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UniProtKB - Q96JH8 (RADIL_HUMAN)
Protein
Ras-associating and dilute domain-containing protein
Gene
RADIL
Organism
Homo sapiens (Human)
Status
Functioni
Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development.
1 PublicationGO - Molecular functioni
- GTPase binding Source: GO_Central
GO - Biological processi
- neural crest cell migration Source: GO_Central
- signal transduction Source: InterPro
- substrate adhesion-dependent cell spreading Source: MGI
Keywordsi
Molecular function | Developmental protein |
Biological process | Cell adhesion |
Enzyme and pathway databases
PathwayCommonsi | Q96JH8 |
SignaLinki | Q96JH8 |
Names & Taxonomyi
Protein namesi | Recommended name: Ras-associating and dilute domain-containing protein |
Gene namesi | Name:RADIL Synonyms:KIAA1849 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:22226, RADIL |
MIMi | 611491, gene |
neXtProti | NX_Q96JH8 |
VEuPathDBi | HostDB:ENSG00000157927 |
Subcellular locationi
Cytoskeleton
- microtubule Source: MGI
Other locations
- protein-containing complex Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 55698 |
OpenTargetsi | ENSG00000157927 |
PharmGKBi | PA164725261 |
Miscellaneous databases
Pharosi | Q96JH8, Tbio |
Genetic variation databases
BioMutai | RADIL |
DMDMi | 317373589 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050803 | 1 – 1075 | Ras-associating and dilute domain-containing proteinAdd BLAST | 1075 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 206 | PhosphoserineCombined sources | 1 | |
Modified residuei | 216 | PhosphoserineBy similarity | 1 | |
Modified residuei | 219 | PhosphoserineBy similarity | 1 | |
Modified residuei | 221 | PhosphoserineBy similarity | 1 | |
Modified residuei | 393 | PhosphoserineCombined sources | 1 | |
Modified residuei | 890 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MassIVEi | Q96JH8 |
PaxDbi | Q96JH8 |
PeptideAtlasi | Q96JH8 |
PRIDEi | Q96JH8 |
ProteomicsDBi | 76964 [Q96JH8-4] 76965 [Q96JH8-1] 76966 [Q96JH8-2] 76967 [Q96JH8-3] |
PTM databases
iPTMneti | Q96JH8 |
PhosphoSitePlusi | Q96JH8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000157927, Expressed in oocyte and 171 other tissues |
ExpressionAtlasi | Q96JH8, baseline and differential |
Genevisiblei | Q96JH8, HS |
Organism-specific databases
HPAi | ENSG00000157927, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Binary interactionsi
Q96JH8
GO - Molecular functioni
- GTPase binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 120823, 39 interactors |
IntActi | Q96JH8, 21 interactors |
MINTi | Q96JH8 |
STRINGi | 9606.ENSP00000382492 |
Miscellaneous databases
RNActi | Q96JH8, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q96JH8 |
SMRi | Q96JH8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q96JH8 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 61 – 164 | Ras-associatingPROSITE-ProRule annotationAdd BLAST | 104 | |
Domaini | 314 – 389 | FHAAdd BLAST | 76 | |
Domaini | 497 – 764 | DilutePROSITE-ProRule annotationAdd BLAST | 268 | |
Domaini | 976 – 1061 | PDZPROSITE-ProRule annotationAdd BLAST | 86 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 183 – 237 | DisorderedSequence analysisAdd BLAST | 55 | |
Regioni | 872 – 967 | DisorderedSequence analysisAdd BLAST | 96 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 211 – 225 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 890 – 906 | Polar residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the RADIL family.Curated
Phylogenomic databases
eggNOGi | KOG0160, Eukaryota |
GeneTreei | ENSGT00940000159293 |
HOGENOMi | CLU_010386_0_0_1 |
InParanoidi | Q96JH8 |
OMAi | CIPFQNE |
OrthoDBi | 447883at2759 |
PhylomeDBi | Q96JH8 |
TreeFami | TF350641 |
Family and domain databases
CDDi | cd15472, Myo5p-like_CBD_Rasip1, 1 hit |
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR037983, CBD_Rasip1/Radil IPR002710, Dilute_dom IPR001478, PDZ IPR036034, PDZ_sf IPR000159, RA_dom IPR008984, SMAD_FHA_dom_sf IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF01843, DIL, 1 hit PF00595, PDZ, 1 hit PF00788, RA, 1 hit |
SMARTi | View protein in SMART SM01132, DIL, 1 hit SM00228, PDZ, 1 hit SM00314, RA, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF50156, SSF50156, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS51126, DILUTE, 1 hit PS50106, PDZ, 1 hit PS50200, RA, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 4 (identifier: Q96JH8-4) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MFYGTHFIMS PPTKSKLKRQ SQLLSSMLSR TLSYKYRDLD STFSSLGASD
60 70 80 90 100
DPAELSTQLS APGVLKVFGD SVCTGTHYKS VLATGTSSAR ELVKEALERY
110 120 130 140 150
ALDPRQAGQY VLCDVVGQAG DAGQRWQARC FRVFGDSEKP LLIQELWKPR
160 170 180 190 200
EGLSRRFELR KRSDVEELAA KEVDTITAGI NAQARRLQRS RAKGTPTPAL
210 220 230 240 250
GDARSSPPPR LRRTVSETSL SPVNALPAAA QGPEEPGPDA MRYSLYQSPH
260 270 280 290 300
LLLLQGYSQQ HDSLVYVLNR DRHTVGQRTP SSKPSISLSA PDILPLHCTI
310 320 330 340 350
RRQPLPDSGQ AAGRLVLEPI PGAHISVNFS EVGHRTVVLH HGDLLSLGLY
360 370 380 390 400
YLLLFKDPAQ AQPLPARALA RLRAVPQSCR LCGAALGARG AASPTQAALP
410 420 430 440 450
RRQQLLLEFE PHLEDTLLQR IMTLIEPGGD DHKLTPAFLL CLCIQHSATH
460 470 480 490 500
FQPGTFGQLL LKIARLIRET VWEKTKELAE KQAQLQEPIS LASCAMADLV
510 520 530 540 550
PDLQPILFWM SNSIELLYFI QQKCPLYMQS MEEQLDITGS KESLFSCTLT
560 570 580 590 600
ASEEAMAVLE EVVLYAFQQC VYYVSKSLYI CLPALLECPP FQTERRESWS
610 620 630 640 650
SAPELPEELR RVVSVYQAAL DLLRQLQVHP EVASQMLAYL FFFSGTLLLN
660 670 680 690 700
QLLDRGPSLS CFHWPRGVQA CARLQQLLEW MRSAGFGAAG EHFFQKLSCT
710 720 730 740 750
LNLLATPRAQ LIQMSWTALR AAFPALSPAQ LHRLLTHYQL ASAMGPMSTW
760 770 780 790 800
EPGAQDSPEA FRSEDVLESY ENPPPIVLPS DGFQVDLEAN CLDDSIYQHL
810 820 830 840 850
LYVRHFLWGL RSRASPGSPG RPGSGASQPV CPEGMHHVVL DGHLEAPSCP
860 870 880 890 900
LAPRDPGPAA REVAPERTLP LRGAPWAQAP PGRQPSRGGS QAGPPHTDSS
910 920 930 940 950
CLLTPPSTPL GPEPGDPDWP ESGGPCGKAL PERQRNGLSG LRGAAPEGDS
960 970 980 990 1000
AALAEESPPA PSSRSSSTED FCYVFTVELE RGPSGLGMGL IDGMHTHLGA
1010 1020 1030 1040 1050
PGLYIQTLLP GSPAAADGRL SLGDRILEVN GSSLLGLGYL RAVDLIRHGG
1060 1070
KKMRFLVAKS DVETAKKIHF RTPPL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8WEM1 | F8WEM1_HUMAN | Ras-associating and dilute domain-c... | RADIL | 407 | Annotation score: | ||
C9J7G0 | C9J7G0_HUMAN | Ras-associating and dilute domain-c... | RADIL | 134 | Annotation score: |
Sequence cautioni
The sequence AAS07559 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAA91543 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB47478 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 700 | T → I in CAB66665 (PubMed:11230166).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_046192 | 239 | D → NCombined sources2 PublicationsCorresponds to variant dbSNP:rs3763384Ensembl. | 1 | |
Natural variantiVAR_046193 | 412 | H → D3 PublicationsCorresponds to variant dbSNP:rs2292498Ensembl. | 1 | |
Natural variantiVAR_023769 | 886 | S → G7 PublicationsCorresponds to variant dbSNP:rs414035Ensembl. | 1 | |
Natural variantiVAR_060193 | 938 | L → P1 PublicationCorresponds to variant dbSNP:rs6966329Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016097 | 1 – 704 | Missing in isoform 3. 1 PublicationAdd BLAST | 704 | |
Alternative sequenceiVSP_016098 | 1 – 495 | Missing in isoform 2. 1 PublicationAdd BLAST | 495 | |
Alternative sequenceiVSP_035179 | 262 – 279 | DSLVY…VGQRT → PGVCAQPGPAHGGPAD in isoform 1. 3 PublicationsAdd BLAST | 18 | |
Alternative sequenceiVSP_016099 | 705 – 763 | ATPRA…EAFRS → MSPRVGPVTVARIPASCVHR AGDSGLNLLAPGFPHRWAGR PGEGGSFSCGHYGHPLSPA in isoform 3. 1 PublicationAdd BLAST | 59 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB058752 mRNA Translation: BAB47478.1 Different initiation. AK000997 mRNA Translation: BAA91459.1 AK001186 mRNA Translation: BAA91543.1 Different initiation. EF560723 mRNA Translation: ABQ59033.1 AC092610 Genomic DNA Translation: AAS07559.1 Sequence problems. CH236953 Genomic DNA Translation: EAL23966.1 CH471144 Genomic DNA Translation: EAW87301.1 BC004919 mRNA Translation: AAH04919.2 BC117317 mRNA Translation: AAI17318.1 BC126311 mRNA Translation: AAI26312.1 BC143526 mRNA Translation: AAI43527.1 AL136731 mRNA Translation: CAB66665.2 |
CCDSi | CCDS43544.1 [Q96JH8-4] |
RefSeqi | NP_060529.4, NM_018059.4 [Q96JH8-4] |
Genome annotation databases
Ensembli | ENST00000399583.4; ENSP00000382492.3; ENSG00000157927.17 |
GeneIDi | 55698 |
KEGGi | hsa:55698 |
MANE-Selecti | ENST00000399583.4; ENSP00000382492.3; NM_018059.5; NP_060529.4 |
UCSCi | uc003snj.2, human [Q96JH8-4] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB058752 mRNA Translation: BAB47478.1 Different initiation. AK000997 mRNA Translation: BAA91459.1 AK001186 mRNA Translation: BAA91543.1 Different initiation. EF560723 mRNA Translation: ABQ59033.1 AC092610 Genomic DNA Translation: AAS07559.1 Sequence problems. CH236953 Genomic DNA Translation: EAL23966.1 CH471144 Genomic DNA Translation: EAW87301.1 BC004919 mRNA Translation: AAH04919.2 BC117317 mRNA Translation: AAI17318.1 BC126311 mRNA Translation: AAI26312.1 BC143526 mRNA Translation: AAI43527.1 AL136731 mRNA Translation: CAB66665.2 |
CCDSi | CCDS43544.1 [Q96JH8-4] |
RefSeqi | NP_060529.4, NM_018059.4 [Q96JH8-4] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1UM1 | NMR | - | A | 973-1069 | [»] | |
3EC8 | X-ray | 2.60 | A | 51-193 | [»] | |
AlphaFoldDBi | Q96JH8 | |||||
SMRi | Q96JH8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120823, 39 interactors |
IntActi | Q96JH8, 21 interactors |
MINTi | Q96JH8 |
STRINGi | 9606.ENSP00000382492 |
PTM databases
iPTMneti | Q96JH8 |
PhosphoSitePlusi | Q96JH8 |
Genetic variation databases
BioMutai | RADIL |
DMDMi | 317373589 |
Proteomic databases
MassIVEi | Q96JH8 |
PaxDbi | Q96JH8 |
PeptideAtlasi | Q96JH8 |
PRIDEi | Q96JH8 |
ProteomicsDBi | 76964 [Q96JH8-4] 76965 [Q96JH8-1] 76966 [Q96JH8-2] 76967 [Q96JH8-3] |
Protocols and materials databases
Antibodypediai | 43694, 147 antibodies from 20 providers |
DNASUi | 55698 |
Genome annotation databases
Ensembli | ENST00000399583.4; ENSP00000382492.3; ENSG00000157927.17 |
GeneIDi | 55698 |
KEGGi | hsa:55698 |
MANE-Selecti | ENST00000399583.4; ENSP00000382492.3; NM_018059.5; NP_060529.4 |
UCSCi | uc003snj.2, human [Q96JH8-4] |
Organism-specific databases
CTDi | 55698 |
DisGeNETi | 55698 |
GeneCardsi | RADIL |
HGNCi | HGNC:22226, RADIL |
HPAi | ENSG00000157927, Tissue enhanced (brain) |
MIMi | 611491, gene |
neXtProti | NX_Q96JH8 |
OpenTargetsi | ENSG00000157927 |
PharmGKBi | PA164725261 |
VEuPathDBi | HostDB:ENSG00000157927 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0160, Eukaryota |
GeneTreei | ENSGT00940000159293 |
HOGENOMi | CLU_010386_0_0_1 |
InParanoidi | Q96JH8 |
OMAi | CIPFQNE |
OrthoDBi | 447883at2759 |
PhylomeDBi | Q96JH8 |
TreeFami | TF350641 |
Enzyme and pathway databases
PathwayCommonsi | Q96JH8 |
SignaLinki | Q96JH8 |
Miscellaneous databases
BioGRID-ORCSi | 55698, 17 hits in 1075 CRISPR screens |
ChiTaRSi | RADIL, human |
EvolutionaryTracei | Q96JH8 |
GeneWikii | RADIL |
GenomeRNAii | 55698 |
Pharosi | Q96JH8, Tbio |
PROi | PR:Q96JH8 |
RNActi | Q96JH8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000157927, Expressed in oocyte and 171 other tissues |
ExpressionAtlasi | Q96JH8, baseline and differential |
Genevisiblei | Q96JH8, HS |
Family and domain databases
CDDi | cd15472, Myo5p-like_CBD_Rasip1, 1 hit |
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR037983, CBD_Rasip1/Radil IPR002710, Dilute_dom IPR001478, PDZ IPR036034, PDZ_sf IPR000159, RA_dom IPR008984, SMAD_FHA_dom_sf IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF01843, DIL, 1 hit PF00595, PDZ, 1 hit PF00788, RA, 1 hit |
SMARTi | View protein in SMART SM01132, DIL, 1 hit SM00228, PDZ, 1 hit SM00314, RA, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF50156, SSF50156, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS51126, DILUTE, 1 hit PS50106, PDZ, 1 hit PS50200, RA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RADIL_HUMAN | |
Accessioni | Q96JH8Primary (citable) accession number: Q96JH8 Secondary accession number(s): A4D1Z5 Q9NWC4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2005 |
Last sequence update: | January 11, 2011 | |
Last modified: | May 25, 2022 | |
This is version 160 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families