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Protein

Mastermind-like protein 3

Gene

MAML3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1.2 Publications

GO - Molecular functioni

  • transcription coactivator activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processNotch signaling pathway, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-1912408 Pre-NOTCH Transcription and Translation
R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2197563 NOTCH2 intracellular domain regulates transcription
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-350054 Notch-HLH transcription pathway
R-HSA-8941856 RUNX3 regulates NOTCH signaling
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription
SignaLinkiQ96JK9
SIGNORiQ96JK9

Names & Taxonomyi

Protein namesi
Recommended name:
Mastermind-like protein 3
Short name:
Mam-3
Gene namesi
Name:MAML3Imported
Synonyms:KIAA1816Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000196782.12
HGNCiHGNC:16272 MAML3
MIMi608991 gene
neXtProtiNX_Q96JK9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55534
OpenTargetsiENSG00000196782
PharmGKBiPA134953776

Polymorphism and mutation databases

BioMutaiMAML3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001294961 – 1138Mastermind-like protein 3Add BLAST1138

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei603N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ96JK9
PaxDbiQ96JK9
PeptideAtlasiQ96JK9
PRIDEiQ96JK9
ProteomicsDBi76979

PTM databases

iPTMnetiQ96JK9
PhosphoSitePlusiQ96JK9
SwissPalmiQ96JK9

Expressioni

Gene expression databases

BgeeiENSG00000196782 Expressed in 182 organ(s), highest expression level in endometrium
CleanExiHS_MAML3
ExpressionAtlasiQ96JK9 baseline and differential
GenevisibleiQ96JK9 HS

Organism-specific databases

HPAiHPA037717

Interactioni

Subunit structurei

Interacts through its N-terminal region with the ankyrin repeat region of the Notch proteins NOTCH1, NOTCH2, NOTCH3 and NOTCH4. Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa.2 Publications

Protein-protein interaction databases

BioGridi120704, 10 interactors
CORUMiQ96JK9
IntActiQ96JK9, 2 interactors
MINTiQ96JK9
STRINGi9606.ENSP00000421180

Structurei

3D structure databases

ProteinModelPortaliQ96JK9
SMRiQ96JK9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi467 – 968Gln-richAdd BLAST502
Compositional biasi548 – 595Asn-richAdd BLAST48

Domaini

The C-terminal domain is required for transcriptional activation.1 Publication

Sequence similaritiesi

Belongs to the mastermind family.Curated

Phylogenomic databases

eggNOGiENOG410IJ3G Eukaryota
ENOG410ZYVU LUCA
GeneTreeiENSGT00530000063317
HOGENOMiHOG000113473
HOVERGENiHBG108116
InParanoidiQ96JK9
KOiK06061
OMAiVKSDPSH
OrthoDBiEOG091G01SE
PhylomeDBiQ96JK9
TreeFamiTF332922

Family and domain databases

InterProiView protein in InterPro
IPR019082 Neuroggenic_mastermind-like_N
PfamiView protein in Pfam
PF09596 MamL-1, 1 hit
SMARTiView protein in SMART
SM01275 MamL-1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q96JK9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDFAAPAAA ANGSSICINS SLNSSLGGAG IGVNNTPNST PAAPSSNHPA
60 70 80 90 100
AGGCGGSGGP GGGSAAVPKH STVVERLRQR IEGCRRHHVN CENRYQQAQV
110 120 130 140 150
EQLELERRDT VSLYQRTLEQ RAKKSGAGTG KQQHPSKPQQ DAEAASAEQR
160 170 180 190 200
NHTLIMLQET VKRKLEGARS PLNGDQQNGA CDGNFSPTSK RIRKDISAGM
210 220 230 240 250
EAINNLPSNM PLPSASPLHQ LDLKPSLPLQ NSGTHTPGLL EDLSKNGRLP
260 270 280 290 300
EIKLPVNGCS DLEDSFTILQ SKDLKQEPLD DPTCIDTSET SLSNQNKLFS
310 320 330 340 350
DINLNDQEWQ ELIDELANTV PEDDIQDLFN EDFEEKKEPE FSQPATETPL
360 370 380 390 400
SQESASVKSD PSHSPFAHVS MGSPQARPSS SGPPFSTVST ATSLPSVAST
410 420 430 440 450
PAAPNPASSP ANCAVQSPQT PNQAHTPGQA PPRPGNGYLL NPAAVTVAGS
460 470 480 490 500
ASGPVAVPSS DMSPAEQLKQ MAAQQQQRAK LMQQKQQQQQ QQQQQQQQQQ
510 520 530 540 550
QQQQQQQQQQ HSNQTSNWSP LGPPSSPYGA AFTAEKPNSP MMYPQAFNNQ
560 570 580 590 600
NPIVPPMANN LQKTTMNNYL PQNHMNMINQ QPNNLGTNSL NKQHNILTYG
610 620 630 640 650
NTKPLTHFNA DLSQRMTPPV ANPNKNPLMP YIQQQQQQQQ QQQQQQQQQQ
660 670 680 690 700
PPPPQLQAPR AHLSEDQKRL LLMKQKGVMN QPMAYAALPS HGQEQHPVGL
710 720 730 740 750
PRTTGPMQSS VPPGSGGMVS GASPAGPGFL GSQPQAAIMK QMLIDQRAQL
760 770 780 790 800
IEQQKQQFLR EQRQQQQQQQ QQILAEQQLQ QSHLPRQHLQ PQRNPYPVQQ
810 820 830 840 850
VNQFQGSPQD IAAVRSQAAL QSMRTSRLMA QNAGMMGIGP SQNPGTMATA
860 870 880 890 900
AAQSEMGLAP YSTTPTSQPG MYNMSTGMTQ MLQHPNQSGM SITHNQAQGP
910 920 930 940 950
RQPASGQGVG MVSGFGQSML VNSAITQQHP QMKGPVGQAL PRPQAPPRLQ
960 970 980 990 1000
SLMGTVQQGA QSWQQRSLQG MPGRTSGELG PFNNGASYPL QAGQPRLTKQ
1010 1020 1030 1040 1050
HFPQGLSQSV VDANTGTVRT LNPAAMGRQM MPSLPGQQGT SQARPMVMSG
1060 1070 1080 1090 1100
LSQGVPGMPA FSQPPAQQQI PSGSFAPSSQ SQAYERNAPQ DVSYNYSGDG
1110 1120 1130
AGGSFPGLPD GADLVDSIIK GGPGDEWMQE LDELFGNP
Length:1,138
Mass (Da):122,293
Last modified:September 3, 2014 - v4
Checksum:i145C1CA5F2F7EEB0
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y920H0Y920_HUMAN
Mastermind-like protein 3
MAML3
186Annotation score:
E7ESR8E7ESR8_HUMAN
Mastermind-like protein 3
MAML3
276Annotation score:

Sequence cautioni

The sequence BAB47445 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAG53919 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti486 – 489Missing in BAB47445 (PubMed:11347906).Curated4
Sequence conflicti486 – 489Missing in BAG53919 (PubMed:14702039).Curated4
Sequence conflicti486 – 489Missing in EAX05107 (Ref. 4) Curated4
Sequence conflicti486 – 489Missing in AAI37132 (PubMed:15489334).Curated4
Sequence conflicti486 – 489Missing in AAI37131 (PubMed:15489334).Curated4
Sequence conflicti1064P → H in BAB47445 (PubMed:11347906).Curated1
Sequence conflicti1064P → H in BAG53919 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046650768Missing 4 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058719 mRNA Translation: BAB47445.1 Different initiation.
AK123604 mRNA Translation: BAG53919.1 Different initiation.
AC097464 Genomic DNA No translation available.
AC104798 Genomic DNA No translation available.
AC108053 Genomic DNA No translation available.
AC131182 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX05107.1
BC137130 mRNA Translation: AAI37131.1
BC137131 mRNA Translation: AAI37132.1
CCDSiCCDS54805.1
RefSeqiNP_061187.2, NM_018717.4
UniGeneiHs.586165

Genome annotation databases

EnsembliENST00000509479; ENSP00000421180; ENSG00000196782
GeneIDi55534
KEGGihsa:55534
UCSCiuc062zte.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058719 mRNA Translation: BAB47445.1 Different initiation.
AK123604 mRNA Translation: BAG53919.1 Different initiation.
AC097464 Genomic DNA No translation available.
AC104798 Genomic DNA No translation available.
AC108053 Genomic DNA No translation available.
AC131182 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX05107.1
BC137130 mRNA Translation: AAI37131.1
BC137131 mRNA Translation: AAI37132.1
CCDSiCCDS54805.1
RefSeqiNP_061187.2, NM_018717.4
UniGeneiHs.586165

3D structure databases

ProteinModelPortaliQ96JK9
SMRiQ96JK9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120704, 10 interactors
CORUMiQ96JK9
IntActiQ96JK9, 2 interactors
MINTiQ96JK9
STRINGi9606.ENSP00000421180

PTM databases

iPTMnetiQ96JK9
PhosphoSitePlusiQ96JK9
SwissPalmiQ96JK9

Polymorphism and mutation databases

BioMutaiMAML3

Proteomic databases

EPDiQ96JK9
PaxDbiQ96JK9
PeptideAtlasiQ96JK9
PRIDEiQ96JK9
ProteomicsDBi76979

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000509479; ENSP00000421180; ENSG00000196782
GeneIDi55534
KEGGihsa:55534
UCSCiuc062zte.1 human

Organism-specific databases

CTDi55534
DisGeNETi55534
EuPathDBiHostDB:ENSG00000196782.12
GeneCardsiMAML3
HGNCiHGNC:16272 MAML3
HPAiHPA037717
MIMi608991 gene
neXtProtiNX_Q96JK9
OpenTargetsiENSG00000196782
PharmGKBiPA134953776
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ3G Eukaryota
ENOG410ZYVU LUCA
GeneTreeiENSGT00530000063317
HOGENOMiHOG000113473
HOVERGENiHBG108116
InParanoidiQ96JK9
KOiK06061
OMAiVKSDPSH
OrthoDBiEOG091G01SE
PhylomeDBiQ96JK9
TreeFamiTF332922

Enzyme and pathway databases

ReactomeiR-HSA-1912408 Pre-NOTCH Transcription and Translation
R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2197563 NOTCH2 intracellular domain regulates transcription
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-350054 Notch-HLH transcription pathway
R-HSA-8941856 RUNX3 regulates NOTCH signaling
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription
SignaLinkiQ96JK9
SIGNORiQ96JK9

Miscellaneous databases

ChiTaRSiMAML3 human
GenomeRNAii55534
PROiPR:Q96JK9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196782 Expressed in 182 organ(s), highest expression level in endometrium
CleanExiHS_MAML3
ExpressionAtlasiQ96JK9 baseline and differential
GenevisibleiQ96JK9 HS

Family and domain databases

InterProiView protein in InterPro
IPR019082 Neuroggenic_mastermind-like_N
PfamiView protein in Pfam
PF09596 MamL-1, 1 hit
SMARTiView protein in SMART
SM01275 MamL-1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMAML3_HUMAN
AccessioniPrimary (citable) accession number: Q96JK9
Secondary accession number(s): B2RNU9, B3KVV7, E7EVW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: September 3, 2014
Last modified: September 12, 2018
This is version 130 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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