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Protein

Mastermind-like protein 3

Gene

MAML3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • transcription coactivator activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processNotch signaling pathway, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1912408 Pre-NOTCH Transcription and Translation
R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2197563 NOTCH2 intracellular domain regulates transcription
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-350054 Notch-HLH transcription pathway
R-HSA-8941856 RUNX3 regulates NOTCH signaling
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q96JK9

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q96JK9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mastermind-like protein 3
Short name:
Mam-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAML3Imported
Synonyms:KIAA1816Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000196782.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16272 MAML3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608991 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96JK9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55534

Open Targets

More...
OpenTargetsi
ENSG00000196782

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134953776

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MAML3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001294961 – 1138Mastermind-like protein 3Add BLAST1138

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei603N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96JK9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96JK9

PeptideAtlas

More...
PeptideAtlasi
Q96JK9

PRoteomics IDEntifications database

More...
PRIDEi
Q96JK9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
76979

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96JK9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96JK9

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q96JK9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196782 Expressed in 182 organ(s), highest expression level in endometrium

CleanEx database of gene expression profiles

More...
CleanExi
HS_MAML3

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96JK9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96JK9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037717

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts through its N-terminal region with the ankyrin repeat region of the Notch proteins NOTCH1, NOTCH2, NOTCH3 and NOTCH4. Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa.2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120704, 10 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q96JK9

Protein interaction database and analysis system

More...
IntActi
Q96JK9, 2 interactors

Molecular INTeraction database

More...
MINTi
Q96JK9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000421180

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q96JK9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96JK9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi467 – 968Gln-richAdd BLAST502
Compositional biasi548 – 595Asn-richAdd BLAST48

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal domain is required for transcriptional activation.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the mastermind family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJ3G Eukaryota
ENOG410ZYVU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153933

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113473

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108116

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96JK9

KEGG Orthology (KO)

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KOi
K06061

Identification of Orthologs from Complete Genome Data

More...
OMAi
SNQTSSW

Database of Orthologous Groups

More...
OrthoDBi
EOG091G01SE

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96JK9

TreeFam database of animal gene trees

More...
TreeFami
TF332922

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019082 Neuroggenic_mastermind-like_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09596 MamL-1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01275 MamL-1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q96JK9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDFAAPAAA ANGSSICINS SLNSSLGGAG IGVNNTPNST PAAPSSNHPA
60 70 80 90 100
AGGCGGSGGP GGGSAAVPKH STVVERLRQR IEGCRRHHVN CENRYQQAQV
110 120 130 140 150
EQLELERRDT VSLYQRTLEQ RAKKSGAGTG KQQHPSKPQQ DAEAASAEQR
160 170 180 190 200
NHTLIMLQET VKRKLEGARS PLNGDQQNGA CDGNFSPTSK RIRKDISAGM
210 220 230 240 250
EAINNLPSNM PLPSASPLHQ LDLKPSLPLQ NSGTHTPGLL EDLSKNGRLP
260 270 280 290 300
EIKLPVNGCS DLEDSFTILQ SKDLKQEPLD DPTCIDTSET SLSNQNKLFS
310 320 330 340 350
DINLNDQEWQ ELIDELANTV PEDDIQDLFN EDFEEKKEPE FSQPATETPL
360 370 380 390 400
SQESASVKSD PSHSPFAHVS MGSPQARPSS SGPPFSTVST ATSLPSVAST
410 420 430 440 450
PAAPNPASSP ANCAVQSPQT PNQAHTPGQA PPRPGNGYLL NPAAVTVAGS
460 470 480 490 500
ASGPVAVPSS DMSPAEQLKQ MAAQQQQRAK LMQQKQQQQQ QQQQQQQQQQ
510 520 530 540 550
QQQQQQQQQQ HSNQTSNWSP LGPPSSPYGA AFTAEKPNSP MMYPQAFNNQ
560 570 580 590 600
NPIVPPMANN LQKTTMNNYL PQNHMNMINQ QPNNLGTNSL NKQHNILTYG
610 620 630 640 650
NTKPLTHFNA DLSQRMTPPV ANPNKNPLMP YIQQQQQQQQ QQQQQQQQQQ
660 670 680 690 700
PPPPQLQAPR AHLSEDQKRL LLMKQKGVMN QPMAYAALPS HGQEQHPVGL
710 720 730 740 750
PRTTGPMQSS VPPGSGGMVS GASPAGPGFL GSQPQAAIMK QMLIDQRAQL
760 770 780 790 800
IEQQKQQFLR EQRQQQQQQQ QQILAEQQLQ QSHLPRQHLQ PQRNPYPVQQ
810 820 830 840 850
VNQFQGSPQD IAAVRSQAAL QSMRTSRLMA QNAGMMGIGP SQNPGTMATA
860 870 880 890 900
AAQSEMGLAP YSTTPTSQPG MYNMSTGMTQ MLQHPNQSGM SITHNQAQGP
910 920 930 940 950
RQPASGQGVG MVSGFGQSML VNSAITQQHP QMKGPVGQAL PRPQAPPRLQ
960 970 980 990 1000
SLMGTVQQGA QSWQQRSLQG MPGRTSGELG PFNNGASYPL QAGQPRLTKQ
1010 1020 1030 1040 1050
HFPQGLSQSV VDANTGTVRT LNPAAMGRQM MPSLPGQQGT SQARPMVMSG
1060 1070 1080 1090 1100
LSQGVPGMPA FSQPPAQQQI PSGSFAPSSQ SQAYERNAPQ DVSYNYSGDG
1110 1120 1130
AGGSFPGLPD GADLVDSIIK GGPGDEWMQE LDELFGNP
Length:1,138
Mass (Da):122,293
Last modified:September 3, 2014 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i145C1CA5F2F7EEB0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y920H0Y920_HUMAN
Mastermind-like protein 3
MAML3
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ESR8E7ESR8_HUMAN
Mastermind-like protein 3
MAML3
276Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB47445 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAG53919 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti486 – 489Missing in BAB47445 (PubMed:11347906).Curated4
Sequence conflicti486 – 489Missing in BAG53919 (PubMed:14702039).Curated4
Sequence conflicti486 – 489Missing in EAX05107 (Ref. 4) Curated4
Sequence conflicti486 – 489Missing in AAI37132 (PubMed:15489334).Curated4
Sequence conflicti486 – 489Missing in AAI37131 (PubMed:15489334).Curated4
Sequence conflicti1064P → H in BAB47445 (PubMed:11347906).Curated1
Sequence conflicti1064P → H in BAG53919 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_046650768Missing 4 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB058719 mRNA Translation: BAB47445.1 Different initiation.
AK123604 mRNA Translation: BAG53919.1 Different initiation.
AC097464 Genomic DNA No translation available.
AC104798 Genomic DNA No translation available.
AC108053 Genomic DNA No translation available.
AC131182 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX05107.1
BC137130 mRNA Translation: AAI37131.1
BC137131 mRNA Translation: AAI37132.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS54805.1

NCBI Reference Sequences

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RefSeqi
NP_061187.2, NM_018717.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.586165

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000509479; ENSP00000421180; ENSG00000196782

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55534

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55534

UCSC genome browser

More...
UCSCi
uc062zte.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058719 mRNA Translation: BAB47445.1 Different initiation.
AK123604 mRNA Translation: BAG53919.1 Different initiation.
AC097464 Genomic DNA No translation available.
AC104798 Genomic DNA No translation available.
AC108053 Genomic DNA No translation available.
AC131182 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX05107.1
BC137130 mRNA Translation: AAI37131.1
BC137131 mRNA Translation: AAI37132.1
CCDSiCCDS54805.1
RefSeqiNP_061187.2, NM_018717.4
UniGeneiHs.586165

3D structure databases

ProteinModelPortaliQ96JK9
SMRiQ96JK9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120704, 10 interactors
CORUMiQ96JK9
IntActiQ96JK9, 2 interactors
MINTiQ96JK9
STRINGi9606.ENSP00000421180

PTM databases

iPTMnetiQ96JK9
PhosphoSitePlusiQ96JK9
SwissPalmiQ96JK9

Polymorphism and mutation databases

BioMutaiMAML3

Proteomic databases

EPDiQ96JK9
PaxDbiQ96JK9
PeptideAtlasiQ96JK9
PRIDEiQ96JK9
ProteomicsDBi76979

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000509479; ENSP00000421180; ENSG00000196782
GeneIDi55534
KEGGihsa:55534
UCSCiuc062zte.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55534
DisGeNETi55534
EuPathDBiHostDB:ENSG00000196782.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MAML3
HGNCiHGNC:16272 MAML3
HPAiHPA037717
MIMi608991 gene
neXtProtiNX_Q96JK9
OpenTargetsiENSG00000196782
PharmGKBiPA134953776

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJ3G Eukaryota
ENOG410ZYVU LUCA
GeneTreeiENSGT00940000153933
HOGENOMiHOG000113473
HOVERGENiHBG108116
InParanoidiQ96JK9
KOiK06061
OMAiSNQTSSW
OrthoDBiEOG091G01SE
PhylomeDBiQ96JK9
TreeFamiTF332922

Enzyme and pathway databases

ReactomeiR-HSA-1912408 Pre-NOTCH Transcription and Translation
R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2197563 NOTCH2 intracellular domain regulates transcription
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-350054 Notch-HLH transcription pathway
R-HSA-8941856 RUNX3 regulates NOTCH signaling
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription
SignaLinkiQ96JK9
SIGNORiQ96JK9

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MAML3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55534

Protein Ontology

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PROi
PR:Q96JK9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000196782 Expressed in 182 organ(s), highest expression level in endometrium
CleanExiHS_MAML3
ExpressionAtlasiQ96JK9 baseline and differential
GenevisibleiQ96JK9 HS

Family and domain databases

InterProiView protein in InterPro
IPR019082 Neuroggenic_mastermind-like_N
PfamiView protein in Pfam
PF09596 MamL-1, 1 hit
SMARTiView protein in SMART
SM01275 MamL-1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAML3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96JK9
Secondary accession number(s): B2RNU9, B3KVV7, E7EVW8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: September 3, 2014
Last modified: December 5, 2018
This is version 132 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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