Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

E3 ubiquitin-protein ligase ZFP91

Gene

ZFP91

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.2 Publications

Miscellaneous

In contrast to other E3 ubiquitin-protein ligase, does not contain any domain (RING-type zinc finger or HECT domain) known to mediate E3 ligase activity.

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri311 – 336C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri342 – 366C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri372 – 394C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri430 – 453C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ96JP5
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase ZFP91 (EC:2.3.2.27)
Alternative name(s):
RING-type E3 ubiquitin transferase ZFP91
Zinc finger protein 757
Zinc finger protein 91 homolog
Short name:
Zfp-91
Gene namesi
Name:ZFP91
Synonyms:ZNF757
ORF Names:FKSG11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000186660.14
HGNCiHGNC:14983 ZFP91
neXtProtiNX_Q96JP5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi344C → A: Abolishes ubiquitination of MAP3K14/NIK; when associated with A-349. 1 Publication1
Mutagenesisi349C → A: Abolishes ubiquitination of MAP3K14/NIK; when associated with A-344. 1 Publication1

Organism-specific databases

DisGeNETi80829
OpenTargetsiENSG00000186660
PharmGKBiPA37955

Polymorphism and mutation databases

BioMutaiZFP91
DMDMi60416377

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000473122 – 570E3 ubiquitin-protein ligase ZFP91Add BLAST569

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei83PhosphoserineBy similarity1
Modified residuei103PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96JP5
MaxQBiQ96JP5
PaxDbiQ96JP5
PeptideAtlasiQ96JP5
PRIDEiQ96JP5
ProteomicsDBi76999
77000 [Q96JP5-2]

PTM databases

iPTMnetiQ96JP5
PhosphoSitePlusiQ96JP5

Expressioni

Tissue specificityi

Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific.

Gene expression databases

BgeeiENSG00000186660 Expressed in 208 organ(s), highest expression level in quadriceps femoris
CleanExiHS_ZFP91
ExpressionAtlasiQ96JP5 baseline and differential
GenevisibleiQ96JP5 HS

Organism-specific databases

HPAiCAB025417
HPA024037
HPA065325

Interactioni

Subunit structurei

Interacts with MAP3K14/NIK.2 Publications

Protein-protein interaction databases

BioGridi123322, 36 interactors
CORUMiQ96JP5
IntActiQ96JP5, 14 interactors
STRINGi9606.ENSP00000339030

Structurei

Secondary structure

1570
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ96JP5
SMRiQ96JP5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni338 – 368Interaction with MAP3K14/NIK1 PublicationAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi21 – 67Ala-richAdd BLAST47
Compositional biasi48 – 81Arg-richAdd BLAST34
Compositional biasi197 – 282Glu-richAdd BLAST86

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri311 – 336C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri342 – 366C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri372 – 394C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri430 – 453C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063153
HOGENOMiHOG000155779
HOVERGENiHBG055547
InParanoidiQ96JP5
OMAiCKSEPNA
OrthoDBiEOG091G055J
PhylomeDBiQ96JP5
TreeFamiTF332664

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96JP5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPGETEEPRP PEQQDQEGGE AAKAAPEEPQ QRPPEAVAAA PAGTTSSRVL
60 70 80 90 100
RGGRDRGRAA AAAAAAAVSR RRKAEYPRRR RSSPSARPPD VPGQQPQAAK
110 120 130 140 150
SPSPVQGKKS PRLLCIEKVT TDKDPKEEKE EEDDSALPQE VSIAASRPSR
160 170 180 190 200
GWRSSRTSVS RHRDTENTRS SRSKTGSLQL ICKSEPNTDQ LDYDVGEEHQ
210 220 230 240 250
SPGGISSEEE EEEEEEMLIS EEEIPFKDDP RDETYKPHLE RETPKPRRKS
260 270 280 290 300
GKVKEEKEKK EIKVEVEVEV KEEENEIRED EEPPRKRGRR RKDDKSPRLP
310 320 330 340 350
KRRKKPPIQY VRCEMEGCGT VLAHPRYLQH HIKYQHLLKK KYVCPHPSCG
360 370 380 390 400
RLFRLQKQLL RHAKHHTDQR DYICEYCARA FKSSHNLAVH RMIHTGEKPL
410 420 430 440 450
QCEICGFTCR QKASLNWHMK KHDADSFYQF SCNICGKKFE KKDSVVAHKA
460 470 480 490 500
KSHPEVLIAE ALAANAGALI TSTDILGTNP ESLTQPSDGQ GLPLLPEPLG
510 520 530 540 550
NSTSGECLLL EAEGMSKSYC SGTERVSLMA DGKIFVGSGS SGGTEGLVMN
560 570
SDILGATTEV LIEDSDSAGP
Length:570
Mass (Da):63,445
Last modified:December 1, 2001 - v1
Checksum:i476F4C21DD453522
GO
Isoform 2 (identifier: Q96JP5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     526-529: VSLM → SIHR
     530-570: Missing.

Show »
Length:529
Mass (Da):59,571
Checksum:iD181F0420D5D004F
GO

Sequence cautioni

The sequence AAL09963 differs from that shown. Reason: Frameshift at positions 72 and 80.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti74A → V in AAL09963 (Ref. 6) Curated1
Sequence conflicti206Missing in AAH51743 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03245437V → I1 PublicationCorresponds to variant dbSNP:rs17854702Ensembl.1
Natural variantiVAR_021889207S → G1 PublicationCorresponds to variant dbSNP:rs8373Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012686526 – 529VSLM → SIHR in isoform 2. 1 Publication4
Alternative sequenceiVSP_012687530 – 570Missing in isoform 2. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB056107 mRNA Translation: BAB63373.1
AB057443 mRNA Translation: BAB63374.1
AP001350 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW73811.1
BC051743 mRNA Translation: AAH51743.1
AF310246 mRNA Translation: AAL09963.1 Frameshift.
CCDSiCCDS31553.1 [Q96JP5-1]
RefSeqiNP_001183980.1, NM_001197051.1
NP_444251.1, NM_053023.4 [Q96JP5-1]
UniGeneiHs.524920

Genome annotation databases

EnsembliENST00000316059; ENSP00000339030; ENSG00000186660 [Q96JP5-1]
GeneIDi80829
KEGGihsa:80829
UCSCiuc001nmx.5 human [Q96JP5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB056107 mRNA Translation: BAB63373.1
AB057443 mRNA Translation: BAB63374.1
AP001350 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW73811.1
BC051743 mRNA Translation: AAH51743.1
AF310246 mRNA Translation: AAL09963.1 Frameshift.
CCDSiCCDS31553.1 [Q96JP5-1]
RefSeqiNP_001183980.1, NM_001197051.1
NP_444251.1, NM_053023.4 [Q96JP5-1]
UniGeneiHs.524920

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M9ANMR-A370-456[»]
ProteinModelPortaliQ96JP5
SMRiQ96JP5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123322, 36 interactors
CORUMiQ96JP5
IntActiQ96JP5, 14 interactors
STRINGi9606.ENSP00000339030

PTM databases

iPTMnetiQ96JP5
PhosphoSitePlusiQ96JP5

Polymorphism and mutation databases

BioMutaiZFP91
DMDMi60416377

Proteomic databases

EPDiQ96JP5
MaxQBiQ96JP5
PaxDbiQ96JP5
PeptideAtlasiQ96JP5
PRIDEiQ96JP5
ProteomicsDBi76999
77000 [Q96JP5-2]

Protocols and materials databases

DNASUi80829
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316059; ENSP00000339030; ENSG00000186660 [Q96JP5-1]
GeneIDi80829
KEGGihsa:80829
UCSCiuc001nmx.5 human [Q96JP5-1]

Organism-specific databases

CTDi80829
DisGeNETi80829
EuPathDBiHostDB:ENSG00000186660.14
GeneCardsiZFP91
HGNCiHGNC:14983 ZFP91
HPAiCAB025417
HPA024037
HPA065325
neXtProtiNX_Q96JP5
OpenTargetsiENSG00000186660
PharmGKBiPA37955
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063153
HOGENOMiHOG000155779
HOVERGENiHBG055547
InParanoidiQ96JP5
OMAiCKSEPNA
OrthoDBiEOG091G055J
PhylomeDBiQ96JP5
TreeFamiTF332664

Enzyme and pathway databases

UniPathwayi
UPA00143

SIGNORiQ96JP5

Miscellaneous databases

ChiTaRSiZFP91 human
GeneWikiiZFP91
GenomeRNAii80829
PROiPR:Q96JP5

Gene expression databases

BgeeiENSG00000186660 Expressed in 208 organ(s), highest expression level in quadriceps femoris
CleanExiHS_ZFP91
ExpressionAtlasiQ96JP5 baseline and differential
GenevisibleiQ96JP5 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZFP91_HUMAN
AccessioniPrimary (citable) accession number: Q96JP5
Secondary accession number(s): A6NHC4
, A8MSG7, Q86V47, Q96JP4, Q96QA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: December 1, 2001
Last modified: October 10, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again