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UniProtKB - Q96JP5 (ZFP91_HUMAN)

Entry version 175 (23 Feb 2022)
Sequence version 1 (01 Dec 2001)
Previous versions | rss
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Protein

E3 ubiquitin-protein ligase ZFP91

Gene

ZFP91

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.

2 Publications

Miscellaneous

In contrast to other E3 ubiquitin-protein ligase, does not contain any domain (RING-type zinc finger or HECT domain) known to mediate E3 ligase activity.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri311 – 336C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri342 – 366C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri372 – 394C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri430 – 453C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96JP5

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q96JP5

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q96JP5

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase ZFP91 (EC:2.3.2.27)
Alternative name(s):
RING-type E3 ubiquitin transferase ZFP91
Zinc finger protein 757
Zinc finger protein 91 homolog
Short name:
Zfp-91
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZFP91
Synonyms:ZNF757
ORF Names:FKSG11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:14983, ZFP91

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		619289, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96JP5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000186660

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi344C → A: Abolishes ubiquitination of MAP3K14/NIK; when associated with A-349. 1 Publication1
Mutagenesisi349C → A: Abolishes ubiquitination of MAP3K14/NIK; when associated with A-344. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		80829

Open Targets

More...OpenTargetsi		ENSG00000186660

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37955

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96JP5, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZFP91

Domain mapping of disease mutations (DMDM)

More...DMDMi		60416377

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000473122 – 570E3 ubiquitin-protein ligase ZFP91Add BLAST569

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei83PhosphoserineBy similarity1
Modified residuei103PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96JP5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96JP5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96JP5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96JP5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96JP5

PeptideAtlas

More...PeptideAtlasi		Q96JP5

PRoteomics IDEntifications database

More...PRIDEi		Q96JP5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		76999 [Q96JP5-1]
77000 [Q96JP5-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q96JP5, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96JP5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96JP5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000186660, Expressed in quadriceps femoris and 223 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96JP5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96JP5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000186660, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MAP3K14/NIK.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123322, 102 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q96JP5

Protein interaction database and analysis system

More...IntActi		Q96JP5, 28 interactors

Molecular INTeraction database

More...MINTi		Q96JP5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000339030

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96JP5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1570
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96JP5

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 306DisorderedSequence analysisAdd BLAST306
Regioni338 – 368Interaction with MAP3K14/NIK1 PublicationAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 16Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi115 – 132Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi171 – 186Polar residuesSequence analysisAdd BLAST16
Compositional biasi207 – 222Acidic residuesSequence analysisAdd BLAST16
Compositional biasi223 – 271Basic and acidic residuesSequence analysisAdd BLAST49
Compositional biasi290 – 306Basic residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri311 – 336C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri342 – 366C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri372 – 394C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri430 – 453C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156393

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_034557_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96JP5

Identification of Orthologs from Complete Genome Data

More...OMAi		YCSGAER

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96JP5

TreeFam database of animal gene trees

More...TreeFami		TF332664

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00096, zf-C2H2, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355, ZnF_C2H2, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667, SSF57667, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 5 hits
PS50157, ZINC_FINGER_C2H2_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96JP5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPGETEEPRP PEQQDQEGGE AAKAAPEEPQ QRPPEAVAAA PAGTTSSRVL 
        60         70         80         90        100
RGGRDRGRAA AAAAAAAVSR RRKAEYPRRR RSSPSARPPD VPGQQPQAAK 
       110        120        130        140        150
SPSPVQGKKS PRLLCIEKVT TDKDPKEEKE EEDDSALPQE VSIAASRPSR 
       160        170        180        190        200
GWRSSRTSVS RHRDTENTRS SRSKTGSLQL ICKSEPNTDQ LDYDVGEEHQ 
       210        220        230        240        250
SPGGISSEEE EEEEEEMLIS EEEIPFKDDP RDETYKPHLE RETPKPRRKS 
       260        270        280        290        300
GKVKEEKEKK EIKVEVEVEV KEEENEIRED EEPPRKRGRR RKDDKSPRLP 
       310        320        330        340        350
KRRKKPPIQY VRCEMEGCGT VLAHPRYLQH HIKYQHLLKK KYVCPHPSCG 
       360        370        380        390        400
RLFRLQKQLL RHAKHHTDQR DYICEYCARA FKSSHNLAVH RMIHTGEKPL 
       410        420        430        440        450
QCEICGFTCR QKASLNWHMK KHDADSFYQF SCNICGKKFE KKDSVVAHKA 
       460        470        480        490        500
KSHPEVLIAE ALAANAGALI TSTDILGTNP ESLTQPSDGQ GLPLLPEPLG 
       510        520        530        540        550
NSTSGECLLL EAEGMSKSYC SGTERVSLMA DGKIFVGSGS SGGTEGLVMN 
       560        570
SDILGATTEV LIEDSDSAGP
Length:570
Mass (Da):63,445
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i476F4C21DD453522
GO
Isoform 2 (identifier: Q96JP5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     526-529: VSLM → SIHR
     530-570: Missing.

Show »
Length:529
Mass (Da):59,571
Checksum:iD181F0420D5D004F
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL09963 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti74A → V in AAL09963 (Ref. 6) Curated1
Sequence conflicti206Missing in AAH51743 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03245437V → I1 PublicationCorresponds to variant dbSNP:rs17854702Ensembl.1
Natural variantiVAR_021889207S → G1 PublicationCorresponds to variant dbSNP:rs8373Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_012686526 – 529VSLM → SIHR in isoform 2. 1 Publication4
Alternative sequenceiVSP_012687530 – 570Missing in isoform 2. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB056107 mRNA Translation: BAB63373.1
AB057443 mRNA Translation: BAB63374.1
AP001350 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW73811.1
BC051743 mRNA Translation: AAH51743.1
AF310246 mRNA Translation: AAL09963.1 Frameshift.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31553.1 [Q96JP5-1]

NCBI Reference Sequences

More...RefSeqi		NP_001183980.1, NM_001197051.1
NP_444251.1, NM_053023.4 [Q96JP5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000316059; ENSP00000339030; ENSG00000186660

Database of genes from NCBI RefSeq genomes

More...GeneIDi		80829

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:80829

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000316059.7; ENSP00000339030.5; NM_053023.5; NP_444251.1

UCSC genome browser

More...UCSCi		uc001nmx.5, human [Q96JP5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB056107 mRNA Translation: BAB63373.1
AB057443 mRNA Translation: BAB63374.1
AP001350 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW73811.1
BC051743 mRNA Translation: AAH51743.1
AF310246 mRNA Translation: AAL09963.1 Frameshift.
CCDSiCCDS31553.1 [Q96JP5-1]
RefSeqiNP_001183980.1, NM_001197051.1
NP_444251.1, NM_053023.4 [Q96JP5-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M9ANMR-A370-456[»]
SMRiQ96JP5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi123322, 102 interactors
CORUMiQ96JP5
IntActiQ96JP5, 28 interactors
MINTiQ96JP5
STRINGi9606.ENSP00000339030

PTM databases

GlyGeniQ96JP5, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ96JP5
PhosphoSitePlusiQ96JP5

Genetic variation databases

BioMutaiZFP91
DMDMi60416377

Proteomic databases

EPDiQ96JP5
jPOSTiQ96JP5
MassIVEiQ96JP5
MaxQBiQ96JP5
PaxDbiQ96JP5
PeptideAtlasiQ96JP5
PRIDEiQ96JP5
ProteomicsDBi76999 [Q96JP5-1]
77000 [Q96JP5-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		14324, 198 antibodies from 24 providers

The DNASU plasmid repository

More...DNASUi		80829

Genome annotation databases

EnsembliENST00000316059; ENSP00000339030; ENSG00000186660
GeneIDi80829
KEGGihsa:80829
MANE-SelectiENST00000316059.7; ENSP00000339030.5; NM_053023.5; NP_444251.1
UCSCiuc001nmx.5, human [Q96JP5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		80829
DisGeNETi80829

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZFP91
HGNCiHGNC:14983, ZFP91
HPAiENSG00000186660, Low tissue specificity
MIMi619289, gene
neXtProtiNX_Q96JP5
OpenTargetsiENSG00000186660
PharmGKBiPA37955
VEuPathDBiHostDB:ENSG00000186660

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000156393
HOGENOMiCLU_034557_0_0_1
InParanoidiQ96JP5
OMAiYCSGAER
PhylomeDBiQ96JP5
TreeFamiTF332664

Enzyme and pathway databases

UniPathwayiUPA00143
PathwayCommonsiQ96JP5
SignaLinkiQ96JP5
SIGNORiQ96JP5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		80829, 23 hits in 1068 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZFP91, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ZFP91

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		80829
PharosiQ96JP5, Tbio

Protein Ontology

More...PROi		PR:Q96JP5
RNActiQ96JP5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000186660, Expressed in quadriceps femoris and 223 other tissues
ExpressionAtlasiQ96JP5, baseline and differential
GenevisibleiQ96JP5, HS

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 5 hits
SUPFAMiSSF57667, SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 5 hits
PS50157, ZINC_FINGER_C2H2_2, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZFP91_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96JP5
Secondary accession number(s): A6NHC4
, A8MSG7, Q86V47, Q96JP4, Q96QA3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: December 1, 2001
Last modified: February 23, 2022
This is version 175 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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