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Entry version 143 (16 Jan 2019)
Sequence version 5 (11 Jan 2011)
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Protein

Ras-associating and dilute domain-containing protein

Gene

RADIL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processCell adhesion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ras-associating and dilute domain-containing protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RADIL
Synonyms:KIAA1849
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000157927.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:22226 RADIL

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611491 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96JH8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000157927

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164725261

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RADIL

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373589

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000508031 – 1075Ras-associating and dilute domain-containing proteinAdd BLAST1075

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei206PhosphoserineCombined sources1
Modified residuei216PhosphoserineBy similarity1
Modified residuei219PhosphoserineBy similarity1
Modified residuei221PhosphoserineBy similarity1
Modified residuei393PhosphoserineCombined sources1
Modified residuei890PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96JH8

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96JH8

PeptideAtlas

More...
PeptideAtlasi
Q96JH8

PRoteomics IDEntifications database

More...
PRIDEi
Q96JH8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
76964
76965 [Q96JH8-1]
76966 [Q96JH8-2]
76967 [Q96JH8-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96JH8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96JH8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000157927 Expressed in 150 organ(s), highest expression level in oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96JH8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96JH8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051776

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RAP1A; in a GTP-dependent manner. Does not interact with members of the Ras family (PubMed:17704304). Interacts (via PDZ domain) with KIF14; is recruited to the microtubule network restricting its interaction with activated RAP1A (PubMed:23209302).2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
120823, 27 interactors

Protein interaction database and analysis system

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IntActi
Q96JH8, 12 interactors

Molecular INTeraction database

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MINTi
Q96JH8

STRING: functional protein association networks

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STRINGi
9606.ENSP00000382492

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11075
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UM1NMR-A973-1069[»]
3EC8X-ray2.60A51-193[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q96JH8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96JH8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q96JH8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini61 – 164Ras-associatingPROSITE-ProRule annotationAdd BLAST104
Domaini314 – 389FHAAdd BLAST76
Domaini497 – 764DilutePROSITE-ProRule annotationAdd BLAST268
Domaini976 – 1061PDZPROSITE-ProRule annotationAdd BLAST86

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi847 – 925Pro-richAdd BLAST79

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RADIL family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IQUG Eukaryota
ENOG410ZVSZ LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159293

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG079536

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96JH8

Identification of Orthologs from Complete Genome Data

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OMAi
YEVHPEI

Database of Orthologous Groups

More...
OrthoDBi
447883at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96JH8

TreeFam database of animal gene trees

More...
TreeFami
TF350641

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15472 Myo5p-like_CBD_Rasip1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037983 CBD_Rasip1/Radil
IPR002710 Dilute_dom
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000159 RA_dom
IPR008984 SMAD_FHA_dom_sf
IPR029071 Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01843 DIL, 1 hit
PF00595 PDZ, 1 hit
PF00788 RA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01132 DIL, 1 hit
SM00228 PDZ, 1 hit
SM00314 RA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49879 SSF49879, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51126 DILUTE, 1 hit
PS50106 PDZ, 1 hit
PS50200 RA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 4 (identifier: Q96JH8-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFYGTHFIMS PPTKSKLKRQ SQLLSSMLSR TLSYKYRDLD STFSSLGASD
60 70 80 90 100
DPAELSTQLS APGVLKVFGD SVCTGTHYKS VLATGTSSAR ELVKEALERY
110 120 130 140 150
ALDPRQAGQY VLCDVVGQAG DAGQRWQARC FRVFGDSEKP LLIQELWKPR
160 170 180 190 200
EGLSRRFELR KRSDVEELAA KEVDTITAGI NAQARRLQRS RAKGTPTPAL
210 220 230 240 250
GDARSSPPPR LRRTVSETSL SPVNALPAAA QGPEEPGPDA MRYSLYQSPH
260 270 280 290 300
LLLLQGYSQQ HDSLVYVLNR DRHTVGQRTP SSKPSISLSA PDILPLHCTI
310 320 330 340 350
RRQPLPDSGQ AAGRLVLEPI PGAHISVNFS EVGHRTVVLH HGDLLSLGLY
360 370 380 390 400
YLLLFKDPAQ AQPLPARALA RLRAVPQSCR LCGAALGARG AASPTQAALP
410 420 430 440 450
RRQQLLLEFE PHLEDTLLQR IMTLIEPGGD DHKLTPAFLL CLCIQHSATH
460 470 480 490 500
FQPGTFGQLL LKIARLIRET VWEKTKELAE KQAQLQEPIS LASCAMADLV
510 520 530 540 550
PDLQPILFWM SNSIELLYFI QQKCPLYMQS MEEQLDITGS KESLFSCTLT
560 570 580 590 600
ASEEAMAVLE EVVLYAFQQC VYYVSKSLYI CLPALLECPP FQTERRESWS
610 620 630 640 650
SAPELPEELR RVVSVYQAAL DLLRQLQVHP EVASQMLAYL FFFSGTLLLN
660 670 680 690 700
QLLDRGPSLS CFHWPRGVQA CARLQQLLEW MRSAGFGAAG EHFFQKLSCT
710 720 730 740 750
LNLLATPRAQ LIQMSWTALR AAFPALSPAQ LHRLLTHYQL ASAMGPMSTW
760 770 780 790 800
EPGAQDSPEA FRSEDVLESY ENPPPIVLPS DGFQVDLEAN CLDDSIYQHL
810 820 830 840 850
LYVRHFLWGL RSRASPGSPG RPGSGASQPV CPEGMHHVVL DGHLEAPSCP
860 870 880 890 900
LAPRDPGPAA REVAPERTLP LRGAPWAQAP PGRQPSRGGS QAGPPHTDSS
910 920 930 940 950
CLLTPPSTPL GPEPGDPDWP ESGGPCGKAL PERQRNGLSG LRGAAPEGDS
960 970 980 990 1000
AALAEESPPA PSSRSSSTED FCYVFTVELE RGPSGLGMGL IDGMHTHLGA
1010 1020 1030 1040 1050
PGLYIQTLLP GSPAAADGRL SLGDRILEVN GSSLLGLGYL RAVDLIRHGG
1060 1070
KKMRFLVAKS DVETAKKIHF RTPPL
Length:1,075
Mass (Da):117,455
Last modified:January 11, 2011 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA071219E8FD10131
GO
Isoform 2 (identifier: Q96JH8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-495: Missing.

Note: No experimental confirmation available.
Show »
Length:580
Mass (Da):63,118
Checksum:iDA26C51AF63798BF
GO
Isoform 3 (identifier: Q96JH8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-704: Missing.
     705-763: ATPRAQLIQM...AQDSPEAFRS → MSPRVGPVTV...GHYGHPLSPA

Note: No experimental confirmation available.
Show »
Length:371
Mass (Da):38,824
Checksum:iFBD298E4B59C5BAB
GO
Isoform 1 (identifier: Q96JH8-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     262-279: DSLVYVLNRDRHTVGQRT → PGVCAQPGPAHGGPAD

Show »
Length:1,073
Mass (Da):116,757
Checksum:iBE16FDC66C40E658
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WEM1F8WEM1_HUMAN
Ras-associating and dilute domain-c...
RADIL
407Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J7G0C9J7G0_HUMAN
Ras-associating and dilute domain-c...
RADIL
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAS07559 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAA91543 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB47478 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti700T → I in CAB66665 (PubMed:11230166).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_046192239D → NCombined sources2 PublicationsCorresponds to variant dbSNP:rs3763384Ensembl.1
Natural variantiVAR_046193412H → D3 PublicationsCorresponds to variant dbSNP:rs2292498Ensembl.1
Natural variantiVAR_023769886S → G7 PublicationsCorresponds to variant dbSNP:rs414035Ensembl.1
Natural variantiVAR_060193938L → P1 PublicationCorresponds to variant dbSNP:rs6966329Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0160971 – 704Missing in isoform 3. 1 PublicationAdd BLAST704
Alternative sequenceiVSP_0160981 – 495Missing in isoform 2. 1 PublicationAdd BLAST495
Alternative sequenceiVSP_035179262 – 279DSLVY…VGQRT → PGVCAQPGPAHGGPAD in isoform 1. 3 PublicationsAdd BLAST18
Alternative sequenceiVSP_016099705 – 763ATPRA…EAFRS → MSPRVGPVTVARIPASCVHR AGDSGLNLLAPGFPHRWAGR PGEGGSFSCGHYGHPLSPA in isoform 3. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB058752 mRNA Translation: BAB47478.1 Different initiation.
AK000997 mRNA Translation: BAA91459.1
AK001186 mRNA Translation: BAA91543.1 Different initiation.
EF560723 mRNA Translation: ABQ59033.1
AC092610 Genomic DNA Translation: AAS07559.1 Sequence problems.
CH236953 Genomic DNA Translation: EAL23966.1
CH471144 Genomic DNA Translation: EAW87301.1
BC004919 mRNA Translation: AAH04919.2
BC117317 mRNA Translation: AAI17318.1
BC126311 mRNA Translation: AAI26312.1
BC143526 mRNA Translation: AAI43527.1
AL136731 mRNA Translation: CAB66665.2

The Consensus CDS (CCDS) project

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CCDSi
CCDS43544.1 [Q96JH8-4]

NCBI Reference Sequences

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RefSeqi
NP_060529.4, NM_018059.4 [Q96JH8-4]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.667336

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000399583; ENSP00000382492; ENSG00000157927 [Q96JH8-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55698

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55698

UCSC genome browser

More...
UCSCi
uc003snj.2 human [Q96JH8-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058752 mRNA Translation: BAB47478.1 Different initiation.
AK000997 mRNA Translation: BAA91459.1
AK001186 mRNA Translation: BAA91543.1 Different initiation.
EF560723 mRNA Translation: ABQ59033.1
AC092610 Genomic DNA Translation: AAS07559.1 Sequence problems.
CH236953 Genomic DNA Translation: EAL23966.1
CH471144 Genomic DNA Translation: EAW87301.1
BC004919 mRNA Translation: AAH04919.2
BC117317 mRNA Translation: AAI17318.1
BC126311 mRNA Translation: AAI26312.1
BC143526 mRNA Translation: AAI43527.1
AL136731 mRNA Translation: CAB66665.2
CCDSiCCDS43544.1 [Q96JH8-4]
RefSeqiNP_060529.4, NM_018059.4 [Q96JH8-4]
UniGeneiHs.667336

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UM1NMR-A973-1069[»]
3EC8X-ray2.60A51-193[»]
ProteinModelPortaliQ96JH8
SMRiQ96JH8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120823, 27 interactors
IntActiQ96JH8, 12 interactors
MINTiQ96JH8
STRINGi9606.ENSP00000382492

PTM databases

iPTMnetiQ96JH8
PhosphoSitePlusiQ96JH8

Polymorphism and mutation databases

BioMutaiRADIL
DMDMi317373589

Proteomic databases

jPOSTiQ96JH8
PaxDbiQ96JH8
PeptideAtlasiQ96JH8
PRIDEiQ96JH8
ProteomicsDBi76964
76965 [Q96JH8-1]
76966 [Q96JH8-2]
76967 [Q96JH8-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399583; ENSP00000382492; ENSG00000157927 [Q96JH8-4]
GeneIDi55698
KEGGihsa:55698
UCSCiuc003snj.2 human [Q96JH8-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55698
EuPathDBiHostDB:ENSG00000157927.16

GeneCards: human genes, protein and diseases

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GeneCardsi
RADIL

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0006446
HGNCiHGNC:22226 RADIL
HPAiHPA051776
MIMi611491 gene
neXtProtiNX_Q96JH8
OpenTargetsiENSG00000157927
PharmGKBiPA164725261

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IQUG Eukaryota
ENOG410ZVSZ LUCA
GeneTreeiENSGT00940000159293
HOVERGENiHBG079536
InParanoidiQ96JH8
OMAiYEVHPEI
OrthoDBi447883at2759
PhylomeDBiQ96JH8
TreeFamiTF350641

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RADIL human
EvolutionaryTraceiQ96JH8

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RADIL

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55698

Protein Ontology

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PROi
PR:Q96JH8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000157927 Expressed in 150 organ(s), highest expression level in oocyte
ExpressionAtlasiQ96JH8 baseline and differential
GenevisibleiQ96JH8 HS

Family and domain databases

CDDicd15472 Myo5p-like_CBD_Rasip1, 1 hit
InterProiView protein in InterPro
IPR037983 CBD_Rasip1/Radil
IPR002710 Dilute_dom
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000159 RA_dom
IPR008984 SMAD_FHA_dom_sf
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF01843 DIL, 1 hit
PF00595 PDZ, 1 hit
PF00788 RA, 1 hit
SMARTiView protein in SMART
SM01132 DIL, 1 hit
SM00228 PDZ, 1 hit
SM00314 RA, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS51126 DILUTE, 1 hit
PS50106 PDZ, 1 hit
PS50200 RA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRADIL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96JH8
Secondary accession number(s): A4D1Z5
, A5YM49, B7ZL20, Q0VFZ9, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: January 11, 2011
Last modified: January 16, 2019
This is version 143 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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