SLAAQKGGLW 
       260        270        280        290        300
CFGGNGLPYA ESFGEVPSAT VEMFCLEAIV KHSEISTHCD KIEANGGLQL 
       310        320        330        340        350
LQRLYRLHKD CPKVQRNIMR VIGNMALNEH LHSSIVRSGW VSIMAEAMKS 
       360        370        380        390        400
PHIMESSHAA RILANLDRET VQEKYQDGVY VLHPQYRTSQ PIKADVLFIH 
       410        420        430        440        450
GLMGAAFKTW RQQDSEQAVI EKPMEDEDRY TTCWPKTWLA KDCPALRIIS 
       460        470        480        490        500
VEYDTSLSDW RARCPMERKS IAFRSNELLR KLRAAGVGDR PVVWISHSMG 
       510        520        530        540        550
GLLVKKMLLE ASTKPEMSTV INNTRGIIFY SVPHHGSRLA EYSVNIRYLL 
       560        570        580        590        600
FPSLEVKELS KDSPALKTLQ DDFLEFAKDK NFQVLNFVET LPTYIGSMIK 
       610        620        630        640        650
LHVVPVESAD LGIGDLIPVD VNHLNICKPK KKDAFLYQRT LQFIREALAK 

DLEN

Length:654

Mass (Da):74,147

Last modified:December 1, 2001 - v1

Checksum:ⁱB40F3B41C0FBEDDE

Isoform 2 (identifier: Q96JX3-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
469-531: KSIAFRSNEL...NNTRGIIFYS → RSLLSISSGI...CCWKPLRSQK
532-654: Missing.

« Hide

        10         20         30         40         50
MSLAAYCVIC CRRIGTSTSP PKSGTHWRDI RNIIKFTGSL ILGGSLFLTY 
        60         70         80         90        100
EVLALKKAVT LDTQVVEREK MKSYIYVHTV SLDKGENHGI AWQARKELHK 
       110        120        130        140        150
AVRKVLATSA KILRNPFADP FSTVDIEDHE CAVWLLLRKS KSDDKTTRLE 
       160        170        180        190        200
AVREMSETHH WHDYQYRIIA QACDPKTLIG LARSEESDLR FFLLPPPLPS 
       210        220        230        240        250
LKEDSSTEEE LRQLLASLPQ TELDECIQYF TSLALSESSQ SLAAQKGGLW 
       260        270        280        290        300
CFGGNGLPYA ESFGEVPSAT VEMFCLEAIV KHSEISTHCD KIEANGGLQL 
       310        320        330        340        350
LQRLYRLHKD CPKVQRNIMR VIGNMALNEH LHSSIVRSGW VSIMAEAMKS 
       360        370        380        390        400
PHIMESSHAA RILANLDRET VQEKYQDGVY VLHPQYRTSQ PIKADVLFIH 
       410        420        430        440        450
GLMGAAFKTW RQQDSEQAVI EKPMEDEDRY TTCWPKTWLA KDCPALRIIS 
       460        470        480        490        500
VEYDTSLSDW RARCPMERRS LLSISSGIVE GLESPLHSEA TNFLGSSELL 
       510        520        530 
VLGIGQWFGY HIAWEVFLSK RCCWKPLRSQ K

Show »

Length:531

Mass (Da):60,215

Checksum:ⁱ49757860C8A77CE5

Isoform 3 (identifier: Q96JX3-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
163-167: DYQYR → GNETT
168-654: Missing.

« Hide

        10         20         30         40         50
MSLAAYCVIC CRRIGTSTSP PKSGTHWRDI RNIIKFTGSL ILGGSLFLTY 
        60         70         80         90        100
EVLALKKAVT LDTQVVEREK MKSYIYVHTV SLDKGENHGI AWQARKELHK 
       110        120        130        140        150
AVRKVLATSA KILRNPFADP FSTVDIEDHE CAVWLLLRKS KSDDKTTRLE 
       160 
AVREMSETHH WHGNETT

Show »

Length:167

Mass (Da):18,952

Checksum:ⁱ3143EEA6FA3AB1DD

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q5JVM6	Q5JVM6_HUMAN	Protein SERAC1 Protein SERAC1	SERAC1	152	Annotation score:
U3KQE4	U3KQE4_HUMAN	Protein SERAC1 Protein SERAC1	SERAC1	409	Annotation score:
U3KQG3	U3KQG3_HUMAN	Protein SERAC1 Protein SERAC1	SERAC1	42	Annotation score:
A0A2R8YD19	A0A2R8YD19_HUMAN	Protein SERAC1 Protein SERAC1	SERAC1	587	Annotation score:
A0A2R8Y511	A0A2R8Y511_HUMAN	Protein SERAC1 Protein SERAC1	SERAC1	611	Annotation score:
A0A2R8Y3S0	A0A2R8Y3S0_HUMAN	Protein SERAC1 Protein SERAC1	SERAC1	624	Annotation score:
A0A2R8YFH3	A0A2R8YFH3_HUMAN	Protein SERAC1 Protein SERAC1	SERAC1	622	Annotation score:
A0A2R8YCL0	A0A2R8YCL0_HUMAN	Protein SERAC1 Protein SERAC1	SERAC1	566	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	47	F → L in AAH28594 (PubMed:15489334).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_068442	401	G → D in MEGDEL. 1 Publication	1
Natural variantⁱVAR_068443	404	G → E in MEGDEL. 1 Publication	1
Natural variantⁱVAR_068444	479	Missing in MEGDEL. 1 Publication	1
Natural variantⁱVAR_068445	498	S → T in MEGDEL. 1 PublicationCorresponds to variant dbSNP:rs201941476Ensembl.	1
Natural variantⁱVAR_080230	526	G → E in MEGDEL; unknown pathological significance. 1 Publication	1
Natural variantⁱVAR_030342	543	S → T1 PublicationCorresponds to variant dbSNP:rs17849527Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_022857	163 – 167	DYQYR → GNETT in isoform 3. 1 Publication	5
Alternative sequenceⁱVSP_022858	168 – 654	Missing in isoform 3. 1 PublicationAdd BLAST	487
Alternative sequenceⁱVSP_022859	469 – 531	KSIAF…IIFYS → RSLLSISSGIVEGLESPLHS EATNFLGSSELLVLGIGQWF GYHIAWEVFLSKRCCWKPLR SQK in isoform 2. CuratedAdd BLAST	63
Alternative sequenceⁱVSP_022860	532 – 654	Missing in isoform 2. CuratedAdd BLAST	123

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK027823 mRNA Translation: BAB55393.1 AL135907 Genomic DNA No translation available. AL590703 Genomic DNA No translation available. BC001705 mRNA Translation: AAH01705.1 BC028594 mRNA Translation: AAH28594.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5255.1 [Q96JX3-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_116250.3, NM_032861.3 [Q96JX3-1]
UniGeneⁱ	Hs.154706

Genome annotation databases

Ensemblⁱ	ENST00000367101; ENSP00000356068; ENSG00000122335 [Q96JX3-2] ENST00000367104; ENSP00000356071; ENSG00000122335 [Q96JX3-1] ENST00000647468; ENSP00000496731; ENSG00000122335 [Q96JX3-1]
GeneIDⁱ	84947
KEGGⁱ	hsa:84947
UCSC genome browser More...UCSCⁱ	uc003qrc.3 human [Q96JX3-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96JX3	Serine active site containing 1		PONAB		744	UniRef90_Q96JX3
Uncharacterized protein		Cebus capucinus imitator		733
Serine active site containing 1		PANTR		713
Uncharacterized protein		PANPA		654
LOW QUALITY PROTEIN: protein SERAC1		LIPVE		658
+74
Q96JX3-2	Protein SERAC1		MACFA		531	UniRef90_Q96JX3-2
Uncharacterized protein		MACMU		531
Uncharacterized protein		CALJA		531
Uncharacterized protein		COLAP		531
SERAC1 isoform 8		PONAB		531
+7
Q96JX3-3	SERAC1 isoform 9		PONAB		167	UniRef90_Q96JX3-3

Protein	Similar proteins		Species	Score	Length	Source
Q96JX3	Protein SERAC1		MOUSE		654	UniRef50_Q96JX3
Protein SERAC1		DANRE		658
Protein SERAC1		BOVIN		654
Serine active site containing 1		PONAB		744
Uncharacterized protein		Cebus capucinus imitator		733
+511
Q96JX3-2	Protein SERAC1		MACFA		531	UniRef50_Q96JX3-2
SERAC1 isoform 8		PONAB		531
Uncharacterized protein		PAPAN		531
Uncharacterized protein		MANLE		531
Uncharacterized protein		CALJA		531
+14
Q96JX3-3	SERAC1 isoform 9		PONAB		167	UniRef50_Q96JX3-3
UPI00093C7063		great roundleaf bat		175

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK027823 mRNA Translation: BAB55393.1 AL135907 Genomic DNA No translation available. AL590703 Genomic DNA No translation available. BC001705 mRNA Translation: AAH01705.1 BC028594 mRNA Translation: AAH28594.1
CCDSⁱ	CCDS5255.1 [Q96JX3-1]
RefSeqⁱ	NP_116250.3, NM_032861.3 [Q96JX3-1]
UniGeneⁱ	Hs.154706

3D structure databases

ProteinModelPortalⁱ	Q96JX3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	124380, 6 interactors
IntActⁱ	Q96JX3, 2 interactors
STRINGⁱ	9606.ENSP00000356071

Protein family/group databases

ESTHERⁱ	human-SERAC1 PGAP1

ESTHERⁱ

human-SERAC1 PGAP1

PTM databases

iPTMnetⁱ	Q96JX3
PhosphoSitePlusⁱ	Q96JX3

Polymorphism and mutation databases

BioMutaⁱ	SERAC1
DMDMⁱ	74751971

Proteomic databases

EPDⁱ	Q96JX3
MaxQBⁱ	Q96JX3
PaxDbⁱ	Q96JX3
PeptideAtlasⁱ	Q96JX3
PRIDEⁱ	Q96JX3
ProteomicsDBⁱ	77011 77012 [Q96JX3-2] 77013 [Q96JX3-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000367101; ENSP00000356068; ENSG00000122335 [Q96JX3-2] ENST00000367104; ENSP00000356071; ENSG00000122335 [Q96JX3-1] ENST00000647468; ENSP00000496731; ENSG00000122335 [Q96JX3-1]
GeneIDⁱ	84947
KEGGⁱ	hsa:84947
UCSCⁱ	uc003qrc.3 human [Q96JX3-1]

Organism-specific databases

CTDⁱ	84947
DisGeNETⁱ	84947
EuPathDBⁱ	HostDB:ENSG00000122335.13
GeneCardsⁱ	SERAC1
HGNCⁱ	HGNC:21061 SERAC1
HPAⁱ	HPA025715 HPA025716
MalaCardsⁱ	SERAC1
MIMⁱ	614725 gene 614739 phenotype
neXtProtⁱ	NX_Q96JX3
OpenTargetsⁱ	ENSG00000122335
Orphanetⁱ	352328 MEGDEL syndrome
PharmGKBⁱ	PA134951844
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2029 Eukaryota ENOG410YIPC LUCA
GeneTreeⁱ	ENSGT00390000003560
HOGENOMⁱ	HOG000154411
HOVERGENⁱ	HBG057428
InParanoidⁱ	Q96JX3
OMAⁱ	KTMANLD
OrthoDBⁱ	EOG091G061M
PhylomeDBⁱ	Q96JX3
TreeFamⁱ	TF319689

Miscellaneous databases

GeneWikiⁱ	SERAC1
GenomeRNAiⁱ	84947
Protein Ontology More...PROⁱ	PR:Q96JX3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000122335 Expressed in 175 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_SERAC1
ExpressionAtlasⁱ	Q96JX3 baseline and differential
Genevisibleⁱ	Q96JX3 HS

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit 3.40.50.1820, 1 hit
InterProⁱ	View protein in InterPro IPR029058 AB_hydrolase IPR011989 ARM-like IPR016024 ARM-type_fold
SUPFAMⁱ	SSF48371 SSF48371, 1 hit SSF53474 SSF53474, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SRAC1_HUMAN
Accessionⁱ	Q96JX3Primary (citable) accession number: Q96JX3 Secondary accession number(s): Q49AT1, Q5VTX3, Q6PKF3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
	Last sequence update:	December 1, 2001
	Last modified:	November 7, 2018
	This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96JX3 (SRAC1_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Protein SERAC1

SERAC1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Mitochondrion

Other locations

Endoplasmic reticulum

Extracellular region or secreted

Mitochondrion

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ