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Entry version 116 (08 May 2019)
Sequence version 3 (08 Feb 2011)
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Protein

Leucine-rich repeat and IQ domain-containing protein 1

Gene

LRRIQ1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat and IQ domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRRIQ1
Synonyms:KIAA1801
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25708 LRRIQ1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96JM4

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000133640

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134962087

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LRRIQ1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
322510118

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003136251 – 1722Leucine-rich repeat and IQ domain-containing protein 1Add BLAST1722

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96JM4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96JM4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96JM4

PeptideAtlas

More...
PeptideAtlasi
Q96JM4

PRoteomics IDEntifications database

More...
PRIDEi
Q96JM4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
76985
76986 [Q96JM4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96JM4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96JM4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000133640 Expressed in 81 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96JM4 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA046162

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123899, 31 interactors

Protein interaction database and analysis system

More...
IntActi
Q96JM4, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000376910

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96JM4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini283 – 312IQ 1PROSITE-ProRule annotationAdd BLAST30
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati819 – 840LRR 1Add BLAST22
Repeati841 – 861LRR 2Add BLAST21
Repeati862 – 883LRR 3Add BLAST22
Repeati884 – 905LRR 4Add BLAST22
Repeati970 – 991LRR 5Add BLAST22
Repeati992 – 1013LRR 6Add BLAST22
Repeati1014 – 1035LRR 7Add BLAST22
Repeati1036 – 1057LRR 8Add BLAST22
Repeati1060 – 1081LRR 9Add BLAST22
Repeati1082 – 1103LRR 10Add BLAST22
Domaini1117 – 1157LRRCTAdd BLAST41
Domaini1335 – 1364IQ 2PROSITE-ProRule annotationAdd BLAST30
Domaini1395 – 1424IQ 3PROSITE-ProRule annotationAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi162 – 376Glu-richAdd BLAST215

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0531 Eukaryota
COG4886 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162858

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113381

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96JM4

Identification of Orthologs from Complete Genome Data

More...
OMAi
ETINCEN

Database of Orthologous Groups

More...
OrthoDBi
433355at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96JM4

TreeFam database of animal gene trees

More...
TreeFami
TF333460

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00612 IQ, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00015 IQ, 3 hits
SM00369 LRR_TYP, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096 IQ, 3 hits
PS51450 LRR, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96JM4-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDDDDAKLKA EIEAELDKLS ISSLEKEDIE SDAKSETQSD DSDTDSVELP
60 70 80 90 100
ESVLHCINII KNRSKAVEEL ILQDLEDTDI LSCSYGAVSN NHMHLRTGLS
110 120 130 140 150
TEYEESSEQL IKILSEIEKE EFMRSKTDCA TPDFVPEPSP HDLPMDEHVL
160 170 180 190 200
PDDADINFGY CEVEEKCRQS FEAWQEKQKE LEDKEKQTLK AQRDREEKQF
210 220 230 240 250
QEEEEKRHCW MKQFKVEKKK LENIQKQEQD KMNDELYKEE KIWKEKFKQH
260 270 280 290 300
EEYIRNLHLQ MEEERTRFKD QQEKEKNSLL KQQNNAAVKI QAKYKAFVAY
310 320 330 340 350
QKYGPIIKEQ IESKKRKAQE WKEKEAKIRQ KEEENRKRLE EEQRIKEERK
360 370 380 390 400
KQKEEERKRR EKEYEEKKNI VKQEREQLIS KEKIILREDA SQQLIISSAL
410 420 430 440 450
KKSGYNNKHL SLEDISNDKG DIAKNLVDEN SKKQEDVLLW LVEESNMKEN
460 470 480 490 500
VDRQTILKES IQVKLKESIS SQTILADFKM EEKNENLAKK RCSEELVKQE
510 520 530 540 550
RKYENTDNKT ELGNSDLKGN LKEQFPLQEL KSDAQKEEKI MKHVINENTG
560 570 580 590 600
QKTQIILGHN QEISEVKTNE EQKIIKDNQQ KKIQKVEKEE IQEQNGLLYK
610 620 630 640 650
DKDTLVISVK QRSLSLTSEN SKDVRENVIL QEKEIYSKSK EIEENPKDNA
660 670 680 690 700
WNSGIVIFNT TDTMINIEGK RNDQDYVLGR HAPCEGLSNY NAESSMVSKE
710 720 730 740 750
VNSLKSEIRN ISEKCHENAP EPDSMTCCVS ESTLLYSIEE RRLAWIKSFK
760 770 780 790 800
PWLEIFKQNQ QKKIVRRKRP VKCPANMTPA LDKLEILRCG PWDTLQQVTT
810 820 830 840 850
VTFQDLPGCV LSTLAECTNL QFLSLRRCGL TSLHSLSNCK KLKYIDAQEN
860 870 880 890 900
HIEAIECENL ENLCVVLLNK NQLTSLHGLD GCTNIQCLEL SYNKITRIGY
910 920 930 940 950
SFFLEEKLVD NAGFCHHLGT STSYLSLAQV WIPTGLCWSW IPITSLTKNS
960 970 980 990 1000
DCNFLISHLY WNCGLESLKN LQQLILDHNQ LINTKGLCDT PTIVYLDCSH
1010 1020 1030 1040 1050
NHLTDVEGVE NCGLLQILKL QGNYLSELPS LENLVLLREL HLDDNSISTV
1060 1070 1080 1090 1100
EAFSSYWLPL LQNITISQNS LTKIVPLFHF VSLEKLDVSH NCLSDLKSAI
1110 1120 1130 1140 1150
KWFDACYSLH ELSLTGNPLL QETNWRDSLL KVLPALRILN GNILNSNSES
1160 1170 1180 1190 1200
RTEEHNQLGS AGFLALCQSQ IREFNLLIEN YITGKGDVFT LDTAENLCHY
1210 1220 1230 1240 1250
FKKLMILSTE YRHAHERGDV TITKKDESEA QKNHLAPTNS DSTLQNGVFY
1260 1270 1280 1290 1300
SCAREGEPDS PDIPEKWMDS VSSHSPLSKS ATCENMEGRH QEILVCQKRE
1310 1320 1330 1340 1350
DSKASSIPTI RIPFKEVVMT NSLLRNHQNI EPSEKIMAAV VIQSYWRGYL
1360 1370 1380 1390 1400
MRRQTHFSTR LHTAATEGLP NSSIKNQTIL KKGKRENIVN IRKQREKAAI
1410 1420 1430 1440 1450
LIQAVWKGFI LRKKLTTALE AIKNEESDEE YREIDLEDFI FDEAALEEEW
1460 1470 1480 1490 1500
LALDSTRFPS QTLLLSNQLH WPKIPGNLKW DDTSFNLPSN PAQAWLCNDK
1510 1520 1530 1540 1550
ENLSSSEHTQ FNSRSENKTS SWTPESKTSR KSLLKSEKEK KISEEWGFKD
1560 1570 1580 1590 1600
ISTAQQMLKR AQKMKSKKLK KKIDSTVRLA LFKNNENKVS LPKSPKMVQP
1610 1620 1630 1640 1650
RRDGYFEGIE EDPIHKDTTA NEKLERNREY TYQWLHTQVG VHETTSSRNM
1660 1670 1680 1690 1700
KCNHFLPELD PDVLNGGRVQ LVARLVSRED TDLDLFSMTN GSALSVNREK
1710 1720
KNQAHRHSAG SSSKLWFPSK LI
Note: No experimental confirmation available. Gene prediction based on EST data.
Length:1,722
Mass (Da):199,300
Last modified:February 8, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5FFE2E824F6F7B1D
GO
Isoform 2 (identifier: Q96JM4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-251: Missing.

Note: No experimental confirmation available.
Show »
Length:1,697
Mass (Da):196,037
Checksum:i1281FBA2C67CFF0F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MY60A8MY60_HUMAN
Leucine-rich repeat and IQ domain-c...
LRRIQ1
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEZ5H0YEZ5_HUMAN
Leucine-rich repeat and IQ domain-c...
LRRIQ1
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IS25A0A3B3IS25_HUMAN
Leucine-rich repeat and IQ domain-c...
LRRIQ1
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCJ9H0YCJ9_HUMAN
Leucine-rich repeat and IQ domain-c...
LRRIQ1
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH93088 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAB47430 differs from that shown. Probable cloning artifact.Curated
The sequence BAB47430 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03767229I → N1 PublicationCorresponds to variant dbSNP:rs7312075Ensembl.1
Natural variantiVAR_03767383C → Y1 PublicationCorresponds to variant dbSNP:rs3765044Ensembl.1
Natural variantiVAR_037674912A → T1 PublicationCorresponds to variant dbSNP:rs17012533Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_030065227 – 251Missing in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC025418 Genomic DNA No translation available.
AC079631 Genomic DNA No translation available.
AC133794 Genomic DNA No translation available.
AK022365 mRNA Translation: BAB14022.1
BC093088 mRNA Translation: AAH93088.1 Sequence problems.
AB058704 mRNA Translation: BAB47430.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41816.1 [Q96JM4-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001073379.1, NM_001079910.1 [Q96JM4-4]
XP_016875508.1, XM_017020019.1 [Q96JM4-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000393217; ENSP00000376910; ENSG00000133640 [Q96JM4-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84125

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84125

UCSC genome browser

More...
UCSCi
uc001tac.4 human [Q96JM4-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025418 Genomic DNA No translation available.
AC079631 Genomic DNA No translation available.
AC133794 Genomic DNA No translation available.
AK022365 mRNA Translation: BAB14022.1
BC093088 mRNA Translation: AAH93088.1 Sequence problems.
AB058704 mRNA Translation: BAB47430.1 Sequence problems.
CCDSiCCDS41816.1 [Q96JM4-4]
RefSeqiNP_001073379.1, NM_001079910.1 [Q96JM4-4]
XP_016875508.1, XM_017020019.1 [Q96JM4-4]

3D structure databases

SMRiQ96JM4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123899, 31 interactors
IntActiQ96JM4, 1 interactor
STRINGi9606.ENSP00000376910

PTM databases

iPTMnetiQ96JM4
PhosphoSitePlusiQ96JM4

Polymorphism and mutation databases

BioMutaiLRRIQ1
DMDMi322510118

Proteomic databases

jPOSTiQ96JM4
MaxQBiQ96JM4
PaxDbiQ96JM4
PeptideAtlasiQ96JM4
PRIDEiQ96JM4
ProteomicsDBi76985
76986 [Q96JM4-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393217; ENSP00000376910; ENSG00000133640 [Q96JM4-4]
GeneIDi84125
KEGGihsa:84125
UCSCiuc001tac.4 human [Q96JM4-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84125

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LRRIQ1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0010860
HGNCiHGNC:25708 LRRIQ1
HPAiHPA046162
neXtProtiNX_Q96JM4
OpenTargetsiENSG00000133640
PharmGKBiPA134962087

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0531 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000162858
HOGENOMiHOG000113381
InParanoidiQ96JM4
OMAiETINCEN
OrthoDBi433355at2759
PhylomeDBiQ96JM4
TreeFamiTF333460

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LRRIQ1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84125

Protein Ontology

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PROi
PR:Q96JM4

Gene expression databases

BgeeiENSG00000133640 Expressed in 81 organ(s), highest expression level in testis
ExpressionAtlasiQ96JM4 baseline and differential

Family and domain databases

Gene3Di3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00612 IQ, 2 hits
SMARTiView protein in SMART
SM00015 IQ, 3 hits
SM00369 LRR_TYP, 4 hits
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 3 hits
PS51450 LRR, 11 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRIQ1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96JM4
Secondary accession number(s): Q567P4, Q9BS17, Q9HA36
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 8, 2011
Last modified: May 8, 2019
This is version 116 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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