Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 164 (31 Jul 2019)
Sequence version 2 (26 Apr 2005)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Lethal(3)malignant brain tumor-like protein 3

Gene

L3MBTL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri549 – 593CCHHC-type; degeneratePROSITE-ProRule annotationAdd BLAST45

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lethal(3)malignant brain tumor-like protein 3
Short name:
H-l(3)mbt-like protein 3
Short name:
L(3)mbt-like protein 3
Alternative name(s):
MBT-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:L3MBTL3
Synonyms:KIAA1798, MBT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23035 L3MBTL3

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96JM7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84456

Open Targets

More...
OpenTargetsi
ENSG00000198945

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134943930

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1287623

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2830

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
L3MBTL3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
62900619

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000844501 – 780Lethal(3)malignant brain tumor-like protein 3Add BLAST780

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei608PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki637Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki704Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96JM7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96JM7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96JM7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96JM7

PeptideAtlas

More...
PeptideAtlasi
Q96JM7

PRoteomics IDEntifications database

More...
PRIDEi
Q96JM7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
76987 [Q96JM7-1]
76988 [Q96JM7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96JM7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96JM7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q96JM7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198945 Expressed in 162 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96JM7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96JM7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA044382
HPA053035

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RNF2.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124091, 48 interactors

Database of interacting proteins

More...
DIPi
DIP-42798N

Protein interaction database and analysis system

More...
IntActi
Q96JM7, 76 interactors

Molecular INTeraction database

More...
MINTi
Q96JM7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000431962

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q96JM7

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1780
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96JM7

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q96JM7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati232 – 332MBT 1Add BLAST101
Repeati340 – 439MBT 2Add BLAST100
Repeati448 – 543MBT 3Add BLAST96
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini708 – 772SAMPROSITE-ProRule annotationAdd BLAST65

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri549 – 593CCHHC-type; degeneratePROSITE-ProRule annotationAdd BLAST45

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3766 Eukaryota
ENOG410Y4AQ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159800

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231019

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96JM7

Identification of Orthologs from Complete Genome Data

More...
OMAi
EYQSFPY

Database of Orthologous Groups

More...
OrthoDBi
903801at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96JM7

TreeFam database of animal gene trees

More...
TreeFami
TF316498

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004092 Mbt
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR002515 Znf_C2H2C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02820 MBT, 3 hits
PF00536 SAM_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00561 MBT, 3 hits
SM00454 SAM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51079 MBT, 3 hits
PS50105 SAM_DOMAIN, 1 hit
PS51802 ZF_CCHHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96JM7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTESASSTSG QEFDVFSVMD WKDGVGTLPG SDLKFRVNEF GALEVITDEN
60 70 80 90 100
EMENVKKATA TTTWMVPTAQ EAPTSPPSSR PVFPPAYWTS PPGCPTVFSE
110 120 130 140 150
KTGMPFRLKD PVKVEGLQFC ENCCQYGNVD ECLSGGNYCS QNCARHIKDK
160 170 180 190 200
DQKEERDVEE DNEEEDPKCS RKKKPKLSLK ADTKEDGEER DDEMENKQDV
210 220 230 240 250
RILRGSQRAR RKRRGDSAVL KQGLPPKGKK AWCWASYLEE EKAVAVPAKL
260 270 280 290 300
FKEHQSFPYN KNGFKVGMKL EGVDPEHQSV YCVLTVAEVC GYRIKLHFDG
310 320 330 340 350
YSDCYDFWVN ADALDIHPVG WCEKTGHKLH PPKGYKEEEF NWQTYLKTCK
360 370 380 390 400
AQAAPKSLFE NQNITVIPSG FRVGMKLEAV DKKNPSFICV ATVTDMVDNR
410 420 430 440 450
FLVHFDNWDE SYDYWCEASS PHIHPVGWCK EHRRTLITPP GYPNVKHFSW
460 470 480 490 500
DKYLEETNSL PAPARAFKVK PPHGFQKKMK LEVVDKRNPM FIRVATVADT
510 520 530 540 550
DDHRVKVHFD GWNNCYDYWI DADSPDIHPV GWCSKTGHPL QPPLSPLELM
560 570 580 590 600
EASEHGGCST PGCKGIGHFK RARHLGPHSA ANCPYSEINL NKDRIFPDRL
610 620 630 640 650
SGEMPPASPS FPRNKRTDAN ESSSSPEIRD QHADDVKEDF EERTESEMRT
660 670 680 690 700
SHEARGAREE PTVQQAQRRS AVFLSFKSPI PCLPLRWEQQ SKLLPTVAGI
710 720 730 740 750
PASKVSKWST DEVSEFIQSL PGCEEHGKVF KDEQIDGEAF LLMTQTDIVK
760 770 780
IMSIKLGPAL KIFNSILMFK AAEKNSHNEL
Length:780
Mass (Da):88,337
Last modified:April 26, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i81F92D4423E25C84
GO
Isoform 2 (identifier: Q96JM7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-96: Missing.

Show »
Length:755
Mass (Da):85,757
Checksum:iCC4B216CF46941EC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PLL7E9PLL7_HUMAN
Lethal(3)malignant brain tumor-like...
L3MBTL3
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PI01E9PI01_HUMAN
Lethal(3)malignant brain tumor-like...
L3MBTL3
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB47427 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_022368183T → N2 PublicationsCorresponds to variant dbSNP:rs9388768Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01350872 – 96Missing in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB058701 mRNA Translation: BAB47427.1 Different initiation.
AL583846 Genomic DNA No translation available.
AL355581 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48073.1
BC060845 mRNA Translation: AAH60845.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34537.1 [Q96JM7-1]
CCDS34538.1 [Q96JM7-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001007103.1, NM_001007102.3 [Q96JM7-2]
NP_001333479.1, NM_001346550.1 [Q96JM7-2]
NP_001333480.1, NM_001346551.1 [Q96JM7-2]
NP_115814.1, NM_032438.3 [Q96JM7-1]
XP_005267218.1, XM_005267161.4 [Q96JM7-1]
XP_006715641.1, XM_006715578.3 [Q96JM7-1]
XP_011534481.1, XM_011536179.2 [Q96JM7-1]
XP_011534482.1, XM_011536180.2 [Q96JM7-1]
XP_011534483.1, XM_011536181.2 [Q96JM7-1]
XP_011534485.1, XM_011536183.2 [Q96JM7-1]
XP_011534486.1, XM_011536184.2 [Q96JM7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000361794; ENSP00000354526; ENSG00000198945 [Q96JM7-1]
ENST00000368136; ENSP00000357118; ENSG00000198945 [Q96JM7-1]
ENST00000368139; ENSP00000357121; ENSG00000198945 [Q96JM7-2]
ENST00000526019; ENSP00000436706; ENSG00000198945 [Q96JM7-2]
ENST00000529410; ENSP00000431962; ENSG00000198945 [Q96JM7-1]
ENST00000533560; ENSP00000437185; ENSG00000198945 [Q96JM7-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84456

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84456

UCSC genome browser

More...
UCSCi
uc003qbt.4 human [Q96JM7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058701 mRNA Translation: BAB47427.1 Different initiation.
AL583846 Genomic DNA No translation available.
AL355581 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48073.1
BC060845 mRNA Translation: AAH60845.1
CCDSiCCDS34537.1 [Q96JM7-1]
CCDS34538.1 [Q96JM7-2]
RefSeqiNP_001007103.1, NM_001007102.3 [Q96JM7-2]
NP_001333479.1, NM_001346550.1 [Q96JM7-2]
NP_001333480.1, NM_001346551.1 [Q96JM7-2]
NP_115814.1, NM_032438.3 [Q96JM7-1]
XP_005267218.1, XM_005267161.4 [Q96JM7-1]
XP_006715641.1, XM_006715578.3 [Q96JM7-1]
XP_011534481.1, XM_011536179.2 [Q96JM7-1]
XP_011534482.1, XM_011536180.2 [Q96JM7-1]
XP_011534483.1, XM_011536181.2 [Q96JM7-1]
XP_011534485.1, XM_011536183.2 [Q96JM7-1]
XP_011534486.1, XM_011536184.2 [Q96JM7-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WJQNMR-A469-562[»]
1WJSNMR-A258-371[»]
3UT1X-ray2.05A228-551[»]
4FL6X-ray2.55A/B229-553[»]
4L59X-ray2.29A228-544[»]
SMRiQ96JM7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi124091, 48 interactors
DIPiDIP-42798N
IntActiQ96JM7, 76 interactors
MINTiQ96JM7
STRINGi9606.ENSP00000431962

Chemistry databases

BindingDBiQ96JM7
ChEMBLiCHEMBL1287623
GuidetoPHARMACOLOGYi2830

PTM databases

iPTMnetiQ96JM7
PhosphoSitePlusiQ96JM7
SwissPalmiQ96JM7

Polymorphism and mutation databases

BioMutaiL3MBTL3
DMDMi62900619

Proteomic databases

EPDiQ96JM7
jPOSTiQ96JM7
MaxQBiQ96JM7
PaxDbiQ96JM7
PeptideAtlasiQ96JM7
PRIDEiQ96JM7
ProteomicsDBi76987 [Q96JM7-1]
76988 [Q96JM7-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
84456
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361794; ENSP00000354526; ENSG00000198945 [Q96JM7-1]
ENST00000368136; ENSP00000357118; ENSG00000198945 [Q96JM7-1]
ENST00000368139; ENSP00000357121; ENSG00000198945 [Q96JM7-2]
ENST00000526019; ENSP00000436706; ENSG00000198945 [Q96JM7-2]
ENST00000529410; ENSP00000431962; ENSG00000198945 [Q96JM7-1]
ENST00000533560; ENSP00000437185; ENSG00000198945 [Q96JM7-2]
GeneIDi84456
KEGGihsa:84456
UCSCiuc003qbt.4 human [Q96JM7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84456
DisGeNETi84456

GeneCards: human genes, protein and diseases

More...
GeneCardsi
L3MBTL3
HGNCiHGNC:23035 L3MBTL3
HPAiHPA044382
HPA053035
neXtProtiNX_Q96JM7
OpenTargetsiENSG00000198945
PharmGKBiPA134943930

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3766 Eukaryota
ENOG410Y4AQ LUCA
GeneTreeiENSGT00940000159800
HOGENOMiHOG000231019
InParanoidiQ96JM7
OMAiEYQSFPY
OrthoDBi903801at2759
PhylomeDBiQ96JM7
TreeFamiTF316498

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
L3MBTL3 human
EvolutionaryTraceiQ96JM7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84456

Protein Ontology

More...
PROi
PR:Q96JM7

Gene expression databases

BgeeiENSG00000198945 Expressed in 162 organ(s), highest expression level in testis
ExpressionAtlasiQ96JM7 baseline and differential
GenevisibleiQ96JM7 HS

Family and domain databases

Gene3Di1.10.150.50, 1 hit
InterProiView protein in InterPro
IPR004092 Mbt
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR002515 Znf_C2H2C
PfamiView protein in Pfam
PF02820 MBT, 3 hits
PF00536 SAM_1, 1 hit
SMARTiView protein in SMART
SM00561 MBT, 3 hits
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS51079 MBT, 3 hits
PS50105 SAM_DOMAIN, 1 hit
PS51802 ZF_CCHHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLMBL3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96JM7
Secondary accession number(s): Q4VXE1, Q5VUM9, Q6P9B5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: July 31, 2019
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again