UniProtKB - Q96JS3 (PGBD1_HUMAN)
Protein
PiggyBac transposable element-derived protein 1
Gene
PGBD1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- identical protein binding Source: IntAct
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- scavenger receptor activity Source: InterPro
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q96JS3 |
Names & Taxonomyi
Protein namesi | Recommended name: PiggyBac transposable element-derived protein 1Alternative name(s): Cerebral protein 4 |
Gene namesi | Name:PGBD1 ORF Names:hucep-4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000137338.5 |
HGNCi | HGNC:19398, PGBD1 |
neXtProti | NX_Q96JS3 |
Subcellular locationi
Other locations
- membrane Source: InterPro
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 84547 |
OpenTargetsi | ENSG00000137338 |
PharmGKBi | PA134919893 |
Miscellaneous databases
Pharosi | Q96JS3, Tbio |
Polymorphism and mutation databases
BioMutai | PGBD1 |
DMDMi | 74751967 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000288052 | 1 – 809 | PiggyBac transposable element-derived protein 1Add BLAST | 809 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 218 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 360 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q96JS3 |
MassIVEi | Q96JS3 |
MaxQBi | Q96JS3 |
PaxDbi | Q96JS3 |
PeptideAtlasi | Q96JS3 |
PRIDEi | Q96JS3 |
ProteomicsDBi | 77007 |
PTM databases
iPTMneti | Q96JS3 |
PhosphoSitePlusi | Q96JS3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000137338, Expressed in cortical plate and 141 other tissues |
Genevisiblei | Q96JS3, HS |
Organism-specific databases
HPAi | ENSG00000137338, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ96JS3
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 124132, 27 interactors |
IntActi | Q96JS3, 26 interactors |
STRINGi | 9606.ENSP00000259883 |
Miscellaneous databases
RNActi | Q96JS3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 44 – 126 | SCAN boxPROSITE-ProRule annotationAdd BLAST | 83 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163016 |
HOGENOMi | CLU_357756_0_0_1 |
InParanoidi | Q96JS3 |
OMAi | GQYPYHL |
OrthoDBi | 279711at2759 |
PhylomeDBi | Q96JS3 |
TreeFami | TF328011 |
Family and domain databases
CDDi | cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR029526, PGBD IPR003309, SCAN_dom IPR038269, SCAN_sf IPR001190, SRCR |
Pfami | View protein in Pfam PF13843, DDE_Tnp_1_7, 1 hit PF02023, SCAN, 1 hit |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit |
PROSITEi | View protein in PROSITE PS50804, SCAN_BOX, 1 hit |
i Sequence
Sequence statusi: Complete.
Q96JS3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYEALPGPAP ENEDGLVKVK EEDPTWEQVC NSQEGSSHTQ EICRLRFRHF
60 70 80 90 100
CYQEAHGPQE ALAQLRELCH QWLRPEMHTK EQIMELLVLE QFLTILPKEL
110 120 130 140 150
QPCVKTYPLE SGEEAVTVLE NLETGSGDTG QQASVYIQGQ DMHPMVAEYQ
160 170 180 190 200
GVSLECQSLQ LLPGITTLKC EPPQRPQGNP QEVSGPVPHG SAHLQEKNPR
210 220 230 240 250
DKAVVPVFNP VRSQTLVKTE EETAQAVAAE KWSHLSLTRR NLCGNSAQET
260 270 280 290 300
VMSLSPMTEE IVTKDRLFKA KQETSEEMEQ SGEASGKPNR ECAPQIPCST
310 320 330 340 350
PIATERTVAH LNTLKDRHPG DLWARMHISS LEYAAGDITR KGRKKDKARV
360 370 380 390 400
SELLQGLSFS GDSDVEKDNE PEIQPAQKKL KVSCFPEKSW TKRDIKPNFP
410 420 430 440 450
SWSALDSGLL NLKSEKLNPV ELFELFFDDE TFNLIVNETN NYASQKNVSL
460 470 480 490 500
EVTVQEMRCV FGVLLLSGFM RHPRREMYWE VSDTDQNLVR DAIRRDRFEL
510 520 530 540 550
IFSNLHFADN GHLDQKDKFT KLRPLIKQMN KNFLLYAPLE EYYCFDKSMC
560 570 580 590 600
ECFDSDQFLN GKPIRIGYKI WCGTTTQGYL VWFEPYQEES TMKVDEDPDL
610 620 630 640 650
GLGGNLVMNF ADVLLERGQY PYHLCFDSFF TSVKLLSALK KKGVRATGTI
660 670 680 690 700
RENRTEKCPL MNVEHMKKMK RGYFDFRIEE NNEIILCRWY GDGIISLCSN
710 720 730 740 750
AVGIEPVNEV SCCDADNEEI PQISQPSIVK VYDECKEGVA KMDQIISKYR
760 770 780 790 800
VRIRSKKWYS ILVSYMIDVA MNNAWQLHRA CNPGASLDPL DFRRFVAHFY
LEHNAHLSD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 99 | E → G in BAD97166 (Ref. 2) Curated | 1 | |
Sequence conflicti | 493 | I → V in BAD97166 (Ref. 2) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032384 | 244 | G → E. Corresponds to variant dbSNP:rs3800324Ensembl. | 1 | |
Natural variantiVAR_051273 | 244 | G → R. Corresponds to variant dbSNP:rs3800324Ensembl. | 1 | |
Natural variantiVAR_032385 | 248 | Q → E. Corresponds to variant dbSNP:rs3800325Ensembl. | 1 | |
Natural variantiVAR_032386 | 256 | P → L. Corresponds to variant dbSNP:rs3800326Ensembl. | 1 | |
Natural variantiVAR_032387 | 398 | N → S. Corresponds to variant dbSNP:rs33932084Ensembl. | 1 | |
Natural variantiVAR_032388 | 592 | M → I. Corresponds to variant dbSNP:rs16893917Ensembl. | 1 | |
Natural variantiVAR_032389 | 678 | I → V. Corresponds to variant dbSNP:rs1997660Ensembl. | 1 | |
Natural variantiVAR_032390 | 806 | H → D. Corresponds to variant dbSNP:rs6456811Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D88259 mRNA Translation: BAB46919.1 AK223446 mRNA Translation: BAD97166.1 AL021997 Genomic DNA No translation available. BC069033 mRNA Translation: AAH69033.1 Different termination. BC128585 mRNA Translation: AAI28586.1 |
CCDSi | CCDS4648.1 |
RefSeqi | NP_001171672.1, NM_001184743.1 NP_115896.1, NM_032507.3 XP_016866850.1, XM_017011361.1 |
Genome annotation databases
Ensembli | ENST00000259883; ENSP00000259883; ENSG00000137338 |
GeneIDi | 84547 |
KEGGi | hsa:84547 |
UCSCi | uc003nkz.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D88259 mRNA Translation: BAB46919.1 AK223446 mRNA Translation: BAD97166.1 AL021997 Genomic DNA No translation available. BC069033 mRNA Translation: AAH69033.1 Different termination. BC128585 mRNA Translation: AAI28586.1 |
CCDSi | CCDS4648.1 |
RefSeqi | NP_001171672.1, NM_001184743.1 NP_115896.1, NM_032507.3 XP_016866850.1, XM_017011361.1 |
3D structure databases
SMRi | Q96JS3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124132, 27 interactors |
IntActi | Q96JS3, 26 interactors |
STRINGi | 9606.ENSP00000259883 |
PTM databases
iPTMneti | Q96JS3 |
PhosphoSitePlusi | Q96JS3 |
Polymorphism and mutation databases
BioMutai | PGBD1 |
DMDMi | 74751967 |
Proteomic databases
EPDi | Q96JS3 |
MassIVEi | Q96JS3 |
MaxQBi | Q96JS3 |
PaxDbi | Q96JS3 |
PeptideAtlasi | Q96JS3 |
PRIDEi | Q96JS3 |
ProteomicsDBi | 77007 |
Protocols and materials databases
ABCDi | Q96JS3, 2 sequenced antibodies |
Antibodypediai | 1792, 244 antibodies |
Genome annotation databases
Ensembli | ENST00000259883; ENSP00000259883; ENSG00000137338 |
GeneIDi | 84547 |
KEGGi | hsa:84547 |
UCSCi | uc003nkz.4, human |
Organism-specific databases
CTDi | 84547 |
DisGeNETi | 84547 |
EuPathDBi | HostDB:ENSG00000137338.5 |
GeneCardsi | PGBD1 |
HGNCi | HGNC:19398, PGBD1 |
HPAi | ENSG00000137338, Low tissue specificity |
neXtProti | NX_Q96JS3 |
OpenTargetsi | ENSG00000137338 |
PharmGKBi | PA134919893 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163016 |
HOGENOMi | CLU_357756_0_0_1 |
InParanoidi | Q96JS3 |
OMAi | GQYPYHL |
OrthoDBi | 279711at2759 |
PhylomeDBi | Q96JS3 |
TreeFami | TF328011 |
Enzyme and pathway databases
PathwayCommonsi | Q96JS3 |
Miscellaneous databases
BioGRID-ORCSi | 84547, 1 hit in 846 CRISPR screens |
GenomeRNAii | 84547 |
Pharosi | Q96JS3, Tbio |
PROi | PR:Q96JS3 |
RNActi | Q96JS3, protein |
Gene expression databases
Bgeei | ENSG00000137338, Expressed in cortical plate and 141 other tissues |
Genevisiblei | Q96JS3, HS |
Family and domain databases
CDDi | cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR029526, PGBD IPR003309, SCAN_dom IPR038269, SCAN_sf IPR001190, SRCR |
Pfami | View protein in Pfam PF13843, DDE_Tnp_1_7, 1 hit PF02023, SCAN, 1 hit |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit |
PROSITEi | View protein in PROSITE PS50804, SCAN_BOX, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PGBD1_HUMAN | |
Accessioni | Q96JS3Primary (citable) accession number: Q96JS3 Secondary accession number(s): Q53F43, Q6NTF5, Q8WWS4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2007 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations