SLC45A3

Functionⁱ

Miscellaneous

Marker for prostate cells. May be used, in case of prostate cancers, as a target antigen for prostate carcinomas-directed cytotoxic T-cell lymphocytes.

GO - Molecular functionⁱ

sucrose:proton symporter activity Source: ParkinsonsUK-UCL
sugar transmembrane transporter activity Source: Reactome

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

hexose transmembrane transport Source: Reactome
positive regulation of fatty acid biosynthetic process Source: ParkinsonsUK-UCL
positive regulation of glucose metabolic process Source: ParkinsonsUK-UCL
regulation of oligodendrocyte differentiation Source: ParkinsonsUK-UCL
sucrose transport Source: ParkinsonsUK-UCL

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transport

Biological process

Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-189200 Cellular hexose transport

Reactomeⁱ

R-HSA-189200 Cellular hexose transport

Protein family/group databases

TCDBⁱ	2.A.2.4.8 the glycoside-pentoside-hexuronide (gph):cation symporter family

TCDBⁱ

2.A.2.4.8 the glycoside-pentoside-hexuronide (gph):cation symporter family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Solute carrier family 45 member 3 Alternative name(s): Prostate cancer-associated protein 6 Prostein
Gene namesⁱ	Name:SLC45A3 Synonyms:PCANAP6, PRST
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000158715.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8642 SLC45A3
MIMⁱ	605097 gene
neXtProtⁱ	NX_Q96JT2

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	19 – 39	Helical; Name=1Sequence analysisAdd BLAST	21
Transmembraneⁱ	52 – 72	Helical; Name=2Sequence analysisAdd BLAST	21
Transmembraneⁱ	88 – 108	Helical; Name=3Sequence analysisAdd BLAST	21
Transmembraneⁱ	120 – 140	Helical; Name=4Sequence analysisAdd BLAST	21
Transmembraneⁱ	161 – 181	Helical; Name=5Sequence analysisAdd BLAST	21
Transmembraneⁱ	198 – 218	Helical; Name=6Sequence analysisAdd BLAST	21
Transmembraneⁱ	275 – 295	Helical; Name=7Sequence analysisAdd BLAST	21
Transmembraneⁱ	323 – 343	Helical; Name=8Sequence analysisAdd BLAST	21
Transmembraneⁱ	353 – 373	Helical; Name=9Sequence analysisAdd BLAST	21
Transmembraneⁱ	382 – 402	Helical; Name=10Sequence analysisAdd BLAST	21
Transmembraneⁱ	522 – 542	Helical; Name=11Sequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	85414
Open Targets More...OpenTargetsⁱ	ENSG00000158715
PharmGKBⁱ	PA32981

Polymorphism and mutation databases

BioMutaⁱ	SLC45A3
DMDMⁱ	46396996

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000122519	1 – 553	Solute carrier family 45 member 3Add BLAST		553

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96JT2
PaxDbⁱ	Q96JT2
PeptideAtlas More...PeptideAtlasⁱ	Q96JT2
PRIDEⁱ	Q96JT2
ProteomicsDBⁱ	77008

PTM databases

iPTMnetⁱ	Q96JT2
PhosphoSitePlusⁱ	Q96JT2

Expressionⁱ

Tissue specificityⁱ

Prostate specific. Expressed in all prostatic glandular cells. Expressed both in normal and cancerous prostates.2 Publications

Inductionⁱ

Up-regulated by androgens.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000158715 Expressed in 155 organ(s), highest expression level in prostate gland
CleanExⁱ	HS_SLC45A3
Genevisibleⁱ	Q96JT2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA019073 HPA019075

HPAⁱ

HPA019073
HPA019075

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000356113

STRINGⁱ

9606.ENSP00000356113

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96JT2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	455 – 458	Poly-Pro		4

Sequence similaritiesⁱ

Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0637 Eukaryota ENOG410XPTR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018882
HOGENOMⁱ	HOG000013046
HOVERGENⁱ	HBG053519
InParanoidⁱ	Q96JT2
KEGG Orthology (KO) More...KOⁱ	K15379
OMAⁱ	CGASACD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DTJ
PhylomeDBⁱ	Q96JT2
TreeFamⁱ	TF325412

Family and domain databases

InterProⁱ	View protein in InterPro IPR011701 MFS IPR036259 MFS_trans_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07690 MFS_1, 1 hit
SUPFAMⁱ	SSF103473 SSF103473, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q96JT2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVQRLWVSRL LRHRKAQLLL VNLLTFGLEV CLAAGITYVP PLLLEVGVEE 
        60         70         80         90        100
KFMTMVLGIG PVLGLVCVPL LGSASDHWRG RYGRRRPFIW ALSLGILLSL 
       110        120        130        140        150
FLIPRAGWLA GLLCPDPRPL ELALLILGVG LLDFCGQVCF TPLEALLSDL 
       160        170        180        190        200
FRDPDHCRQA YSVYAFMISL GGCLGYLLPA IDWDTSALAP YLGTQEECLF 
       210        220        230        240        250
GLLTLIFLTC VAATLLVAEE AALGPTEPAE GLSAPSLSPH CCPCRARLAF 
       260        270        280        290        300
RNLGALLPRL HQLCCRMPRT LRRLFVAELC SWMALMTFTL FYTDFVGEGL 
       310        320        330        340        350
YQGVPRAEPG TEARRHYDEG VRMGSLGLFL QCAISLVFSL VMDRLVQRFG 
       360        370        380        390        400
TRAVYLASVA AFPVAAGATC LSHSVAVVTA SAALTGFTFS ALQILPYTLA 
       410        420        430        440        450
SLYHREKQVF LPKYRGDTGG ASSEDSLMTS FLPGPKPGAP FPNGHVGAGG 
       460        470        480        490        500
SGLLPPPPAL CGASACDVSV RVVVGEPTEA RVVPGRGICL DLAILDSAFL 
       510        520        530        540        550
LSQVAPSLFM GSIVQLSQSV TAYMVSAAGL GLVAIYFATQ VVFDKSDLAK 

YSA

Length:553

Mass (Da):59,323

Last modified:December 1, 2001 - v1

Checksum:ⁱ0AFA23FBC742A667

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY033593 mRNA Translation: AAK54386.1 AK290364 mRNA Translation: BAF83053.1 AK313479 mRNA Translation: BAG36263.1 CH471067 Genomic DNA Translation: EAW91575.1 BC050416 mRNA Translation: AAH50416.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1458.1
NCBI Reference Sequences More...RefSeqⁱ	NP_149093.1, NM_033102.2 XP_005245613.1, XM_005245556.3 XP_005245614.1, XM_005245557.4 XP_016858127.1, XM_017002638.1
UniGeneⁱ	Hs.278695

Genome annotation databases

Ensemblⁱ	ENST00000367145; ENSP00000356113; ENSG00000158715
GeneIDⁱ	85414
KEGGⁱ	hsa:85414
UCSC genome browser More...UCSCⁱ	uc001hda.2 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96JT2	Uncharacterized protein DKFZp666D0110		HUMAN		231	UniRef100_Q96JT2

Protein	Similar proteins		Species	Score	Length	Source
Q96JT2	Solute carrier family 45 member 3		MACFA		553	UniRef90_Q96JT2
Uncharacterized protein DKFZp666D0110		HUMAN		231
Solute carrier family 45 member 3		HORSE		565
Putative sucrose transporter		DESRO		559
Uncharacterized protein		COLAP		553
+67

Protein	Similar proteins		Species	Score	Length	Source
Q96JT2	Solute carrier family 45 member 3		MACFA		553	UniRef50_Q96JT2
Solute carrier family 45 member 3		MOUSE		553
Uncharacterized protein DKFZp666D0110		HUMAN		231
Solute carrier family 45 member 3		HORSE		565
Putative sucrose transporter		DESRO		559
+320

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY033593 mRNA Translation: AAK54386.1 AK290364 mRNA Translation: BAF83053.1 AK313479 mRNA Translation: BAG36263.1 CH471067 Genomic DNA Translation: EAW91575.1 BC050416 mRNA Translation: AAH50416.1
CCDSⁱ	CCDS1458.1
RefSeqⁱ	NP_149093.1, NM_033102.2 XP_005245613.1, XM_005245556.3 XP_005245614.1, XM_005245557.4 XP_016858127.1, XM_017002638.1
UniGeneⁱ	Hs.278695

3D structure databases

ProteinModelPortalⁱ	Q96JT2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000356113

STRINGⁱ

9606.ENSP00000356113

Protein family/group databases

TCDBⁱ	2.A.2.4.8 the glycoside-pentoside-hexuronide (gph):cation symporter family

TCDBⁱ

2.A.2.4.8 the glycoside-pentoside-hexuronide (gph):cation symporter family

PTM databases

iPTMnetⁱ	Q96JT2
PhosphoSitePlusⁱ	Q96JT2

Polymorphism and mutation databases

BioMutaⁱ	SLC45A3
DMDMⁱ	46396996

Proteomic databases

MaxQBⁱ	Q96JT2
PaxDbⁱ	Q96JT2
PeptideAtlasⁱ	Q96JT2
PRIDEⁱ	Q96JT2
ProteomicsDBⁱ	77008

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000367145; ENSP00000356113; ENSG00000158715
GeneIDⁱ	85414
KEGGⁱ	hsa:85414
UCSCⁱ	uc001hda.2 human

Organism-specific databases

CTDⁱ	85414
DisGeNETⁱ	85414
EuPathDBⁱ	HostDB:ENSG00000158715.5
GeneCardsⁱ	SLC45A3
HGNCⁱ	HGNC:8642 SLC45A3
HPAⁱ	HPA019073 HPA019075
MIMⁱ	605097 gene
neXtProtⁱ	NX_Q96JT2
OpenTargetsⁱ	ENSG00000158715
PharmGKBⁱ	PA32981
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0637 Eukaryota ENOG410XPTR LUCA
GeneTreeⁱ	ENSGT00390000018882
HOGENOMⁱ	HOG000013046
HOVERGENⁱ	HBG053519
InParanoidⁱ	Q96JT2
KOⁱ	K15379
OMAⁱ	CGASACD
OrthoDBⁱ	EOG091G0DTJ
PhylomeDBⁱ	Q96JT2
TreeFamⁱ	TF325412

Enzyme and pathway databases

Reactomeⁱ	R-HSA-189200 Cellular hexose transport

Reactomeⁱ

R-HSA-189200 Cellular hexose transport

Miscellaneous databases

ChiTaRSⁱ	SLC45A3 human
GeneWikiⁱ	SLC45A3
GenomeRNAiⁱ	85414
Protein Ontology More...PROⁱ	PR:Q96JT2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000158715 Expressed in 155 organ(s), highest expression level in prostate gland
CleanExⁱ	HS_SLC45A3
Genevisibleⁱ	Q96JT2 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011701 MFS IPR036259 MFS_trans_sf
Pfamⁱ	View protein in Pfam PF07690 MFS_1, 1 hit
SUPFAMⁱ	SSF103473 SSF103473, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	S45A3_HUMAN
Accessionⁱ	Q96JT2Primary (citable) accession number: Q96JT2 Secondary accession number(s): A8K2U9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
	Last sequence update:	December 1, 2001
	Last modified:	September 12, 2018
	This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96JT2 (S45A3_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Solute carrier family 45 member 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ