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Entry version 139 (31 Jul 2019)
Sequence version 3 (24 Jul 2007)
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Protein

Zinc finger protein 469

Gene

ZNF469

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri2444 – 2470C2H2-type 1PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri3087 – 3109C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri3309 – 3331C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri3337 – 3360C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri3390 – 3414C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 469
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF469
Synonyms:KIAA1858
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23216 ZNF469

Online Mendelian Inheritance in Man (OMIM)

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MIMi
612078 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96JG9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Brittle cornea syndrome 1 (BCS1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by extreme corneal thinning resulting in corneal rupture after minor trauma, blue sclerae, keratoconus or keratoglobus, hyperelasticity of the skin, and hypermobility of the joints. It shares some features with, but is much less severe than, the ocular form of Ehlers-Danlos syndrome (EDS6).
Related information in OMIM

Organism-specific databases

DisGeNET

More...
DisGeNETi
84627

MalaCards human disease database

More...
MalaCardsi
ZNF469
MIMi229200 phenotype

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
90354 Brittle cornea syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134861470

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF469

Domain mapping of disease mutations (DMDM)

More...
DMDMi
158518658

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000476021 – 3925Zinc finger protein 469Add BLAST3925

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96JG9

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96JG9

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96JG9

PeptideAtlas

More...
PeptideAtlasi
Q96JG9

PRoteomics IDEntifications database

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PRIDEi
Q96JG9

ProteomicsDB human proteome resource

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ProteomicsDBi
76962

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96JG9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96JG9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in cornea, sclera, skin fibroblasts and striated muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000225614 Expressed in 175 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96JG9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96JG9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA069784

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
124156, 2 interactors

Protein interaction database and analysis system

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IntActi
Q96JG9, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000402343

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2 – 713Pro-richAdd BLAST712
Compositional biasi974 – 1042Arg-richAdd BLAST69
Compositional biasi1232 – 1515Pro-richAdd BLAST284

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri2444 – 2470C2H2-type 1PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri3087 – 3109C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri3309 – 3331C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri3337 – 3360C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri3390 – 3414C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000155797

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96JG9

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96JG9

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR039270 ZNF469
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

The PANTHER Classification System

More...
PANTHERi
PTHR21465 PTHR21465, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 8 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57667 SSF57667, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q96JG9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGERPRGAP PPTMTGDLQP RQVASSPGHP SQPPLEDNTP ATRTTKGARE
60 70 80 90 100
AGGQAQAMEL PEAQPRQARD GELKPPSLRG QAPSSTPGKR GSPQTPPGRS
110 120 130 140 150
PLQAPSRLAG RAEGSPPQRY ILGIASSRTK PTLDETPENP QLEAAQLPEV
160 170 180 190 200
DTPQGPGTGA PLRPGLPRTE AQPAAEELGF HRCFQEPPSS FTSTNYTSPS
210 220 230 240 250
ATPRPPAPGP PQSRGTSPLQ PGSYPEYQAS GADSWPPAAE NSFPGANFGV
260 270 280 290 300
PPAEPEPIPK GSRPGGSPRG VSFQFPFPAL HGASTKPFPA DVAGHAFTNG
310 320 330 340 350
PLVFAFHQPQ GAWPEEAVGT GPAYPLPTQP APSPLPCYQG QPGGLNRHSD
360 370 380 390 400
LSGALSSPGA AHSAPRPFSD SLHKSLTKIL PERPPSAQDG LGSTRGPPSS
410 420 430 440 450
LPQRHFPGQA YRASGVDTSP GPPDTELAAP GPPPARLPQL WDPTAAPYPT
460 470 480 490 500
PPGGPLAATR SMFFNGQPSP GQRLCLPQSA PLPWPQVLPT ARPSPHGMEM
510 520 530 540 550
LSRLPFPAGG PEWQGGSQGA LGTAGKTPGP REKLPAVRSS QGGSPALFTY
560 570 580 590 600
NGMTDPGAQP LFFGVAQPQV SPHGTPSLPP PRVVGASPSE SPLPSPATNT
610 620 630 640 650
AGSTCSSLSP MSSSPANPSS EESQLPGPLG PSAFFHPPTH PQETGSPFPS
660 670 680 690 700
PEPPHSLPTH YQPEPAKAFP FPADGLGAEG AFQCLEETPF PHEGPEVGRG
710 720 730 740 750
GLQGFPRAPP PYPTHHFSLS SASLDQLDVL LTCRQCDRNY SSLAAFLAHR
760 770 780 790 800
QFCGLLLARA KDGHQRSPGP PGLPSPPAAP RVPADAHAGL LSHAKTFLLA
810 820 830 840 850
GDAQAEGKDD PLRTGFLPSL AATPFPLPAS DLDMEDDAKL DSLITEALNG
860 870 880 890 900
MEYQSDNPEI DSSFIDVFAD EEPSGPRGPS SGHPLKSKAG VTPESKAPPP
910 920 930 940 950
LPAATPDPQT PRPGDRGCPA RGRPKTRSLG LAPTEADAPS QGRQQRRGKQ
960 970 980 990 1000
LKLFRKDLDS GGAAEGSGSG GGGRASGLRP RRNDGLGERP PPRPRRPRTQ
1010 1020 1030 1040 1050
APGSRADPAP RVPRAAALPE ETRSSRRRRL PPRKDPRKRK ARGGAWGKEL
1060 1070 1080 1090 1100
ILKIVQQKNR LREYDFASES EEDEQPPPRG PGFRGRRGRG EKRKEVELTQ
1110 1120 1130 1140 1150
GPREDEPQKP RKAARQEAGG DGAPANPEEP GGSRPGPGRS PQARGPSRSL
1160 1170 1180 1190 1200
ETGAAAREGG PKCADRPSVA PKDPLQVPTN TETSEETRPS LDFPQEAKEP
1210 1220 1230 1240 1250
ETAEESAPDS TEFTEALRSP PAACAGEMGA SPGLLIPEQP PPSRHDTGTP
1260 1270 1280 1290 1300
KPSGSLANTA PHGSSPTPGV GSLLGGPGGT QAPVSHNSKD PPARQPGEFL
1310 1320 1330 1340 1350
APVANPSSTA CPKPSVLSSK ISSFGCDPAG FNRDPLGVPV AKKGPQPYSS
1360 1370 1380 1390 1400
PHSELFLGPK DLAGCFLEEL HPKPSARDAP PASSSCLCQD GEDAGSLEPQ
1410 1420 1430 1440 1450
LPRSPPGTAE TEPGRAASPP TLESSSLFPD LPVDRFDPPL YGSLSANRDS
1460 1470 1480 1490 1500
GLPFACADPP QKTVPSDPPY PSFLLLEEVS PMLPSHFPDL SGGKVLSKTC
1510 1520 1530 1540 1550
PPERTVVPGA APSLPGKGSG CSVALMSHLS EDELEIQKLV TELESQLQRS
1560 1570 1580 1590 1600
KDTRGAPREL AEAESVGRVE LGTGTEPPSQ RRTCQATVPH EDTFSAADLT
1610 1620 1630 1640 1650
RVGESTAHRE GAESAVATVE AVQGRPGGTW PCPASFHPGH AALLPCAQED
1660 1670 1680 1690 1700
LVSGAPFSPR GANFHFQPVQ KAGASKTGLC QAEGDSRPPQ DVCLPEPSKQ
1710 1720 1730 1740 1750
PGPQLDAGSL AKCSPDQELS FPKNKEAASS QESEDSLRLL PCEQRGGFLP
1760 1770 1780 1790 1800
EPGTADQPHR GAPAPEAFGS PAVHLAPDLA FQGDGAPPLD ATWPFGASPS
1810 1820 1830 1840 1850
HAAQGHSAGR AGGHLHPTAG RPGFEGNEFA PAGASSLTAP RGREAWLVPV
1860 1870 1880 1890 1900
PSPACVSNTH PSRRSQDPAL SPPIRQLQLP GPGVAKSKDG ILGLQELTPA
1910 1920 1930 1940 1950
AQSPPRVNPS GLEGGTVEGG KVACGPAQGS PGGVQVTTLP AVAGHQLGLE
1960 1970 1980 1990 2000
ADGHWGLLGQ AEKTQGQGTA NQLQPENGVS PGGTDNHASV NASPKTALTG
2010 2020 2030 2040 2050
PTEGAVLLEK CKGSRAAMSL QEEAEPTPSP PSPNRESLAL ALTAAHSRSG
2060 2070 2080 2090 2100
SEGRTPERAS SPGLNKPLLA TGDSPAPSVG DLAACAPSPT SAAHMPCSLG
2110 2120 2130 2140 2150
PLPREDPLTS PSRAQGGLGG QLPASPSCRD PPGPQQLLAC SPAWAPLEEA
2160 2170 2180 2190 2200
DGVQATTDTG AEDSPVAPPS LTTSPCDPKE ALAGCLLQGE GSPLEDPSSW
2210 2220 2230 2240 2250
PPGSVSAVTC THSGDTPKDS TLRIPEDSRK EKLWESPGRA TSPPLAGAVS
2260 2270 2280 2290 2300
PSVAVRATGL SSTPTGDEAQ AGRGLPGPDP QSRGAPPHTN PDRMPRGHSS
2310 2320 2330 2340 2350
YSPSNTARLG HREGQAVTAV PTEPPTLQGA GPDSPACLEG EMGTSSKEPE
2360 2370 2380 2390 2400
DPGTPETGRS GATKMPRVTC PSTGLGLGRT TAPSSTASDF QSDSPQSHRN
2410 2420 2430 2440 2450
ASHQTPQGDP LGPQDLKQRS RGYKKKPAST ENGQWKGQAP HGPVTCEVCA
2460 2470 2480 2490 2500
ASFRSGPGLS RHKARKHRPH PGAPAEPSPA ALPAQQPLEP LAQKCQPPRK
2510 2520 2530 2540 2550
KSHRVSGKER PNHSRGDPSH VTQPPPAQGS KEVLRAPGSP HSQQLHPPSP
2560 2570 2580 2590 2600
TEHEVDVKTP ASKPRPDQAR EDELHPKQAE KREGRRWRRE PTVDSPSHSE
2610 2620 2630 2640 2650
GKSNKKRGKL RGRRLREESI LPVSADVISD GRGSRPSPAM ASYAASPSHC
2660 2670 2680 2690 2700
LSVEGGPEAD GEQPPRLATL GPGVMEGAAE TDQEALCAGE TGAQKPPGDR
2710 2720 2730 2740 2750
MLCPGRMDGA ALGEQPTGQK GASARGFWGP RETKALGVCK ESGSEPAEDS
2760 2770 2780 2790 2800
SRAHSRSEEG VWEENTPPLG PLGFPETSSS PADSTTSSCL QGLPDNPDTQ
2810 2820 2830 2840 2850
GGVQGPEGPT PDASGSSAKD PPSLFDDEVS FSQLFPPGGR LTRKRNPHVY
2860 2870 2880 2890 2900
GKRCEKPVLP LPTQPSFEEG GDPTLGPARL PTDLSDSSSL CLCHEDPWED
2910 2920 2930 2940 2950
EDPAGLPESF LLDGFLNSRV PGIDPWAPGL SLWALEPSRE AGAEKLPSHC
2960 2970 2980 2990 3000
PEDDRPEAIP ELHMVPAAWR GLEMPAPADD SSSSLGDVSP EPPSLERERC
3010 3020 3030 3040 3050
DGGLPGNTHL LPLRATDFEV LSTKFEMQDL CFLGPFEDPV GLPGPSFLDF
3060 3070 3080 3090 3100
EGTASSQGPQ SRRTEEAAGA GRAQGRGRPA KGRRASYKCK VCFQRFRSLG
3110 3120 3130 3140 3150
ELDLHKLAHT PAPPPTCYMC VERRFGSREL LRGHLQERHA QSKAGPWACG
3160 3170 3180 3190 3200
MCLKEVADVW MYNEHLREHA VRFARRGQAR RSLGDLPGGL EGSSAVAHLL
3210 3220 3230 3240 3250
NSITEPAPKH HRGKRSAGKA AGSPGDPWGQ EGEAKKDSPG ERAKPRARST
3260 3270 3280 3290 3300
PSNPDGAATP DSASATALAD AGSPGPPRTT PSPSPDPWAG GEPLLQATPV
3310 3320 3330 3340 3350
HEACKDPSRD CHHCGKRFPK PFKLQRHLAV HSPQRVYLCP RCPRVYPEHG
3360 3370 3380 3390 3400
ELLAHLGGAH GLLERPELQH TPLYACELCA TVMRIIKKSF ACSSCNYTFA
3410 3420 3430 3440 3450
KKEQFDRHMN KHLRGGRQPF AFRGVRRPGA PGQKARALEG TLPSKRRRVA
3460 3470 3480 3490 3500
MPGSAPGPGE DRPPPRGSSP ILSEGSLPAL LHLCSEVAPS TTKGWPETLE
3510 3520 3530 3540 3550
RPVDPVTHPI RGCELPSNHQ ECPPPSLSPF PAALADGRGD CALDGALERP
3560 3570 3580 3590 3600
ENEASPGSPG PLLQQALPLG ASLPRPGARG QDAEGKRAPL VFSGKRRAPG
3610 3620 3630 3640 3650
ARGRCAPDHF QEDHLLQKEK EVSSSHMVSE GGPRGTFHKG SATKPAGCQS
3660 3670 3680 3690 3700
SSKDRSAAST PSKALKFPVH PRKAVGSLAP GELARGTENG MKPATPKAKP
3710 3720 3730 3740 3750
GPSSQGSGSP RPGTKTGGGS QPQPASGQLQ SETATTPAKP SFPSRSPAPE
3760 3770 3780 3790 3800
RLPARAQAKS CTKGPREAGE QGPHGSLGPK EKGESSTKRK KGQVPGPARS
3810 3820 3830 3840 3850
ESVGSFGRAP SAPDKPPRTP RKQATPSRVL PTKPKPNSQN KPRPPPSEQR
3860 3870 3880 3890 3900
KAEPGHTQRK DRLGKAFPQG RPLLRPPKRG TAVHGAEPAE PHTHRTAEAQ
3910 3920
SDLLSQLFGQ RLTGFKIPLK KDASE
Length:3,925
Mass (Da):410,202
Last modified:July 24, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7F4DDFA690574319
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BS19H3BS19_HUMAN
Zinc finger protein 469
ZNF469
3,953Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061949357S → P. Corresponds to variant dbSNP:rs11648572EnsemblClinVar.1
Natural variantiVAR_033285366R → S. Corresponds to variant dbSNP:rs11640794EnsemblClinVar.1
Natural variantiVAR_0332861162K → E. Corresponds to variant dbSNP:rs7197071EnsemblClinVar.1
Natural variantiVAR_0332871420P → L. Corresponds to variant dbSNP:rs4782300EnsemblClinVar.1
Natural variantiVAR_0332882129R → K. Corresponds to variant dbSNP:rs13334190EnsemblClinVar.1
Natural variantiVAR_0332892358G → R1 PublicationCorresponds to variant dbSNP:rs12598474EnsemblClinVar.1
Natural variantiVAR_0332902670L → Q1 PublicationCorresponds to variant dbSNP:rs3812956EnsemblClinVar.1
Natural variantiVAR_0332912710A → T. Corresponds to variant dbSNP:rs3812955EnsemblClinVar.1
Natural variantiVAR_0332922749D → V. Corresponds to variant dbSNP:rs3812954EnsemblClinVar.1
Natural variantiVAR_0332932848H → R1 PublicationCorresponds to variant dbSNP:rs1983014EnsemblClinVar.1
Natural variantiVAR_0332943630E → Q1 PublicationCorresponds to variant dbSNP:rs1105066EnsemblClinVar.1
Natural variantiVAR_0332953636T → A1 PublicationCorresponds to variant dbSNP:rs904783Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC135049 Genomic DNA No translation available.
AB058761 mRNA Translation: BAB47487.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000437464; ENSP00000402343; ENSG00000225614

UCSC genome browser

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UCSCi
uc002fku.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC135049 Genomic DNA No translation available.
AB058761 mRNA Translation: BAB47487.2

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi124156, 2 interactors
IntActiQ96JG9, 3 interactors
STRINGi9606.ENSP00000402343

PTM databases

iPTMnetiQ96JG9
PhosphoSitePlusiQ96JG9

Polymorphism and mutation databases

BioMutaiZNF469
DMDMi158518658

Proteomic databases

jPOSTiQ96JG9
MaxQBiQ96JG9
PaxDbiQ96JG9
PeptideAtlasiQ96JG9
PRIDEiQ96JG9
ProteomicsDBi76962

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000437464; ENSP00000402343; ENSG00000225614
UCSCiuc002fku.2 human

Organism-specific databases

DisGeNETi84627

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZNF469
HGNCiHGNC:23216 ZNF469
HPAiHPA069784
MalaCardsiZNF469
MIMi229200 phenotype
612078 gene
neXtProtiNX_Q96JG9
Orphaneti90354 Brittle cornea syndrome
PharmGKBiPA134861470

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000155797
InParanoidiQ96JG9
PhylomeDBiQ96JG9

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF469 human

Protein Ontology

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PROi
PR:Q96JG9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000225614 Expressed in 175 organ(s), highest expression level in testis
ExpressionAtlasiQ96JG9 baseline and differential
GenevisibleiQ96JG9 HS

Family and domain databases

InterProiView protein in InterPro
IPR039270 ZNF469
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR21465 PTHR21465, 1 hit
PfamiView protein in Pfam
PF00096 zf-C2H2, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN469_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96JG9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: July 24, 2007
Last modified: July 31, 2019
This is version 139 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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