LCOR

Functionⁱ

May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR.By similarity1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	368 – 388	H-T-H motifPROSITE-ProRule annotationAdd BLAST		21

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
RNA polymerase II transcription factor activity, sequence-specific DNA binding
Source: NTNU_SB
Inferred from sequence modelⁱ
- 19274049
transcription factor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of transcription by RNA polymerase II Source: Ensembl
transcription by RNA polymerase II Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Repressor
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ligand-dependent corepressor Short name: LCoR Alternative name(s): Mblk1-related protein 2
Gene namesⁱ	Name:LCORImported Synonyms:C10orf12Imported, KIAA1795Imported, MLR2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000155640.6 HostDB:ENSG00000196233.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29503 LCOR
MIMⁱ	607698 gene
neXtProtⁱ	NX_Q96JN0

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	56 – 57	LL → AA: Loss of estradiol-dependent interaction with ESR1 and ESR2. 1 Publication		2

Organism-specific databases

DisGeNET More...DisGeNETⁱ	84458
Open Targets More...OpenTargetsⁱ	ENSG00000196233
PharmGKBⁱ	PA134866687 PA145148487

Polymorphism and mutation databases

BioMutaⁱ	C10orf12 LCOR
DMDMⁱ	68565212

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000236807	1 – 433	Ligand-dependent corepressorAdd BLAST		433

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	42	PhosphoserineCombined sources	1
Modified residueⁱ	63	PhosphoserineCombined sources	1
Modified residueⁱ	249	PhosphoserineCombined sources	1
Cross-linkⁱ	254	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	414	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 3 (identifier: Q96JN0-3)
Cross-linkⁱ	345	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sourcesCurated
Cross-linkⁱ	391	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sourcesCurated
Cross-linkⁱ	543	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sourcesCurated
Modified residueⁱ	583	PhosphoserineCombined sourcesCurated	1
Modified residueⁱ	605	PhosphoserineCombined sourcesCurated	1
Modified residueⁱ	792	PhosphoserineCombined sourcesCurated	1
Cross-linkⁱ	976	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sourcesCurated
Modified residueⁱ	1048	PhosphoserineCombined sourcesCurated	1
Modified residueⁱ	1077	PhosphoserineCombined sourcesCurated	1
Modified residueⁱ	1214	N6,N6-dimethyllysineCombined sourcesCurated	1
Modified residueⁱ	1219	N6,N6-dimethyllysineCombined sourcesCurated	1
Modified residueⁱ	1274	PhosphoserineCombined sourcesCurated	1

Keywords - PTMⁱ

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q96JN0
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96JN0
PaxDbⁱ	Q96JN0
PeptideAtlas More...PeptideAtlasⁱ	Q96JN0
PRIDEⁱ	Q96JN0
ProteomicsDBⁱ	72131 76989 76990 [Q96JN0-2]

PTM databases

iPTMnetⁱ	Q96JN0
PhosphoSitePlusⁱ	Q96JN0

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000196233 Expressed in 214 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_C10orf12 HS_LCOR
ExpressionAtlasⁱ	Q96JN0 baseline and differential
Genevisibleⁱ	Q96JN0 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA031428 HPA031429 HPA038954 HPA057621 HPA077000

HPAⁱ

HPA031428
HPA031429
HPA038954
HPA057621
HPA077000

Interactionⁱ

Subunit structureⁱ

Interacts with ESR1 and ESR2 in the presence of estradiol. Interacts with CTBP1, HDAC3 and HDAC6. Component of a large corepressor complex that contains about 20 proteins, including CTBP1, CTBP2, HDAC1 and HDAC2.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CTBP2	P56545	4	EBI-746045,EBI-741533
CTBP2	P56545-3	3	EBI-746045,EBI-10171902
EHMT2	A2ABF9	3	EBI-746045,EBI-10174566
GOLGA2	Q08379	3	EBI-746045,EBI-618309
TRAF1	Q13077	3	EBI-746045,EBI-359224

GO - Molecular functionⁱ

transcription factor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	117579, 32 interactors 124093, 48 interactors
CORUMⁱ	Q96JN0
ELMⁱ	Q96JN0
IntActⁱ	Q96JN0, 75 interactors
STRINGⁱ	9606.ENSP00000348298

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	351 – 362	Combined sources	12
Helixⁱ	368 – 375	Combined sources	8
Helixⁱ	379 – 389	Combined sources	11
Turnⁱ	390 – 393	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	Q96JN0
SMRⁱ	Q96JN0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q96JN0

EvolutionaryTraceⁱ

Q96JN0

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	340 – 392	HTH psq-typePROSITE-ProRule annotationAdd BLAST		53

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	53 – 57	Interaction with nuclear receptors		5
Motifⁱ	339 – 345	Nuclear localization signalSequence analysis		7

Phylogenomic databases

eggNOGⁱ	ENOG410IHUE Eukaryota KOG4565 Eukaryota ENOG4111GCI LUCA ENOG4111MRK LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00520000055615
HOGENOMⁱ	HOG000111679
HOVERGENⁱ	HBG079596
InParanoidⁱ	Q96JN0
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0N6A
PhylomeDBⁱ	Q96JN0
TreeFamⁱ	TF319589 TF332137

Family and domain databases

InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR007889 HTH_Psq
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05225 HTH_psq, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS50960 HTH_PSQ, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q96JN0-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQRMIQQFAA EYTSKNSSTQ DPSQPNSTKN QSLPKASPVT TSPTAATTQN 
        60         70         80         90        100
PVLSKLLMAD QDSPLDLTVR KSQSEPSEQD GVLDLSTKKS PCAGSTSLSH 
       110        120        130        140        150
SPGCSSTQGN GRPGRPSQYR PDGLRSGDGV PPRSLQDGTR EGFGHSTSLK 
       160        170        180        190        200
VPLARSLQIS EELLSRNQLS TAASLGPSGL QNHGQHLILS REASWAKPHY 
       210        220        230        240        250
EFNLSRMKFR GNGALSNISD LPFLAENSAF PKMALQAKQD GKKDVSHSSP 
       260        270        280        290        300
VDLKIPQVRG MDLSWESRTG DQYSYSSLVM GSQTESALSK KLRAILPKQS 
       310        320        330        340        350
RKSMLDAGPD SWGSDAEQST SGQPYPTSDQ EGDPGSKQPR KKRGRYRQYN 
       360        370        380        390        400
SEILEEAISV VMSGKMSVSK AQSIYGIPHS TLEYKVKERL GTLKNPPKKK 
       410        420        430 
MKLMRSEGPD VSVKIELDPQ GEAAQSANES KNE

Length:433

Mass (Da):47,007

Last modified:May 30, 2006 - v2

Checksum:ⁱ5F934FE687417740

GO

Isoform 2 (identifier: Q96JN0-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
405-406: RS → SG
407-433: Missing.

« Hide

        10         20         30         40         50
MQRMIQQFAA EYTSKNSSTQ DPSQPNSTKN QSLPKASPVT TSPTAATTQN 
        60         70         80         90        100
PVLSKLLMAD QDSPLDLTVR KSQSEPSEQD GVLDLSTKKS PCAGSTSLSH 
       110        120        130        140        150
SPGCSSTQGN GRPGRPSQYR PDGLRSGDGV PPRSLQDGTR EGFGHSTSLK 
       160        170        180        190        200
VPLARSLQIS EELLSRNQLS TAASLGPSGL QNHGQHLILS REASWAKPHY 
       210        220        230        240        250
EFNLSRMKFR GNGALSNISD LPFLAENSAF PKMALQAKQD GKKDVSHSSP 
       260        270        280        290        300
VDLKIPQVRG MDLSWESRTG DQYSYSSLVM GSQTESALSK KLRAILPKQS 
       310        320        330        340        350
RKSMLDAGPD SWGSDAEQST SGQPYPTSDQ EGDPGSKQPR KKRGRYRQYN 
       360        370        380        390        400
SEILEEAISV VMSGKMSVSK AQSIYGIPHS TLEYKVKERL GTLKNPPKKK 

MKLMSG

Show »

Length:406

Mass (Da):44,083

Checksum:ⁱACE760CF3CB1F2EF

GO

Isoform 3 (identifier: Q96JN0-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
112-433: RPGRPSQYRP...AQSANESKNE → ENSTEAKAVD...HSKRRRLDAK

« Hide

        10         20         30         40         50
MQRMIQQFAA EYTSKNSSTQ DPSQPNSTKN QSLPKASPVT TSPTAATTQN 
        60         70         80         90        100
PVLSKLLMAD QDSPLDLTVR KSQSEPSEQD GVLDLSTKKS PCAGSTSLSH 
       110        120        130        140        150
SPGCSSTQGN GENSTEAKAV DSNNQSKSPL EKFMVKLCTH HQKQFIRVLN 
       160        170        180        190        200
DLYTESQPGT EDLQPSDSGA MDVSTCNAGC AQLSTKHKEK DALCLDMKSS 
       210        220        230        240        250
ASVDLFVDSS DSHSPLHLTE QTPKKPPPEI NPVDGRENAL TVVQKDSSEL 
       260        270        280        290        300
PTTKSNSINS SSVDSFTPGY LTASNCSSVN FHHIPKILEG QTTGQEQDTN 
       310        320        330        340        350
VNICEDGKDH MQSSALVESL ITVKMAAENS EEGNTCIIPQ RNLFKALSEE 
       360        370        380        390        400
AWNSGFMGNS SRTADKENTL QCPKTPLRQD LEANEQDARP KQENHLHSLG 
       410        420        430        440        450
RNKVGYHLHP SDKGQFDHSK DGWLGPGPMP AVHKAANGHS RTKMISTSIK 
       460        470        480        490        500
TARKSKRASG LRINDYDNQC DVVYISQPIT ECHFENQKSI LSSRKTARKS 
       510        520        530        540        550
TRGYFFNGDC CELPTVRTLA RNLHSQEKAS CSALASEAVF TPKQTLTIPA 
       560        570        580        590        600
PRHTVDVQLP REDNPEEPSK EITSHEEGGG DVSPRKEPQE PEVCPTKIKP 
       610        620        630        640        650
NLSSSPRSEE TTASSLVWPL PAHLPEEDLP EGGSTVSAPT ASGMSSPEHN 
       660        670        680        690        700
QPPVALLDTE EMSVPQDCHL LPSTESFSGG VSEDVISRPH SPPEIVSREE 
       710        720        730        740        750
SPQCSENQSS PMGLEPPMSL GKAEDNQSIS AEVESGDTQE LNVDPLLKES 
       760        770        780        790        800
STFTDENPSE TEESEAAGGI GKLEGEDGDV KCLSEKDTYD TSIDSLEENL 
       810        820        830        840        850
DKKKKGKKFP EASDRCLRSQ LSDSSSADRC LRNQSSDSSS ACLEIKVPKN 
       860        870        880        890        900
PSAKRSKKEG HPGGTTPKGL LPDSFHTETL EDTEKPSVNE RPSEKDAEQE 
       910        920        930        940        950
GEGGGIITRQ TLKNMLDKEV KELRGEIFPS RDPITTAGQP LPGERLEIYV 
       960        970        980        990       1000
QSKMDEKNAH IPSESIACKR DPEQAKEEPG HIPTQHVEEA VNEVDNENTQ 
      1010       1020       1030       1040       1050
QKDDESDAPC SSLGLSSSGS GDAARAPKSV PRPKRLTSST YNLRHAHSLG 
      1060       1070       1080       1090       1100
SLDASKVTSE KEAAQVNPIM PKENGASESG DPLDEDDVDT VVDEQPKFME 
      1110       1120       1130       1140       1150
WCAEEENQEL IANFNAQYMK VQKGWIQLEK EGQPTPRARN KSDKLKEIWK 
      1160       1170       1180       1190       1200
SKKRSRKCRS SLESQKCSPV QMLFMTNFKL SNVCKWFLET TETRSLVIVK 
      1210       1220       1230       1240       1250
KLNTRLPGDV PPVKHPLQKY APSSLYPSSL QAERLKKHLK KFPGATPAKN 
      1260       1270       1280       1290       1300
NWKMQKLWAK FRENPDQVEP EDGSDVSPGP NSEDSIEEVK EDRNSHPPAN 
      1310       1320       1330       1340       1350
LPTPASTRIL RKYSNIRGKL RAQQRLIKNE KMECPDALAV ESKPSRKSVC 
      1360       1370       1380       1390       1400
INPLMSPKLA LQVDADGFPV KPKSTEGMKG RKGKQVSEIL PKAEVQSKRK 
      1410       1420       1430       1440       1450
RTEGSSPPDS KNKGPTVKAS KEKHADGATK TPAAKRPAAR DRSSQPPKKT 
      1460       1470       1480       1490       1500
SLKENKVKIP KKSAGKSCPP SRKEKENTNK RPSQSIASET LTKPAKQKGA 
      1510       1520       1530       1540       1550
GESSSRPQKA TNRKQSSGKT RARPSTKTPE SSAAQRKRKL KAKLDCSHSK 

RRRLDAK

Show »

Length:1,557

Mass (Da):170,478

Checksum:ⁱA16B9688C8FC40E4

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A1P0AZG4	A0A1P0AZG4_HUMAN		Ligand-dependent corepressor Ligand-dependent corepressor	LCOR	1,247	Annotation score:

Sequence cautionⁱ

The sequence AAH24315 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAB14396 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAB47424 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	6	Q → P in CAD91159 (PubMed:17974005).Curated	1
Sequence conflictⁱ	321	S → P in CAD38921 (PubMed:17974005).Curated	1
Isoform 3 (identifier: Q96JN0-3)
Sequence conflictⁱ	922	E → G in BAB14396 (PubMed:14702039).Combined sourcesCurated	1
Sequence conflictⁱ	1209	D → G in BAB14396 (PubMed:14702039).Combined sourcesCurated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_058760	112 – 433	RPGRP…ESKNE → ENSTEAKAVDSNNQSKSPLE KFMVKLCTHHQKQFIRVLND LYTESQPGTEDLQPSDSGAM DVSTCNAGCAQLSTKHKEKD ALCLDMKSSASVDLFVDSSD SHSPLHLTEQTPKKPPPEIN PVDGRENALTVVQKDSSELP TTKSNSINSSSVDSFTPGYL TASNCSSVNFHHIPKILEGQ TTGQEQDTNVNICEDGKDHM QSSALVESLITVKMAAENSE EGNTCIIPQRNLFKALSEEA WNSGFMGNSSRTADKENTLQ CPKTPLRQDLEANEQDARPK QENHLHSLGRNKVGYHLHPS DKGQFDHSKDGWLGPGPMPA VHKAANGHSRTKMISTSIKT ARKSKRASGLRINDYDNQCD VVYISQPITECHFENQKSIL SSRKTARKSTRGYFFNGDCC ELPTVRTLARNLHSQEKASC SALASEAVFTPKQTLTIPAP RHTVDVQLPREDNPEEPSKE ITSHEEGGGDVSPRKEPQEP EVCPTKIKPNLSSSPRSEET TASSLVWPLPAHLPEEDLPE GGSTVSAPTASGMSSPEHNQ PPVALLDTEEMSVPQDCHLL PSTESFSGGVSEDVISRPHS PPEIVSREESPQCSENQSSP MGLEPPMSLGKAEDNQSISA EVESGDTQELNVDPLLKESS TFTDENPSETEESEAAGGIG KLEGEDGDVKCLSEKDTYDT SIDSLEENLDKKKKGKKFPE ASDRCLRSQLSDSSSADRCL RNQSSDSSSACLEIKVPKNP SAKRSKKEGHPGGTTPKGLL PDSFHTETLEDTEKPSVNER PSEKDAEQEGEGGGIITRQT LKNMLDKEVKELRGEIFPSR DPITTAGQPLPGERLEIYVQ SKMDEKNAHIPSESIACKRD PEQAKEEPGHIPTQHVEEAV NEVDNENTQQKDDESDAPCS SLGLSSSGSGDAARAPKSVP RPKRLTSSTYNLRHAHSLGS LDASKVTSEKEAAQVNPIMP KENGASESGDPLDEDDVDTV VDEQPKFMEWCAEEENQELI ANFNAQYMKVQKGWIQLEKE GQPTPRARNKSDKLKEIWKS KKRSRKCRSSLESQKCSPVQ MLFMTNFKLSNVCKWFLETT ETRSLVIVKKLNTRLPGDVP PVKHPLQKYAPSSLYPSSLQ AERLKKHLKKFPGATPAKNN WKMQKLWAKFRENPDQVEPE DGSDVSPGPNSEDSIEEVKE DRNSHPPANLPTPASTRILR KYSNIRGKLRAQQRLIKNEK MECPDALAVESKPSRKSVCI NPLMSPKLALQVDADGFPVK PKSTEGMKGRKGKQVSEILP KAEVQSKRKRTEGSSPPDSK NKGPTVKASKEKHADGATKT PAAKRPAARDRSSQPPKKTS LKENKVKIPKKSAGKSCPPS RKEKENTNKRPSQSIASETL TKPAKQKGAGESSSRPQKAT NRKQSSGKTRARPSTKTPES SAAQRKRKLKAKLDCSHSKR RRLDAK in isoform 3. Add BLAST	322
Alternative sequenceⁱVSP_018585	405 – 406	RS → SG in isoform 2. 1 Publication	2
Alternative sequenceⁱVSP_018586	407 – 433	Missing in isoform 2. 1 PublicationAdd BLAST	27

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB058698 mRNA Translation: BAB47424.1 Different initiation. AL834245 mRNA Translation: CAD38921.2 AL832106 mRNA Translation: CAD91159.1 AL832044 mRNA Translation: CAD91160.1 AL049938 mRNA Translation: CAB43214.1 AL442123 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49963.1 CH471066 Genomic DNA Translation: EAW49965.1 CH471066 Genomic DNA Translation: EAW49966.1 BC024315 mRNA Translation: AAH24315.1 Different initiation. BC053359 mRNA Translation: AAH53359.1 AK023084 mRNA Translation: BAB14396.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS53561.1 [Q96JN0-2] CCDS7451.1 [Q96JN0-1] CCDS86132.1 [Q96JN0-3]
PIRⁱ	T08672
NCBI Reference Sequences More...RefSeqⁱ	NP_001164236.1, NM_001170765.1 [Q96JN0-1] NP_001164237.1, NM_001170766.1 [Q96JN0-2] NP_001333445.1, NM_001346516.1 [Q96JN0-3] NP_115816.2, NM_032440.3 [Q96JN0-1] XP_016872275.1, XM_017016786.1 XP_016872276.1, XM_017016787.1 XP_016872277.1, XM_017016788.1
UniGeneⁱ	Hs.427927 Hs.734580 Hs.745068

Genome annotation databases

Ensemblⁱ	ENST00000356016; ENSP00000348298; ENSG00000196233 [Q96JN0-1] ENST00000371097; ENSP00000360138; ENSG00000196233 [Q96JN0-1] ENST00000371103; ENSP00000360144; ENSG00000196233 [Q96JN0-1] ENST00000421806; ENSP00000490116; ENSG00000196233 [Q96JN0-3] ENST00000540664; ENSP00000443431; ENSG00000196233 [Q96JN0-2]
GeneIDⁱ	84458
KEGGⁱ	hsa:84458
UCSC genome browser More...UCSCⁱ	uc001kmr.4 human [Q96JN0-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
Q96JN0	LCOR isoform 3		PANTR		433	UniRef100_Q96JN0
Uncharacterized protein		GORGO		433
UPI0003EAE9E1		PANTR		593
Q96JN0-2	LCOR isoform 5		PANTR		406	UniRef100_A0A2I3SC12
Uncharacterized protein		GORGO		406
Q96JN0-3	Ligand-dependent corepressor		HUMAN		1247	UniRef100_A0A1P0AZG4

Protein	Similar proteins		Species	Score	Length	Source
Q96JN0	Ligand-dependent corepressor		MOUSE		433	UniRef90_Q96JN0
LCOR isoform 3		PANTR		433
Uncharacterized protein		GORGO		433
ligand-dependent corepressor isoform X5		TURTR		607
ligand-dependent corepressor isoform X9		DELLE		433
+95
Q96JN0-2	Ligand dependent nuclear receptor corepressor		ANOCA		354	UniRef90_H9GIV9
Ligand-dependent corepressor		TYTAL		431
Ligand-dependent corepressor		CATAU		429
Uncharacterized protein		RHIBE		417
LCOR isoform 5		PANTR		406
+37
Q96JN0-3	Uncharacterized protein		MACMU		1681	UniRef90_F7EFY1
Uncharacterized protein		MACFA		1246
Uncharacterized protein		Cebus capucinus imitator		1693
Uncharacterized protein		AOTNA		1691
Uncharacterized protein		NOMLE		1559
+67

Protein	Similar proteins		Species	Score	Length	Source
Q96JN0	Ligand-dependent corepressor		MOUSE		433	UniRef50_Q96JN0
LCOR isoform 3		PANTR		433
Uncharacterized protein		GORGO		433
ligand-dependent corepressor isoform X5		TURTR		607
ligand-dependent corepressor isoform X9		DELLE		433
+169
Q96JN0-2	Ligand dependent nuclear receptor corepressor		ANOCA		354	UniRef50_H9GIV9
Ligand-dependent corepressor		TYTAL		431
Ligand-dependent corepressor		CATAU		429
Uncharacterized protein		RHIBE		417
Uncharacterized protein		FELCA		406
+61
Q96JN0-3	Uncharacterized protein		ICTTR		433	UniRef50_I3MG54
Uncharacterized protein		BOVIN		1247
Uncharacterized protein		SHEEP		1247
Uncharacterized protein		MYOLU		1245
Uncharacterized protein		MYODS		1484
+217

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB058698 mRNA Translation: BAB47424.1 Different initiation. AL834245 mRNA Translation: CAD38921.2 AL832106 mRNA Translation: CAD91159.1 AL832044 mRNA Translation: CAD91160.1 AL049938 mRNA Translation: CAB43214.1 AL442123 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49963.1 CH471066 Genomic DNA Translation: EAW49965.1 CH471066 Genomic DNA Translation: EAW49966.1 BC024315 mRNA Translation: AAH24315.1 Different initiation. BC053359 mRNA Translation: AAH53359.1 AK023084 mRNA Translation: BAB14396.1 Different initiation.
CCDSⁱ	CCDS53561.1 [Q96JN0-2] CCDS7451.1 [Q96JN0-1] CCDS86132.1 [Q96JN0-3]
PIRⁱ	T08672
RefSeqⁱ	NP_001164236.1, NM_001170765.1 [Q96JN0-1] NP_001164237.1, NM_001170766.1 [Q96JN0-2] NP_001333445.1, NM_001346516.1 [Q96JN0-3] NP_115816.2, NM_032440.3 [Q96JN0-1] XP_016872275.1, XM_017016786.1 XP_016872276.1, XM_017016787.1 XP_016872277.1, XM_017016788.1
UniGeneⁱ	Hs.427927 Hs.734580 Hs.745068

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2COB	NMR	-	A	343-405	[»]
ProteinModelPortalⁱ	Q96JN0
SMRⁱ	Q96JN0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117579, 32 interactors 124093, 48 interactors
CORUMⁱ	Q96JN0
ELMⁱ	Q96JN0
IntActⁱ	Q96JN0, 75 interactors
STRINGⁱ	9606.ENSP00000348298

PTM databases

iPTMnetⁱ	Q96JN0
PhosphoSitePlusⁱ	Q96JN0

Polymorphism and mutation databases

BioMutaⁱ	C10orf12 LCOR
DMDMⁱ	68565212

Proteomic databases

EPDⁱ	Q96JN0
MaxQBⁱ	Q96JN0
PaxDbⁱ	Q96JN0
PeptideAtlasⁱ	Q96JN0
PRIDEⁱ	Q96JN0
ProteomicsDBⁱ	72131 76989 76990 [Q96JN0-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	26148 84458
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000356016; ENSP00000348298; ENSG00000196233 [Q96JN0-1] ENST00000371097; ENSP00000360138; ENSG00000196233 [Q96JN0-1] ENST00000371103; ENSP00000360144; ENSG00000196233 [Q96JN0-1] ENST00000421806; ENSP00000490116; ENSG00000196233 [Q96JN0-3] ENST00000540664; ENSP00000443431; ENSG00000196233 [Q96JN0-2]
GeneIDⁱ	84458
KEGGⁱ	hsa:84458
UCSCⁱ	uc001kmr.4 human [Q96JN0-1]

Organism-specific databases

CTDⁱ	84458
DisGeNETⁱ	84458
EuPathDBⁱ	HostDB:ENSG00000155640.6 HostDB:ENSG00000196233.11
GeneCardsⁱ	LCOR
H-InvDBⁱ	HIX0170441
HGNCⁱ	HGNC:29503 LCOR
HPAⁱ	HPA031428 HPA031429 HPA038954 HPA057621 HPA077000
MIMⁱ	607698 gene
neXtProtⁱ	NX_Q96JN0
OpenTargetsⁱ	ENSG00000196233
PharmGKBⁱ	PA134866687 PA145148487
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IHUE Eukaryota KOG4565 Eukaryota ENOG4111GCI LUCA ENOG4111MRK LUCA
GeneTreeⁱ	ENSGT00520000055615
HOGENOMⁱ	HOG000111679
HOVERGENⁱ	HBG079596
InParanoidⁱ	Q96JN0
OrthoDBⁱ	EOG091G0N6A
PhylomeDBⁱ	Q96JN0
TreeFamⁱ	TF319589 TF332137

Miscellaneous databases

ChiTaRSⁱ	LCOR human
EvolutionaryTraceⁱ	Q96JN0
GeneWikiⁱ	LCOR
GenomeRNAiⁱ	84458
Protein Ontology More...PROⁱ	PR:Q96JN0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000196233 Expressed in 214 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_C10orf12 HS_LCOR
ExpressionAtlasⁱ	Q96JN0 baseline and differential
Genevisibleⁱ	Q96JN0 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR007889 HTH_Psq
Pfamⁱ	View protein in Pfam PF05225 HTH_psq, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS50960 HTH_PSQ, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LCOR_HUMAN
Accessionⁱ	Q96JN0Primary (citable) accession number: Q96JN0 Secondary accession number(s): D3DR47 Q9Y457
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
	Last sequence update:	May 30, 2006
	Last modified:	October 10, 2018
	This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q96JN0 (LCOR_HUMAN)

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<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

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Miscellaneousⁱ

Keywords - Technical termⁱ