UniProtKB - Q96JL9 (ZN333_HUMAN)
Protein
Zinc finger protein 333
Gene
ZNF333
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 366 – 388 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 394 – 416 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 422 – 444 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 450 – 472 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 478 – 500 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 506 – 528 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 534 – 556 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 562 – 584 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 590 – 612 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 618 – 640 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q96JL9 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 333 |
Gene namesi | Name:ZNF333 Synonyms:KIAA1806 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000160961.11 |
HGNCi | HGNC:15624, ZNF333 |
MIMi | 611811, gene |
neXtProti | NX_Q96JL9 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 84449 |
OpenTargetsi | ENSG00000160961 |
PharmGKBi | PA134929553 |
Miscellaneous databases
Pharosi | Q96JL9, Tdark |
Polymorphism and mutation databases
BioMutai | ZNF333 |
DMDMi | 29840870 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047536 | 1 – 665 | Zinc finger protein 333Add BLAST | 665 |
Proteomic databases
jPOSTi | Q96JL9 |
MassIVEi | Q96JL9 |
PaxDbi | Q96JL9 |
PeptideAtlasi | Q96JL9 |
PRIDEi | Q96JL9 |
ProteomicsDBi | 66895 76980 [Q96JL9-1] |
PTM databases
iPTMneti | Q96JL9 |
PhosphoSitePlusi | Q96JL9 |
Expressioni
Tissue specificityi
Highly expressed in heart.
Gene expression databases
Bgeei | ENSG00000160961, Expressed in sural nerve and 160 other tissues |
ExpressionAtlasi | Q96JL9, baseline and differential |
Genevisiblei | Q96JL9, HS |
Organism-specific databases
HPAi | ENSG00000160961, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 124087, 9 interactors |
IntActi | Q96JL9, 4 interactors |
MINTi | Q96JL9 |
STRINGi | 9606.ENSP00000292530 |
Miscellaneous databases
RNActi | Q96JL9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 74 | KRAB 1PROSITE-ProRule annotationAdd BLAST | 71 | |
Domaini | 203 – 274 | KRAB 2PROSITE-ProRule annotationAdd BLAST | 72 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 366 – 388 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 394 – 416 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 422 – 444 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 450 – 472 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 478 – 500 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 506 – 528 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 534 – 556 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 562 – 584 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 590 – 612 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 618 – 640 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163161 |
HOGENOMi | CLU_081476_0_0_1 |
InParanoidi | Q96JL9 |
OMAi | HTTEKCF |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q96JL9 |
TreeFami | TF350814 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 2 hits |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 2 hits PF00096, zf-C2H2, 8 hits |
SMARTi | View protein in SMART SM00349, KRAB, 2 hits SM00355, ZnF_C2H2, 10 hits |
SUPFAMi | SSF109640, SSF109640, 2 hits SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 2 hits PS00028, ZINC_FINGER_C2H2_1, 10 hits PS50157, ZINC_FINGER_C2H2_2, 10 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96JL9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MESVTFEDVA VEFIQEWALL DSARRSLCKY RMLDQCRTLA SRGTPPCKPS
60 70 80 90 100
CVSQLGQRAE PKATERGILR ATGVAWESQL KPEELPSMQD LLEEASSRDM
110 120 130 140 150
QMGPGLFLRM QLVPSIEERE TPLTREDRPA LQEPPWSLGC TGLKAAMQIQ
160 170 180 190 200
RVVIPVPTLG HRNPWVARDS AVPARDPAWL QEDKVEEEAM APGLPTACSQ
210 220 230 240 250
EPVTFADVAV VFTPEEWVFL DSTQRSLYRD VMLENYRNLA SVADQLCKPN
260 270 280 290 300
ALSYLEERGE QWTTDRGVLS DTCAEPQCQP QEAIPSQDTF TEILSIDVKG
310 320 330 340 350
EQPQPGEKLY KYNELEKPFN SIEPLFQYQR IHAGEASCEC QEIRNSFFQS
360 370 380 390 400
AHLIVPEKIR SGDKSYACNK CEKSFRYSSD LIRHEKTHTA EKCFDCQECG
410 420 430 440 450
QAFKYSSNLR RHMRTHTGEK PFECSQCGKT FTRNFNLILH QRNHTGEKPY
460 470 480 490 500
ECKDCGKAFN QPSSLRSHVR THTGEKPFEC SQCGKAFREH SSLKTHLRTH
510 520 530 540 550
TREKPYECNQ CGKPFRTSTH LNVHKRIHTG EKLYECATCG QVLSRLSTLK
560 570 580 590 600
SHMRTHTGEK PYVCQECGRA FSEPSSLRKH ARTHSGKKPY ACQECGRAFG
610 620 630 640 650
QSSHLIVHVR THSAGRPYQC NQCEKAFRHS SSLTVHKRTH VGRETIRNGS
660
LPLSMSHPYC GPLAN
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0R1P1 | M0R1P1_HUMAN | Zinc finger protein 333 | ZNF333 | 166 | Annotation score: | ||
M0R0S8 | M0R0S8_HUMAN | Zinc finger protein 333 | ZNF333 | 195 | Annotation score: | ||
M0R113 | M0R113_HUMAN | Zinc finger protein 333 | ZNF333 | 106 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 115 | S → P in AAH48107 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024210 | 251 | A → E. Corresponds to variant dbSNP:rs3885179Ensembl. | 1 | |
Natural variantiVAR_052812 | 537 | A → V. Corresponds to variant dbSNP:rs3764626Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055945 | 142 – 182 | GLKAA…AWLQE → LPLLSLLLPSCPEPPLVLLD SSSAPDRHLGSTLDTEARGI P in isoform 2. 2 PublicationsAdd BLAST | 41 | |
Alternative sequenceiVSP_055946 | 183 – 665 | Missing in isoform 2. 2 PublicationsAdd BLAST | 483 | |
Alternative sequenceiVSP_055947 | 301 – 302 | EQ → PPN in isoform 3. 1 Publication | 2 | |
Alternative sequenceiVSP_055948 | 303 – 665 | Missing in isoform 3. 1 PublicationAdd BLAST | 363 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF372702 mRNA Translation: AAM15528.1 AK291471 mRNA Translation: BAF84160.1 BC048107 mRNA Translation: AAH48107.1 BC064571 mRNA Translation: AAH64571.1 AB058709 mRNA Translation: BAB47435.1 |
CCDSi | CCDS12316.1 [Q96JL9-1] CCDS74298.1 [Q96JL9-3] |
RefSeqi | NP_001287841.1, NM_001300912.1 [Q96JL9-3] NP_115809.1, NM_032433.2 [Q96JL9-1] XP_011526664.1, XM_011528362.2 [Q96JL9-1] XP_016882856.1, XM_017027367.1 [Q96JL9-1] |
Genome annotation databases
Ensembli | ENST00000292530; ENSP00000292530; ENSG00000160961 [Q96JL9-1] ENST00000540689; ENSP00000438130; ENSG00000160961 [Q96JL9-3] |
GeneIDi | 84449 |
KEGGi | hsa:84449 |
UCSCi | uc002mzn.4, human [Q96JL9-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF372702 mRNA Translation: AAM15528.1 AK291471 mRNA Translation: BAF84160.1 BC048107 mRNA Translation: AAH48107.1 BC064571 mRNA Translation: AAH64571.1 AB058709 mRNA Translation: BAB47435.1 |
CCDSi | CCDS12316.1 [Q96JL9-1] CCDS74298.1 [Q96JL9-3] |
RefSeqi | NP_001287841.1, NM_001300912.1 [Q96JL9-3] NP_115809.1, NM_032433.2 [Q96JL9-1] XP_011526664.1, XM_011528362.2 [Q96JL9-1] XP_016882856.1, XM_017027367.1 [Q96JL9-1] |
3D structure databases
SMRi | Q96JL9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124087, 9 interactors |
IntActi | Q96JL9, 4 interactors |
MINTi | Q96JL9 |
STRINGi | 9606.ENSP00000292530 |
PTM databases
iPTMneti | Q96JL9 |
PhosphoSitePlusi | Q96JL9 |
Polymorphism and mutation databases
BioMutai | ZNF333 |
DMDMi | 29840870 |
Proteomic databases
jPOSTi | Q96JL9 |
MassIVEi | Q96JL9 |
PaxDbi | Q96JL9 |
PeptideAtlasi | Q96JL9 |
PRIDEi | Q96JL9 |
ProteomicsDBi | 66895 76980 [Q96JL9-1] |
Protocols and materials databases
Antibodypediai | 26832, 82 antibodies |
DNASUi | 84449 |
Genome annotation databases
Ensembli | ENST00000292530; ENSP00000292530; ENSG00000160961 [Q96JL9-1] ENST00000540689; ENSP00000438130; ENSG00000160961 [Q96JL9-3] |
GeneIDi | 84449 |
KEGGi | hsa:84449 |
UCSCi | uc002mzn.4, human [Q96JL9-1] |
Organism-specific databases
CTDi | 84449 |
DisGeNETi | 84449 |
EuPathDBi | HostDB:ENSG00000160961.11 |
GeneCardsi | ZNF333 |
HGNCi | HGNC:15624, ZNF333 |
HPAi | ENSG00000160961, Low tissue specificity |
MIMi | 611811, gene |
neXtProti | NX_Q96JL9 |
OpenTargetsi | ENSG00000160961 |
PharmGKBi | PA134929553 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163161 |
HOGENOMi | CLU_081476_0_0_1 |
InParanoidi | Q96JL9 |
OMAi | HTTEKCF |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q96JL9 |
TreeFami | TF350814 |
Enzyme and pathway databases
PathwayCommonsi | Q96JL9 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 84449, 10 hits in 866 CRISPR screens |
ChiTaRSi | ZNF333, human |
GenomeRNAii | 84449 |
Pharosi | Q96JL9, Tdark |
PROi | PR:Q96JL9 |
RNActi | Q96JL9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000160961, Expressed in sural nerve and 160 other tissues |
ExpressionAtlasi | Q96JL9, baseline and differential |
Genevisiblei | Q96JL9, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 2 hits |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 2 hits PF00096, zf-C2H2, 8 hits |
SMARTi | View protein in SMART SM00349, KRAB, 2 hits SM00355, ZnF_C2H2, 10 hits |
SUPFAMi | SSF109640, SSF109640, 2 hits SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 2 hits PS00028, ZINC_FINGER_C2H2_1, 10 hits PS50157, ZINC_FINGER_C2H2_2, 10 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN333_HUMAN | |
Accessioni | Q96JL9Primary (citable) accession number: Q96JL9 Secondary accession number(s): Q6P2E6, Q86WS6, Q8TDL0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2002 |
Last sequence update: | February 28, 2003 | |
Last modified: | December 2, 2020 | |
This is version 162 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations