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Entry version 136 (08 May 2019)
Sequence version 2 (30 May 2006)
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Protein

Ligand-dependent corepressor

Gene

LCOR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi368 – 388H-T-H motifPROSITE-ProRule annotationAdd BLAST21

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ligand-dependent corepressor
Short name:
LCoR
Alternative name(s):
Mblk1-related protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LCORImported
Synonyms:C10orf12Imported, KIAA1795Imported, MLR2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29503 LCOR

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607698 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96JN0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi56 – 57LL → AA: Loss of estradiol-dependent interaction with ESR1 and ESR2. 1 Publication2

Organism-specific databases

DisGeNET

More...
DisGeNETi
84458

Open Targets

More...
OpenTargetsi
ENSG00000196233

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134866687
PA145148487

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
LCOR

Domain mapping of disease mutations (DMDM)

More...
DMDMi
68565212

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002368071 – 433Ligand-dependent corepressorAdd BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei42PhosphoserineCombined sources1
Modified residuei63PhosphoserineCombined sources1
Modified residuei249PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki254Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki414Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 3 (identifier: Q96JN0-3)
Cross-linki345Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sourcesCurated
Cross-linki391Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sourcesCurated
Cross-linki543Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sourcesCurated
Modified residuei583PhosphoserineCombined sourcesCurated1
Modified residuei605PhosphoserineCombined sourcesCurated1
Modified residuei792PhosphoserineCombined sourcesCurated1
Cross-linki976Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sourcesCurated
Modified residuei1048PhosphoserineCombined sourcesCurated1
Modified residuei1077PhosphoserineCombined sourcesCurated1
Modified residuei1214N6,N6-dimethyllysineCombined sourcesCurated1
Modified residuei1219N6,N6-dimethyllysineCombined sourcesCurated1
Modified residuei1274PhosphoserineCombined sourcesCurated1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96JN0

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96JN0

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96JN0

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96JN0

PeptideAtlas

More...
PeptideAtlasi
Q96JN0

PRoteomics IDEntifications database

More...
PRIDEi
Q96JN0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
72131
76989
76990 [Q96JN0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q96JN0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96JN0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000196233 Expressed in 214 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96JN0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96JN0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA031428
HPA031429
HPA038954
HPA057621
HPA077000

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ESR1 and ESR2 in the presence of estradiol. Interacts with CTBP1, HDAC3 and HDAC6. Component of a large corepressor complex that contains about 20 proteins, including CTBP1, CTBP2, HDAC1 and HDAC2.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
117579, 35 interactors
124093, 64 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q96JN0

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q96JN0

Protein interaction database and analysis system

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IntActi
Q96JN0, 76 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000360138

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1433
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2COBNMR-A343-405[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96JN0

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q96JN0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini340 – 392HTH psq-typePROSITE-ProRule annotationAdd BLAST53

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi53 – 57Interaction with nuclear receptors5
Motifi339 – 345Nuclear localization signalSequence analysis7

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IHUE Eukaryota
KOG4565 Eukaryota
ENOG4111GCI LUCA
ENOG4111MRK LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000162611

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000111679

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96JN0

Database of Orthologous Groups

More...
OrthoDBi
134164at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96JN0

TreeFam database of animal gene trees

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TreeFami
TF319589
TF332137

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009057 Homeobox-like_sf
IPR007889 HTH_Psq

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05225 HTH_psq, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46689 SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50960 HTH_PSQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96JN0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQRMIQQFAA EYTSKNSSTQ DPSQPNSTKN QSLPKASPVT TSPTAATTQN
60 70 80 90 100
PVLSKLLMAD QDSPLDLTVR KSQSEPSEQD GVLDLSTKKS PCAGSTSLSH
110 120 130 140 150
SPGCSSTQGN GRPGRPSQYR PDGLRSGDGV PPRSLQDGTR EGFGHSTSLK
160 170 180 190 200
VPLARSLQIS EELLSRNQLS TAASLGPSGL QNHGQHLILS REASWAKPHY
210 220 230 240 250
EFNLSRMKFR GNGALSNISD LPFLAENSAF PKMALQAKQD GKKDVSHSSP
260 270 280 290 300
VDLKIPQVRG MDLSWESRTG DQYSYSSLVM GSQTESALSK KLRAILPKQS
310 320 330 340 350
RKSMLDAGPD SWGSDAEQST SGQPYPTSDQ EGDPGSKQPR KKRGRYRQYN
360 370 380 390 400
SEILEEAISV VMSGKMSVSK AQSIYGIPHS TLEYKVKERL GTLKNPPKKK
410 420 430
MKLMRSEGPD VSVKIELDPQ GEAAQSANES KNE
Length:433
Mass (Da):47,007
Last modified:May 30, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5F934FE687417740
GO
Isoform 2 (identifier: Q96JN0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     405-406: RS → SG
     407-433: Missing.

Show »
Length:406
Mass (Da):44,083
Checksum:iACE760CF3CB1F2EF
GO
Isoform 3 (identifier: Q96JN0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-433: RPGRPSQYRP...AQSANESKNE → ENSTEAKAVD...HSKRRRLDAK

Show »
Length:1,557
Mass (Da):170,478
Checksum:iA16B9688C8FC40E4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1P0AZG4A0A1P0AZG4_HUMAN
Ligand-dependent corepressor
LCOR
1,247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH24315 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14396 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB47424 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6Q → P in CAD91159 (PubMed:17974005).Curated1
Sequence conflicti321S → P in CAD38921 (PubMed:17974005).Curated1
Isoform 3 (identifier: Q96JN0-3)
Sequence conflicti922E → G in BAB14396 (PubMed:14702039).Combined sourcesCurated1
Sequence conflicti1209D → G in BAB14396 (PubMed:14702039).Combined sourcesCurated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_058760112 – 433RPGRP…ESKNE → ENSTEAKAVDSNNQSKSPLE KFMVKLCTHHQKQFIRVLND LYTESQPGTEDLQPSDSGAM DVSTCNAGCAQLSTKHKEKD ALCLDMKSSASVDLFVDSSD SHSPLHLTEQTPKKPPPEIN PVDGRENALTVVQKDSSELP TTKSNSINSSSVDSFTPGYL TASNCSSVNFHHIPKILEGQ TTGQEQDTNVNICEDGKDHM QSSALVESLITVKMAAENSE EGNTCIIPQRNLFKALSEEA WNSGFMGNSSRTADKENTLQ CPKTPLRQDLEANEQDARPK QENHLHSLGRNKVGYHLHPS DKGQFDHSKDGWLGPGPMPA VHKAANGHSRTKMISTSIKT ARKSKRASGLRINDYDNQCD VVYISQPITECHFENQKSIL SSRKTARKSTRGYFFNGDCC ELPTVRTLARNLHSQEKASC SALASEAVFTPKQTLTIPAP RHTVDVQLPREDNPEEPSKE ITSHEEGGGDVSPRKEPQEP EVCPTKIKPNLSSSPRSEET TASSLVWPLPAHLPEEDLPE GGSTVSAPTASGMSSPEHNQ PPVALLDTEEMSVPQDCHLL PSTESFSGGVSEDVISRPHS PPEIVSREESPQCSENQSSP MGLEPPMSLGKAEDNQSISA EVESGDTQELNVDPLLKESS TFTDENPSETEESEAAGGIG KLEGEDGDVKCLSEKDTYDT SIDSLEENLDKKKKGKKFPE ASDRCLRSQLSDSSSADRCL RNQSSDSSSACLEIKVPKNP SAKRSKKEGHPGGTTPKGLL PDSFHTETLEDTEKPSVNER PSEKDAEQEGEGGGIITRQT LKNMLDKEVKELRGEIFPSR DPITTAGQPLPGERLEIYVQ SKMDEKNAHIPSESIACKRD PEQAKEEPGHIPTQHVEEAV NEVDNENTQQKDDESDAPCS SLGLSSSGSGDAARAPKSVP RPKRLTSSTYNLRHAHSLGS LDASKVTSEKEAAQVNPIMP KENGASESGDPLDEDDVDTV VDEQPKFMEWCAEEENQELI ANFNAQYMKVQKGWIQLEKE GQPTPRARNKSDKLKEIWKS KKRSRKCRSSLESQKCSPVQ MLFMTNFKLSNVCKWFLETT ETRSLVIVKKLNTRLPGDVP PVKHPLQKYAPSSLYPSSLQ AERLKKHLKKFPGATPAKNN WKMQKLWAKFRENPDQVEPE DGSDVSPGPNSEDSIEEVKE DRNSHPPANLPTPASTRILR KYSNIRGKLRAQQRLIKNEK MECPDALAVESKPSRKSVCI NPLMSPKLALQVDADGFPVK PKSTEGMKGRKGKQVSEILP KAEVQSKRKRTEGSSPPDSK NKGPTVKASKEKHADGATKT PAAKRPAARDRSSQPPKKTS LKENKVKIPKKSAGKSCPPS RKEKENTNKRPSQSIASETL TKPAKQKGAGESSSRPQKAT NRKQSSGKTRARPSTKTPES SAAQRKRKLKAKLDCSHSKR RRLDAK in isoform 3. Add BLAST322
Alternative sequenceiVSP_018585405 – 406RS → SG in isoform 2. 1 Publication2
Alternative sequenceiVSP_018586407 – 433Missing in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB058698 mRNA Translation: BAB47424.1 Different initiation.
AL834245 mRNA Translation: CAD38921.2
AL832106 mRNA Translation: CAD91159.1
AL832044 mRNA Translation: CAD91160.1
AL049938 mRNA Translation: CAB43214.1
AL442123 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49963.1
CH471066 Genomic DNA Translation: EAW49965.1
CH471066 Genomic DNA Translation: EAW49966.1
BC024315 mRNA Translation: AAH24315.1 Different initiation.
BC053359 mRNA Translation: AAH53359.1
AK023084 mRNA Translation: BAB14396.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS53561.1 [Q96JN0-2]
CCDS7451.1 [Q96JN0-1]
CCDS86132.1 [Q96JN0-3]

Protein sequence database of the Protein Information Resource

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PIRi
T08672

NCBI Reference Sequences

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RefSeqi
NP_001164236.1, NM_001170765.1 [Q96JN0-1]
NP_001164237.1, NM_001170766.1 [Q96JN0-2]
NP_001333445.1, NM_001346516.1 [Q96JN0-3]
NP_115816.2, NM_032440.3 [Q96JN0-1]
XP_016872275.1, XM_017016786.1
XP_016872276.1, XM_017016787.1
XP_016872277.1, XM_017016788.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000356016; ENSP00000348298; ENSG00000196233 [Q96JN0-1]
ENST00000371097; ENSP00000360138; ENSG00000196233 [Q96JN0-1]
ENST00000371103; ENSP00000360144; ENSG00000196233 [Q96JN0-1]
ENST00000421806; ENSP00000490116; ENSG00000196233 [Q96JN0-3]
ENST00000540664; ENSP00000443431; ENSG00000196233 [Q96JN0-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84458

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84458

UCSC genome browser

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UCSCi
uc001kmr.4 human [Q96JN0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058698 mRNA Translation: BAB47424.1 Different initiation.
AL834245 mRNA Translation: CAD38921.2
AL832106 mRNA Translation: CAD91159.1
AL832044 mRNA Translation: CAD91160.1
AL049938 mRNA Translation: CAB43214.1
AL442123 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49963.1
CH471066 Genomic DNA Translation: EAW49965.1
CH471066 Genomic DNA Translation: EAW49966.1
BC024315 mRNA Translation: AAH24315.1 Different initiation.
BC053359 mRNA Translation: AAH53359.1
AK023084 mRNA Translation: BAB14396.1 Different initiation.
CCDSiCCDS53561.1 [Q96JN0-2]
CCDS7451.1 [Q96JN0-1]
CCDS86132.1 [Q96JN0-3]
PIRiT08672
RefSeqiNP_001164236.1, NM_001170765.1 [Q96JN0-1]
NP_001164237.1, NM_001170766.1 [Q96JN0-2]
NP_001333445.1, NM_001346516.1 [Q96JN0-3]
NP_115816.2, NM_032440.3 [Q96JN0-1]
XP_016872275.1, XM_017016786.1
XP_016872276.1, XM_017016787.1
XP_016872277.1, XM_017016788.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2COBNMR-A343-405[»]
SMRiQ96JN0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117579, 35 interactors
124093, 64 interactors
CORUMiQ96JN0
ELMiQ96JN0
IntActiQ96JN0, 76 interactors
STRINGi9606.ENSP00000360138

PTM databases

iPTMnetiQ96JN0
PhosphoSitePlusiQ96JN0

Polymorphism and mutation databases

BioMutaiLCOR
DMDMi68565212

Proteomic databases

EPDiQ96JN0
jPOSTiQ96JN0
MaxQBiQ96JN0
PaxDbiQ96JN0
PeptideAtlasiQ96JN0
PRIDEiQ96JN0
ProteomicsDBi72131
76989
76990 [Q96JN0-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
26148
84458
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356016; ENSP00000348298; ENSG00000196233 [Q96JN0-1]
ENST00000371097; ENSP00000360138; ENSG00000196233 [Q96JN0-1]
ENST00000371103; ENSP00000360144; ENSG00000196233 [Q96JN0-1]
ENST00000421806; ENSP00000490116; ENSG00000196233 [Q96JN0-3]
ENST00000540664; ENSP00000443431; ENSG00000196233 [Q96JN0-2]
GeneIDi84458
KEGGihsa:84458
UCSCiuc001kmr.4 human [Q96JN0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84458
DisGeNETi84458

GeneCards: human genes, protein and diseases

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GeneCardsi
LCOR

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0170441
HGNCiHGNC:29503 LCOR
HPAiHPA031428
HPA031429
HPA038954
HPA057621
HPA077000
MIMi607698 gene
neXtProtiNX_Q96JN0
OpenTargetsiENSG00000196233
PharmGKBiPA134866687
PA145148487

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHUE Eukaryota
KOG4565 Eukaryota
ENOG4111GCI LUCA
ENOG4111MRK LUCA
GeneTreeiENSGT00940000162611
HOGENOMiHOG000111679
InParanoidiQ96JN0
OrthoDBi134164at2759
PhylomeDBiQ96JN0
TreeFamiTF319589
TF332137

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LCOR human
EvolutionaryTraceiQ96JN0

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
LCOR

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84458

Protein Ontology

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PROi
PR:Q96JN0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000196233 Expressed in 214 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ96JN0 baseline and differential
GenevisibleiQ96JN0 HS

Family and domain databases

InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR007889 HTH_Psq
PfamiView protein in Pfam
PF05225 HTH_psq, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50960 HTH_PSQ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLCOR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96JN0
Secondary accession number(s): D3DR47
, Q5VW16, Q7Z723, Q86T32, Q86T33, Q8N3L6, Q8N655, Q9H945, Q9Y457
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: May 8, 2019
This is version 136 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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