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UniProtKB - Q96JN0 (LCOR_HUMAN)

Entry version 153 (25 May 2022)
Sequence version 2 (30 May 2006)
Previous versions | rss
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Protein

Ligand-dependent corepressor

Gene

LCOR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity).

Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR.

By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi368 – 388H-T-H motifPROSITE-ProRule annotationAdd BLAST21

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96JN0

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q96JN0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ligand-dependent corepressor
Short name:
LCoR
Alternative name(s):
Mblk1-related protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LCORImported
Synonyms:C10orf12Imported, KIAA1795Imported, MLR2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29503, LCOR

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607698, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96JN0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000196233

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi56 – 57LL → AA: Loss of estradiol-dependent interaction with ESR1 and ESR2. 1 Publication2

Organism-specific databases

DisGeNET

More...DisGeNETi		84458

Open Targets

More...OpenTargetsi		ENSG00000196233

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA145148487

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96JN0, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LCOR

Domain mapping of disease mutations (DMDM)

More...DMDMi		68565212

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002368071 – 433Ligand-dependent corepressorAdd BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei42PhosphoserineCombined sources1
Modified residuei63PhosphoserineCombined sources1
Modified residuei249PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki254Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki414Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 3 (identifier: Q96JN0-3)
Cross-linki345Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki391Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki543Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei583PhosphoserineCombined sources1
Modified residuei605PhosphoserineCombined sources1
Modified residuei792PhosphoserineCombined sources1
Cross-linki976Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1048PhosphoserineCombined sources1
Modified residuei1077PhosphoserineCombined sources1
Modified residuei1214N6,N6-dimethyllysineCombined sources1
Modified residuei1219N6,N6-dimethyllysineCombined sources1
Modified residuei1274PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96JN0

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96JN0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96JN0

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96JN0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96JN0

PeptideAtlas

More...PeptideAtlasi		Q96JN0

PRoteomics IDEntifications database

More...PRIDEi		Q96JN0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		72131
76989 [Q96JN0-1]
76990 [Q96JN0-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q96JN0, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96JN0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96JN0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000196233, Expressed in secondary oocyte and 227 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96JN0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96JN0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000196233, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ESR1 and ESR2 in the presence of estradiol.

Interacts with CTBP1, HDAC3 and HDAC6.

Component of a large corepressor complex that contains about 20 proteins, including CTBP1, CTBP2, HDAC1 and HDAC2.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117579, 53 interactors
124093, 79 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q96JN0

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q96JN0

Protein interaction database and analysis system

More...IntActi		Q96JN0, 86 interactors

Molecular INTeraction database

More...MINTi		Q96JN0

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000360138

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96JN0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1433
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q96JN0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96JN0

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q96JN0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini340 – 392HTH psq-typePROSITE-ProRule annotationAdd BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 51DisorderedSequence analysisAdd BLAST51
Regioni64 – 147DisorderedSequence analysisAdd BLAST84
Regioni299 – 348DisorderedSequence analysisAdd BLAST50
Regioni393 – 412DisorderedSequence analysisAdd BLAST20

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi53 – 57Interaction with nuclear receptors5
Motifi339 – 345Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi66 – 114Polar residuesSequence analysisAdd BLAST49
Compositional biasi313 – 333Polar residuesSequence analysisAdd BLAST21
Compositional biasi334 – 348Basic and acidic residuesSequence analysisAdd BLAST15

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4565, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154965

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_040042_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96JN0

Identification of Orthologs from Complete Genome Data

More...OMAi		IYVQSKM

Database of Orthologous Groups

More...OrthoDBi		134164at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96JN0

TreeFam database of animal gene trees

More...TreeFami		TF319589
TF332137

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009057, Homeobox-like_sf
IPR007889, HTH_Psq

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05225, HTH_psq, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46689, SSF46689, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50960, HTH_PSQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 16 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96JN0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQRMIQQFAA EYTSKNSSTQ DPSQPNSTKN QSLPKASPVT TSPTAATTQN 
        60         70         80         90        100
PVLSKLLMAD QDSPLDLTVR KSQSEPSEQD GVLDLSTKKS PCAGSTSLSH 
       110        120        130        140        150
SPGCSSTQGN GRPGRPSQYR PDGLRSGDGV PPRSLQDGTR EGFGHSTSLK 
       160        170        180        190        200
VPLARSLQIS EELLSRNQLS TAASLGPSGL QNHGQHLILS REASWAKPHY 
       210        220        230        240        250
EFNLSRMKFR GNGALSNISD LPFLAENSAF PKMALQAKQD GKKDVSHSSP 
       260        270        280        290        300
VDLKIPQVRG MDLSWESRTG DQYSYSSLVM GSQTESALSK KLRAILPKQS 
       310        320        330        340        350
RKSMLDAGPD SWGSDAEQST SGQPYPTSDQ EGDPGSKQPR KKRGRYRQYN 
       360        370        380        390        400
SEILEEAISV VMSGKMSVSK AQSIYGIPHS TLEYKVKERL GTLKNPPKKK 
       410        420        430 
MKLMRSEGPD VSVKIELDPQ GEAAQSANES KNE
Length:433
Mass (Da):47,007
Last modified:May 30, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5F934FE687417740
GO
Isoform 2 (identifier: Q96JN0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     405-406: RS → SG
     407-433: Missing.

Show »
Length:406
Mass (Da):44,083
Checksum:iACE760CF3CB1F2EF
GO
Isoform 3 (identifier: Q96JN0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-433: RPGRPSQYRP...AQSANESKNE → ENSTEAKAVD...HSKRRRLDAK

Show »
Length:1,557
Mass (Da):170,478
Checksum:iA16B9688C8FC40E4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A6Q8PFM9A0A6Q8PFM9_HUMAN
Ligand-dependent corepressor
LCOR
575Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PGL8A0A6Q8PGL8_HUMAN
Ligand-dependent corepressor
LCOR
558Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PGR8A0A6Q8PGR8_HUMAN
Ligand-dependent corepressor
LCOR
593Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PG83A0A6Q8PG83_HUMAN
Ligand-dependent corepressor
LCOR
443Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PGP3A0A6Q8PGP3_HUMAN
Ligand-dependent corepressor
LCOR
661Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PFQ9A0A6Q8PFQ9_HUMAN
Ligand-dependent corepressor
LCOR
568Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PH28A0A6Q8PH28_HUMAN
Ligand-dependent corepressor
LCOR
292Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PGD6A0A6Q8PGD6_HUMAN
Ligand-dependent corepressor
LCOR
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PGQ5A0A6Q8PGQ5_HUMAN
Ligand-dependent corepressor
LCOR
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PG56A0A6Q8PG56_HUMAN
Ligand-dependent corepressor
LCOR
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH24315 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB14396 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB47424 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6Q → P in CAD91159 (PubMed:17974005).Curated1
Sequence conflicti321S → P in CAD38921 (PubMed:17974005).Curated1
Isoform 3 (identifier: Q96JN0-3)
Sequence conflicti922E → G in BAB14396 (PubMed:14702039).Curated1
Sequence conflicti1209D → G in BAB14396 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_058760112 – 433RPGRP…ESKNE → ENSTEAKAVDSNNQSKSPLE KFMVKLCTHHQKQFIRVLND LYTESQPGTEDLQPSDSGAM DVSTCNAGCAQLSTKHKEKD ALCLDMKSSASVDLFVDSSD SHSPLHLTEQTPKKPPPEIN PVDGRENALTVVQKDSSELP TTKSNSINSSSVDSFTPGYL TASNCSSVNFHHIPKILEGQ TTGQEQDTNVNICEDGKDHM QSSALVESLITVKMAAENSE EGNTCIIPQRNLFKALSEEA WNSGFMGNSSRTADKENTLQ CPKTPLRQDLEANEQDARPK QENHLHSLGRNKVGYHLHPS DKGQFDHSKDGWLGPGPMPA VHKAANGHSRTKMISTSIKT ARKSKRASGLRINDYDNQCD VVYISQPITECHFENQKSIL SSRKTARKSTRGYFFNGDCC ELPTVRTLARNLHSQEKASC SALASEAVFTPKQTLTIPAP RHTVDVQLPREDNPEEPSKE ITSHEEGGGDVSPRKEPQEP EVCPTKIKPNLSSSPRSEET TASSLVWPLPAHLPEEDLPE GGSTVSAPTASGMSSPEHNQ PPVALLDTEEMSVPQDCHLL PSTESFSGGVSEDVISRPHS PPEIVSREESPQCSENQSSP MGLEPPMSLGKAEDNQSISA EVESGDTQELNVDPLLKESS TFTDENPSETEESEAAGGIG KLEGEDGDVKCLSEKDTYDT SIDSLEENLDKKKKGKKFPE ASDRCLRSQLSDSSSADRCL RNQSSDSSSACLEIKVPKNP SAKRSKKEGHPGGTTPKGLL PDSFHTETLEDTEKPSVNER PSEKDAEQEGEGGGIITRQT LKNMLDKEVKELRGEIFPSR DPITTAGQPLPGERLEIYVQ SKMDEKNAHIPSESIACKRD PEQAKEEPGHIPTQHVEEAV NEVDNENTQQKDDESDAPCS SLGLSSSGSGDAARAPKSVP RPKRLTSSTYNLRHAHSLGS LDASKVTSEKEAAQVNPIMP KENGASESGDPLDEDDVDTV VDEQPKFMEWCAEEENQELI ANFNAQYMKVQKGWIQLEKE GQPTPRARNKSDKLKEIWKS KKRSRKCRSSLESQKCSPVQ MLFMTNFKLSNVCKWFLETT ETRSLVIVKKLNTRLPGDVP PVKHPLQKYAPSSLYPSSLQ AERLKKHLKKFPGATPAKNN WKMQKLWAKFRENPDQVEPE DGSDVSPGPNSEDSIEEVKE DRNSHPPANLPTPASTRILR KYSNIRGKLRAQQRLIKNEK MECPDALAVESKPSRKSVCI NPLMSPKLALQVDADGFPVK PKSTEGMKGRKGKQVSEILP KAEVQSKRKRTEGSSPPDSK NKGPTVKASKEKHADGATKT PAAKRPAARDRSSQPPKKTS LKENKVKIPKKSAGKSCPPS RKEKENTNKRPSQSIASETL TKPAKQKGAGESSSRPQKAT NRKQSSGKTRARPSTKTPES SAAQRKRKLKAKLDCSHSKR RRLDAK in isoform 3. Add BLAST322
Alternative sequenceiVSP_018585405 – 406RS → SG in isoform 2. 1 Publication2
Alternative sequenceiVSP_018586407 – 433Missing in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB058698 mRNA Translation: BAB47424.1 Different initiation.
AL834245 mRNA Translation: CAD38921.2
AL832106 mRNA Translation: CAD91159.1
AL832044 mRNA Translation: CAD91160.1
AL049938 mRNA Translation: CAB43214.1
AL442123 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49963.1
CH471066 Genomic DNA Translation: EAW49965.1
CH471066 Genomic DNA Translation: EAW49966.1
BC024315 mRNA Translation: AAH24315.1 Different initiation.
BC053359 mRNA Translation: AAH53359.1
AK023084 mRNA Translation: BAB14396.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS53561.1 [Q96JN0-2]
CCDS7451.1 [Q96JN0-1]
CCDS86132.1 [Q96JN0-3]

Protein sequence database of the Protein Information Resource

More...PIRi		T08672

NCBI Reference Sequences

More...RefSeqi		NP_001164236.1, NM_001170765.1 [Q96JN0-1]
NP_001164237.1, NM_001170766.1 [Q96JN0-2]
NP_001333445.1, NM_001346516.1 [Q96JN0-3]
NP_115816.2, NM_032440.3 [Q96JN0-1]
XP_016872275.1, XM_017016786.1
XP_016872276.1, XM_017016787.1
XP_016872277.1, XM_017016788.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000356016.7; ENSP00000348298.2; ENSG00000196233.14
ENST00000371097.8; ENSP00000360138.3; ENSG00000196233.14
ENST00000371103.8; ENSP00000360144.3; ENSG00000196233.14
ENST00000421806.4; ENSP00000490116.2; ENSG00000196233.14 [Q96JN0-3]
ENST00000540664.6; ENSP00000443431.1; ENSG00000196233.14 [Q96JN0-2]
ENST00000675471.1; ENSP00000502633.1; ENSG00000196233.14
ENST00000675537.1; ENSP00000501560.1; ENSG00000196233.14
ENST00000675971.1; ENSP00000501639.1; ENSG00000196233.14

Database of genes from NCBI RefSeq genomes

More...GeneIDi		84458

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:84458

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000421806.4; ENSP00000490116.2; NM_001346516.2; NP_001333445.1 [Q96JN0-3]

UCSC genome browser

More...UCSCi		uc001kmr.4, human [Q96JN0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058698 mRNA Translation: BAB47424.1 Different initiation.
AL834245 mRNA Translation: CAD38921.2
AL832106 mRNA Translation: CAD91159.1
AL832044 mRNA Translation: CAD91160.1
AL049938 mRNA Translation: CAB43214.1
AL442123 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49963.1
CH471066 Genomic DNA Translation: EAW49965.1
CH471066 Genomic DNA Translation: EAW49966.1
BC024315 mRNA Translation: AAH24315.1 Different initiation.
BC053359 mRNA Translation: AAH53359.1
AK023084 mRNA Translation: BAB14396.1 Different initiation.
CCDSiCCDS53561.1 [Q96JN0-2]
CCDS7451.1 [Q96JN0-1]
CCDS86132.1 [Q96JN0-3]
PIRiT08672
RefSeqiNP_001164236.1, NM_001170765.1 [Q96JN0-1]
NP_001164237.1, NM_001170766.1 [Q96JN0-2]
NP_001333445.1, NM_001346516.1 [Q96JN0-3]
NP_115816.2, NM_032440.3 [Q96JN0-1]
XP_016872275.1, XM_017016786.1
XP_016872276.1, XM_017016787.1
XP_016872277.1, XM_017016788.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2COBNMR-A343-405[»]
6V3XX-ray1.70B98-103[»]
6V3YX-ray1.63B5-9[»]
AlphaFoldDBiQ96JN0
SMRiQ96JN0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi117579, 53 interactors
124093, 79 interactors
CORUMiQ96JN0
ELMiQ96JN0
IntActiQ96JN0, 86 interactors
MINTiQ96JN0
STRINGi9606.ENSP00000360138

PTM databases

GlyGeniQ96JN0, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ96JN0
PhosphoSitePlusiQ96JN0

Genetic variation databases

BioMutaiLCOR
DMDMi68565212

Proteomic databases

EPDiQ96JN0
jPOSTiQ96JN0
MassIVEiQ96JN0
MaxQBiQ96JN0
PaxDbiQ96JN0
PeptideAtlasiQ96JN0
PRIDEiQ96JN0
ProteomicsDBi72131
76989 [Q96JN0-1]
76990 [Q96JN0-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		30781, 223 antibodies from 25 providers

The DNASU plasmid repository

More...DNASUi		26148
84458

Genome annotation databases

EnsembliENST00000356016.7; ENSP00000348298.2; ENSG00000196233.14
ENST00000371097.8; ENSP00000360138.3; ENSG00000196233.14
ENST00000371103.8; ENSP00000360144.3; ENSG00000196233.14
ENST00000421806.4; ENSP00000490116.2; ENSG00000196233.14 [Q96JN0-3]
ENST00000540664.6; ENSP00000443431.1; ENSG00000196233.14 [Q96JN0-2]
ENST00000675471.1; ENSP00000502633.1; ENSG00000196233.14
ENST00000675537.1; ENSP00000501560.1; ENSG00000196233.14
ENST00000675971.1; ENSP00000501639.1; ENSG00000196233.14
GeneIDi84458
KEGGihsa:84458
MANE-SelectiENST00000421806.4; ENSP00000490116.2; NM_001346516.2; NP_001333445.1 [Q96JN0-3]
UCSCiuc001kmr.4, human [Q96JN0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		84458
DisGeNETi84458

GeneCards: human genes, protein and diseases

More...GeneCardsi		LCOR
HGNCiHGNC:29503, LCOR
HPAiENSG00000196233, Low tissue specificity
MIMi607698, gene
neXtProtiNX_Q96JN0
OpenTargetsiENSG00000196233
PharmGKBiPA145148487
VEuPathDBiHostDB:ENSG00000196233

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4565, Eukaryota
GeneTreeiENSGT00940000154965
HOGENOMiCLU_040042_0_0_1
InParanoidiQ96JN0
OMAiIYVQSKM
OrthoDBi134164at2759
PhylomeDBiQ96JN0
TreeFamiTF319589
TF332137

Enzyme and pathway databases

PathwayCommonsiQ96JN0
SignaLinkiQ96JN0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		84458, 25 hits in 1108 CRISPR screens
EvolutionaryTraceiQ96JN0

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		LCOR

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		84458
PharosiQ96JN0, Tbio

Protein Ontology

More...PROi		PR:Q96JN0
RNActiQ96JN0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000196233, Expressed in secondary oocyte and 227 other tissues
ExpressionAtlasiQ96JN0, baseline and differential
GenevisibleiQ96JN0, HS

Family and domain databases

InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR007889, HTH_Psq
PfamiView protein in Pfam
PF05225, HTH_psq, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50960, HTH_PSQ, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLCOR_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96JN0
Secondary accession number(s): D3DR47
, Q5VW16, Q7Z723, Q86T32, Q86T33, Q8N3L6, Q8N655, Q9H945, Q9Y457
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: May 25, 2022
This is version 153 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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