PGBD1

Functionⁱ

GO - Molecular functionⁱ

DNA-binding transcription factor activity Source: InterPro
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 25416956
scavenger receptor activity Source: InterPro

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: PiggyBac transposable element-derived protein 1 Alternative name(s): Cerebral protein 4
Gene namesⁱ	Name:PGBD1 ORF Names:hucep-4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000137338.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19398 PGBD1
neXtProtⁱ	NX_Q96JS3

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	84547
Open Targets More...OpenTargetsⁱ	ENSG00000137338
PharmGKBⁱ	PA134919893

Polymorphism and mutation databases

BioMutaⁱ	PGBD1
DMDMⁱ	74751967

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000288052	1 – 809	PiggyBac transposable element-derived protein 1Add BLAST		809

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	218	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	360	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q96JS3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96JS3
PaxDbⁱ	Q96JS3
PeptideAtlas More...PeptideAtlasⁱ	Q96JS3
PRIDEⁱ	Q96JS3
ProteomicsDBⁱ	77007

PTM databases

iPTMnetⁱ	Q96JS3
PhosphoSitePlusⁱ	Q96JS3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000137338 Expressed in 122 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_PGBD1
Genevisibleⁱ	Q96JS3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA007267

HPAⁱ

HPA007267

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
itself		3	EBI-10290053,EBI-10290053
MEOX2	P50222	6	EBI-10290053,EBI-748397
NR4A1	P22736	3	EBI-10290053,EBI-721550
NR4A1	P22736-2	3	EBI-10290053,EBI-12697871
SCAND1	P57086	8	EBI-10290053,EBI-745846
TRAF2	Q12933	6	EBI-10290053,EBI-355744
ZKSCAN4	Q969J2	3	EBI-10290053,EBI-2818641
ZNF24	P17028	6	EBI-10290053,EBI-707773
ZNF446	A0A087WUM8	3	EBI-10290053,EBI-11955977
ZNF446	Q9NWS9-2	7	EBI-10290053,EBI-740232
ZNF496	Q96IT1	5	EBI-10290053,EBI-743906
ZSCAN22	P10073	7	EBI-10290053,EBI-10178224

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 25416956

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	124132, 24 interactors
IntActⁱ	Q96JS3, 13 interactors
STRINGⁱ	9606.ENSP00000259883

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96JS3
SMRⁱ	Q96JS3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	44 – 126	SCAN boxPROSITE-ProRule annotationAdd BLAST		83

Phylogenomic databases

eggNOGⁱ	ENOG410IHMN Eukaryota ENOG410ZDPG LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063278
HOGENOMⁱ	HOG000115518
HOVERGENⁱ	HBG099853
InParanoidⁱ	Q96JS3
OMAⁱ	KEEDPTW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05IL
PhylomeDBⁱ	Q96JS3
TreeFamⁱ	TF328011

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07936 SCAN, 1 hit
Gene3Dⁱ	1.10.4020.10, 1 hit
InterProⁱ	View protein in InterPro IPR029526 PGBD IPR003309 SCAN_dom IPR038269 SCAN_sf IPR001190 SRCR
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13843 DDE_Tnp_1_7, 1 hit PF02023 SCAN, 1 hit
SMARTⁱ	View protein in SMART SM00431 SCAN, 1 hit
PROSITEⁱ	View protein in PROSITE PS50804 SCAN_BOX, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q96JS3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MYEALPGPAP ENEDGLVKVK EEDPTWEQVC NSQEGSSHTQ EICRLRFRHF 
        60         70         80         90        100
CYQEAHGPQE ALAQLRELCH QWLRPEMHTK EQIMELLVLE QFLTILPKEL 
       110        120        130        140        150
QPCVKTYPLE SGEEAVTVLE NLETGSGDTG QQASVYIQGQ DMHPMVAEYQ 
       160        170        180        190        200
GVSLECQSLQ LLPGITTLKC EPPQRPQGNP QEVSGPVPHG SAHLQEKNPR 
       210        220        230        240        250
DKAVVPVFNP VRSQTLVKTE EETAQAVAAE KWSHLSLTRR NLCGNSAQET 
       260        270        280        290        300
VMSLSPMTEE IVTKDRLFKA KQETSEEMEQ SGEASGKPNR ECAPQIPCST 
       310        320        330        340        350
PIATERTVAH LNTLKDRHPG DLWARMHISS LEYAAGDITR KGRKKDKARV 
       360        370        380        390        400
SELLQGLSFS GDSDVEKDNE PEIQPAQKKL KVSCFPEKSW TKRDIKPNFP 
       410        420        430        440        450
SWSALDSGLL NLKSEKLNPV ELFELFFDDE TFNLIVNETN NYASQKNVSL 
       460        470        480        490        500
EVTVQEMRCV FGVLLLSGFM RHPRREMYWE VSDTDQNLVR DAIRRDRFEL 
       510        520        530        540        550
IFSNLHFADN GHLDQKDKFT KLRPLIKQMN KNFLLYAPLE EYYCFDKSMC 
       560        570        580        590        600
ECFDSDQFLN GKPIRIGYKI WCGTTTQGYL VWFEPYQEES TMKVDEDPDL 
       610        620        630        640        650
GLGGNLVMNF ADVLLERGQY PYHLCFDSFF TSVKLLSALK KKGVRATGTI 
       660        670        680        690        700
RENRTEKCPL MNVEHMKKMK RGYFDFRIEE NNEIILCRWY GDGIISLCSN 
       710        720        730        740        750
AVGIEPVNEV SCCDADNEEI PQISQPSIVK VYDECKEGVA KMDQIISKYR 
       760        770        780        790        800
VRIRSKKWYS ILVSYMIDVA MNNAWQLHRA CNPGASLDPL DFRRFVAHFY 

LEHNAHLSD

Length:809

Mass (Da):92,515

Last modified:December 1, 2001 - v1

Checksum:ⁱB311C58D171ABF3E

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	99	E → G in BAD97166 (Ref. 2) Curated		1
Sequence conflictⁱ	493	I → V in BAD97166 (Ref. 2) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_032384	244	G → E. Corresponds to variant dbSNP:rs3800324Ensembl.	1
Natural variantⁱVAR_051273	244	G → R. Corresponds to variant dbSNP:rs3800324Ensembl.	1
Natural variantⁱVAR_032385	248	Q → E. Corresponds to variant dbSNP:rs3800325Ensembl.	1
Natural variantⁱVAR_032386	256	P → L. Corresponds to variant dbSNP:rs3800326Ensembl.	1
Natural variantⁱVAR_032387	398	N → S. Corresponds to variant dbSNP:rs33932084Ensembl.	1
Natural variantⁱVAR_032388	592	M → I. Corresponds to variant dbSNP:rs16893917Ensembl.	1
Natural variantⁱVAR_032389	678	I → V. Corresponds to variant dbSNP:rs1997660Ensembl.	1
Natural variantⁱVAR_032390	806	H → D. Corresponds to variant dbSNP:rs6456811Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D88259 mRNA Translation: BAB46919.1 AK223446 mRNA Translation: BAD97166.1 AL021997 Genomic DNA No translation available. BC069033 mRNA Translation: AAH69033.1 Different termination. BC128585 mRNA Translation: AAI28586.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4648.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001171672.1, NM_001184743.1 NP_115896.1, NM_032507.3 XP_016866850.1, XM_017011361.1
UniGeneⁱ	Hs.144527

Genome annotation databases

Ensemblⁱ	ENST00000259883; ENSP00000259883; ENSG00000137338
GeneIDⁱ	84547
KEGGⁱ	hsa:84547
UCSC genome browser More...UCSCⁱ	uc003nkz.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q96JS3	PiggyBac transposable element-derived protein 1		MACMU		809	UniRef90_Q96JS3
Uncharacterized protein		PONAB		809
Uncharacterized protein		MACFA		809
Uncharacterized protein		MACNE		809
PiggyBac transposable element derived 1		GORGO		809
+30

Protein	Similar proteins		Species	Score	Length	Source
Q96JS3	Cerebral protein 4		MACMU		809	UniRef50_Q96JS3
PiggyBac transposable element derived 1		PANTR		809
Uncharacterized protein		MANLE		809
PiggyBac transposable element derived 1		GORGO		809
Uncharacterized protein		AOTNA		809
+136

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D88259 mRNA Translation: BAB46919.1 AK223446 mRNA Translation: BAD97166.1 AL021997 Genomic DNA No translation available. BC069033 mRNA Translation: AAH69033.1 Different termination. BC128585 mRNA Translation: AAI28586.1
CCDSⁱ	CCDS4648.1
RefSeqⁱ	NP_001171672.1, NM_001184743.1 NP_115896.1, NM_032507.3 XP_016866850.1, XM_017011361.1
UniGeneⁱ	Hs.144527

3D structure databases

ProteinModelPortalⁱ	Q96JS3
SMRⁱ	Q96JS3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	124132, 24 interactors
IntActⁱ	Q96JS3, 13 interactors
STRINGⁱ	9606.ENSP00000259883

PTM databases

iPTMnetⁱ	Q96JS3
PhosphoSitePlusⁱ	Q96JS3

Polymorphism and mutation databases

BioMutaⁱ	PGBD1
DMDMⁱ	74751967

Proteomic databases

EPDⁱ	Q96JS3
MaxQBⁱ	Q96JS3
PaxDbⁱ	Q96JS3
PeptideAtlasⁱ	Q96JS3
PRIDEⁱ	Q96JS3
ProteomicsDBⁱ	77007

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000259883; ENSP00000259883; ENSG00000137338
GeneIDⁱ	84547
KEGGⁱ	hsa:84547
UCSCⁱ	uc003nkz.4 human

Organism-specific databases

CTDⁱ	84547
DisGeNETⁱ	84547
EuPathDBⁱ	HostDB:ENSG00000137338.5
GeneCardsⁱ	PGBD1
HGNCⁱ	HGNC:19398 PGBD1
HPAⁱ	HPA007267
neXtProtⁱ	NX_Q96JS3
OpenTargetsⁱ	ENSG00000137338
PharmGKBⁱ	PA134919893
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IHMN Eukaryota ENOG410ZDPG LUCA
GeneTreeⁱ	ENSGT00530000063278
HOGENOMⁱ	HOG000115518
HOVERGENⁱ	HBG099853
InParanoidⁱ	Q96JS3
OMAⁱ	KEEDPTW
OrthoDBⁱ	EOG091G05IL
PhylomeDBⁱ	Q96JS3
TreeFamⁱ	TF328011

Miscellaneous databases

GenomeRNAiⁱ	84547
Protein Ontology More...PROⁱ	PR:Q96JS3

Gene expression databases

Bgeeⁱ	ENSG00000137338 Expressed in 122 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_PGBD1
Genevisibleⁱ	Q96JS3 HS

Family and domain databases

CDDⁱ	cd07936 SCAN, 1 hit
Gene3Dⁱ	1.10.4020.10, 1 hit
InterProⁱ	View protein in InterPro IPR029526 PGBD IPR003309 SCAN_dom IPR038269 SCAN_sf IPR001190 SRCR
Pfamⁱ	View protein in Pfam PF13843 DDE_Tnp_1_7, 1 hit PF02023 SCAN, 1 hit
SMARTⁱ	View protein in SMART SM00431 SCAN, 1 hit
PROSITEⁱ	View protein in PROSITE PS50804 SCAN_BOX, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PGBD1_HUMAN
Accessionⁱ	Q96JS3Primary (citable) accession number: Q96JS3 Secondary accession number(s): Q53F43, Q6NTF5, Q8WWS4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
	Last sequence update:	December 1, 2001
	Last modified:	November 7, 2018
	This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

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UniRef

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Supporting data

UniProtKB - Q96JS3 (PGBD1_HUMAN)

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PiggyBac transposable element-derived protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ