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Entry version 151 (16 Oct 2019)
Sequence version 2 (05 Sep 2006)
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Protein

Chromosome alignment-maintaining phosphoprotein 1

Gene

CHAMP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri738 – 760C2H2-typePROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chromosome alignment-maintaining phosphoprotein 1
Alternative name(s):
Zinc finger protein 828
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHAMP1
Synonyms:C13orf8, CAMP, CHAMP, KIAA1802, ZNF828
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20311 CHAMP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616327 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96JM3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mental retardation, autosomal dominant 40 (MRD40)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
Related information in OMIM

Keywords - Diseasei

Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
283489

MalaCards human disease database

More...
MalaCardsi
CHAMP1
MIMi616579 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000198824

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
178469 Autosomal dominant non-syndromic intellectual disability

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162410749

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96JM3

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CHAMP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
114149935

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002483191 – 812Chromosome alignment-maintaining phosphoprotein 1Add BLAST812

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei87PhosphoserineCombined sources1
Modified residuei108PhosphoserineCombined sources1
Modified residuei173PhosphoserineCombined sources1
Modified residuei184PhosphoserineCombined sources1
Modified residuei204PhosphoserineCombined sources1
Modified residuei214PhosphoserineCombined sources1
Modified residuei217PhosphoserineCombined sources1
Modified residuei244PhosphoserineBy similarity1
Modified residuei247PhosphoserineCombined sources1
Modified residuei253PhosphoserineCombined sources1
Modified residuei264PhosphoserineCombined sources1
Modified residuei275PhosphoserineCombined sources1
Modified residuei282PhosphoserineCombined sources1
Modified residuei286PhosphoserineCombined sources1
Modified residuei297PhosphoserineCombined sources1
Modified residuei308PhosphoserineCombined sources1
Modified residuei319PhosphoserineCombined sources1
Modified residuei344PhosphoserineCombined sources1
Modified residuei355PhosphoserineCombined sources1
Modified residuei376PhosphoserineCombined sources1
Modified residuei382PhosphoserineCombined sources1
Modified residuei386PhosphoserineCombined sources1
Modified residuei403PhosphothreonineCombined sources1
Modified residuei405PhosphoserineCombined sources1
Modified residuei416PhosphoserineCombined sources1
Modified residuei427PhosphoserineCombined sources1
Modified residuei432PhosphoserineCombined sources1
Modified residuei436PhosphoserineCombined sources1
Modified residuei443PhosphoserineCombined sources1
Modified residuei445PhosphoserineCombined sources1
Modified residuei452PhosphoserineCombined sources1
Modified residuei458PhosphothreonineCombined sources1
Modified residuei459PhosphoserineCombined sources1
Modified residuei462PhosphoserineCombined sources1
Modified residuei472PhosphoserineCombined sources1
Modified residuei476PhosphoserineCombined sources1
Modified residuei490N6-acetyllysine; alternateCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki490Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei507PhosphoserineCombined sources1
Modified residuei512PhosphoserineCombined sources1
Modified residuei542PhosphoserineCombined sources1
Cross-linki565Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei572PhosphoserineCombined sources1
Modified residuei603PhosphoserineCombined sources1
Cross-linki606Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei615PhosphoserineCombined sources1
Modified residuei626PhosphoserineCombined sources1
Modified residuei627PhosphoserineCombined sources1
Modified residuei632PhosphoserineCombined sources1
Cross-linki638Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei651PhosphoserineCombined sources1
Modified residuei652PhosphoserineCombined sources1
Modified residuei653PhosphoserineCombined sources1
Cross-linki670Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei675PhosphoserineCombined sources1
Cross-linki689Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei736PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by CDK1. Mitotic phosphorylation is required for the attachment of spindle microtubules to the kinetochore.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96JM3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96JM3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96JM3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96JM3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96JM3

PeptideAtlas

More...
PeptideAtlasi
Q96JM3

PRoteomics IDEntifications database

More...
PRIDEi
Q96JM3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76984

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96JM3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96JM3

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q96JM3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198824 Expressed in 188 organ(s), highest expression level in amniotic fluid

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96JM3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96JM3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA006623
HPA008900

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MAD2L2.

Interacts with POGZ, CBX1, CBX3 and CBX5.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
MAD2L2Q9UI956EBI-2560420,EBI-77889

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
129584, 54 interactors

Protein interaction database and analysis system

More...
IntActi
Q96JM3, 34 interactors

Molecular INTeraction database

More...
MINTi
Q96JM3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000354730

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1812
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96JM3

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni271 – 490Mediates interaction with MAD2L21 PublicationAdd BLAST220
Regioni451 – 590Mediates localization to the spindle and the kinetochore and is required for the attachment of spindle microtubules to the kinetochoreAdd BLAST140
Regioni591 – 812Mediates localization to the chromosome and the spindle and negatively regulates chromosome alignmentAdd BLAST222

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi105 – 564Pro-richAdd BLAST460

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri738 – 760C2H2-typePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IFC8 Eukaryota
ENOG410XXII LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111351

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000065731

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96JM3

KEGG Orthology (KO)

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KOi
K22593

Identification of Orthologs from Complete Genome Data

More...
OMAi
TSKMYSN

Database of Orthologous Groups

More...
OrthoDBi
277957at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96JM3

TreeFam database of animal gene trees

More...
TreeFami
TF350859

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR039330 CAMP
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

The PANTHER Classification System

More...
PANTHERi
PTHR37354 PTHR37354, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 5 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57667 SSF57667, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q96JM3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAFQELRKP SARLECDHCS FRGTDYENVQ IHMGTIHPEF CDEMDAGGLG
60 70 80 90 100
KMIFYQKSAK LFHCHKCFFT SKMYSNVYYH ITSKHASPDK WNDKPKNQLN
110 120 130 140 150
KETDPVKSPP LPEHQKIPCN SAEPKSIPAL SMETQKLGSV LSPESPKPTP
160 170 180 190 200
LTPLEPQKPG SVVSPELQTP LPSPEPSKPA SVSSPEPPKS VPVCESQKLA
210 220 230 240 250
PVPSPEPQKP APVSPESVKA TLSNPKPQKQ SHFPETLGPP SASSPESPVL
260 270 280 290 300
AASPEPWGPS PAASPESRKS ARTTSPEPRK PSPSESPEPW KPFPAVSPEP
310 320 330 340 350
RRPAPAVSPG SWKPGPPGSP RPWKSNPSAS SGPWKPAKPA PSVSPGPWKP
360 370 380 390 400
IPSVSPGPWK PTPSVSSASW KSSSVSPSSW KSPPASPESW KSGPPELRKT
410 420 430 440 450
APTLSPEHWK AVPPVSPELR KPGPPLSPEI RSPAGSPELR KPSGSPDLWK
460 470 480 490 500
LSPDQRKTSP ASLDFPESQK SSRGGSPDLW KSSFFIEPQK PVFPETRKPG
510 520 530 540 550
PSGPSESPKA ASDIWKPVLS IDTEPRKPAL FPEPAKTAPP ASPEARKRAL
560 570 580 590 600
FPEPRKHALF PELPKSALFS ESQKAVELGD ELQIDAIDDQ KCDILVQEEL
610 620 630 640 650
LASPKKLLED TLFPSSKKLK KDNQESSDAE LSSSEYIKTD LDAMDIKGQE
660 670 680 690 700
SSSDQEQVDV ESIDFSKENK MDMTSPEQSR NVLQFTEEKE AFISEEEIAK
710 720 730 740 750
YMKRGKGKYY CKICCCRAMK KGAVLHHLVN KHNVHSPYKC TICGKAFLLE
760 770 780 790 800
SLLKNHVAAH GQSLLKCPRC NFESNFPRGF KKHLTHCQSR HNEEANKKLM
810
EALEPPLEEQ QI
Length:812
Mass (Da):89,099
Last modified:September 5, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0276EF84795D89F2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R3K0S4R3K0_HUMAN
Chromosome alignment-maintaining ph...
CHAMP1
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y4S6A0A2R8Y4S6_HUMAN
Chromosome alignment-maintaining ph...
CHAMP1
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y735A0A2R8Y735_HUMAN
Chromosome alignment-maintaining ph...
CHAMP1
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB47431 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAC11273 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti81I → T in BAC11273 (PubMed:14702039).Curated1
Sequence conflicti140V → A in BAC11273 (PubMed:14702039).Curated1
Sequence conflicti576V → A in BAC11273 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_027270568L → V. Corresponds to variant dbSNP:rs3764522Ensembl.1
Natural variantiVAR_052910591K → R. Corresponds to variant dbSNP:rs35564629Ensembl.1
Natural variantiVAR_027271604P → R. Corresponds to variant dbSNP:rs12428067Ensembl.1

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB058705 mRNA Translation: BAB47431.1 Different initiation.
AK074894 mRNA Translation: BAC11273.1 Different initiation.
AK096346 mRNA Translation: BAG53268.1
AL845154 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX09253.1
BC004820 mRNA Translation: AAH04820.1
BC065237 mRNA Translation: AAH65237.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS9545.1

NCBI Reference Sequences

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RefSeqi
NP_001157616.1, NM_001164144.2
NP_001157617.1, NM_001164145.2
NP_115812.1, NM_032436.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000361283; ENSP00000354730; ENSG00000198824
ENST00000643483; ENSP00000496699; ENSG00000198824

Database of genes from NCBI RefSeq genomes

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GeneIDi
283489

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:283489

UCSC genome browser

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UCSCi
uc001vuv.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058705 mRNA Translation: BAB47431.1 Different initiation.
AK074894 mRNA Translation: BAC11273.1 Different initiation.
AK096346 mRNA Translation: BAG53268.1
AL845154 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX09253.1
BC004820 mRNA Translation: AAH04820.1
BC065237 mRNA Translation: AAH65237.1
CCDSiCCDS9545.1
RefSeqiNP_001157616.1, NM_001164144.2
NP_001157617.1, NM_001164145.2
NP_115812.1, NM_032436.3

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XPTX-ray2.10B325-344[»]
5XPUX-ray2.30B325-344[»]
6EKJX-ray1.60B328-355[»]
6EKLX-ray1.60B328-355[»]
SMRiQ96JM3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi129584, 54 interactors
IntActiQ96JM3, 34 interactors
MINTiQ96JM3
STRINGi9606.ENSP00000354730

PTM databases

iPTMnetiQ96JM3
PhosphoSitePlusiQ96JM3
SwissPalmiQ96JM3

Polymorphism and mutation databases

BioMutaiCHAMP1
DMDMi114149935

Proteomic databases

EPDiQ96JM3
jPOSTiQ96JM3
MassIVEiQ96JM3
MaxQBiQ96JM3
PaxDbiQ96JM3
PeptideAtlasiQ96JM3
PRIDEiQ96JM3
ProteomicsDBi76984

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
283489

Genome annotation databases

EnsembliENST00000361283; ENSP00000354730; ENSG00000198824
ENST00000643483; ENSP00000496699; ENSG00000198824
GeneIDi283489
KEGGihsa:283489
UCSCiuc001vuv.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
283489
DisGeNETi283489

GeneCards: human genes, protein and diseases

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GeneCardsi
CHAMP1
HGNCiHGNC:20311 CHAMP1
HPAiHPA006623
HPA008900
MalaCardsiCHAMP1
MIMi616327 gene
616579 phenotype
neXtProtiNX_Q96JM3
OpenTargetsiENSG00000198824
Orphaneti178469 Autosomal dominant non-syndromic intellectual disability
PharmGKBiPA162410749

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFC8 Eukaryota
ENOG410XXII LUCA
GeneTreeiENSGT00730000111351
HOGENOMiHOG000065731
InParanoidiQ96JM3
KOiK22593
OMAiTSKMYSN
OrthoDBi277957at2759
PhylomeDBiQ96JM3
TreeFamiTF350859

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CHAMP1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
C13orf8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
283489
PharosiQ96JM3

Protein Ontology

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PROi
PR:Q96JM3

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000198824 Expressed in 188 organ(s), highest expression level in amniotic fluid
ExpressionAtlasiQ96JM3 baseline and differential
GenevisibleiQ96JM3 HS

Family and domain databases

InterProiView protein in InterPro
IPR039330 CAMP
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR37354 PTHR37354, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHAP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96JM3
Secondary accession number(s): B3KU06
, Q6P181, Q8NC88, Q9BST0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: September 5, 2006
Last modified: October 16, 2019
This is version 151 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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