UniProtKB - Q96JP5 (ZFP91_HUMAN)

BLAST

>sp|Q96JP5|ZFP91_HUMAN E3 ubiquitin-protein ligase ZFP91 OS=Homo sapiens OX=9606 GN=ZFP91 PE=1 SV=1
MPGETEEPRPPEQQDQEGGEAAKAAPEEPQQRPPEAVAAAPAGTTSSRVLRGGRDRGRAA
AAAAAAAVSRRRKAEYPRRRRSSPSARPPDVPGQQPQAAKSPSPVQGKKSPRLLCIEKVT
TDKDPKEEKEEEDDSALPQEVSIAASRPSRGWRSSRTSVSRHRDTENTRSSRSKTGSLQL
ICKSEPNTDQLDYDVGEEHQSPGGISSEEEEEEEEEMLISEEEIPFKDDPRDETYKPHLE
RETPKPRRKSGKVKEEKEKKEIKVEVEVEVKEEENEIREDEEPPRKRGRRRKDDKSPRLP
KRRKKPPIQYVRCEMEGCGTVLAHPRYLQHHIKYQHLLKKKYVCPHPSCGRLFRLQKQLL
RHAKHHTDQRDYICEYCARAFKSSHNLAVHRMIHTGEKPLQCEICGFTCRQKASLNWHMK
KHDADSFYQFSCNICGKKFEKKDSVVAHKAKSHPEVLIAEALAANAGALITSTDILGTNP
ESLTQPSDGQGLPLLPEPLGNSTSGECLLLEAEGMSKSYCSGTERVSLMADGKIFVGSGS
SGGTEGLVMNSDILGATTEVLIEDSDSAGP

Align

Format
Add to basket Added to basket
History
Entry version 154 (10 Oct 2018)
Sequence version 1 (01 Dec 2001)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

E3 ubiquitin-protein ligase ZFP91

Gene

ZFP91

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.2 Publications

Miscellaneous

In contrast to other E3 ubiquitin-protein ligase, does not contain any domain (RING-type zinc finger or HECT domain) known to mediate E3 ligase activity.

Catalytic activityⁱ

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N₆-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayⁱ: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	311 – 336	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	26
Zinc fingerⁱ	342 – 366	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	372 – 394	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	400 – 422	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	430 – 453	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	24

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
nucleic acid binding Source: InterPro
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
ubiquitin-protein transferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 20682767

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of NF-kappaB-inducing kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 20682767
protein K63-linked ubiquitination
Source: UniProtKB
Inferred from direct assayⁱ
- 20682767

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Transferase
Biological process	Ubl conjugation pathway
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

SIGNORⁱ	Q96JP5
UniPathwayⁱ	UPA00143

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: E3 ubiquitin-protein ligase ZFP91 (EC:2.3.2.27) Alternative name(s): RING-type E3 ubiquitin transferase ZFP91 Zinc finger protein 757 Zinc finger protein 91 homolog Short name: Zfp-91
Gene namesⁱ	Name:ZFP91 Synonyms:ZNF757 ORF Names:FKSG11
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000186660.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14983 ZFP91
neXtProtⁱ	NX_Q96JP5

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	344	C → A: Abolishes ubiquitination of MAP3K14/NIK; when associated with A-349. 1 Publication		1
Mutagenesisⁱ	349	C → A: Abolishes ubiquitination of MAP3K14/NIK; when associated with A-344. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	80829
Open Targets More...OpenTargetsⁱ	ENSG00000186660
PharmGKBⁱ	PA37955

Polymorphism and mutation databases

BioMutaⁱ	ZFP91
DMDMⁱ	60416377

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000047312	2 – 570	E3 ubiquitin-protein ligase ZFP91Add BLAST		569

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	83	PhosphoserineBy similarity		1
Modified residueⁱ	103	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q96JP5
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96JP5
PaxDbⁱ	Q96JP5
PeptideAtlas More...PeptideAtlasⁱ	Q96JP5
PRIDEⁱ	Q96JP5
ProteomicsDBⁱ	76999 77000 [Q96JP5-2]

PTM databases

iPTMnetⁱ	Q96JP5
PhosphoSitePlusⁱ	Q96JP5

Expressionⁱ

Tissue specificityⁱ

Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific.

Gene expression databases

Bgeeⁱ	ENSG00000186660 Expressed in 208 organ(s), highest expression level in quadriceps femoris
CleanExⁱ	HS_ZFP91
ExpressionAtlasⁱ	Q96JP5 baseline and differential
Genevisibleⁱ	Q96JP5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB025417 HPA024037 HPA065325

HPAⁱ

CAB025417
HPA024037
HPA065325

Interactionⁱ

Subunit structureⁱ

Interacts with MAP3K14/NIK.2 Publications

Protein-protein interaction databases

BioGridⁱ	123322, 36 interactors
CORUMⁱ	Q96JP5
IntActⁱ	Q96JP5, 14 interactors
STRINGⁱ	9606.ENSP00000339030

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	381 – 383	Combined sources	3
Helixⁱ	384 – 390	Combined sources	7
Helixⁱ	391 – 393	Combined sources	3
Beta strandⁱ	395 – 397	Combined sources	3
Beta strandⁱ	408 – 411	Combined sources	4
Helixⁱ	412 – 423	Combined sources	12
Beta strandⁱ	426 – 429	Combined sources	4
Turnⁱ	433 – 435	Combined sources	3
Helixⁱ	442 – 452	Combined sources	11

Show more details

3D structure databases

ProteinModelPortalⁱ	Q96JP5
SMRⁱ	Q96JP5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	338 – 368	Interaction with MAP3K14/NIK1 PublicationAdd BLAST		31

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	21 – 67	Ala-richAdd BLAST	47
Compositional biasⁱ	48 – 81	Arg-richAdd BLAST	34
Compositional biasⁱ	197 – 282	Glu-richAdd BLAST	86

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	311 – 336	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	26
Zinc fingerⁱ	342 – 366	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	372 – 394	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	400 – 422	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	430 – 453	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063153
HOGENOMⁱ	HOG000155779
HOVERGENⁱ	HBG055547
InParanoidⁱ	Q96JP5
OMAⁱ	CKSEPNA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G055J
PhylomeDBⁱ	Q96JP5
TreeFamⁱ	TF332664

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 5 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q96JP5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGETEEPRP PEQQDQEGGE AAKAAPEEPQ QRPPEAVAAA PAGTTSSRVL 
        60         70         80         90        100
RGGRDRGRAA AAAAAAAVSR RRKAEYPRRR RSSPSARPPD VPGQQPQAAK 
       110        120        130        140        150
SPSPVQGKKS PRLLCIEKVT TDKDPKEEKE EEDDSALPQE VSIAASRPSR 
       160        170        180        190        200
GWRSSRTSVS RHRDTENTRS SRSKTGSLQL ICKSEPNTDQ LDYDVGEEHQ 
       210        220        230        240        250
SPGGISSEEE EEEEEEMLIS EEEIPFKDDP RDETYKPHLE RETPKPRRKS 
       260        270        280        290        300
GKVKEEKEKK EIKVEVEVEV KEEENEIRED EEPPRKRGRR RKDDKSPRLP 
       310        320        330        340        350
KRRKKPPIQY VRCEMEGCGT VLAHPRYLQH HIKYQHLLKK KYVCPHPSCG 
       360        370        380        390        400
RLFRLQKQLL RHAKHHTDQR DYICEYCARA FKSSHNLAVH RMIHTGEKPL 
       410        420        430        440        450
QCEICGFTCR QKASLNWHMK KHDADSFYQF SCNICGKKFE KKDSVVAHKA 
       460        470        480        490        500
KSHPEVLIAE ALAANAGALI TSTDILGTNP ESLTQPSDGQ GLPLLPEPLG 
       510        520        530        540        550
NSTSGECLLL EAEGMSKSYC SGTERVSLMA DGKIFVGSGS SGGTEGLVMN 
       560        570
SDILGATTEV LIEDSDSAGP

Length:570

Mass (Da):63,445

Last modified:December 1, 2001 - v1

Checksum:ⁱ476F4C21DD453522

Isoform 2 (identifier: Q96JP5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
526-529: VSLM → SIHR
530-570: Missing.

« Hide

        10         20         30         40         50
MPGETEEPRP PEQQDQEGGE AAKAAPEEPQ QRPPEAVAAA PAGTTSSRVL 
        60         70         80         90        100
RGGRDRGRAA AAAAAAAVSR RRKAEYPRRR RSSPSARPPD VPGQQPQAAK 
       110        120        130        140        150
SPSPVQGKKS PRLLCIEKVT TDKDPKEEKE EEDDSALPQE VSIAASRPSR 
       160        170        180        190        200
GWRSSRTSVS RHRDTENTRS SRSKTGSLQL ICKSEPNTDQ LDYDVGEEHQ 
       210        220        230        240        250
SPGGISSEEE EEEEEEMLIS EEEIPFKDDP RDETYKPHLE RETPKPRRKS 
       260        270        280        290        300
GKVKEEKEKK EIKVEVEVEV KEEENEIRED EEPPRKRGRR RKDDKSPRLP 
       310        320        330        340        350
KRRKKPPIQY VRCEMEGCGT VLAHPRYLQH HIKYQHLLKK KYVCPHPSCG 
       360        370        380        390        400
RLFRLQKQLL RHAKHHTDQR DYICEYCARA FKSSHNLAVH RMIHTGEKPL 
       410        420        430        440        450
QCEICGFTCR QKASLNWHMK KHDADSFYQF SCNICGKKFE KKDSVVAHKA 
       460        470        480        490        500
KSHPEVLIAE ALAANAGALI TSTDILGTNP ESLTQPSDGQ GLPLLPEPLG 
       510        520 
NSTSGECLLL EAEGMSKSYC SGTERSIHR

Show »

Length:529

Mass (Da):59,571

Checksum:ⁱD181F0420D5D004F

Sequence cautionⁱ

The sequence AAL09963 differs from that shown. Reason: Frameshift at positions 72 and 80.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	74	A → V in AAL09963 (Ref. 6) Curated		1
Sequence conflictⁱ	206	Missing in AAH51743 (PubMed:15489334).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_032454	37	V → I1 PublicationCorresponds to variant dbSNP:rs17854702Ensembl.		1
Natural variantⁱVAR_021889	207	S → G1 PublicationCorresponds to variant dbSNP:rs8373Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_012686	526 – 529	VSLM → SIHR in isoform 2. 1 Publication		4
Alternative sequenceⁱVSP_012687	530 – 570	Missing in isoform 2. 1 PublicationAdd BLAST		41

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB056107 mRNA Translation: BAB63373.1 AB057443 mRNA Translation: BAB63374.1 AP001350 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW73811.1 BC051743 mRNA Translation: AAH51743.1 AF310246 mRNA Translation: AAL09963.1 Frameshift.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31553.1 [Q96JP5-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001183980.1, NM_001197051.1 NP_444251.1, NM_053023.4 [Q96JP5-1]
UniGeneⁱ	Hs.524920

Genome annotation databases

Ensemblⁱ	ENST00000316059; ENSP00000339030; ENSG00000186660 [Q96JP5-1]
GeneIDⁱ	80829
KEGGⁱ	hsa:80829
UCSC genome browser More...UCSCⁱ	uc001nmx.5 human [Q96JP5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96JP5	HCG2042749, isoform CRA_b		HUMAN		570	UniRef100_Q96JP5
Q96JP5-2	HCG2042749, isoform CRA_d		HUMAN		529	UniRef100_A0A0A6YYC7

Protein	Similar proteins		Species	Score	Length	Source
Q96JP5	HCG2042749, isoform CRA_b		HUMAN		570	UniRef90_Q96JP5
Uncharacterized protein		PIG		619
E3 ubiquitin-protein ligase ZFP91 isoform X1		LEPWE		577
E3 ubiquitin-protein ligase ZFP91 isoform 1		MACMU		576
Zinc finger protein 91-like protein (Fragment)		MACFA		488
+98

Protein	Similar proteins		Species	Score	Length	Source
Q96JP5	HCG2042749, isoform CRA_b		HUMAN		570	UniRef50_Q96JP5
Uncharacterized protein		PIG		619
E3 ubiquitin-protein ligase ZFP91 isoform X1		LEPWE		577
E3 ubiquitin-protein ligase ZFP91 isoform 1		MACMU		576
Zinc finger protein 91-like protein (Fragment)		MACFA		488
+105

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB056107 mRNA Translation: BAB63373.1 AB057443 mRNA Translation: BAB63374.1 AP001350 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW73811.1 BC051743 mRNA Translation: AAH51743.1 AF310246 mRNA Translation: AAL09963.1 Frameshift.
CCDSⁱ	CCDS31553.1 [Q96JP5-1]
RefSeqⁱ	NP_001183980.1, NM_001197051.1 NP_444251.1, NM_053023.4 [Q96JP5-1]
UniGeneⁱ	Hs.524920

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2M9A	NMR	-	A	370-456	[»]
ProteinModelPortalⁱ	Q96JP5
SMRⁱ	Q96JP5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	123322, 36 interactors
CORUMⁱ	Q96JP5
IntActⁱ	Q96JP5, 14 interactors
STRINGⁱ	9606.ENSP00000339030

PTM databases

iPTMnetⁱ	Q96JP5
PhosphoSitePlusⁱ	Q96JP5

Polymorphism and mutation databases

BioMutaⁱ	ZFP91
DMDMⁱ	60416377

Proteomic databases

EPDⁱ	Q96JP5
MaxQBⁱ	Q96JP5
PaxDbⁱ	Q96JP5
PeptideAtlasⁱ	Q96JP5
PRIDEⁱ	Q96JP5
ProteomicsDBⁱ	76999 77000 [Q96JP5-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	80829
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000316059; ENSP00000339030; ENSG00000186660 [Q96JP5-1]
GeneIDⁱ	80829
KEGGⁱ	hsa:80829
UCSCⁱ	uc001nmx.5 human [Q96JP5-1]

Organism-specific databases

CTDⁱ	80829
DisGeNETⁱ	80829
EuPathDBⁱ	HostDB:ENSG00000186660.14
GeneCardsⁱ	ZFP91
HGNCⁱ	HGNC:14983 ZFP91
HPAⁱ	CAB025417 HPA024037 HPA065325
neXtProtⁱ	NX_Q96JP5
OpenTargetsⁱ	ENSG00000186660
PharmGKBⁱ	PA37955
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00530000063153
HOGENOMⁱ	HOG000155779
HOVERGENⁱ	HBG055547
InParanoidⁱ	Q96JP5
OMAⁱ	CKSEPNA
OrthoDBⁱ	EOG091G055J
PhylomeDBⁱ	Q96JP5
TreeFamⁱ	TF332664

Enzyme and pathway databases

UniPathwayⁱ	UPA00143
SIGNORⁱ	Q96JP5

Miscellaneous databases

ChiTaRSⁱ	ZFP91 human
GeneWikiⁱ	ZFP91
GenomeRNAiⁱ	80829
Protein Ontology More...PROⁱ	PR:Q96JP5

Gene expression databases

Bgeeⁱ	ENSG00000186660 Expressed in 208 organ(s), highest expression level in quadriceps femoris
CleanExⁱ	HS_ZFP91
ExpressionAtlasⁱ	Q96JP5 baseline and differential
Genevisibleⁱ	Q96JP5 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 5 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZFP91_HUMAN
Accessionⁱ	Q96JP5Primary (citable) accession number: Q96JP5 Secondary accession number(s): A6NHC4 , A8MSG7, Q86V47, Q96JP4, Q96QA3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
	Last sequence update:	December 1, 2001
	Last modified:	October 10, 2018
	This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
PATHWAY comments
Index of metabolic and biosynthesis pathways
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96JP5 (ZFP91_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

E3 ubiquitin-protein ligase ZFP91

ZFP91

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

Pathwayⁱ: protein ubiquitination

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ