Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ras-associating and dilute domain-containing protein

Gene

RADIL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development.1 Publication

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-associating and dilute domain-containing protein
Gene namesi
Name:RADIL
Synonyms:KIAA1849
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000157927.16
HGNCiHGNC:22226 RADIL
MIMi611491 gene
neXtProtiNX_Q96JH8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000157927
PharmGKBiPA164725261

Polymorphism and mutation databases

BioMutaiRADIL
DMDMi317373589

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000508031 – 1075Ras-associating and dilute domain-containing proteinAdd BLAST1075

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei206PhosphoserineCombined sources1
Modified residuei216PhosphoserineBy similarity1
Modified residuei219PhosphoserineBy similarity1
Modified residuei221PhosphoserineBy similarity1
Modified residuei393PhosphoserineCombined sources1
Modified residuei890PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ96JH8
PeptideAtlasiQ96JH8
PRIDEiQ96JH8
ProteomicsDBi76964
76965 [Q96JH8-1]
76966 [Q96JH8-2]
76967 [Q96JH8-3]

PTM databases

iPTMnetiQ96JH8
PhosphoSitePlusiQ96JH8

Expressioni

Gene expression databases

BgeeiENSG00000157927 Expressed in 150 organ(s), highest expression level in oocyte
ExpressionAtlasiQ96JH8 baseline and differential
GenevisibleiQ96JH8 HS

Organism-specific databases

HPAiHPA051776

Interactioni

Subunit structurei

Interacts with RAP1A; in a GTP-dependent manner. Does not interact with members of the Ras family (PubMed:17704304). Interacts (via PDZ domain) with KIF14; is recruited to the microtubule network restricting its interaction with activated RAP1A (PubMed:23209302).2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi120823, 26 interactors
IntActiQ96JH8, 11 interactors
MINTiQ96JH8
STRINGi9606.ENSP00000382492

Structurei

Secondary structure

11075
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ96JH8
SMRiQ96JH8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96JH8

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 164Ras-associatingPROSITE-ProRule annotationAdd BLAST104
Domaini314 – 389FHAAdd BLAST76
Domaini497 – 764DilutePROSITE-ProRule annotationAdd BLAST268
Domaini976 – 1061PDZPROSITE-ProRule annotationAdd BLAST86

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi847 – 925Pro-richAdd BLAST79

Sequence similaritiesi

Belongs to the RADIL family.Curated

Phylogenomic databases

eggNOGiENOG410IQUG Eukaryota
ENOG410ZVSZ LUCA
GeneTreeiENSGT00530000063674
HOVERGENiHBG079536
InParanoidiQ96JH8
OMAiYEVHPEI
OrthoDBiEOG091G00X4
PhylomeDBiQ96JH8
TreeFamiTF350641

Family and domain databases

CDDicd15472 Myo5p-like_CBD_Rasip1, 1 hit
InterProiView protein in InterPro
IPR037983 CBD_Rasip1/Radil
IPR002710 Dilute_dom
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000159 RA_dom
IPR008984 SMAD_FHA_dom_sf
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF01843 DIL, 1 hit
PF00595 PDZ, 1 hit
PF00788 RA, 1 hit
SMARTiView protein in SMART
SM01132 DIL, 1 hit
SM00228 PDZ, 1 hit
SM00314 RA, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS51126 DILUTE, 1 hit
PS50106 PDZ, 1 hit
PS50200 RA, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 4 (identifier: Q96JH8-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFYGTHFIMS PPTKSKLKRQ SQLLSSMLSR TLSYKYRDLD STFSSLGASD
60 70 80 90 100
DPAELSTQLS APGVLKVFGD SVCTGTHYKS VLATGTSSAR ELVKEALERY
110 120 130 140 150
ALDPRQAGQY VLCDVVGQAG DAGQRWQARC FRVFGDSEKP LLIQELWKPR
160 170 180 190 200
EGLSRRFELR KRSDVEELAA KEVDTITAGI NAQARRLQRS RAKGTPTPAL
210 220 230 240 250
GDARSSPPPR LRRTVSETSL SPVNALPAAA QGPEEPGPDA MRYSLYQSPH
260 270 280 290 300
LLLLQGYSQQ HDSLVYVLNR DRHTVGQRTP SSKPSISLSA PDILPLHCTI
310 320 330 340 350
RRQPLPDSGQ AAGRLVLEPI PGAHISVNFS EVGHRTVVLH HGDLLSLGLY
360 370 380 390 400
YLLLFKDPAQ AQPLPARALA RLRAVPQSCR LCGAALGARG AASPTQAALP
410 420 430 440 450
RRQQLLLEFE PHLEDTLLQR IMTLIEPGGD DHKLTPAFLL CLCIQHSATH
460 470 480 490 500
FQPGTFGQLL LKIARLIRET VWEKTKELAE KQAQLQEPIS LASCAMADLV
510 520 530 540 550
PDLQPILFWM SNSIELLYFI QQKCPLYMQS MEEQLDITGS KESLFSCTLT
560 570 580 590 600
ASEEAMAVLE EVVLYAFQQC VYYVSKSLYI CLPALLECPP FQTERRESWS
610 620 630 640 650
SAPELPEELR RVVSVYQAAL DLLRQLQVHP EVASQMLAYL FFFSGTLLLN
660 670 680 690 700
QLLDRGPSLS CFHWPRGVQA CARLQQLLEW MRSAGFGAAG EHFFQKLSCT
710 720 730 740 750
LNLLATPRAQ LIQMSWTALR AAFPALSPAQ LHRLLTHYQL ASAMGPMSTW
760 770 780 790 800
EPGAQDSPEA FRSEDVLESY ENPPPIVLPS DGFQVDLEAN CLDDSIYQHL
810 820 830 840 850
LYVRHFLWGL RSRASPGSPG RPGSGASQPV CPEGMHHVVL DGHLEAPSCP
860 870 880 890 900
LAPRDPGPAA REVAPERTLP LRGAPWAQAP PGRQPSRGGS QAGPPHTDSS
910 920 930 940 950
CLLTPPSTPL GPEPGDPDWP ESGGPCGKAL PERQRNGLSG LRGAAPEGDS
960 970 980 990 1000
AALAEESPPA PSSRSSSTED FCYVFTVELE RGPSGLGMGL IDGMHTHLGA
1010 1020 1030 1040 1050
PGLYIQTLLP GSPAAADGRL SLGDRILEVN GSSLLGLGYL RAVDLIRHGG
1060 1070
KKMRFLVAKS DVETAKKIHF RTPPL
Length:1,075
Mass (Da):117,455
Last modified:January 11, 2011 - v5
Checksum:iA071219E8FD10131
GO
Isoform 2 (identifier: Q96JH8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-495: Missing.

Note: No experimental confirmation available.
Show »
Length:580
Mass (Da):63,118
Checksum:iDA26C51AF63798BF
GO
Isoform 3 (identifier: Q96JH8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-704: Missing.
     705-763: ATPRAQLIQM...AQDSPEAFRS → MSPRVGPVTV...GHYGHPLSPA

Note: No experimental confirmation available.
Show »
Length:371
Mass (Da):38,824
Checksum:iFBD298E4B59C5BAB
GO
Isoform 1 (identifier: Q96JH8-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     262-279: DSLVYVLNRDRHTVGQRT → PGVCAQPGPAHGGPAD

Show »
Length:1,073
Mass (Da):116,757
Checksum:iBE16FDC66C40E658
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WEM1F8WEM1_HUMAN
Ras-associating and dilute domain-c...
RADIL
407Annotation score:
C9J7G0C9J7G0_HUMAN
Ras-associating and dilute domain-c...
RADIL
134Annotation score:

Sequence cautioni

The sequence AAS07559 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAA91543 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB47478 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti700T → I in CAB66665 (PubMed:11230166).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046192239D → NCombined sources2 PublicationsCorresponds to variant dbSNP:rs3763384Ensembl.1
Natural variantiVAR_046193412H → D3 PublicationsCorresponds to variant dbSNP:rs2292498Ensembl.1
Natural variantiVAR_023769886S → G7 PublicationsCorresponds to variant dbSNP:rs414035Ensembl.1
Natural variantiVAR_060193938L → P1 PublicationCorresponds to variant dbSNP:rs6966329Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0160971 – 704Missing in isoform 3. 1 PublicationAdd BLAST704
Alternative sequenceiVSP_0160981 – 495Missing in isoform 2. 1 PublicationAdd BLAST495
Alternative sequenceiVSP_035179262 – 279DSLVY…VGQRT → PGVCAQPGPAHGGPAD in isoform 1. 3 PublicationsAdd BLAST18
Alternative sequenceiVSP_016099705 – 763ATPRA…EAFRS → MSPRVGPVTVARIPASCVHR AGDSGLNLLAPGFPHRWAGR PGEGGSFSCGHYGHPLSPA in isoform 3. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058752 mRNA Translation: BAB47478.1 Different initiation.
AK000997 mRNA Translation: BAA91459.1
AK001186 mRNA Translation: BAA91543.1 Different initiation.
EF560723 mRNA Translation: ABQ59033.1
AC092610 Genomic DNA Translation: AAS07559.1 Sequence problems.
CH236953 Genomic DNA Translation: EAL23966.1
CH471144 Genomic DNA Translation: EAW87301.1
BC004919 mRNA Translation: AAH04919.2
BC117317 mRNA Translation: AAI17318.1
BC126311 mRNA Translation: AAI26312.1
BC143526 mRNA Translation: AAI43527.1
AL136731 mRNA Translation: CAB66665.2
CCDSiCCDS43544.1 [Q96JH8-4]
RefSeqiNP_060529.4, NM_018059.4 [Q96JH8-4]
UniGeneiHs.667336

Genome annotation databases

EnsembliENST00000399583; ENSP00000382492; ENSG00000157927 [Q96JH8-4]
GeneIDi55698
KEGGihsa:55698
UCSCiuc003snj.2 human [Q96JH8-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058752 mRNA Translation: BAB47478.1 Different initiation.
AK000997 mRNA Translation: BAA91459.1
AK001186 mRNA Translation: BAA91543.1 Different initiation.
EF560723 mRNA Translation: ABQ59033.1
AC092610 Genomic DNA Translation: AAS07559.1 Sequence problems.
CH236953 Genomic DNA Translation: EAL23966.1
CH471144 Genomic DNA Translation: EAW87301.1
BC004919 mRNA Translation: AAH04919.2
BC117317 mRNA Translation: AAI17318.1
BC126311 mRNA Translation: AAI26312.1
BC143526 mRNA Translation: AAI43527.1
AL136731 mRNA Translation: CAB66665.2
CCDSiCCDS43544.1 [Q96JH8-4]
RefSeqiNP_060529.4, NM_018059.4 [Q96JH8-4]
UniGeneiHs.667336

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UM1NMR-A973-1069[»]
3EC8X-ray2.60A51-193[»]
ProteinModelPortaliQ96JH8
SMRiQ96JH8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120823, 26 interactors
IntActiQ96JH8, 11 interactors
MINTiQ96JH8
STRINGi9606.ENSP00000382492

PTM databases

iPTMnetiQ96JH8
PhosphoSitePlusiQ96JH8

Polymorphism and mutation databases

BioMutaiRADIL
DMDMi317373589

Proteomic databases

PaxDbiQ96JH8
PeptideAtlasiQ96JH8
PRIDEiQ96JH8
ProteomicsDBi76964
76965 [Q96JH8-1]
76966 [Q96JH8-2]
76967 [Q96JH8-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399583; ENSP00000382492; ENSG00000157927 [Q96JH8-4]
GeneIDi55698
KEGGihsa:55698
UCSCiuc003snj.2 human [Q96JH8-4]

Organism-specific databases

CTDi55698
EuPathDBiHostDB:ENSG00000157927.16
GeneCardsiRADIL
H-InvDBiHIX0006446
HGNCiHGNC:22226 RADIL
HPAiHPA051776
MIMi611491 gene
neXtProtiNX_Q96JH8
OpenTargetsiENSG00000157927
PharmGKBiPA164725261
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQUG Eukaryota
ENOG410ZVSZ LUCA
GeneTreeiENSGT00530000063674
HOVERGENiHBG079536
InParanoidiQ96JH8
OMAiYEVHPEI
OrthoDBiEOG091G00X4
PhylomeDBiQ96JH8
TreeFamiTF350641

Miscellaneous databases

ChiTaRSiRADIL human
EvolutionaryTraceiQ96JH8
GeneWikiiRADIL
GenomeRNAii55698
PROiPR:Q96JH8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157927 Expressed in 150 organ(s), highest expression level in oocyte
ExpressionAtlasiQ96JH8 baseline and differential
GenevisibleiQ96JH8 HS

Family and domain databases

CDDicd15472 Myo5p-like_CBD_Rasip1, 1 hit
InterProiView protein in InterPro
IPR037983 CBD_Rasip1/Radil
IPR002710 Dilute_dom
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000159 RA_dom
IPR008984 SMAD_FHA_dom_sf
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF01843 DIL, 1 hit
PF00595 PDZ, 1 hit
PF00788 RA, 1 hit
SMARTiView protein in SMART
SM01132 DIL, 1 hit
SM00228 PDZ, 1 hit
SM00314 RA, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS51126 DILUTE, 1 hit
PS50106 PDZ, 1 hit
PS50200 RA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRADIL_HUMAN
AccessioniPrimary (citable) accession number: Q96JH8
Secondary accession number(s): A4D1Z5
, A5YM49, B7ZL20, Q0VFZ9, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: January 11, 2011
Last modified: November 7, 2018
This is version 141 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again