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UniProtKB - Q96JQ5 (M4A4A_HUMAN)

Entry version 135 (08 May 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Membrane-spanning 4-domains subfamily A member 4A

Gene

MS4A4A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in signal transduction as a component of a multimeric receptor complex.

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Membrane-spanning 4-domains subfamily A member 4A
Alternative name(s):
CD20 antigen-like 1
Four-span transmembrane protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MS4A4A
Synonyms:4SPAN1, CD20L1, MS4A4
ORF Names:HDCME31P
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:13371 MS4A4A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606547 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96JQ5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 64CytoplasmicSequence analysisAdd BLAST64
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Topological domaini86 – 98ExtracellularSequence analysisAdd BLAST13
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Topological domaini120 – 137CytoplasmicSequence analysisAdd BLAST18
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Topological domaini159 – 179ExtracellularSequence analysisAdd BLAST21
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Topological domaini201 – 239CytoplasmicSequence analysisAdd BLAST39

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		51338

Open Targets

More...OpenTargetsi		ENSG00000110079

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31113

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MS4A4A

Domain mapping of disease mutations (DMDM)

More...DMDMi		30580442

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001586341 – 239Membrane-spanning 4-domains subfamily A member 4AAdd BLAST239

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96JQ5

PeptideAtlas

More...PeptideAtlasi		Q96JQ5

PRoteomics IDEntifications database

More...PRIDEi		Q96JQ5

ProteomicsDB human proteome resource

More...ProteomicsDBi		77005
77006 [Q96JQ5-2]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Variable expression in multiple hemopoietic cell lines.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000110079 Expressed in 180 organ(s), highest expression level in esophagus

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96JQ5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96JQ5 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA029323

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
CSE1LP550602EBI-12820341,EBI-286709

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q96JQ5, 41 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000338648

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MS4A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410J084 Eukaryota
ENOG4112CBR LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155376

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000113440

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96JQ5

KEGG Orthology (KO)

More...KOi		K22190

Identification of Orthologs from Complete Genome Data

More...OMAi		NNCHGTV

Database of Orthologous Groups

More...OrthoDBi		1178983at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96JQ5

TreeFam database of animal gene trees

More...TreeFami		TF335157

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007237 CD20-like
IPR030417 MS4A
IPR030425 MS4A_4A

The PANTHER Classification System

More...PANTHERi		PTHR23320 PTHR23320, 1 hit
PTHR23320:SF126 PTHR23320:SF126, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04103 CD20, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96JQ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHQTYSRHCR PEESTFSAAM TTMQGMEQAM PGAGPGVPQL GNMAVIHSHL 
        60         70         80         90        100
WKGLQEKFLK GEPKVLGVVQ ILTALMSLSM GITMMCMASN TYGSNPISVY 
       110        120        130        140        150
IGYTIWGSVM FIISGSLSIA AGIRTTKGLV RGSLGMNITS SVLAASGILI 
       160        170        180        190        200
NTFSLAFYSF HHPYCNYYGN SNNCHGTMSI LMGLDGMVLL LSVLEFCIAV 
       210        220        230 
SLSAFGCKVL CCTPGGVVLI LPSHSHMAET ASPTPLNEV
Length:239
Mass (Da):25,441
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF0617D94669CB447
GO
Isoform 2 (identifier: Q96JQ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     130-182: Missing.

Show »
Length:186
Mass (Da):19,682
Checksum:i14A89883D4417D17
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B3ITV6A0A3B3ITV6_HUMAN
Membrane-spanning 4-domains subfami...
MS4A4A
248Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W866F8W866_HUMAN
Membrane-spanning 4-domains subfami...
MS4A4A
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YE49H0YE49_HUMAN
Membrane-spanning 4-domains subfami...
MS4A4A
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF65507 differs from that shown. Reason: Frameshift at position 33.Curated
The sequence AAK37594 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL08486 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL56220 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB18738 differs from that shown. Reason: Frameshift at position 34.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti26M → I (PubMed:11245982).Curated1
Sequence conflicti100Y → H in AAF65507 (Ref. 5) Curated1
Sequence conflicti200V → C in AAL56220 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05351752K → E. Corresponds to variant dbSNP:rs10750931Ensembl.1
Natural variantiVAR_024540178M → V. Corresponds to variant dbSNP:rs6591561Ensembl.1
Natural variantiVAR_062123191L → I. Corresponds to variant dbSNP:rs4644658Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_007380130 – 182Missing in isoform 2. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB022821 mRNA Translation: BAB61018.1
AB013102 mRNA Translation: BAB18738.1 Frameshift.
AF237912 mRNA Translation: AAK37594.1 Different initiation.
AF350500 mRNA Translation: AAL56220.1 Different initiation.
AF068288 mRNA Translation: AAF65507.1 Frameshift.
AF354928 mRNA Translation: AAL08486.1 Different initiation.
BC020648 mRNA Translation: AAH20648.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS58135.1 [Q96JQ5-2]
CCDS7982.1 [Q96JQ5-1]

NCBI Reference Sequences

More...RefSeqi		NP_001230195.1, NM_001243266.1 [Q96JQ5-2]
NP_076926.2, NM_024021.3
NP_683876.1, NM_148975.2 [Q96JQ5-1]
XP_016873398.1, XM_017017909.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000337908; ENSP00000338648; ENSG00000110079 [Q96JQ5-1]
ENST00000532114; ENSP00000434506; ENSG00000110079 [Q96JQ5-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51338

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51338

UCSC genome browser

More...UCSCi		uc001noz.4 human [Q96JQ5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022821 mRNA Translation: BAB61018.1
AB013102 mRNA Translation: BAB18738.1 Frameshift.
AF237912 mRNA Translation: AAK37594.1 Different initiation.
AF350500 mRNA Translation: AAL56220.1 Different initiation.
AF068288 mRNA Translation: AAF65507.1 Frameshift.
AF354928 mRNA Translation: AAL08486.1 Different initiation.
BC020648 mRNA Translation: AAH20648.1
CCDSiCCDS58135.1 [Q96JQ5-2]
CCDS7982.1 [Q96JQ5-1]
RefSeqiNP_001230195.1, NM_001243266.1 [Q96JQ5-2]
NP_076926.2, NM_024021.3
NP_683876.1, NM_148975.2 [Q96JQ5-1]
XP_016873398.1, XM_017017909.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

IntActiQ96JQ5, 41 interactors
STRINGi9606.ENSP00000338648

Polymorphism and mutation databases

BioMutaiMS4A4A
DMDMi30580442

Proteomic databases

PaxDbiQ96JQ5
PeptideAtlasiQ96JQ5
PRIDEiQ96JQ5
ProteomicsDBi77005
77006 [Q96JQ5-2]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		51338
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337908; ENSP00000338648; ENSG00000110079 [Q96JQ5-1]
ENST00000532114; ENSP00000434506; ENSG00000110079 [Q96JQ5-2]
GeneIDi51338
KEGGihsa:51338
UCSCiuc001noz.4 human [Q96JQ5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51338
DisGeNETi51338

GeneCards: human genes, protein and diseases

More...GeneCardsi		MS4A4A

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0058934
HGNCiHGNC:13371 MS4A4A
HPAiHPA029323
MIMi606547 gene
neXtProtiNX_Q96JQ5
OpenTargetsiENSG00000110079
PharmGKBiPA31113

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410J084 Eukaryota
ENOG4112CBR LUCA
GeneTreeiENSGT00940000155376
HOGENOMiHOG000113440
InParanoidiQ96JQ5
KOiK22190
OMAiNNCHGTV
OrthoDBi1178983at2759
PhylomeDBiQ96JQ5
TreeFamiTF335157

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51338

Protein Ontology

More...PROi		PR:Q96JQ5

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000110079 Expressed in 180 organ(s), highest expression level in esophagus
ExpressionAtlasiQ96JQ5 baseline and differential
GenevisibleiQ96JQ5 HS

Family and domain databases

InterProiView protein in InterPro
IPR007237 CD20-like
IPR030417 MS4A
IPR030425 MS4A_4A
PANTHERiPTHR23320 PTHR23320, 1 hit
PTHR23320:SF126 PTHR23320:SF126, 1 hit
PfamiView protein in Pfam
PF04103 CD20, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM4A4A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96JQ5
Secondary accession number(s): Q8TEZ6
, Q96PG7, Q9BY18, Q9H3V3, Q9P1S3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: December 1, 2001
Last modified: May 8, 2019
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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