UniProtKB - Q96JT2 (S45A3_HUMAN)
Protein
Solute carrier family 45 member 3
Gene
SLC45A3
Organism
Homo sapiens (Human)
Status
Functioni
Miscellaneous
Marker for prostate cells. May be used, in case of prostate cancers, as a target antigen for prostate carcinomas-directed cytotoxic T-cell lymphocytes.
GO - Molecular functioni
- sucrose:proton symporter activity Source: ParkinsonsUK-UCL
- sugar transmembrane transporter activity Source: Reactome
GO - Biological processi
- hexose transmembrane transport Source: Reactome
- positive regulation of fatty acid biosynthetic process Source: ParkinsonsUK-UCL
- positive regulation of glucose metabolic process Source: ParkinsonsUK-UCL
- regulation of oligodendrocyte differentiation Source: ParkinsonsUK-UCL
- sucrose transport Source: ParkinsonsUK-UCL
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
PathwayCommonsi | Q96JT2 |
Reactomei | R-HSA-189200, Cellular hexose transport |
Protein family/group databases
TCDBi | 2.A.2.4.8, the glycoside-pentoside-hexuronide (gph):cation symporter family |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 45 member 3Alternative name(s): Prostate cancer-associated protein 6 Prostein |
Gene namesi | Name:SLC45A3 Synonyms:PCANAP6, PRST |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000158715.5 |
HGNCi | HGNC:8642, SLC45A3 |
MIMi | 605097, gene |
neXtProti | NX_Q96JT2 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 19 – 39 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Transmembranei | 52 – 72 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Transmembranei | 88 – 108 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Transmembranei | 120 – 140 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Transmembranei | 161 – 181 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Transmembranei | 198 – 218 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Transmembranei | 275 – 295 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Transmembranei | 323 – 343 | Helical; Name=8Sequence analysisAdd BLAST | 21 | |
Transmembranei | 353 – 373 | Helical; Name=9Sequence analysisAdd BLAST | 21 | |
Transmembranei | 382 – 402 | Helical; Name=10Sequence analysisAdd BLAST | 21 | |
Transmembranei | 522 – 542 | Helical; Name=11Sequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 85414 |
OpenTargetsi | ENSG00000158715 |
PharmGKBi | PA32981 |
Miscellaneous databases
Pharosi | Q96JT2, Tbio |
Polymorphism and mutation databases
BioMutai | SLC45A3 |
DMDMi | 46396996 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000122519 | 1 – 553 | Solute carrier family 45 member 3Add BLAST | 553 |
Proteomic databases
MassIVEi | Q96JT2 |
MaxQBi | Q96JT2 |
PaxDbi | Q96JT2 |
PeptideAtlasi | Q96JT2 |
PRIDEi | Q96JT2 |
ProteomicsDBi | 77008 |
PTM databases
iPTMneti | Q96JT2 |
PhosphoSitePlusi | Q96JT2 |
Expressioni
Tissue specificityi
Prostate specific. Expressed in all prostatic glandular cells. Expressed both in normal and cancerous prostates.2 Publications
Inductioni
Up-regulated by androgens.1 Publication
Gene expression databases
Bgeei | ENSG00000158715, Expressed in prostate gland and 172 other tissues |
Genevisiblei | Q96JT2, HS |
Organism-specific databases
HPAi | ENSG00000158715, Tissue enriched (prostate) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 124520, 1 interactor |
STRINGi | 9606.ENSP00000356113 |
Miscellaneous databases
RNActi | Q96JT2, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 455 – 458 | Poly-Pro | 4 |
Sequence similaritiesi
Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0637, Eukaryota |
GeneTreei | ENSGT00950000182914 |
HOGENOMi | CLU_015081_2_2_1 |
InParanoidi | Q96JT2 |
OMAi | SACDVSM |
OrthoDBi | 1230185at2759 |
PhylomeDBi | Q96JT2 |
TreeFami | TF325412 |
Family and domain databases
InterProi | View protein in InterPro IPR011701, MFS IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
i Sequence
Sequence statusi: Complete.
Q96JT2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVQRLWVSRL LRHRKAQLLL VNLLTFGLEV CLAAGITYVP PLLLEVGVEE
60 70 80 90 100
KFMTMVLGIG PVLGLVCVPL LGSASDHWRG RYGRRRPFIW ALSLGILLSL
110 120 130 140 150
FLIPRAGWLA GLLCPDPRPL ELALLILGVG LLDFCGQVCF TPLEALLSDL
160 170 180 190 200
FRDPDHCRQA YSVYAFMISL GGCLGYLLPA IDWDTSALAP YLGTQEECLF
210 220 230 240 250
GLLTLIFLTC VAATLLVAEE AALGPTEPAE GLSAPSLSPH CCPCRARLAF
260 270 280 290 300
RNLGALLPRL HQLCCRMPRT LRRLFVAELC SWMALMTFTL FYTDFVGEGL
310 320 330 340 350
YQGVPRAEPG TEARRHYDEG VRMGSLGLFL QCAISLVFSL VMDRLVQRFG
360 370 380 390 400
TRAVYLASVA AFPVAAGATC LSHSVAVVTA SAALTGFTFS ALQILPYTLA
410 420 430 440 450
SLYHREKQVF LPKYRGDTGG ASSEDSLMTS FLPGPKPGAP FPNGHVGAGG
460 470 480 490 500
SGLLPPPPAL CGASACDVSV RVVVGEPTEA RVVPGRGICL DLAILDSAFL
510 520 530 540 550
LSQVAPSLFM GSIVQLSQSV TAYMVSAAGL GLVAIYFATQ VVFDKSDLAK
YSA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY033593 mRNA Translation: AAK54386.1 AK290364 mRNA Translation: BAF83053.1 AK313479 mRNA Translation: BAG36263.1 CH471067 Genomic DNA Translation: EAW91575.1 BC050416 mRNA Translation: AAH50416.1 |
CCDSi | CCDS1458.1 |
RefSeqi | NP_149093.1, NM_033102.2 XP_005245613.1, XM_005245556.3 XP_005245614.1, XM_005245557.4 XP_016858127.1, XM_017002638.1 |
Genome annotation databases
Ensembli | ENST00000367145; ENSP00000356113; ENSG00000158715 |
GeneIDi | 85414 |
KEGGi | hsa:85414 |
UCSCi | uc001hda.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY033593 mRNA Translation: AAK54386.1 AK290364 mRNA Translation: BAF83053.1 AK313479 mRNA Translation: BAG36263.1 CH471067 Genomic DNA Translation: EAW91575.1 BC050416 mRNA Translation: AAH50416.1 |
CCDSi | CCDS1458.1 |
RefSeqi | NP_149093.1, NM_033102.2 XP_005245613.1, XM_005245556.3 XP_005245614.1, XM_005245557.4 XP_016858127.1, XM_017002638.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 124520, 1 interactor |
STRINGi | 9606.ENSP00000356113 |
Protein family/group databases
TCDBi | 2.A.2.4.8, the glycoside-pentoside-hexuronide (gph):cation symporter family |
PTM databases
iPTMneti | Q96JT2 |
PhosphoSitePlusi | Q96JT2 |
Polymorphism and mutation databases
BioMutai | SLC45A3 |
DMDMi | 46396996 |
Proteomic databases
MassIVEi | Q96JT2 |
MaxQBi | Q96JT2 |
PaxDbi | Q96JT2 |
PeptideAtlasi | Q96JT2 |
PRIDEi | Q96JT2 |
ProteomicsDBi | 77008 |
Protocols and materials databases
Antibodypediai | 20683, 193 antibodies |
Genome annotation databases
Ensembli | ENST00000367145; ENSP00000356113; ENSG00000158715 |
GeneIDi | 85414 |
KEGGi | hsa:85414 |
UCSCi | uc001hda.2, human |
Organism-specific databases
CTDi | 85414 |
DisGeNETi | 85414 |
EuPathDBi | HostDB:ENSG00000158715.5 |
GeneCardsi | SLC45A3 |
HGNCi | HGNC:8642, SLC45A3 |
HPAi | ENSG00000158715, Tissue enriched (prostate) |
MIMi | 605097, gene |
neXtProti | NX_Q96JT2 |
OpenTargetsi | ENSG00000158715 |
PharmGKBi | PA32981 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0637, Eukaryota |
GeneTreei | ENSGT00950000182914 |
HOGENOMi | CLU_015081_2_2_1 |
InParanoidi | Q96JT2 |
OMAi | SACDVSM |
OrthoDBi | 1230185at2759 |
PhylomeDBi | Q96JT2 |
TreeFami | TF325412 |
Enzyme and pathway databases
PathwayCommonsi | Q96JT2 |
Reactomei | R-HSA-189200, Cellular hexose transport |
Miscellaneous databases
BioGRID-ORCSi | 85414, 6 hits in 843 CRISPR screens |
ChiTaRSi | SLC45A3, human |
GeneWikii | SLC45A3 |
GenomeRNAii | 85414 |
Pharosi | Q96JT2, Tbio |
PROi | PR:Q96JT2 |
RNActi | Q96JT2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000158715, Expressed in prostate gland and 172 other tissues |
Genevisiblei | Q96JT2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011701, MFS IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S45A3_HUMAN | |
Accessioni | Q96JT2Primary (citable) accession number: Q96JT2 Secondary accession number(s): A8K2U9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2004 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM