UniProtKB - Q96JH8 (RADIL_HUMAN)

BLAST

>sp|Q96JH8|RADIL_HUMAN Ras-associating and dilute domain-containing protein OS=Homo sapiens OX=9606 GN=RADIL PE=1 SV=5
MFYGTHFIMSPPTKSKLKRQSQLLSSMLSRTLSYKYRDLDSTFSSLGASDDPAELSTQLS
APGVLKVFGDSVCTGTHYKSVLATGTSSARELVKEALERYALDPRQAGQYVLCDVVGQAG
DAGQRWQARCFRVFGDSEKPLLIQELWKPREGLSRRFELRKRSDVEELAAKEVDTITAGI
NAQARRLQRSRAKGTPTPALGDARSSPPPRLRRTVSETSLSPVNALPAAAQGPEEPGPDA
MRYSLYQSPHLLLLQGYSQQHDSLVYVLNRDRHTVGQRTPSSKPSISLSAPDILPLHCTI
RRQPLPDSGQAAGRLVLEPIPGAHISVNFSEVGHRTVVLHHGDLLSLGLYYLLLFKDPAQ
AQPLPARALARLRAVPQSCRLCGAALGARGAASPTQAALPRRQQLLLEFEPHLEDTLLQR
IMTLIEPGGDDHKLTPAFLLCLCIQHSATHFQPGTFGQLLLKIARLIRETVWEKTKELAE
KQAQLQEPISLASCAMADLVPDLQPILFWMSNSIELLYFIQQKCPLYMQSMEEQLDITGS
KESLFSCTLTASEEAMAVLEEVVLYAFQQCVYYVSKSLYICLPALLECPPFQTERRESWS
SAPELPEELRRVVSVYQAALDLLRQLQVHPEVASQMLAYLFFFSGTLLLNQLLDRGPSLS
CFHWPRGVQACARLQQLLEWMRSAGFGAAGEHFFQKLSCTLNLLATPRAQLIQMSWTALR
AAFPALSPAQLHRLLTHYQLASAMGPMSTWEPGAQDSPEAFRSEDVLESYENPPPIVLPS
DGFQVDLEANCLDDSIYQHLLYVRHFLWGLRSRASPGSPGRPGSGASQPVCPEGMHHVVL
DGHLEAPSCPLAPRDPGPAAREVAPERTLPLRGAPWAQAPPGRQPSRGGSQAGPPHTDSS
CLLTPPSTPLGPEPGDPDWPESGGPCGKALPERQRNGLSGLRGAAPEGDSAALAEESPPA
PSSRSSSTEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRL
SLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAKSDVETAKKIHFRTPPL

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History
Entry version 141 (07 Nov 2018)
Sequence version 5 (11 Jan 2011)
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Protein

Ras-associating and dilute domain-containing protein

Gene

RADIL

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development.1 Publication

GO - Biological processⁱ

multicellular organism development Source: UniProtKB-KW
signal transduction Source: InterPro
substrate adhesion-dependent cell spreading
Source: MGI
Inferred from direct assayⁱ
- 23209302

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein
Biological process	Cell adhesion

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras-associating and dilute domain-containing protein
Gene namesⁱ	Name:RADIL Synonyms:KIAA1849
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000157927.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:22226 RADIL
MIMⁱ	611491 gene
neXtProtⁱ	NX_Q96JH8

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000157927
PharmGKBⁱ	PA164725261

Polymorphism and mutation databases

BioMutaⁱ	RADIL
DMDMⁱ	317373589

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000050803	1 – 1075	Ras-associating and dilute domain-containing proteinAdd BLAST		1075

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	206	PhosphoserineCombined sources	1
Modified residueⁱ	216	PhosphoserineBy similarity	1
Modified residueⁱ	219	PhosphoserineBy similarity	1
Modified residueⁱ	221	PhosphoserineBy similarity	1
Modified residueⁱ	393	PhosphoserineCombined sources	1
Modified residueⁱ	890	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q96JH8
PeptideAtlas More...PeptideAtlasⁱ	Q96JH8
PRIDEⁱ	Q96JH8
ProteomicsDBⁱ	76964 76965 [Q96JH8-1] 76966 [Q96JH8-2] 76967 [Q96JH8-3]

PTM databases

iPTMnetⁱ	Q96JH8
PhosphoSitePlusⁱ	Q96JH8

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000157927 Expressed in 150 organ(s), highest expression level in oocyte
ExpressionAtlasⁱ	Q96JH8 baseline and differential
Genevisibleⁱ	Q96JH8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA051776

HPAⁱ

HPA051776

Interactionⁱ

Subunit structureⁱ

Interacts with RAP1A; in a GTP-dependent manner. Does not interact with members of the Ras family (PubMed:17704304). Interacts (via PDZ domain) with KIF14; is recruited to the microtubule network restricting its interaction with activated RAP1A (PubMed:23209302).2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CEP76	Q8TAP6	3	EBI-744267,EBI-742887
GATA1	P15976	3	EBI-744267,EBI-3909284
KRT31	Q15323	5	EBI-744267,EBI-948001
MAGEA11	P43364-2	3	EBI-744267,EBI-10178634
MRFAP1L1	Q96HT8	3	EBI-744267,EBI-748896

Protein-protein interaction databases

BioGridⁱ	120823, 26 interactors
IntActⁱ	Q96JH8, 11 interactors
Molecular INTeraction database More...MINTⁱ	Q96JH8
STRINGⁱ	9606.ENSP00000382492

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	52 – 60	Combined sources	9
Beta strandⁱ	62 – 68	Combined sources	7
Beta strandⁱ	79 – 84	Combined sources	6
Helixⁱ	89 – 99	Combined sources	11
Helixⁱ	104 – 109	Combined sources	6
Beta strandⁱ	110 – 117	Combined sources	8
Beta strandⁱ	130 – 133	Combined sources	4
Helixⁱ	140 – 146	Combined sources	7
Beta strandⁱ	154 – 161	Combined sources	8
Helixⁱ	162 – 188	Combined sources	27
Beta strandⁱ	974 – 980	Combined sources	7
Beta strandⁱ	988 – 992	Combined sources	5
Turnⁱ	993 – 995	Combined sources	3
Beta strandⁱ	1001 – 1008	Combined sources	8
Helixⁱ	1013 – 1017	Combined sources	5
Beta strandⁱ	1025 – 1031	Combined sources	7
Helixⁱ	1039 – 1047	Combined sources	9
Beta strandⁱ	1051 – 1058	Combined sources	8
Helixⁱ	1062 – 1068	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	Q96JH8
SMRⁱ	Q96JH8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q96JH8

EvolutionaryTraceⁱ

Q96JH8

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	61 – 164	Ras-associatingPROSITE-ProRule annotationAdd BLAST	104
Domainⁱ	314 – 389	FHAAdd BLAST	76
Domainⁱ	497 – 764	DilutePROSITE-ProRule annotationAdd BLAST	268
Domainⁱ	976 – 1061	PDZPROSITE-ProRule annotationAdd BLAST	86

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	847 – 925	Pro-richAdd BLAST		79

Sequence similaritiesⁱ

Belongs to the RADIL family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IQUG Eukaryota ENOG410ZVSZ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063674
HOVERGENⁱ	HBG079536
InParanoidⁱ	Q96JH8
OMAⁱ	YEVHPEI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00X4
PhylomeDBⁱ	Q96JH8
TreeFamⁱ	TF350641

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd15472 Myo5p-like_CBD_Rasip1, 1 hit
InterProⁱ	View protein in InterPro IPR037983 CBD_Rasip1/Radil IPR002710 Dilute_dom IPR001478 PDZ IPR036034 PDZ_sf IPR000159 RA_dom IPR008984 SMAD_FHA_dom_sf IPR029071 Ubiquitin-like_domsf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01843 DIL, 1 hit PF00595 PDZ, 1 hit PF00788 RA, 1 hit
SMARTⁱ	View protein in SMART SM01132 DIL, 1 hit SM00228 PDZ, 1 hit SM00314 RA, 1 hit
SUPFAMⁱ	SSF49879 SSF49879, 1 hit SSF50156 SSF50156, 1 hit SSF54236 SSF54236, 1 hit
PROSITEⁱ	View protein in PROSITE PS51126 DILUTE, 1 hit PS50106 PDZ, 1 hit PS50200 RA, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 4 (identifier: Q96JH8-4) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MFYGTHFIMS PPTKSKLKRQ SQLLSSMLSR TLSYKYRDLD STFSSLGASD 
        60         70         80         90        100
DPAELSTQLS APGVLKVFGD SVCTGTHYKS VLATGTSSAR ELVKEALERY 
       110        120        130        140        150
ALDPRQAGQY VLCDVVGQAG DAGQRWQARC FRVFGDSEKP LLIQELWKPR 
       160        170        180        190        200
EGLSRRFELR KRSDVEELAA KEVDTITAGI NAQARRLQRS RAKGTPTPAL 
       210        220        230        240        250
GDARSSPPPR LRRTVSETSL SPVNALPAAA QGPEEPGPDA MRYSLYQSPH 
       260        270        280        290        300
LLLLQGYSQQ HDSLVYVLNR DRHTVGQRTP SSKPSISLSA PDILPLHCTI 
       310        320        330        340        350
RRQPLPDSGQ AAGRLVLEPI PGAHISVNFS EVGHRTVVLH HGDLLSLGLY 
       360        370        380        390        400
YLLLFKDPAQ AQPLPARALA RLRAVPQSCR LCGAALGARG AASPTQAALP 
       410        420        430        440        450
RRQQLLLEFE PHLEDTLLQR IMTLIEPGGD DHKLTPAFLL CLCIQHSATH 
       460        470        480        490        500
FQPGTFGQLL LKIARLIRET VWEKTKELAE KQAQLQEPIS LASCAMADLV 
       510        520        530        540        550
PDLQPILFWM SNSIELLYFI QQKCPLYMQS MEEQLDITGS KESLFSCTLT 
       560        570        580        590        600
ASEEAMAVLE EVVLYAFQQC VYYVSKSLYI CLPALLECPP FQTERRESWS 
       610        620        630        640        650
SAPELPEELR RVVSVYQAAL DLLRQLQVHP EVASQMLAYL FFFSGTLLLN 
       660        670        680        690        700
QLLDRGPSLS CFHWPRGVQA CARLQQLLEW MRSAGFGAAG EHFFQKLSCT 
       710        720        730        740        750
LNLLATPRAQ LIQMSWTALR AAFPALSPAQ LHRLLTHYQL ASAMGPMSTW 
       760        770        780        790        800
EPGAQDSPEA FRSEDVLESY ENPPPIVLPS DGFQVDLEAN CLDDSIYQHL 
       810        820        830        840        850
LYVRHFLWGL RSRASPGSPG RPGSGASQPV CPEGMHHVVL DGHLEAPSCP 
       860        870        880        890        900
LAPRDPGPAA REVAPERTLP LRGAPWAQAP PGRQPSRGGS QAGPPHTDSS 
       910        920        930        940        950
CLLTPPSTPL GPEPGDPDWP ESGGPCGKAL PERQRNGLSG LRGAAPEGDS 
       960        970        980        990       1000
AALAEESPPA PSSRSSSTED FCYVFTVELE RGPSGLGMGL IDGMHTHLGA 
      1010       1020       1030       1040       1050
PGLYIQTLLP GSPAAADGRL SLGDRILEVN GSSLLGLGYL RAVDLIRHGG 
      1060       1070 
KKMRFLVAKS DVETAKKIHF RTPPL

Length:1,075

Mass (Da):117,455

Last modified:January 11, 2011 - v5

Checksum:ⁱA071219E8FD10131

Isoform 2 (identifier: Q96JH8-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-495: Missing.

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        10         20         30         40         50
MADLVPDLQP ILFWMSNSIE LLYFIQQKCP LYMQSMEEQL DITGSKESLF 
        60         70         80         90        100
SCTLTASEEA MAVLEEVVLY AFQQCVYYVS KSLYICLPAL LECPPFQTER 
       110        120        130        140        150
RESWSSAPEL PEELRRVVSV YQAALDLLRQ LQVHPEVASQ MLAYLFFFSG 
       160        170        180        190        200
TLLLNQLLDR GPSLSCFHWP RGVQACARLQ QLLEWMRSAG FGAAGEHFFQ 
       210        220        230        240        250
KLSCTLNLLA TPRAQLIQMS WTALRAAFPA LSPAQLHRLL THYQLASAMG 
       260        270        280        290        300
PMSTWEPGAQ DSPEAFRSED VLESYENPPP IVLPSDGFQV DLEANCLDDS 
       310        320        330        340        350
IYQHLLYVRH FLWGLRSRAS PGSPGRPGSG ASQPVCPEGM HHVVLDGHLE 
       360        370        380        390        400
APSCPLAPRD PGPAAREVAP ERTLPLRGAP WAQAPPGRQP SRGGSQAGPP 
       410        420        430        440        450
HTDSSCLLTP PSTPLGPEPG DPDWPESGGP CGKALPERQR NGLSGLRGAA 
       460        470        480        490        500
PEGDSAALAE ESPPAPSSRS SSTEDFCYVF TVELERGPSG LGMGLIDGMH 
       510        520        530        540        550
THLGAPGLYI QTLLPGSPAA ADGRLSLGDR ILEVNGSSLL GLGYLRAVDL 
       560        570        580
IRHGGKKMRF LVAKSDVETA KKIHFRTPPL

Note: No experimental confirmation available.

Show »

Length:580

Mass (Da):63,118

Checksum:ⁱDA26C51AF63798BF

Isoform 3 (identifier: Q96JH8-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-704: Missing.
705-763: ATPRAQLIQM...AQDSPEAFRS → MSPRVGPVTV...GHYGHPLSPA

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        10         20         30         40         50
MSPRVGPVTV ARIPASCVHR AGDSGLNLLA PGFPHRWAGR PGEGGSFSCG 
        60         70         80         90        100
HYGHPLSPAE DVLESYENPP PIVLPSDGFQ VDLEANCLDD SIYQHLLYVR 
       110        120        130        140        150
HFLWGLRSRA SPGSPGRPGS GASQPVCPEG MHHVVLDGHL EAPSCPLAPR 
       160        170        180        190        200
DPGPAAREVA PERTLPLRGA PWAQAPPGRQ PSRGGSQAGP PHTDSSCLLT 
       210        220        230        240        250
PPSTPLGPEP GDPDWPESGG PCGKALPERQ RNGLSGLRGA APEGDSAALA 
       260        270        280        290        300
EESPPAPSSR SSSTEDFCYV FTVELERGPS GLGMGLIDGM HTHLGAPGLY 
       310        320        330        340        350
IQTLLPGSPA AADGRLSLGD RILEVNGSSL LGLGYLRAVD LIRHGGKKMR 
       360        370 
FLVAKSDVET AKKIHFRTPP L

Note: No experimental confirmation available.

Show »

Length:371

Mass (Da):38,824

Checksum:ⁱFBD298E4B59C5BAB

Isoform 1 (identifier: Q96JH8-1) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
262-279: DSLVYVLNRDRHTVGQRT → PGVCAQPGPAHGGPAD

« Hide

        10         20         30         40         50
MFYGTHFIMS PPTKSKLKRQ SQLLSSMLSR TLSYKYRDLD STFSSLGASD 
        60         70         80         90        100
DPAELSTQLS APGVLKVFGD SVCTGTHYKS VLATGTSSAR ELVKEALERY 
       110        120        130        140        150
ALDPRQAGQY VLCDVVGQAG DAGQRWQARC FRVFGDSEKP LLIQELWKPR 
       160        170        180        190        200
EGLSRRFELR KRSDVEELAA KEVDTITAGI NAQARRLQRS RAKGTPTPAL 
       210        220        230        240        250
GDARSSPPPR LRRTVSETSL SPVNALPAAA QGPEEPGPDA MRYSLYQSPH 
       260        270        280        290        300
LLLLQGYSQQ HPGVCAQPGP AHGGPADPSS KPSISLSAPD ILPLHCTIRR 
       310        320        330        340        350
QPLPDSGQAA GRLVLEPIPG AHISVNFSEV GHRTVVLHHG DLLSLGLYYL 
       360        370        380        390        400
LLFKDPAQAQ PLPARALARL RAVPQSCRLC GAALGARGAA SPTQAALPRR 
       410        420        430        440        450
QQLLLEFEPH LEDTLLQRIM TLIEPGGDDH KLTPAFLLCL CIQHSATHFQ 
       460        470        480        490        500
PGTFGQLLLK IARLIRETVW EKTKELAEKQ AQLQEPISLA SCAMADLVPD 
       510        520        530        540        550
LQPILFWMSN SIELLYFIQQ KCPLYMQSME EQLDITGSKE SLFSCTLTAS 
       560        570        580        590        600
EEAMAVLEEV VLYAFQQCVY YVSKSLYICL PALLECPPFQ TERRESWSSA 
       610        620        630        640        650
PELPEELRRV VSVYQAALDL LRQLQVHPEV ASQMLAYLFF FSGTLLLNQL 
       660        670        680        690        700
LDRGPSLSCF HWPRGVQACA RLQQLLEWMR SAGFGAAGEH FFQKLSCTLN 
       710        720        730        740        750
LLATPRAQLI QMSWTALRAA FPALSPAQLH RLLTHYQLAS AMGPMSTWEP 
       760        770        780        790        800
GAQDSPEAFR SEDVLESYEN PPPIVLPSDG FQVDLEANCL DDSIYQHLLY 
       810        820        830        840        850
VRHFLWGLRS RASPGSPGRP GSGASQPVCP EGMHHVVLDG HLEAPSCPLA 
       860        870        880        890        900
PRDPGPAARE VAPERTLPLR GAPWAQAPPG RQPSRGGSQA GPPHTDSSCL 
       910        920        930        940        950
LTPPSTPLGP EPGDPDWPES GGPCGKALPE RQRNGLSGLR GAAPEGDSAA 
       960        970        980        990       1000
LAEESPPAPS SRSSSTEDFC YVFTVELERG PSGLGMGLID GMHTHLGAPG 
      1010       1020       1030       1040       1050
LYIQTLLPGS PAAADGRLSL GDRILEVNGS SLLGLGYLRA VDLIRHGGKK 
      1060       1070 
MRFLVAKSDV ETAKKIHFRT PPL

Show »

Length:1,073

Mass (Da):116,757

Checksum:ⁱBE16FDC66C40E658

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8WEM1	F8WEM1_HUMAN	Ras-associating and dilute domain-c... Ras-associating and dilute domain-containing protein	RADIL	407	Annotation score:
C9J7G0	C9J7G0_HUMAN	Ras-associating and dilute domain-c... Ras-associating and dilute domain-containing protein	RADIL	134	Annotation score:

Sequence cautionⁱ

The sequence AAS07559 differs from that shown. Reason: Erroneous gene model prediction.Curated

The sequence BAA91543 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAB47478 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	700	T → I in CAB66665 (PubMed:11230166).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_046192	239	D → NCombined sources2 PublicationsCorresponds to variant dbSNP:rs3763384Ensembl.	1
Natural variantⁱVAR_046193	412	H → D3 PublicationsCorresponds to variant dbSNP:rs2292498Ensembl.	1
Natural variantⁱVAR_023769	886	S → G7 PublicationsCorresponds to variant dbSNP:rs414035Ensembl.	1
Natural variantⁱVAR_060193	938	L → P1 PublicationCorresponds to variant dbSNP:rs6966329Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_016097	1 – 704	Missing in isoform 3. 1 PublicationAdd BLAST	704
Alternative sequenceⁱVSP_016098	1 – 495	Missing in isoform 2. 1 PublicationAdd BLAST	495
Alternative sequenceⁱVSP_035179	262 – 279	DSLVY…VGQRT → PGVCAQPGPAHGGPAD in isoform 1. 3 PublicationsAdd BLAST	18
Alternative sequenceⁱVSP_016099	705 – 763	ATPRA…EAFRS → MSPRVGPVTVARIPASCVHR AGDSGLNLLAPGFPHRWAGR PGEGGSFSCGHYGHPLSPA in isoform 3. 1 PublicationAdd BLAST	59

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB058752 mRNA Translation: BAB47478.1 Different initiation. AK000997 mRNA Translation: BAA91459.1 AK001186 mRNA Translation: BAA91543.1 Different initiation. EF560723 mRNA Translation: ABQ59033.1 AC092610 Genomic DNA Translation: AAS07559.1 Sequence problems. CH236953 Genomic DNA Translation: EAL23966.1 CH471144 Genomic DNA Translation: EAW87301.1 BC004919 mRNA Translation: AAH04919.2 BC117317 mRNA Translation: AAI17318.1 BC126311 mRNA Translation: AAI26312.1 BC143526 mRNA Translation: AAI43527.1 AL136731 mRNA Translation: CAB66665.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS43544.1 [Q96JH8-4]
NCBI Reference Sequences More...RefSeqⁱ	NP_060529.4, NM_018059.4 [Q96JH8-4]
UniGeneⁱ	Hs.667336

Genome annotation databases

Ensemblⁱ	ENST00000399583; ENSP00000382492; ENSG00000157927 [Q96JH8-4]
GeneIDⁱ	55698
KEGGⁱ	hsa:55698
UCSC genome browser More...UCSCⁱ	uc003snj.2 human [Q96JH8-4]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q96JH8	Ras-associating and dilute domain-containing protein (Fragment)		HUMAN		134	UniRef100_Q96JH8
Isoform 2 of Ras-associating and dilute domain-containing protein		HUMAN		580
Q96JH8-3	Uncharacterized protein FLJ10324		HUMAN		383	UniRef100_Q75LH2

Protein	Similar proteins		Species	Score	Length	Source
Q96JH8	Ras-associating and dilute domain-containing protein (Fragment)		HUMAN		134	UniRef90_Q96JH8
Rap associating with DIL domain		CHLSB		1100
RADIL isoform 3		PANTR		1075
Uncharacterized protein		AOTNA		1072
Rap associating with DIL domain		GORGO		1072
+47
Q96JH8-3	Uncharacterized protein FLJ10324		HUMAN		383	UniRef90_Q75LH2

Protein	Similar proteins		Species	Score	Length	Source
Q96JH8	Ras-associating and dilute domain-containing protein		MOUSE		1099	UniRef50_Q96JH8
Ras-associating and dilute domain-containing protein (Fragment)		HUMAN		134
Rap associating with DIL domain		CHLSB		1100
RADIL isoform 3		PANTR		1075
Rap associating with DIL domain		CALJA		1072
+223
Q96JH8-3	Uncharacterized protein FLJ10324		HUMAN		383	UniRef50_Q75LH2

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB058752 mRNA Translation: BAB47478.1 Different initiation. AK000997 mRNA Translation: BAA91459.1 AK001186 mRNA Translation: BAA91543.1 Different initiation. EF560723 mRNA Translation: ABQ59033.1 AC092610 Genomic DNA Translation: AAS07559.1 Sequence problems. CH236953 Genomic DNA Translation: EAL23966.1 CH471144 Genomic DNA Translation: EAW87301.1 BC004919 mRNA Translation: AAH04919.2 BC117317 mRNA Translation: AAI17318.1 BC126311 mRNA Translation: AAI26312.1 BC143526 mRNA Translation: AAI43527.1 AL136731 mRNA Translation: CAB66665.2
CCDSⁱ	CCDS43544.1 [Q96JH8-4]
RefSeqⁱ	NP_060529.4, NM_018059.4 [Q96JH8-4]
UniGeneⁱ	Hs.667336

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1UM1	NMR	-	A	973-1069	[»]
	3EC8	X-ray	2.60	A	51-193	[»]
ProteinModelPortalⁱ	Q96JH8
SMRⁱ	Q96JH8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120823, 26 interactors
IntActⁱ	Q96JH8, 11 interactors
MINTⁱ	Q96JH8
STRINGⁱ	9606.ENSP00000382492

PTM databases

iPTMnetⁱ	Q96JH8
PhosphoSitePlusⁱ	Q96JH8

Polymorphism and mutation databases

BioMutaⁱ	RADIL
DMDMⁱ	317373589

Proteomic databases

PaxDbⁱ	Q96JH8
PeptideAtlasⁱ	Q96JH8
PRIDEⁱ	Q96JH8
ProteomicsDBⁱ	76964 76965 [Q96JH8-1] 76966 [Q96JH8-2] 76967 [Q96JH8-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000399583; ENSP00000382492; ENSG00000157927 [Q96JH8-4]
GeneIDⁱ	55698
KEGGⁱ	hsa:55698
UCSCⁱ	uc003snj.2 human [Q96JH8-4]

Organism-specific databases

CTDⁱ	55698
EuPathDBⁱ	HostDB:ENSG00000157927.16
GeneCardsⁱ	RADIL
H-InvDBⁱ	HIX0006446
HGNCⁱ	HGNC:22226 RADIL
HPAⁱ	HPA051776
MIMⁱ	611491 gene
neXtProtⁱ	NX_Q96JH8
OpenTargetsⁱ	ENSG00000157927
PharmGKBⁱ	PA164725261
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IQUG Eukaryota ENOG410ZVSZ LUCA
GeneTreeⁱ	ENSGT00530000063674
HOVERGENⁱ	HBG079536
InParanoidⁱ	Q96JH8
OMAⁱ	YEVHPEI
OrthoDBⁱ	EOG091G00X4
PhylomeDBⁱ	Q96JH8
TreeFamⁱ	TF350641

Miscellaneous databases

ChiTaRSⁱ	RADIL human
EvolutionaryTraceⁱ	Q96JH8
GeneWikiⁱ	RADIL
GenomeRNAiⁱ	55698
Protein Ontology More...PROⁱ	PR:Q96JH8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000157927 Expressed in 150 organ(s), highest expression level in oocyte
ExpressionAtlasⁱ	Q96JH8 baseline and differential
Genevisibleⁱ	Q96JH8 HS

Family and domain databases

CDDⁱ	cd15472 Myo5p-like_CBD_Rasip1, 1 hit
InterProⁱ	View protein in InterPro IPR037983 CBD_Rasip1/Radil IPR002710 Dilute_dom IPR001478 PDZ IPR036034 PDZ_sf IPR000159 RA_dom IPR008984 SMAD_FHA_dom_sf IPR029071 Ubiquitin-like_domsf
Pfamⁱ	View protein in Pfam PF01843 DIL, 1 hit PF00595 PDZ, 1 hit PF00788 RA, 1 hit
SMARTⁱ	View protein in SMART SM01132 DIL, 1 hit SM00228 PDZ, 1 hit SM00314 RA, 1 hit
SUPFAMⁱ	SSF49879 SSF49879, 1 hit SSF50156 SSF50156, 1 hit SSF54236 SSF54236, 1 hit
PROSITEⁱ	View protein in PROSITE PS51126 DILUTE, 1 hit PS50106 PDZ, 1 hit PS50200 RA, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RADIL_HUMAN
Accessionⁱ	Q96JH8Primary (citable) accession number: Q96JH8 Secondary accession number(s): A4D1Z5 Q9NWC4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
	Last sequence update:	January 11, 2011
	Last modified:	November 7, 2018
	This is version 141 of the entry and version 5 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

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UniProtKB - Q96JH8 (RADIL_HUMAN)

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Ras-associating and dilute domain-containing protein

RADIL

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ