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Entry version 136 (11 Dec 2019)
Sequence version 2 (21 Aug 2007)
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Protein

Neuralized-like protein 4

Gene

NEURL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neuralized-like protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NEURL4
Synonyms:KIAA1787
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000215041.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:34410 NEURL4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615865 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96JN8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000215041

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164723835

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96JN8 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NEURL4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
156630938

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002991051 – 1562Neuralized-like protein 4Add BLAST1562

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei502PhosphoserineCombined sources1
Modified residuei907PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated; undergoes HERC2-dependent 'Lys-48' ubiquitination. This ubiquitination leads to proteasomal degradation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96JN8

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96JN8

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96JN8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96JN8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96JN8

PeptideAtlas

More...
PeptideAtlasi
Q96JN8

PRoteomics IDEntifications database

More...
PRIDEi
Q96JN8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76995 [Q96JN8-1]
76996 [Q96JN8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96JN8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96JN8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed at high levels (including brain).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000215041 Expressed in 164 organ(s), highest expression level in adult mammalian kidney

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96JN8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96JN8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043678
HPA055314

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CCP110; this interaction propmotes CCP110 ubiquitination and degradation via the proteasome pathway. Via its interaction with CCP110, may indirectly interact with CEP97.

Interacts with the E3 ubiquitin-protein ligase HERC2 and UBE3A. May interact with MAPK6 and hence mediate MAPK6 interaction with UBE3A. Interaction with UBE3A may be indirect and mediated by HERC2.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
O433039EBI-1053406,EBI-1566217

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124095, 84 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q96JN8

Protein interaction database and analysis system

More...
IntActi
Q96JN8, 166 interactors

Molecular INTeraction database

More...
MINTi
Q96JN8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000382390

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96JN8 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11562
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96JN8

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q96JN8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 207NHR 1PROSITE-ProRule annotationAdd BLAST167
Domaini317 – 484NHR 2PROSITE-ProRule annotationAdd BLAST168
Domaini520 – 686NHR 3PROSITE-ProRule annotationAdd BLAST167
Domaini716 – 884NHR 4PROSITE-ProRule annotationAdd BLAST169
Domaini913 – 1086NHR 5PROSITE-ProRule annotationAdd BLAST174
Domaini1131 – 1294NHR 6PROSITE-ProRule annotationAdd BLAST164

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The third NHR domain (NHR 3) is required for localization to both mother and daughter centrioles. NHR 1 restricts targeting to daughter centriole (PubMed:22441691). NHR 3 and 4 are required for CCP110/CEP97-binding, but not for HERC2-binding. NHR 5 and 6 are important for HERC2-binding and centrosomal localization (PubMed:22261722).2 Publications

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IMDW Eukaryota
ENOG410XT3C LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159866

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000007538

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96JN8

KEGG Orthology (KO)

More...
KOi
K16777

Identification of Orthologs from Complete Genome Data

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OMAi
SNTEIEW

Database of Orthologous Groups

More...
OrthoDBi
74097at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96JN8

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR037962 Neuralized
IPR006573 NHR_dom

The PANTHER Classification System

More...
PANTHERi
PTHR12429 PTHR12429, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07177 Neuralized, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00588 NEUZ, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51065 NHR, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96JN8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAGSGGSGG SGGGPGPGPG GGGGPSGSGS GPGSNGGLGS GGELHPRTGR
60 70 80 90 100
LVSLSACGRT ARRQQPGQEF NHGLVLSREP LRDGRVFTVR IDRKVNSWSG
110 120 130 140 150
SIEIGVTALD PSVLDFPSSA TGLKGGSWVV SGCSVLRDGR SVLEEYGQDL
160 170 180 190 200
DQLGEGDRVG VERTVAGELR LWVNGRDCGV AATGLPPRVW AVVDLYGKCT
210 220 230 240 250
QITVLPPEPG FSPPTPIPTP PLEPLAPTED SALAEQGTSA DEAFMVSPAQ
260 270 280 290 300
ARPETFPNSL ESHNDFANME LSEVVSNTIL SAYNGGLLNV NLSSPPAGEG
310 320 330 340 350
LGSSGAATSP ILTSNDALLF HEKCGTLIKL SNNNKTAERR RPLDEFNNGV
360 370 380 390 400
VMTNRPLRDN EMFEIRIDKL VDKWSGSIEI GVTTHNPNSL EYPATMTNLQ
410 420 430 440 450
SGTIMMSGCG ILTNGKGTRR EYCEFSLDEL QEGDHIGLTR KSNSALHFFI
460 470 480 490 500
NGIDQGVATP LTPPVVYGVV DLYGMAVKVT IVHNNNHSDR LRRNNAILRA
510 520 530 540 550
LSPEGALRRA APAAQAEPER LLFHPNCGQK AAITHEGRTA LRPHATDDFN
560 570 580 590 600
HGVVLSSRAL RDGEVFQVRI DKMVDKWAGS IEIGVTTHNP AYLQLPSTMT
610 620 630 640 650
NLRSGTWMMT GNGVMHNGTT ILDEYGHNLD RLKAGDTVGV VRREDGTLHF
660 670 680 690 700
FVNGMTQGPA AWNVPPGVYA VVDLYGQAAQ ATIVDDVEVA PVPEPLPEGN
710 720 730 740 750
NQVSPSSPSS GAGGSDLRFH QLHGSNAVIT NGGRTALRHN CRSEFNDAIV
760 770 780 790 800
ISNRALRDGE LFEIVIQKMV DRWSGSIEAG VTAIRPEDLE FPNTMTDIDY
810 820 830 840 850
DTWMLSGTAI MQDGNTMRNN YGCDLDALGT GARIGMMRTA KGDLHYFING
860 870 880 890 900
QDQGAACSGL PPGKEVYAVV DLYGQCVQVS ITNATGPMDN SLATSNTATE
910 920 930 940 950
KSFPLHSPVA GVAHRFHSTC GKNVTLEEDG TRAVRAAGYA HGLVFSTKEL
960 970 980 990 1000
RAEEVFEVKV EELDEKWAGS LRLGLTTLAP GEMGPGAGGG GPGLPPSLPE
1010 1020 1030 1040 1050
LRTKTTWMVS SCEVRRDGQL QRMNYGRNLE RLGVGSRVGV RRGADDTMHI
1060 1070 1080 1090 1100
LVDGEDMGPA ATGIAKNVWA VLDLYGPVRG VSIVSSTRLE ESEGTQPPSP
1110 1120 1130 1140 1150
SSDTGSEGEE DDEGEEHGLG GQNEVGIIPT TLEFLENHGK NILLSNGNRT
1160 1170 1180 1190 1200
ATRVASYNQG IVVINQPLVP QLLVQVRIDF LNRQWTSSLV LGVITCAPER
1210 1220 1230 1240 1250
LNFPASACAL KRAAWLLRGR GVFHNGLKIC EKFGPNLDTC PEGTILGLRL
1260 1270 1280 1290 1300
DSSGGLHLHV NGVDQGVAVP DVPQPCHALV DLYGQCEQVT IVNPEPGAAS
1310 1320 1330 1340 1350
GKSAGTQGDM EKADMVDGIK ESVCWGPPPA ASPLKSCEYH ALCSRFQELL
1360 1370 1380 1390 1400
LLPEDYFMPP PKRSLCYCES CRKLRGDEAH RRRGEPPREY ALPFGWCRFN
1410 1420 1430 1440 1450
LRVNPRLEAG TLTKKWHMAY HGSNVAAVRR VLDRGELGAG TASILSCRPL
1460 1470 1480 1490 1500
KGEPGVGFEE PGENCAPPRE EQPPPVLLSP SLQYAGAETL ASKVQFRDPK
1510 1520 1530 1540 1550
SQRTHQAQVA FQVCVRPGSY TPGPPSAALG EPPDPHFSPA ELEWVTKEKG
1560
ATLLCALLVR VE
Length:1,562
Mass (Da):166,907
Last modified:August 21, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCB25753A5D127246
GO
Isoform 2 (identifier: Q96JN8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     863-864: Missing.

Show »
Length:1,560
Mass (Da):166,722
Checksum:i7DE44AED5D555460
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L2W2I3L2W2_HUMAN
Neuralized-like protein 4
NEURL4
1,538Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2Z9I3L2Z9_HUMAN
Neuralized-like protein 4
NEURL4
1,017Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L100I3L100_HUMAN
Neuralized-like protein 4
NEURL4
1,430Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPS7K7EPS7_HUMAN
Neuralized-like protein 4
NEURL4
249Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH07227 differs from that shown. Reason: Frameshift.Curated
The sequence BAB47416 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti228T → S in CAB66804 (PubMed:11230166).Curated1
Sequence conflicti359D → G in CAB66804 (PubMed:11230166).Curated1
Sequence conflicti637T → A in CAB66804 (PubMed:11230166).Curated1
Sequence conflicti1262G → A in AAH07227 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0495271019Q → H1 PublicationCorresponds to variant dbSNP:rs3809813Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_027563863 – 864Missing in isoform 2. 2 Publications2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB058690 mRNA Translation: BAB47416.1 Different initiation.
AL136870 mRNA Translation: CAB66804.1
BC007227 mRNA Translation: AAH07227.1 Frameshift.
BC073134 mRNA Translation: AAH73134.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS42251.1 [Q96JN8-1]
CCDS42252.1 [Q96JN8-2]

NCBI Reference Sequences

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RefSeqi
NP_001005408.1, NM_001005408.1 [Q96JN8-2]
NP_115818.2, NM_032442.2 [Q96JN8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000315614; ENSP00000319826; ENSG00000215041 [Q96JN8-2]
ENST00000399464; ENSP00000382390; ENSG00000215041 [Q96JN8-1]
ENST00000671847; ENSP00000500916; ENSG00000288301 [Q96JN8-1]
ENST00000673081; ENSP00000500667; ENSG00000288301 [Q96JN8-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84461

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84461

UCSC genome browser

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UCSCi
uc002gga.2 human [Q96JN8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058690 mRNA Translation: BAB47416.1 Different initiation.
AL136870 mRNA Translation: CAB66804.1
BC007227 mRNA Translation: AAH07227.1 Frameshift.
BC073134 mRNA Translation: AAH73134.1
CCDSiCCDS42251.1 [Q96JN8-1]
CCDS42252.1 [Q96JN8-2]
RefSeqiNP_001005408.1, NM_001005408.1 [Q96JN8-2]
NP_115818.2, NM_032442.2 [Q96JN8-1]

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E63NMR-A43-205[»]
SMRiQ96JN8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi124095, 84 interactors
CORUMiQ96JN8
IntActiQ96JN8, 166 interactors
MINTiQ96JN8
STRINGi9606.ENSP00000382390

PTM databases

iPTMnetiQ96JN8
PhosphoSitePlusiQ96JN8

Polymorphism and mutation databases

BioMutaiNEURL4
DMDMi156630938

Proteomic databases

EPDiQ96JN8
jPOSTiQ96JN8
MassIVEiQ96JN8
MaxQBiQ96JN8
PaxDbiQ96JN8
PeptideAtlasiQ96JN8
PRIDEiQ96JN8
ProteomicsDBi76995 [Q96JN8-1]
76996 [Q96JN8-2]

Genome annotation databases

EnsembliENST00000315614; ENSP00000319826; ENSG00000215041 [Q96JN8-2]
ENST00000399464; ENSP00000382390; ENSG00000215041 [Q96JN8-1]
ENST00000671847; ENSP00000500916; ENSG00000288301 [Q96JN8-1]
ENST00000673081; ENSP00000500667; ENSG00000288301 [Q96JN8-2]
GeneIDi84461
KEGGihsa:84461
UCSCiuc002gga.2 human [Q96JN8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84461
EuPathDBiHostDB:ENSG00000215041.9

GeneCards: human genes, protein and diseases

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GeneCardsi
NEURL4
HGNCiHGNC:34410 NEURL4
HPAiHPA043678
HPA055314
MIMi615865 gene
neXtProtiNX_Q96JN8
OpenTargetsiENSG00000215041
PharmGKBiPA164723835

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IMDW Eukaryota
ENOG410XT3C LUCA
GeneTreeiENSGT00940000159866
HOGENOMiHOG000007538
InParanoidiQ96JN8
KOiK16777
OMAiSNTEIEW
OrthoDBi74097at2759
PhylomeDBiQ96JN8

Miscellaneous databases

EvolutionaryTraceiQ96JN8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84461
PharosiQ96JN8 Tdark

Protein Ontology

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PROi
PR:Q96JN8
RNActiQ96JN8 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000215041 Expressed in 164 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiQ96JN8 baseline and differential
GenevisibleiQ96JN8 HS

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR037962 Neuralized
IPR006573 NHR_dom
PANTHERiPTHR12429 PTHR12429, 1 hit
PfamiView protein in Pfam
PF07177 Neuralized, 6 hits
SMARTiView protein in SMART
SM00588 NEUZ, 6 hits
SUPFAMiSSF49899 SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS51065 NHR, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNEUL4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96JN8
Secondary accession number(s): Q6GPI8, Q96IU9, Q9H0B0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: December 11, 2019
This is version 136 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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