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Protein

Ligand-dependent corepressor

Gene

LCOR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi368 – 388H-T-H motifPROSITE-ProRule annotationAdd BLAST21

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Ligand-dependent corepressor
Short name:
LCoR
Alternative name(s):
Mblk1-related protein 2
Gene namesi
Name:LCORImported
Synonyms:C10orf12Imported, KIAA1795Imported, MLR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000155640.6
HostDB:ENSG00000196233.11
HGNCiHGNC:29503 LCOR
MIMi607698 gene
neXtProtiNX_Q96JN0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi56 – 57LL → AA: Loss of estradiol-dependent interaction with ESR1 and ESR2. 1 Publication2

Organism-specific databases

DisGeNETi84458
OpenTargetsiENSG00000196233
PharmGKBiPA134866687
PA145148487

Polymorphism and mutation databases

BioMutaiC10orf12
LCOR
DMDMi68565212

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002368071 – 433Ligand-dependent corepressorAdd BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42PhosphoserineCombined sources1
Modified residuei63PhosphoserineCombined sources1
Modified residuei249PhosphoserineCombined sources1
Cross-linki254Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki414Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 3 (identifier: Q96JN0-3)
Cross-linki345Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sourcesCurated
Cross-linki391Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sourcesCurated
Cross-linki543Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sourcesCurated
Modified residuei583PhosphoserineCombined sourcesCurated1
Modified residuei605PhosphoserineCombined sourcesCurated1
Modified residuei792PhosphoserineCombined sourcesCurated1
Cross-linki976Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sourcesCurated
Modified residuei1048PhosphoserineCombined sourcesCurated1
Modified residuei1077PhosphoserineCombined sourcesCurated1
Modified residuei1214N6,N6-dimethyllysineCombined sourcesCurated1
Modified residuei1219N6,N6-dimethyllysineCombined sourcesCurated1
Modified residuei1274PhosphoserineCombined sourcesCurated1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ96JN0
MaxQBiQ96JN0
PaxDbiQ96JN0
PeptideAtlasiQ96JN0
PRIDEiQ96JN0
ProteomicsDBi72131
76989
76990 [Q96JN0-2]

PTM databases

iPTMnetiQ96JN0
PhosphoSitePlusiQ96JN0

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000196233 Expressed in 214 organ(s), highest expression level in secondary oocyte
CleanExiHS_C10orf12
HS_LCOR
ExpressionAtlasiQ96JN0 baseline and differential
GenevisibleiQ96JN0 HS

Organism-specific databases

HPAiHPA031428
HPA031429
HPA038954
HPA057621
HPA077000

Interactioni

Subunit structurei

Interacts with ESR1 and ESR2 in the presence of estradiol. Interacts with CTBP1, HDAC3 and HDAC6. Component of a large corepressor complex that contains about 20 proteins, including CTBP1, CTBP2, HDAC1 and HDAC2.2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117579, 32 interactors
124093, 48 interactors
CORUMiQ96JN0
ELMiQ96JN0
IntActiQ96JN0, 75 interactors
STRINGi9606.ENSP00000348298

Structurei

Secondary structure

1433
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ96JN0
SMRiQ96JN0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96JN0

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini340 – 392HTH psq-typePROSITE-ProRule annotationAdd BLAST53

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi53 – 57Interaction with nuclear receptors5
Motifi339 – 345Nuclear localization signalSequence analysis7

Phylogenomic databases

eggNOGiENOG410IHUE Eukaryota
KOG4565 Eukaryota
ENOG4111GCI LUCA
ENOG4111MRK LUCA
GeneTreeiENSGT00520000055615
HOGENOMiHOG000111679
HOVERGENiHBG079596
InParanoidiQ96JN0
OrthoDBiEOG091G0N6A
PhylomeDBiQ96JN0
TreeFamiTF319589
TF332137

Family and domain databases

InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR007889 HTH_Psq
PfamiView protein in Pfam
PF05225 HTH_psq, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50960 HTH_PSQ, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96JN0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQRMIQQFAA EYTSKNSSTQ DPSQPNSTKN QSLPKASPVT TSPTAATTQN
60 70 80 90 100
PVLSKLLMAD QDSPLDLTVR KSQSEPSEQD GVLDLSTKKS PCAGSTSLSH
110 120 130 140 150
SPGCSSTQGN GRPGRPSQYR PDGLRSGDGV PPRSLQDGTR EGFGHSTSLK
160 170 180 190 200
VPLARSLQIS EELLSRNQLS TAASLGPSGL QNHGQHLILS REASWAKPHY
210 220 230 240 250
EFNLSRMKFR GNGALSNISD LPFLAENSAF PKMALQAKQD GKKDVSHSSP
260 270 280 290 300
VDLKIPQVRG MDLSWESRTG DQYSYSSLVM GSQTESALSK KLRAILPKQS
310 320 330 340 350
RKSMLDAGPD SWGSDAEQST SGQPYPTSDQ EGDPGSKQPR KKRGRYRQYN
360 370 380 390 400
SEILEEAISV VMSGKMSVSK AQSIYGIPHS TLEYKVKERL GTLKNPPKKK
410 420 430
MKLMRSEGPD VSVKIELDPQ GEAAQSANES KNE
Length:433
Mass (Da):47,007
Last modified:May 30, 2006 - v2
Checksum:i5F934FE687417740
GO
Isoform 2 (identifier: Q96JN0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     405-406: RS → SG
     407-433: Missing.

Show »
Length:406
Mass (Da):44,083
Checksum:iACE760CF3CB1F2EF
GO
Isoform 3 (identifier: Q96JN0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-433: RPGRPSQYRP...AQSANESKNE → ENSTEAKAVD...HSKRRRLDAK

Show »
Length:1,557
Mass (Da):170,478
Checksum:iA16B9688C8FC40E4
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1P0AZG4A0A1P0AZG4_HUMAN
Ligand-dependent corepressor
LCOR
1,247Annotation score:

Sequence cautioni

The sequence AAH24315 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14396 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB47424 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6Q → P in CAD91159 (PubMed:17974005).Curated1
Sequence conflicti321S → P in CAD38921 (PubMed:17974005).Curated1
Isoform 3 (identifier: Q96JN0-3)
Sequence conflicti922E → G in BAB14396 (PubMed:14702039).Combined sourcesCurated1
Sequence conflicti1209D → G in BAB14396 (PubMed:14702039).Combined sourcesCurated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_058760112 – 433RPGRP…ESKNE → ENSTEAKAVDSNNQSKSPLE KFMVKLCTHHQKQFIRVLND LYTESQPGTEDLQPSDSGAM DVSTCNAGCAQLSTKHKEKD ALCLDMKSSASVDLFVDSSD SHSPLHLTEQTPKKPPPEIN PVDGRENALTVVQKDSSELP TTKSNSINSSSVDSFTPGYL TASNCSSVNFHHIPKILEGQ TTGQEQDTNVNICEDGKDHM QSSALVESLITVKMAAENSE EGNTCIIPQRNLFKALSEEA WNSGFMGNSSRTADKENTLQ CPKTPLRQDLEANEQDARPK QENHLHSLGRNKVGYHLHPS DKGQFDHSKDGWLGPGPMPA VHKAANGHSRTKMISTSIKT ARKSKRASGLRINDYDNQCD VVYISQPITECHFENQKSIL SSRKTARKSTRGYFFNGDCC ELPTVRTLARNLHSQEKASC SALASEAVFTPKQTLTIPAP RHTVDVQLPREDNPEEPSKE ITSHEEGGGDVSPRKEPQEP EVCPTKIKPNLSSSPRSEET TASSLVWPLPAHLPEEDLPE GGSTVSAPTASGMSSPEHNQ PPVALLDTEEMSVPQDCHLL PSTESFSGGVSEDVISRPHS PPEIVSREESPQCSENQSSP MGLEPPMSLGKAEDNQSISA EVESGDTQELNVDPLLKESS TFTDENPSETEESEAAGGIG KLEGEDGDVKCLSEKDTYDT SIDSLEENLDKKKKGKKFPE ASDRCLRSQLSDSSSADRCL RNQSSDSSSACLEIKVPKNP SAKRSKKEGHPGGTTPKGLL PDSFHTETLEDTEKPSVNER PSEKDAEQEGEGGGIITRQT LKNMLDKEVKELRGEIFPSR DPITTAGQPLPGERLEIYVQ SKMDEKNAHIPSESIACKRD PEQAKEEPGHIPTQHVEEAV NEVDNENTQQKDDESDAPCS SLGLSSSGSGDAARAPKSVP RPKRLTSSTYNLRHAHSLGS LDASKVTSEKEAAQVNPIMP KENGASESGDPLDEDDVDTV VDEQPKFMEWCAEEENQELI ANFNAQYMKVQKGWIQLEKE GQPTPRARNKSDKLKEIWKS KKRSRKCRSSLESQKCSPVQ MLFMTNFKLSNVCKWFLETT ETRSLVIVKKLNTRLPGDVP PVKHPLQKYAPSSLYPSSLQ AERLKKHLKKFPGATPAKNN WKMQKLWAKFRENPDQVEPE DGSDVSPGPNSEDSIEEVKE DRNSHPPANLPTPASTRILR KYSNIRGKLRAQQRLIKNEK MECPDALAVESKPSRKSVCI NPLMSPKLALQVDADGFPVK PKSTEGMKGRKGKQVSEILP KAEVQSKRKRTEGSSPPDSK NKGPTVKASKEKHADGATKT PAAKRPAARDRSSQPPKKTS LKENKVKIPKKSAGKSCPPS RKEKENTNKRPSQSIASETL TKPAKQKGAGESSSRPQKAT NRKQSSGKTRARPSTKTPES SAAQRKRKLKAKLDCSHSKR RRLDAK in isoform 3. Add BLAST322
Alternative sequenceiVSP_018585405 – 406RS → SG in isoform 2. 1 Publication2
Alternative sequenceiVSP_018586407 – 433Missing in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058698 mRNA Translation: BAB47424.1 Different initiation.
AL834245 mRNA Translation: CAD38921.2
AL832106 mRNA Translation: CAD91159.1
AL832044 mRNA Translation: CAD91160.1
AL049938 mRNA Translation: CAB43214.1
AL442123 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49963.1
CH471066 Genomic DNA Translation: EAW49965.1
CH471066 Genomic DNA Translation: EAW49966.1
BC024315 mRNA Translation: AAH24315.1 Different initiation.
BC053359 mRNA Translation: AAH53359.1
AK023084 mRNA Translation: BAB14396.1 Different initiation.
CCDSiCCDS53561.1 [Q96JN0-2]
CCDS7451.1 [Q96JN0-1]
CCDS86132.1 [Q96JN0-3]
PIRiT08672
RefSeqiNP_001164236.1, NM_001170765.1 [Q96JN0-1]
NP_001164237.1, NM_001170766.1 [Q96JN0-2]
NP_001333445.1, NM_001346516.1 [Q96JN0-3]
NP_115816.2, NM_032440.3 [Q96JN0-1]
XP_016872275.1, XM_017016786.1
XP_016872276.1, XM_017016787.1
XP_016872277.1, XM_017016788.1
UniGeneiHs.427927
Hs.734580
Hs.745068

Genome annotation databases

EnsembliENST00000356016; ENSP00000348298; ENSG00000196233 [Q96JN0-1]
ENST00000371097; ENSP00000360138; ENSG00000196233 [Q96JN0-1]
ENST00000371103; ENSP00000360144; ENSG00000196233 [Q96JN0-1]
ENST00000421806; ENSP00000490116; ENSG00000196233 [Q96JN0-3]
ENST00000540664; ENSP00000443431; ENSG00000196233 [Q96JN0-2]
GeneIDi84458
KEGGihsa:84458
UCSCiuc001kmr.4 human [Q96JN0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058698 mRNA Translation: BAB47424.1 Different initiation.
AL834245 mRNA Translation: CAD38921.2
AL832106 mRNA Translation: CAD91159.1
AL832044 mRNA Translation: CAD91160.1
AL049938 mRNA Translation: CAB43214.1
AL442123 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49963.1
CH471066 Genomic DNA Translation: EAW49965.1
CH471066 Genomic DNA Translation: EAW49966.1
BC024315 mRNA Translation: AAH24315.1 Different initiation.
BC053359 mRNA Translation: AAH53359.1
AK023084 mRNA Translation: BAB14396.1 Different initiation.
CCDSiCCDS53561.1 [Q96JN0-2]
CCDS7451.1 [Q96JN0-1]
CCDS86132.1 [Q96JN0-3]
PIRiT08672
RefSeqiNP_001164236.1, NM_001170765.1 [Q96JN0-1]
NP_001164237.1, NM_001170766.1 [Q96JN0-2]
NP_001333445.1, NM_001346516.1 [Q96JN0-3]
NP_115816.2, NM_032440.3 [Q96JN0-1]
XP_016872275.1, XM_017016786.1
XP_016872276.1, XM_017016787.1
XP_016872277.1, XM_017016788.1
UniGeneiHs.427927
Hs.734580
Hs.745068

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2COBNMR-A343-405[»]
ProteinModelPortaliQ96JN0
SMRiQ96JN0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117579, 32 interactors
124093, 48 interactors
CORUMiQ96JN0
ELMiQ96JN0
IntActiQ96JN0, 75 interactors
STRINGi9606.ENSP00000348298

PTM databases

iPTMnetiQ96JN0
PhosphoSitePlusiQ96JN0

Polymorphism and mutation databases

BioMutaiC10orf12
LCOR
DMDMi68565212

Proteomic databases

EPDiQ96JN0
MaxQBiQ96JN0
PaxDbiQ96JN0
PeptideAtlasiQ96JN0
PRIDEiQ96JN0
ProteomicsDBi72131
76989
76990 [Q96JN0-2]

Protocols and materials databases

DNASUi26148
84458
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356016; ENSP00000348298; ENSG00000196233 [Q96JN0-1]
ENST00000371097; ENSP00000360138; ENSG00000196233 [Q96JN0-1]
ENST00000371103; ENSP00000360144; ENSG00000196233 [Q96JN0-1]
ENST00000421806; ENSP00000490116; ENSG00000196233 [Q96JN0-3]
ENST00000540664; ENSP00000443431; ENSG00000196233 [Q96JN0-2]
GeneIDi84458
KEGGihsa:84458
UCSCiuc001kmr.4 human [Q96JN0-1]

Organism-specific databases

CTDi84458
DisGeNETi84458
EuPathDBiHostDB:ENSG00000155640.6
HostDB:ENSG00000196233.11
GeneCardsiLCOR
H-InvDBiHIX0170441
HGNCiHGNC:29503 LCOR
HPAiHPA031428
HPA031429
HPA038954
HPA057621
HPA077000
MIMi607698 gene
neXtProtiNX_Q96JN0
OpenTargetsiENSG00000196233
PharmGKBiPA134866687
PA145148487
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHUE Eukaryota
KOG4565 Eukaryota
ENOG4111GCI LUCA
ENOG4111MRK LUCA
GeneTreeiENSGT00520000055615
HOGENOMiHOG000111679
HOVERGENiHBG079596
InParanoidiQ96JN0
OrthoDBiEOG091G0N6A
PhylomeDBiQ96JN0
TreeFamiTF319589
TF332137

Miscellaneous databases

ChiTaRSiLCOR human
EvolutionaryTraceiQ96JN0
GeneWikiiLCOR
GenomeRNAii84458
PROiPR:Q96JN0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196233 Expressed in 214 organ(s), highest expression level in secondary oocyte
CleanExiHS_C10orf12
HS_LCOR
ExpressionAtlasiQ96JN0 baseline and differential
GenevisibleiQ96JN0 HS

Family and domain databases

InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR007889 HTH_Psq
PfamiView protein in Pfam
PF05225 HTH_psq, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50960 HTH_PSQ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLCOR_HUMAN
AccessioniPrimary (citable) accession number: Q96JN0
Secondary accession number(s): D3DR47
, Q5VW16, Q7Z723, Q86T32, Q86T33, Q8N3L6, Q8N655, Q9H945, Q9Y457
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: October 10, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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