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Protein

Solute carrier family 45 member 3

Gene

SLC45A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

Marker for prostate cells. May be used, in case of prostate cancers, as a target antigen for prostate carcinomas-directed cytotoxic T-cell lymphocytes.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-HSA-189200 Cellular hexose transport

Protein family/group databases

TCDBi2.A.2.4.8 the glycoside-pentoside-hexuronide (gph):cation symporter family

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 45 member 3
Alternative name(s):
Prostate cancer-associated protein 6
Prostein
Gene namesi
Name:SLC45A3
Synonyms:PCANAP6, PRST
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000158715.5
HGNCiHGNC:8642 SLC45A3
MIMi605097 gene
neXtProtiNX_Q96JT2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei52 – 72Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei88 – 108Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei120 – 140Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei161 – 181Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei198 – 218Helical; Name=6Sequence analysisAdd BLAST21
Transmembranei275 – 295Helical; Name=7Sequence analysisAdd BLAST21
Transmembranei323 – 343Helical; Name=8Sequence analysisAdd BLAST21
Transmembranei353 – 373Helical; Name=9Sequence analysisAdd BLAST21
Transmembranei382 – 402Helical; Name=10Sequence analysisAdd BLAST21
Transmembranei522 – 542Helical; Name=11Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi85414
OpenTargetsiENSG00000158715
PharmGKBiPA32981

Polymorphism and mutation databases

BioMutaiSLC45A3
DMDMi46396996

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001225191 – 553Solute carrier family 45 member 3Add BLAST553

Proteomic databases

MaxQBiQ96JT2
PaxDbiQ96JT2
PeptideAtlasiQ96JT2
PRIDEiQ96JT2
ProteomicsDBi77008

PTM databases

iPTMnetiQ96JT2
PhosphoSitePlusiQ96JT2

Expressioni

Tissue specificityi

Prostate specific. Expressed in all prostatic glandular cells. Expressed both in normal and cancerous prostates.2 Publications

Inductioni

Up-regulated by androgens.1 Publication

Gene expression databases

BgeeiENSG00000158715 Expressed in 155 organ(s), highest expression level in prostate gland
CleanExiHS_SLC45A3
GenevisibleiQ96JT2 HS

Organism-specific databases

HPAiHPA019073
HPA019075

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000356113

Structurei

3D structure databases

ProteinModelPortaliQ96JT2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi455 – 458Poly-Pro4

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0637 Eukaryota
ENOG410XPTR LUCA
GeneTreeiENSGT00390000018882
HOGENOMiHOG000013046
HOVERGENiHBG053519
InParanoidiQ96JT2
KOiK15379
OMAiCGASACD
OrthoDBiEOG091G0DTJ
PhylomeDBiQ96JT2
TreeFamiTF325412

Family and domain databases

InterProiView protein in InterPro
IPR011701 MFS
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit

Sequencei

Sequence statusi: Complete.

Q96JT2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVQRLWVSRL LRHRKAQLLL VNLLTFGLEV CLAAGITYVP PLLLEVGVEE
60 70 80 90 100
KFMTMVLGIG PVLGLVCVPL LGSASDHWRG RYGRRRPFIW ALSLGILLSL
110 120 130 140 150
FLIPRAGWLA GLLCPDPRPL ELALLILGVG LLDFCGQVCF TPLEALLSDL
160 170 180 190 200
FRDPDHCRQA YSVYAFMISL GGCLGYLLPA IDWDTSALAP YLGTQEECLF
210 220 230 240 250
GLLTLIFLTC VAATLLVAEE AALGPTEPAE GLSAPSLSPH CCPCRARLAF
260 270 280 290 300
RNLGALLPRL HQLCCRMPRT LRRLFVAELC SWMALMTFTL FYTDFVGEGL
310 320 330 340 350
YQGVPRAEPG TEARRHYDEG VRMGSLGLFL QCAISLVFSL VMDRLVQRFG
360 370 380 390 400
TRAVYLASVA AFPVAAGATC LSHSVAVVTA SAALTGFTFS ALQILPYTLA
410 420 430 440 450
SLYHREKQVF LPKYRGDTGG ASSEDSLMTS FLPGPKPGAP FPNGHVGAGG
460 470 480 490 500
SGLLPPPPAL CGASACDVSV RVVVGEPTEA RVVPGRGICL DLAILDSAFL
510 520 530 540 550
LSQVAPSLFM GSIVQLSQSV TAYMVSAAGL GLVAIYFATQ VVFDKSDLAK

YSA
Length:553
Mass (Da):59,323
Last modified:December 1, 2001 - v1
Checksum:i0AFA23FBC742A667
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY033593 mRNA Translation: AAK54386.1
AK290364 mRNA Translation: BAF83053.1
AK313479 mRNA Translation: BAG36263.1
CH471067 Genomic DNA Translation: EAW91575.1
BC050416 mRNA Translation: AAH50416.1
CCDSiCCDS1458.1
RefSeqiNP_149093.1, NM_033102.2
XP_005245613.1, XM_005245556.3
XP_005245614.1, XM_005245557.4
XP_016858127.1, XM_017002638.1
UniGeneiHs.278695

Genome annotation databases

EnsembliENST00000367145; ENSP00000356113; ENSG00000158715
GeneIDi85414
KEGGihsa:85414
UCSCiuc001hda.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY033593 mRNA Translation: AAK54386.1
AK290364 mRNA Translation: BAF83053.1
AK313479 mRNA Translation: BAG36263.1
CH471067 Genomic DNA Translation: EAW91575.1
BC050416 mRNA Translation: AAH50416.1
CCDSiCCDS1458.1
RefSeqiNP_149093.1, NM_033102.2
XP_005245613.1, XM_005245556.3
XP_005245614.1, XM_005245557.4
XP_016858127.1, XM_017002638.1
UniGeneiHs.278695

3D structure databases

ProteinModelPortaliQ96JT2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000356113

Protein family/group databases

TCDBi2.A.2.4.8 the glycoside-pentoside-hexuronide (gph):cation symporter family

PTM databases

iPTMnetiQ96JT2
PhosphoSitePlusiQ96JT2

Polymorphism and mutation databases

BioMutaiSLC45A3
DMDMi46396996

Proteomic databases

MaxQBiQ96JT2
PaxDbiQ96JT2
PeptideAtlasiQ96JT2
PRIDEiQ96JT2
ProteomicsDBi77008

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367145; ENSP00000356113; ENSG00000158715
GeneIDi85414
KEGGihsa:85414
UCSCiuc001hda.2 human

Organism-specific databases

CTDi85414
DisGeNETi85414
EuPathDBiHostDB:ENSG00000158715.5
GeneCardsiSLC45A3
HGNCiHGNC:8642 SLC45A3
HPAiHPA019073
HPA019075
MIMi605097 gene
neXtProtiNX_Q96JT2
OpenTargetsiENSG00000158715
PharmGKBiPA32981
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0637 Eukaryota
ENOG410XPTR LUCA
GeneTreeiENSGT00390000018882
HOGENOMiHOG000013046
HOVERGENiHBG053519
InParanoidiQ96JT2
KOiK15379
OMAiCGASACD
OrthoDBiEOG091G0DTJ
PhylomeDBiQ96JT2
TreeFamiTF325412

Enzyme and pathway databases

ReactomeiR-HSA-189200 Cellular hexose transport

Miscellaneous databases

ChiTaRSiSLC45A3 human
GeneWikiiSLC45A3
GenomeRNAii85414
PROiPR:Q96JT2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158715 Expressed in 155 organ(s), highest expression level in prostate gland
CleanExiHS_SLC45A3
GenevisibleiQ96JT2 HS

Family and domain databases

InterProiView protein in InterPro
IPR011701 MFS
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS45A3_HUMAN
AccessioniPrimary (citable) accession number: Q96JT2
Secondary accession number(s): A8K2U9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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