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Entry version 128 (08 May 2019)
Sequence version 3 (28 Mar 2018)
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Protein

Unconventional myosin-XVB

Gene

MYO15B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Unknown, due to the absence of a functional motor domain.

Caution

Was thought be the product of a pseudogene due to the substitution or deletion of many conserved amino acids in the motor domain. However it has been observed with several high-quality proteotypic peptides in several independent proteomic studies.Curated
Represents an unconventional myosin. This protein should not be confused with the conventional myosin-15 (MYH15).Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Unconventional myosin-XVB
Alternative name(s):
Myosin XVBP
Unconventional myosin-15B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYO15B
Synonyms:KIAA1783, MYO15BP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14083 MYO15B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96JP2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000266714

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MYO15B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
150384690

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002920471 – 1530Unconventional myosin-XVBAdd BLAST1530

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96JP2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96JP2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96JP2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96JP2

PeptideAtlas

More...
PeptideAtlasi
Q96JP2

PRoteomics IDEntifications database

More...
PRIDEi
Q96JP2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
76998

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain, stomach and kidney.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000266714 Expressed in 180 organ(s), highest expression level in myometrium

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96JP2 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q96JP2, 3 interactors

Molecular INTeraction database

More...
MINTi
Q96JP2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11530
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96JP2

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q96JP2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 335Myosin motorPROSITE-ProRule annotationAdd BLAST335
Domaini355 – 384IQPROSITE-ProRule annotationAdd BLAST30
Domaini492 – 643MyTH4PROSITE-ProRule annotationAdd BLAST152
Domaini1422 – 1483SH3PROSITE-ProRule annotationAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi722 – 763Pro-richAdd BLAST42
Compositional biasi820 – 865Met/Pro-richAdd BLAST46
Compositional biasi871 – 910Gln-richAdd BLAST40
Compositional biasi999 – 1019Glu-richAdd BLAST21
Compositional biasi1024 – 1204Pro-richAdd BLAST181

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4229 Eukaryota
COG5022 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00930000151032

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000169369

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96JP2

KEGG Orthology (KO)

More...
KOi
K10361

Database of Orthologous Groups

More...
OrthoDBi
14609at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96JP2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12068 SH3_MYO15B, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.530, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR035489 MYO15B_SH3
IPR001609 Myosin_head_motor_dom
IPR000857 MyTH4_dom
IPR038185 MyTH4_dom_sf
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00063 Myosin_head, 1 hit
PF00784 MyTH4, 1 hit
PF07653 SH3_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00242 MYSc, 1 hit
SM00139 MyTH4, 1 hit
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044 SSF50044, 1 hit
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51016 MYTH4, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 16 potential isoforms that are computationally mapped.Show allAlign All

Q96JP2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKEASGVGGG HSPMCPPHCH MPPGPAGEWP GATVQQPRQR APTALLQPDA
60 70 80 90 100
AGPGGGGVSA GVAVLGACPS ASEGVLPRPP GRSAPQPPEY PGRPDMAVPG
110 120 130 140 150
WSAMVRSRLT ATSTSQATDH TFLQKSHYHH GDHPSYAKPR LPLPVFTVRH
160 170 180 190 200
YAGTVTYQVH KFLNRNRDQL DPAVVEMLGQ SQLQLVGSLF QEAEPQSRGG
210 220 230 240 250
RGRPTLASRF QQALEDLIAR LGRSHVYFIQ CLTPNPGKLP GLFDVGHVTE
260 270 280 290 300
QLHQAAILEA VGTRSANFPV RVPFEAFLAS FQALGSEGQE DLSDREKCGA
310 320 330 340 350
VLSQVLGAES PLYHLGATKV LLQEQGWQRL EELRDQQRSQ ALVDLHRSFH
360 370 380 390 400
TCISRQRVLP RMQARMRGFQ ARKRYLRRRA ALGQLNTILL VAQPLLQRRQ
410 420 430 440 450
RLQLGRWQGW HSSERALERV PSMELGRLEI PAELAVMLKT AESHRDALAG
460 470 480 490 500
SITECLPPEV PARPSLTLPA DIDLFPFSSF VAIGFQEPSL PRPGQPLAKP
510 520 530 540 550
LTQLDGDNPQ RALDINKVML RLLGDGSLES WQRQIMGAYL VRQGQCRPGL
560 570 580 590 600
RNELFSQLVA QLWQNPDEQQ SQRGWALMAV LLSAFPPLPV LQKPLLKFVS
610 620 630 640 650
DQAPRGMAAL CQHKLLGALE QSQLASGATR AHPPTQLEWL AGWRRGRMAL
660 670 680 690 700
DVFTFSEECY SAEVESWTTG EQLAGWILQS RGLEAPPRGW SVSLHSRDAW
710 720 730 740 750
QDLAGCDFVL DLISQTEDLG DPARPRSYPI TPLGSAEAIP LAPGIQAPSL
760 770 780 790 800
PPGPPPGPAP TLPSRDHTGE VQRSGSLDGF LDQIFQPVIS SGLSDLEQSW
810 820 830 840 850
ALSSRMKGGG AIGPTQQGYP MVYPGMIQMP AYQPGMVPAP MPMMPAMGTV
860 870 880 890 900
PAMPAMVVPP QPPLPSLDAG QLAVQQQNFI QQQALILAQQ MTAQAMSLSL
910 920 930 940 950
EQQMQQRQQQ ARASEAASQA SPSAVTSKPR KPPTPPEKPQ RDLGSEGGCL
960 970 980 990 1000
RETSEEAEDR PYQPKSFQQK RNYFQRMGQP QITVRTMKPP AKVHIPQGEA
1010 1020 1030 1040 1050
QEEEEEEEEE EEQEEQEVET RAVPSPPPPP IVKKPLKQGG AKAPKEAEAE
1060 1070 1080 1090 1100
PAKETAAKGH GQGPAQGRGT VVRSSDSKPK RPQPSREIGN IIRMYQSRPG
1110 1120 1130 1140 1150
PVPVPVQPSR PPKAFLRKID PKDEALAKLG INGAHSSPPM LSPSPGKGPP
1160 1170 1180 1190 1200
PAVAPRPKAP LQLGPSSSIK EKQGPLLDLF GQKLPIAHTP PPPPAPPLPL
1210 1220 1230 1240 1250
PEDPGTLSAE RRCLTQPVED QGVSTQLLAP SGSVCFSYTG TPWKLFLRKE
1260 1270 1280 1290 1300
VFYPRENFSH PYYLRLLCEQ ILRDTFSESC IRISQNERRK MKDLLGGLEV
1310 1320 1330 1340 1350
DLDSLTTTED SVKKRIVVAA RDNWANYFSR FFPVSGESGS DVQLLAVSHR
1360 1370 1380 1390 1400
GLRLLKVTQG PGLRPDQLKI LCSYSFAEVL GVECRGGSTL ELSLKSEQLV
1410 1420 1430 1440 1450
LHTARARAIE ALVELFLNEL KKDSGYVIAL RSYITDNCSL LSFHRGDLIK
1460 1470 1480 1490 1500
LLPVATLEPG WQFGSAGGRS GLFPADIVQP AAAPDFSFSK EQRSGWHKGQ
1510 1520 1530
LSNGEPGLAR WDRASEVRKM GEGQAEARPA
Length:1,530
Mass (Da):167,088
Last modified:March 28, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5CFC724850DDA4A1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YW50A0A0J9YW50_HUMAN
Unconventional myosin-XVB
MYO15B
1,543Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YFM0A0A2R8YFM0_HUMAN
Unconventional myosin-XVB
MYO15B
3,112Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YY01A0A0J9YY01_HUMAN
Unconventional myosin-XVB
MYO15B
3,064Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YX07A0A0J9YX07_HUMAN
Unconventional myosin-XVB
MYO15B
256Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YWC2A0A0J9YWC2_HUMAN
Unconventional myosin-XVB
MYO15B
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YF23A0A286YF23_HUMAN
Unconventional myosin-XVB
MYO15B
1,600Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YXD6A0A0J9YXD6_HUMAN
Unconventional myosin-XVB
MYO15B
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YXA6A0A0J9YXA6_HUMAN
Unconventional myosin-XVB
MYO15B
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YYJ7A0A0J9YYJ7_HUMAN
Unconventional myosin-XVB
MYO15B
760Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YX32A0A0J9YX32_HUMAN
Unconventional myosin-XVB
MYO15B
192Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB47412 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_080141547R → W. Corresponds to variant dbSNP:rs3803728Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF418286 mRNA No translation available.
AF418287 mRNA No translation available.
AF418288 mRNA No translation available.
AF418289 mRNA No translation available.
AF418290 mRNA No translation available.
AF418291 mRNA No translation available.
AF418292 mRNA No translation available.
AF418293 mRNA No translation available.
AB058686 mRNA Translation: BAB47412.1 Different initiation.
AC087749 Genomic DNA No translation available.
KF511237 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001296171.1, NM_001309242.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000633867; ENSP00000487744; ENSG00000266714

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
80022

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:80022

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF418286 mRNA No translation available.
AF418287 mRNA No translation available.
AF418288 mRNA No translation available.
AF418289 mRNA No translation available.
AF418290 mRNA No translation available.
AF418291 mRNA No translation available.
AF418292 mRNA No translation available.
AF418293 mRNA No translation available.
AB058686 mRNA Translation: BAB47412.1 Different initiation.
AC087749 Genomic DNA No translation available.
KF511237 Genomic DNA No translation available.
RefSeqiNP_001296171.1, NM_001309242.1

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DLPNMR-A1424-1495[»]
SMRiQ96JP2
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ96JP2, 3 interactors
MINTiQ96JP2

Polymorphism and mutation databases

BioMutaiMYO15B
DMDMi150384690

Proteomic databases

EPDiQ96JP2
jPOSTiQ96JP2
MaxQBiQ96JP2
PaxDbiQ96JP2
PeptideAtlasiQ96JP2
PRIDEiQ96JP2
ProteomicsDBi76998

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000633867; ENSP00000487744; ENSG00000266714
GeneIDi80022
KEGGihsa:80022

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
80022

GeneCards: human genes, protein and diseases

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GeneCardsi
MYO15B
HGNCiHGNC:14083 MYO15B
neXtProtiNX_Q96JP2
OpenTargetsiENSG00000266714

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4229 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00930000151032
HOGENOMiHOG000169369
InParanoidiQ96JP2
KOiK10361
OrthoDBi14609at2759
PhylomeDBiQ96JP2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MYO15B human
EvolutionaryTraceiQ96JP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
80022

Gene expression databases

BgeeiENSG00000266714 Expressed in 180 organ(s), highest expression level in myometrium
ExpressionAtlasiQ96JP2 baseline and differential

Family and domain databases

CDDicd12068 SH3_MYO15B, 1 hit
Gene3Di1.25.40.530, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR035489 MYO15B_SH3
IPR001609 Myosin_head_motor_dom
IPR000857 MyTH4_dom
IPR038185 MyTH4_dom_sf
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF00784 MyTH4, 1 hit
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SM00139 MyTH4, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51016 MYTH4, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMY15B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96JP2
Secondary accession number(s): A0A0J9YVZ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 28, 2018
Last modified: May 8, 2019
This is version 128 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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