UniProtKB - Q96JQ5 (M4A4A_HUMAN)
Protein
Membrane-spanning 4-domains subfamily A member 4A
Gene
MS4A4A
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in signal transduction as a component of a multimeric receptor complex.
Keywordsi
Molecular function | Receptor |
Enzyme and pathway databases
PathwayCommonsi | Q96JQ5 |
Names & Taxonomyi
Protein namesi | Recommended name: Membrane-spanning 4-domains subfamily A member 4AAlternative name(s): CD20 antigen-like 1 Four-span transmembrane protein 1 |
Gene namesi | Name:MS4A4A Synonyms:4SPAN1, CD20L1, MS4A4 ORF Names:HDCME31P |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000110079.16 |
HGNCi | HGNC:13371, MS4A4A |
MIMi | 606547, gene |
neXtProti | NX_Q96JQ5 |
Subcellular locationi
Other locations
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 64 | CytoplasmicSequence analysisAdd BLAST | 64 | |
Transmembranei | 65 – 85 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 86 – 98 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 99 – 119 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 120 – 137 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 138 – 158 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 159 – 179 | ExtracellularSequence analysisAdd BLAST | 21 | |
Transmembranei | 180 – 200 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 201 – 239 | CytoplasmicSequence analysisAdd BLAST | 39 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 51338 |
NIAGADSi | ENSG00000110079 |
OpenTargetsi | ENSG00000110079 |
PharmGKBi | PA31113 |
Miscellaneous databases
Pharosi | Q96JQ5, Tbio |
Polymorphism and mutation databases
BioMutai | MS4A4A |
DMDMi | 30580442 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000158634 | 1 – 239 | Membrane-spanning 4-domains subfamily A member 4AAdd BLAST | 239 |
Proteomic databases
MassIVEi | Q96JQ5 |
PaxDbi | Q96JQ5 |
PeptideAtlasi | Q96JQ5 |
PRIDEi | Q96JQ5 |
ProteomicsDBi | 77005 [Q96JQ5-1] 77006 [Q96JQ5-2] |
Expressioni
Tissue specificityi
Variable expression in multiple hemopoietic cell lines.
Gene expression databases
Bgeei | ENSG00000110079, Expressed in esophagus and 192 other tissues |
ExpressionAtlasi | Q96JQ5, baseline and differential |
Genevisiblei | Q96JQ5, HS |
Organism-specific databases
HPAi | ENSG00000110079, Tissue enhanced (adipose) |
Interactioni
Binary interactionsi
Hide detailsQ96JQ5
Protein-protein interaction databases
BioGRIDi | 119485, 41 interactors |
IntActi | Q96JQ5, 41 interactors |
STRINGi | 9606.ENSP00000338648 |
Miscellaneous databases
RNActi | Q96JQ5, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the MS4A family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S3XD, Eukaryota |
GeneTreei | ENSGT00940000155376 |
HOGENOMi | CLU_091032_3_1_1 |
InParanoidi | Q96JQ5 |
OMAi | WGSLMFI |
OrthoDBi | 1178983at2759 |
PhylomeDBi | Q96JQ5 |
TreeFami | TF335157 |
Family and domain databases
InterProi | View protein in InterPro IPR007237, CD20-like IPR030417, MS4A IPR030425, MS4A_4A |
PANTHERi | PTHR23320, PTHR23320, 1 hit PTHR23320:SF126, PTHR23320:SF126, 1 hit |
Pfami | View protein in Pfam PF04103, CD20, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96JQ5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MHQTYSRHCR PEESTFSAAM TTMQGMEQAM PGAGPGVPQL GNMAVIHSHL
60 70 80 90 100
WKGLQEKFLK GEPKVLGVVQ ILTALMSLSM GITMMCMASN TYGSNPISVY
110 120 130 140 150
IGYTIWGSVM FIISGSLSIA AGIRTTKGLV RGSLGMNITS SVLAASGILI
160 170 180 190 200
NTFSLAFYSF HHPYCNYYGN SNNCHGTMSI LMGLDGMVLL LSVLEFCIAV
210 220 230
SLSAFGCKVL CCTPGGVVLI LPSHSHMAET ASPTPLNEV
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3B3ITV6 | A0A3B3ITV6_HUMAN | Membrane-spanning 4-domains subfami... | MS4A4A | 248 | Annotation score: | ||
H0YE49 | H0YE49_HUMAN | Membrane-spanning 4-domains subfami... | MS4A4A | 35 | Annotation score: | ||
F8W866 | F8W866_HUMAN | Membrane-spanning 4-domains subfami... | MS4A4A | 68 | Annotation score: |
Sequence cautioni
The sequence AAF65507 differs from that shown. Reason: Frameshift.Curated
The sequence AAK37594 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL08486 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL56220 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB18738 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 26 | M → I (PubMed:11245982).Curated | 1 | |
Sequence conflicti | 100 | Y → H in AAF65507 (Ref. 5) Curated | 1 | |
Sequence conflicti | 200 | V → C in AAL56220 (Ref. 4) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053517 | 52 | K → E. Corresponds to variant dbSNP:rs10750931Ensembl. | 1 | |
Natural variantiVAR_024540 | 178 | M → V. Corresponds to variant dbSNP:rs6591561Ensembl. | 1 | |
Natural variantiVAR_062123 | 191 | L → I. Corresponds to variant dbSNP:rs4644658Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_007380 | 130 – 182 | Missing in isoform 2. 1 PublicationAdd BLAST | 53 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB022821 mRNA Translation: BAB61018.1 AB013102 mRNA Translation: BAB18738.1 Frameshift. AF237912 mRNA Translation: AAK37594.1 Different initiation. AF350500 mRNA Translation: AAL56220.1 Different initiation. AF068288 mRNA Translation: AAF65507.1 Frameshift. AF354928 mRNA Translation: AAL08486.1 Different initiation. BC020648 mRNA Translation: AAH20648.1 |
CCDSi | CCDS58135.1 [Q96JQ5-2] CCDS7982.1 [Q96JQ5-1] |
RefSeqi | NP_001230195.1, NM_001243266.1 [Q96JQ5-2] NP_076926.2, NM_024021.3 NP_683876.1, NM_148975.2 [Q96JQ5-1] XP_016873398.1, XM_017017909.1 |
Genome annotation databases
Ensembli | ENST00000337908; ENSP00000338648; ENSG00000110079 [Q96JQ5-1] ENST00000532114; ENSP00000434506; ENSG00000110079 [Q96JQ5-2] |
GeneIDi | 51338 |
KEGGi | hsa:51338 |
UCSCi | uc001noz.4, human [Q96JQ5-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB022821 mRNA Translation: BAB61018.1 AB013102 mRNA Translation: BAB18738.1 Frameshift. AF237912 mRNA Translation: AAK37594.1 Different initiation. AF350500 mRNA Translation: AAL56220.1 Different initiation. AF068288 mRNA Translation: AAF65507.1 Frameshift. AF354928 mRNA Translation: AAL08486.1 Different initiation. BC020648 mRNA Translation: AAH20648.1 |
CCDSi | CCDS58135.1 [Q96JQ5-2] CCDS7982.1 [Q96JQ5-1] |
RefSeqi | NP_001230195.1, NM_001243266.1 [Q96JQ5-2] NP_076926.2, NM_024021.3 NP_683876.1, NM_148975.2 [Q96JQ5-1] XP_016873398.1, XM_017017909.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 119485, 41 interactors |
IntActi | Q96JQ5, 41 interactors |
STRINGi | 9606.ENSP00000338648 |
Polymorphism and mutation databases
BioMutai | MS4A4A |
DMDMi | 30580442 |
Proteomic databases
MassIVEi | Q96JQ5 |
PaxDbi | Q96JQ5 |
PeptideAtlasi | Q96JQ5 |
PRIDEi | Q96JQ5 |
ProteomicsDBi | 77005 [Q96JQ5-1] 77006 [Q96JQ5-2] |
Protocols and materials databases
Antibodypediai | 27893, 158 antibodies |
DNASUi | 51338 |
Genome annotation databases
Ensembli | ENST00000337908; ENSP00000338648; ENSG00000110079 [Q96JQ5-1] ENST00000532114; ENSP00000434506; ENSG00000110079 [Q96JQ5-2] |
GeneIDi | 51338 |
KEGGi | hsa:51338 |
UCSCi | uc001noz.4, human [Q96JQ5-1] |
Organism-specific databases
CTDi | 51338 |
DisGeNETi | 51338 |
EuPathDBi | HostDB:ENSG00000110079.16 |
GeneCardsi | MS4A4A |
HGNCi | HGNC:13371, MS4A4A |
HPAi | ENSG00000110079, Tissue enhanced (adipose) |
MIMi | 606547, gene |
neXtProti | NX_Q96JQ5 |
NIAGADSi | ENSG00000110079 |
OpenTargetsi | ENSG00000110079 |
PharmGKBi | PA31113 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S3XD, Eukaryota |
GeneTreei | ENSGT00940000155376 |
HOGENOMi | CLU_091032_3_1_1 |
InParanoidi | Q96JQ5 |
OMAi | WGSLMFI |
OrthoDBi | 1178983at2759 |
PhylomeDBi | Q96JQ5 |
TreeFami | TF335157 |
Enzyme and pathway databases
PathwayCommonsi | Q96JQ5 |
Miscellaneous databases
BioGRID-ORCSi | 51338, 5 hits in 845 CRISPR screens |
GenomeRNAii | 51338 |
Pharosi | Q96JQ5, Tbio |
PROi | PR:Q96JQ5 |
RNActi | Q96JQ5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000110079, Expressed in esophagus and 192 other tissues |
ExpressionAtlasi | Q96JQ5, baseline and differential |
Genevisiblei | Q96JQ5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007237, CD20-like IPR030417, MS4A IPR030425, MS4A_4A |
PANTHERi | PTHR23320, PTHR23320, 1 hit PTHR23320:SF126, PTHR23320:SF126, 1 hit |
Pfami | View protein in Pfam PF04103, CD20, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | M4A4A_HUMAN | |
Accessioni | Q96JQ5Primary (citable) accession number: Q96JQ5 Secondary accession number(s): Q8TEZ6 Q9P1S3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 9, 2003 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations