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Protein

Lethal(3)malignant brain tumor-like protein 3

Gene

L3MBTL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri549 – 593CCHHC-type; degeneratePROSITE-ProRule annotationAdd BLAST45

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Lethal(3)malignant brain tumor-like protein 3
Short name:
H-l(3)mbt-like protein 3
Short name:
L(3)mbt-like protein 3
Alternative name(s):
MBT-1
Gene namesi
Name:L3MBTL3
Synonyms:KIAA1798, MBT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000198945.7
HGNCiHGNC:23035 L3MBTL3
neXtProtiNX_Q96JM7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi84456
OpenTargetsiENSG00000198945
PharmGKBiPA134943930

Chemistry databases

ChEMBLiCHEMBL1287623
GuidetoPHARMACOLOGYi2830

Polymorphism and mutation databases

BioMutaiL3MBTL3
DMDMi62900619

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000844501 – 780Lethal(3)malignant brain tumor-like protein 3Add BLAST780

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei608PhosphoserineCombined sources1
Cross-linki637Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki704Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ96JM7
MaxQBiQ96JM7
PaxDbiQ96JM7
PeptideAtlasiQ96JM7
PRIDEiQ96JM7
ProteomicsDBi76987
76988 [Q96JM7-2]

PTM databases

iPTMnetiQ96JM7
PhosphoSitePlusiQ96JM7
SwissPalmiQ96JM7

Expressioni

Gene expression databases

BgeeiENSG00000198945
CleanExiHS_L3MBTL3
ExpressionAtlasiQ96JM7 baseline and differential
GenevisibleiQ96JM7 HS

Organism-specific databases

HPAiHPA044382
HPA053035

Interactioni

Subunit structurei

Interacts with RNF2.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi124091, 38 interactors
DIPiDIP-42798N
IntActiQ96JM7, 75 interactors
MINTiQ96JM7
STRINGi9606.ENSP00000354526

Chemistry databases

BindingDBiQ96JM7

Structurei

Secondary structure

1780
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi234 – 241Combined sources8
Helixi248 – 250Combined sources3
Turni253 – 255Combined sources3
Beta strandi269 – 274Combined sources6
Beta strandi277 – 290Combined sources14
Beta strandi293 – 298Combined sources6
Helixi303 – 305Combined sources3
Beta strandi307 – 310Combined sources4
Beta strandi314 – 317Combined sources4
Helixi321 – 325Combined sources5
Turni337 – 339Combined sources3
Helixi342 – 348Combined sources7
Helixi356 – 358Combined sources3
Turni360 – 363Combined sources4
Beta strandi376 – 381Combined sources6
Beta strandi384 – 397Combined sources14
Beta strandi400 – 405Combined sources6
Helixi410 – 412Combined sources3
Beta strandi414 – 416Combined sources3
Helixi428 – 431Combined sources4
Helixi445 – 447Combined sources3
Helixi450 – 456Combined sources7
Helixi464 – 466Combined sources3
Beta strandi472 – 474Combined sources3
Beta strandi480 – 484Combined sources5
Beta strandi486 – 488Combined sources3
Beta strandi492 – 500Combined sources9
Beta strandi502 – 509Combined sources8
Beta strandi510 – 512Combined sources3
Helixi514 – 516Combined sources3
Beta strandi518 – 521Combined sources4
Helixi532 – 536Combined sources5
Turni546 – 549Combined sources4

3D structure databases

ProteinModelPortaliQ96JM7
SMRiQ96JM7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96JM7

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati232 – 332MBT 1Add BLAST101
Repeati340 – 439MBT 2Add BLAST100
Repeati448 – 543MBT 3Add BLAST96
Domaini708 – 772SAMPROSITE-ProRule annotationAdd BLAST65

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri549 – 593CCHHC-type; degeneratePROSITE-ProRule annotationAdd BLAST45

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3766 Eukaryota
ENOG410Y4AQ LUCA
GeneTreeiENSGT00760000119024
HOGENOMiHOG000231019
HOVERGENiHBG071375
InParanoidiQ96JM7
OMAiDPEHQSV
OrthoDBiEOG091G01BW
PhylomeDBiQ96JM7
TreeFamiTF316498

Family and domain databases

InterProiView protein in InterPro
IPR004092 Mbt
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR002515 Znf_C2HC
PfamiView protein in Pfam
PF02820 MBT, 3 hits
PF00536 SAM_1, 1 hit
SMARTiView protein in SMART
SM00561 MBT, 3 hits
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS51079 MBT, 3 hits
PS50105 SAM_DOMAIN, 1 hit
PS51802 ZF_CCHHC, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96JM7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTESASSTSG QEFDVFSVMD WKDGVGTLPG SDLKFRVNEF GALEVITDEN
60 70 80 90 100
EMENVKKATA TTTWMVPTAQ EAPTSPPSSR PVFPPAYWTS PPGCPTVFSE
110 120 130 140 150
KTGMPFRLKD PVKVEGLQFC ENCCQYGNVD ECLSGGNYCS QNCARHIKDK
160 170 180 190 200
DQKEERDVEE DNEEEDPKCS RKKKPKLSLK ADTKEDGEER DDEMENKQDV
210 220 230 240 250
RILRGSQRAR RKRRGDSAVL KQGLPPKGKK AWCWASYLEE EKAVAVPAKL
260 270 280 290 300
FKEHQSFPYN KNGFKVGMKL EGVDPEHQSV YCVLTVAEVC GYRIKLHFDG
310 320 330 340 350
YSDCYDFWVN ADALDIHPVG WCEKTGHKLH PPKGYKEEEF NWQTYLKTCK
360 370 380 390 400
AQAAPKSLFE NQNITVIPSG FRVGMKLEAV DKKNPSFICV ATVTDMVDNR
410 420 430 440 450
FLVHFDNWDE SYDYWCEASS PHIHPVGWCK EHRRTLITPP GYPNVKHFSW
460 470 480 490 500
DKYLEETNSL PAPARAFKVK PPHGFQKKMK LEVVDKRNPM FIRVATVADT
510 520 530 540 550
DDHRVKVHFD GWNNCYDYWI DADSPDIHPV GWCSKTGHPL QPPLSPLELM
560 570 580 590 600
EASEHGGCST PGCKGIGHFK RARHLGPHSA ANCPYSEINL NKDRIFPDRL
610 620 630 640 650
SGEMPPASPS FPRNKRTDAN ESSSSPEIRD QHADDVKEDF EERTESEMRT
660 670 680 690 700
SHEARGAREE PTVQQAQRRS AVFLSFKSPI PCLPLRWEQQ SKLLPTVAGI
710 720 730 740 750
PASKVSKWST DEVSEFIQSL PGCEEHGKVF KDEQIDGEAF LLMTQTDIVK
760 770 780
IMSIKLGPAL KIFNSILMFK AAEKNSHNEL
Length:780
Mass (Da):88,337
Last modified:April 26, 2005 - v2
Checksum:i81F92D4423E25C84
GO
Isoform 2 (identifier: Q96JM7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-96: Missing.

Show »
Length:755
Mass (Da):85,757
Checksum:iCC4B216CF46941EC
GO

Sequence cautioni

The sequence BAB47427 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022368183T → N2 PublicationsCorresponds to variant dbSNP:rs9388768Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01350872 – 96Missing in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058701 mRNA Translation: BAB47427.1 Different initiation.
AL583846 Genomic DNA No translation available.
AL355581 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48073.1
BC060845 mRNA Translation: AAH60845.1
CCDSiCCDS34537.1 [Q96JM7-1]
CCDS34538.1 [Q96JM7-2]
RefSeqiNP_001007103.1, NM_001007102.3 [Q96JM7-2]
NP_001333479.1, NM_001346550.1 [Q96JM7-2]
NP_001333480.1, NM_001346551.1 [Q96JM7-2]
NP_115814.1, NM_032438.3 [Q96JM7-1]
XP_005267218.1, XM_005267161.4 [Q96JM7-1]
XP_006715641.1, XM_006715578.3 [Q96JM7-1]
XP_011534481.1, XM_011536179.2 [Q96JM7-1]
XP_011534482.1, XM_011536180.2 [Q96JM7-1]
XP_011534483.1, XM_011536181.2 [Q96JM7-1]
XP_011534485.1, XM_011536183.2 [Q96JM7-1]
XP_011534486.1, XM_011536184.2 [Q96JM7-1]
UniGeneiHs.658051

Genome annotation databases

EnsembliENST00000361794; ENSP00000354526; ENSG00000198945 [Q96JM7-1]
ENST00000368136; ENSP00000357118; ENSG00000198945 [Q96JM7-1]
ENST00000368139; ENSP00000357121; ENSG00000198945 [Q96JM7-2]
ENST00000526019; ENSP00000436706; ENSG00000198945 [Q96JM7-2]
ENST00000529410; ENSP00000431962; ENSG00000198945 [Q96JM7-1]
ENST00000533560; ENSP00000437185; ENSG00000198945 [Q96JM7-2]
GeneIDi84456
KEGGihsa:84456
UCSCiuc003qbt.4 human [Q96JM7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLMBL3_HUMAN
AccessioniPrimary (citable) accession number: Q96JM7
Secondary accession number(s): Q4VXE1, Q5VUM9, Q6P9B5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: July 18, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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