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UniProtKB - Q96JH8 (RADIL_HUMAN)

Entry version 160 (25 May 2022)
Sequence version 5 (11 Jan 2011)
Previous versions | rss
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Protein

Ras-associating and dilute domain-containing protein

Gene

RADIL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase binding Source: GO_Central
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processCell adhesion

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96JH8

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q96JH8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ras-associating and dilute domain-containing protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RADIL
Synonyms:KIAA1849
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:22226, RADIL

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611491, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96JH8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000157927

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		55698

Open Targets

More...OpenTargetsi		ENSG00000157927

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA164725261

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96JH8, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RADIL

Domain mapping of disease mutations (DMDM)

More...DMDMi		317373589

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000508031 – 1075Ras-associating and dilute domain-containing proteinAdd BLAST1075

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei206PhosphoserineCombined sources1
Modified residuei216PhosphoserineBy similarity1
Modified residuei219PhosphoserineBy similarity1
Modified residuei221PhosphoserineBy similarity1
Modified residuei393PhosphoserineCombined sources1
Modified residuei890PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96JH8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96JH8

PeptideAtlas

More...PeptideAtlasi		Q96JH8

PRoteomics IDEntifications database

More...PRIDEi		Q96JH8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		76964 [Q96JH8-4]
76965 [Q96JH8-1]
76966 [Q96JH8-2]
76967 [Q96JH8-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96JH8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96JH8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000157927, Expressed in oocyte and 171 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96JH8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96JH8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000157927, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RAP1A; in a GTP-dependent manner. Does not interact with members of the Ras family (PubMed:17704304).

Interacts (via PDZ domain) with KIF14; is recruited to the microtubule network restricting its interaction with activated RAP1A (PubMed:23209302).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120823, 39 interactors

Protein interaction database and analysis system

More...IntActi		Q96JH8, 21 interactors

Molecular INTeraction database

More...MINTi		Q96JH8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000382492

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96JH8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11075
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q96JH8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96JH8

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q96JH8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini61 – 164Ras-associatingPROSITE-ProRule annotationAdd BLAST104
Domaini314 – 389FHAAdd BLAST76
Domaini497 – 764DilutePROSITE-ProRule annotationAdd BLAST268
Domaini976 – 1061PDZPROSITE-ProRule annotationAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni183 – 237DisorderedSequence analysisAdd BLAST55
Regioni872 – 967DisorderedSequence analysisAdd BLAST96

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi211 – 225Polar residuesSequence analysisAdd BLAST15
Compositional biasi890 – 906Polar residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RADIL family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0160, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159293

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_010386_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96JH8

Identification of Orthologs from Complete Genome Data

More...OMAi		CIPFQNE

Database of Orthologous Groups

More...OrthoDBi		447883at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96JH8

TreeFam database of animal gene trees

More...TreeFami		TF350641

Family and domain databases

Conserved Domains Database

More...CDDi		cd15472, Myo5p-like_CBD_Rasip1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037983, CBD_Rasip1/Radil
IPR002710, Dilute_dom
IPR001478, PDZ
IPR036034, PDZ_sf
IPR000159, RA_dom
IPR008984, SMAD_FHA_dom_sf
IPR029071, Ubiquitin-like_domsf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01843, DIL, 1 hit
PF00595, PDZ, 1 hit
PF00788, RA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01132, DIL, 1 hit
SM00228, PDZ, 1 hit
SM00314, RA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49879, SSF49879, 1 hit
SSF50156, SSF50156, 1 hit
SSF54236, SSF54236, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51126, DILUTE, 1 hit
PS50106, PDZ, 1 hit
PS50200, RA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 4 (identifier: Q96JH8-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFYGTHFIMS PPTKSKLKRQ SQLLSSMLSR TLSYKYRDLD STFSSLGASD 
        60         70         80         90        100
DPAELSTQLS APGVLKVFGD SVCTGTHYKS VLATGTSSAR ELVKEALERY 
       110        120        130        140        150
ALDPRQAGQY VLCDVVGQAG DAGQRWQARC FRVFGDSEKP LLIQELWKPR 
       160        170        180        190        200
EGLSRRFELR KRSDVEELAA KEVDTITAGI NAQARRLQRS RAKGTPTPAL 
       210        220        230        240        250
GDARSSPPPR LRRTVSETSL SPVNALPAAA QGPEEPGPDA MRYSLYQSPH 
       260        270        280        290        300
LLLLQGYSQQ HDSLVYVLNR DRHTVGQRTP SSKPSISLSA PDILPLHCTI 
       310        320        330        340        350
RRQPLPDSGQ AAGRLVLEPI PGAHISVNFS EVGHRTVVLH HGDLLSLGLY 
       360        370        380        390        400
YLLLFKDPAQ AQPLPARALA RLRAVPQSCR LCGAALGARG AASPTQAALP 
       410        420        430        440        450
RRQQLLLEFE PHLEDTLLQR IMTLIEPGGD DHKLTPAFLL CLCIQHSATH 
       460        470        480        490        500
FQPGTFGQLL LKIARLIRET VWEKTKELAE KQAQLQEPIS LASCAMADLV 
       510        520        530        540        550
PDLQPILFWM SNSIELLYFI QQKCPLYMQS MEEQLDITGS KESLFSCTLT 
       560        570        580        590        600
ASEEAMAVLE EVVLYAFQQC VYYVSKSLYI CLPALLECPP FQTERRESWS 
       610        620        630        640        650
SAPELPEELR RVVSVYQAAL DLLRQLQVHP EVASQMLAYL FFFSGTLLLN 
       660        670        680        690        700
QLLDRGPSLS CFHWPRGVQA CARLQQLLEW MRSAGFGAAG EHFFQKLSCT 
       710        720        730        740        750
LNLLATPRAQ LIQMSWTALR AAFPALSPAQ LHRLLTHYQL ASAMGPMSTW 
       760        770        780        790        800
EPGAQDSPEA FRSEDVLESY ENPPPIVLPS DGFQVDLEAN CLDDSIYQHL 
       810        820        830        840        850
LYVRHFLWGL RSRASPGSPG RPGSGASQPV CPEGMHHVVL DGHLEAPSCP 
       860        870        880        890        900
LAPRDPGPAA REVAPERTLP LRGAPWAQAP PGRQPSRGGS QAGPPHTDSS 
       910        920        930        940        950
CLLTPPSTPL GPEPGDPDWP ESGGPCGKAL PERQRNGLSG LRGAAPEGDS 
       960        970        980        990       1000
AALAEESPPA PSSRSSSTED FCYVFTVELE RGPSGLGMGL IDGMHTHLGA 
      1010       1020       1030       1040       1050
PGLYIQTLLP GSPAAADGRL SLGDRILEVN GSSLLGLGYL RAVDLIRHGG 
      1060       1070 
KKMRFLVAKS DVETAKKIHF RTPPL
Length:1,075
Mass (Da):117,455
Last modified:January 11, 2011 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA071219E8FD10131
GO
Isoform 2 (identifier: Q96JH8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-495: Missing.

Show »
Length:580
Mass (Da):63,118
Checksum:iDA26C51AF63798BF
GO
Isoform 3 (identifier: Q96JH8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-704: Missing.
     705-763: ATPRAQLIQM...AQDSPEAFRS → MSPRVGPVTV...GHYGHPLSPA

Show »
Length:371
Mass (Da):38,824
Checksum:iFBD298E4B59C5BAB
GO
Isoform 1 (identifier: Q96JH8-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     262-279: DSLVYVLNRDRHTVGQRT → PGVCAQPGPAHGGPAD

Show »
Length:1,073
Mass (Da):116,757
Checksum:iBE16FDC66C40E658
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WEM1F8WEM1_HUMAN
Ras-associating and dilute domain-c...
RADIL
407Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J7G0C9J7G0_HUMAN
Ras-associating and dilute domain-c...
RADIL
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAS07559 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAA91543 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB47478 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti700T → I in CAB66665 (PubMed:11230166).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_046192239D → NCombined sources2 PublicationsCorresponds to variant dbSNP:rs3763384Ensembl.1
Natural variantiVAR_046193412H → D3 PublicationsCorresponds to variant dbSNP:rs2292498Ensembl.1
Natural variantiVAR_023769886S → G7 PublicationsCorresponds to variant dbSNP:rs414035Ensembl.1
Natural variantiVAR_060193938L → P1 PublicationCorresponds to variant dbSNP:rs6966329Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0160971 – 704Missing in isoform 3. 1 PublicationAdd BLAST704
Alternative sequenceiVSP_0160981 – 495Missing in isoform 2. 1 PublicationAdd BLAST495
Alternative sequenceiVSP_035179262 – 279DSLVY…VGQRT → PGVCAQPGPAHGGPAD in isoform 1. 3 PublicationsAdd BLAST18
Alternative sequenceiVSP_016099705 – 763ATPRA…EAFRS → MSPRVGPVTVARIPASCVHR AGDSGLNLLAPGFPHRWAGR PGEGGSFSCGHYGHPLSPA in isoform 3. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB058752 mRNA Translation: BAB47478.1 Different initiation.
AK000997 mRNA Translation: BAA91459.1
AK001186 mRNA Translation: BAA91543.1 Different initiation.
EF560723 mRNA Translation: ABQ59033.1
AC092610 Genomic DNA Translation: AAS07559.1 Sequence problems.
CH236953 Genomic DNA Translation: EAL23966.1
CH471144 Genomic DNA Translation: EAW87301.1
BC004919 mRNA Translation: AAH04919.2
BC117317 mRNA Translation: AAI17318.1
BC126311 mRNA Translation: AAI26312.1
BC143526 mRNA Translation: AAI43527.1
AL136731 mRNA Translation: CAB66665.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS43544.1 [Q96JH8-4]

NCBI Reference Sequences

More...RefSeqi		NP_060529.4, NM_018059.4 [Q96JH8-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000399583.4; ENSP00000382492.3; ENSG00000157927.17

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55698

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55698

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000399583.4; ENSP00000382492.3; NM_018059.5; NP_060529.4

UCSC genome browser

More...UCSCi		uc003snj.2, human [Q96JH8-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058752 mRNA Translation: BAB47478.1 Different initiation.
AK000997 mRNA Translation: BAA91459.1
AK001186 mRNA Translation: BAA91543.1 Different initiation.
EF560723 mRNA Translation: ABQ59033.1
AC092610 Genomic DNA Translation: AAS07559.1 Sequence problems.
CH236953 Genomic DNA Translation: EAL23966.1
CH471144 Genomic DNA Translation: EAW87301.1
BC004919 mRNA Translation: AAH04919.2
BC117317 mRNA Translation: AAI17318.1
BC126311 mRNA Translation: AAI26312.1
BC143526 mRNA Translation: AAI43527.1
AL136731 mRNA Translation: CAB66665.2
CCDSiCCDS43544.1 [Q96JH8-4]
RefSeqiNP_060529.4, NM_018059.4 [Q96JH8-4]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UM1NMR-A973-1069[»]
3EC8X-ray2.60A51-193[»]
AlphaFoldDBiQ96JH8
SMRiQ96JH8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120823, 39 interactors
IntActiQ96JH8, 21 interactors
MINTiQ96JH8
STRINGi9606.ENSP00000382492

PTM databases

iPTMnetiQ96JH8
PhosphoSitePlusiQ96JH8

Genetic variation databases

BioMutaiRADIL
DMDMi317373589

Proteomic databases

MassIVEiQ96JH8
PaxDbiQ96JH8
PeptideAtlasiQ96JH8
PRIDEiQ96JH8
ProteomicsDBi76964 [Q96JH8-4]
76965 [Q96JH8-1]
76966 [Q96JH8-2]
76967 [Q96JH8-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		43694, 147 antibodies from 20 providers

The DNASU plasmid repository

More...DNASUi		55698

Genome annotation databases

EnsembliENST00000399583.4; ENSP00000382492.3; ENSG00000157927.17
GeneIDi55698
KEGGihsa:55698
MANE-SelectiENST00000399583.4; ENSP00000382492.3; NM_018059.5; NP_060529.4
UCSCiuc003snj.2, human [Q96JH8-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55698
DisGeNETi55698

GeneCards: human genes, protein and diseases

More...GeneCardsi		RADIL
HGNCiHGNC:22226, RADIL
HPAiENSG00000157927, Tissue enhanced (brain)
MIMi611491, gene
neXtProtiNX_Q96JH8
OpenTargetsiENSG00000157927
PharmGKBiPA164725261
VEuPathDBiHostDB:ENSG00000157927

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0160, Eukaryota
GeneTreeiENSGT00940000159293
HOGENOMiCLU_010386_0_0_1
InParanoidiQ96JH8
OMAiCIPFQNE
OrthoDBi447883at2759
PhylomeDBiQ96JH8
TreeFamiTF350641

Enzyme and pathway databases

PathwayCommonsiQ96JH8
SignaLinkiQ96JH8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55698, 17 hits in 1075 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RADIL, human
EvolutionaryTraceiQ96JH8

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RADIL

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55698
PharosiQ96JH8, Tbio

Protein Ontology

More...PROi		PR:Q96JH8
RNActiQ96JH8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000157927, Expressed in oocyte and 171 other tissues
ExpressionAtlasiQ96JH8, baseline and differential
GenevisibleiQ96JH8, HS

Family and domain databases

CDDicd15472, Myo5p-like_CBD_Rasip1, 1 hit
Gene3Di2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR037983, CBD_Rasip1/Radil
IPR002710, Dilute_dom
IPR001478, PDZ
IPR036034, PDZ_sf
IPR000159, RA_dom
IPR008984, SMAD_FHA_dom_sf
IPR029071, Ubiquitin-like_domsf
PfamiView protein in Pfam
PF01843, DIL, 1 hit
PF00595, PDZ, 1 hit
PF00788, RA, 1 hit
SMARTiView protein in SMART
SM01132, DIL, 1 hit
SM00228, PDZ, 1 hit
SM00314, RA, 1 hit
SUPFAMiSSF49879, SSF49879, 1 hit
SSF50156, SSF50156, 1 hit
SSF54236, SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS51126, DILUTE, 1 hit
PS50106, PDZ, 1 hit
PS50200, RA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRADIL_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96JH8
Secondary accession number(s): A4D1Z5
, A5YM49, B7ZL20, Q0VFZ9, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: January 11, 2011
Last modified: May 25, 2022
This is version 160 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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