Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 125 (08 May 2019)
Sequence version 2 (15 Jan 2008)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Beta-galactoside alpha-2,6-sialyltransferase 2

Gene

ST6GAL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.74 mM for Gal-beta-1,4-GlcNAc-beta-O-octyl2 Publications
  2. KM=0.71 mM for Gal-beta-1,4-GlcNAc2 Publications
  3. KM=0.48 mM for lacto-N-neotetraose2 Publications

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • beta-galactoside alpha-2,6-sialyltransferase activity Source: UniProtKB

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionGlycosyltransferase, Transferase

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.4.99.1 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-4085001 Sialic acid metabolism

    Protein family/group databases

    Carbohydrate-Active enZymes

    More...
    CAZyi
    GT29 Glycosyltransferase Family 29

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Beta-galactoside alpha-2,6-sialyltransferase 2 (EC:2.4.99.13 Publications)
    Short name:
    Alpha 2,6-ST 2
    Alternative name(s):
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2
    ST6Gal II
    Short name:
    ST6GalII
    Short name:
    hST6Gal II
    Sialyltransferase 2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:ST6GAL2
    Synonyms:KIAA1877, SIAT2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:10861 ST6GAL2

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    608472 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q96JF0

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 32Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
    Topological domaini33 – 529LumenalSequence analysisAdd BLAST497

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    84620

    Open Targets

    More...
    OpenTargetsi
    ENSG00000144057

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA35763

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    ST6GAL2

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    166219772

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003147851 – 529Beta-galactoside alpha-2,6-sialyltransferase 2Add BLAST529

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi69O-linked (GalNAc...) serine1 Publication1
    Glycosylationi211N-linked (GlcNAc...) asparagineSequence analysis1
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi253 ↔ 519By similarity
    Disulfide bondi296 ↔ 448By similarity
    Disulfide bondi466 ↔ 477By similarity

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    O-glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q96JF0

    PeptideAtlas

    More...
    PeptideAtlasi
    Q96JF0

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q96JF0

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    76953
    76954 [Q96JF0-2]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q96JF0

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q96JF0

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Weakly expressed in some tissues, such as small intestine, colon and fetal brain.2 Publications

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    By IL6/interleukin-6 and IL8//interleukin-8.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000144057 Expressed in 129 organ(s), highest expression level in neocortex

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q96JF0 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q96JF0 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA014459

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    124151, 1 interactor

    Protein interaction database and analysis system

    More...
    IntActi
    Q96JF0, 14 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000386942

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q96JF0

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the glycosyltransferase 29 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2692 Eukaryota
    ENOG410XT8P LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000158714

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000013206

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q96JF0

    KEGG Orthology (KO)

    More...
    KOi
    K00779

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    HSHTQGT

    Database of Orthologous Groups

    More...
    OrthoDBi
    494294at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q96JF0

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF323961

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.90.1480.20, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR011330 Glyco_hydro/deAcase_b/a-brl
    IPR001675 Glyco_trans_29
    IPR038578 GT29-like_sf

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00777 Glyco_transf_29, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF88713 SSF88713, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q96JF0-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MKPHLKQWRQ RMLFGIFAWG LLFLLIFIYF TDSNPAEPVP SSLSFLETRR
    60 70 80 90 100
    LLPVQGKQRA IMGAAHEPSP PGGLDARQAL PRAHPAGSFH AGPGDLQKWA
    110 120 130 140 150
    QSQDGFEHKE FFSSQVGRKS QSAFYPEDDD YFFAAGQPGW HSHTQGTLGF
    160 170 180 190 200
    PSPGEPGPRE GAFPAAQVQR RRVKKRHRRQ RRSHVLEEGD DGDRLYSSMS
    210 220 230 240 250
    RAFLYRLWKG NVSSKMLNPR LQKAMKDYLT ANKHGVRFRG KREAGLSRAQ
    260 270 280 290 300
    LLCQLRSRAR VRTLDGTEAP FSALGWRRLV PAVPLSQLHP RGLRSCAVVM
    310 320 330 340 350
    SAGAILNSSL GEEIDSHDAV LRFNSAPTRG YEKDVGNKTT IRIINSQILT
    360 370 380 390 400
    NPSHHFIDSS LYKDVILVAW DPAPYSANLN LWYKKPDYNL FTPYIQHRQR
    410 420 430 440 450
    NPNQPFYILH PKFIWQLWDI IQENTKEKIQ PNPPSSGFIG ILIMMSMCRE
    460 470 480 490 500
    VHVYEYIPSV RQTELCHYHE LYYDAACTLG AYHPLLYEKL LVQRLNMGTQ
    510 520
    GDLHRKGKVV LPGFQAVHCP APSPVIPHS
    Length:529
    Mass (Da):60,158
    Last modified:January 15, 2008 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC3647E6DC0A9EFE3
    GO
    Isoform 2 (identifier: Q96JF0-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         441-529: ILIMMSMCRE...PAPSPVIPHS → SFVKIGHIRACSEPRSRDCTPAWTTE

    Note: No experimental confirmation available.
    Show »
    Length:466
    Mass (Da):52,927
    Checksum:i9180AF089B7A181C
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    H7BY52H7BY52_HUMAN
    Beta-galactoside alpha-2,6-sialyltr...
    ST6GAL2
    95Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    C9JIK2C9JIK2_HUMAN
    Beta-galactoside alpha-2,6-sialyltr...
    ST6GAL2
    34Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAH08680 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
    The sequence BAB47506 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038046154G → R. Corresponds to variant dbSNP:rs3796110Ensembl.1
    Natural variantiVAR_038047341I → V. Corresponds to variant dbSNP:rs12615112Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_030356441 – 529ILIMM…VIPHS → SFVKIGHIRACSEPRSRDCT PAWTTE in isoform 2. 1 PublicationAdd BLAST89

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AB059555 mRNA Translation: BAC24793.1
    AB058780 mRNA Translation: BAB47506.1 Different initiation.
    AC016994 Genomic DNA No translation available.
    AC108049 Genomic DNA Translation: AAY15022.1
    CH471127 Genomic DNA Translation: EAX01742.1
    CH471127 Genomic DNA Translation: EAX01743.1
    BC008680 mRNA Translation: AAH08680.1 Different initiation.
    AJ512141 mRNA Translation: CAD54408.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS2073.1 [Q96JF0-1]
    CCDS46380.1 [Q96JF0-2]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001135823.1, NM_001142351.1 [Q96JF0-1]
    NP_001135824.1, NM_001142352.1 [Q96JF0-2]
    NP_001309291.1, NM_001322362.1 [Q96JF0-1]
    NP_115917.1, NM_032528.2 [Q96JF0-1]
    XP_006712865.1, XM_006712802.1 [Q96JF0-1]
    XP_011510301.1, XM_011511999.2 [Q96JF0-1]
    XP_011510303.1, XM_011512001.2 [Q96JF0-2]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000361686; ENSP00000355273; ENSG00000144057 [Q96JF0-1]
    ENST00000409087; ENSP00000387332; ENSG00000144057 [Q96JF0-2]
    ENST00000409382; ENSP00000386942; ENSG00000144057 [Q96JF0-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    84620

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:84620

    UCSC genome browser

    More...
    UCSCi
    uc002tdq.4 human [Q96JF0-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB059555 mRNA Translation: BAC24793.1
    AB058780 mRNA Translation: BAB47506.1 Different initiation.
    AC016994 Genomic DNA No translation available.
    AC108049 Genomic DNA Translation: AAY15022.1
    CH471127 Genomic DNA Translation: EAX01742.1
    CH471127 Genomic DNA Translation: EAX01743.1
    BC008680 mRNA Translation: AAH08680.1 Different initiation.
    AJ512141 mRNA Translation: CAD54408.1
    CCDSiCCDS2073.1 [Q96JF0-1]
    CCDS46380.1 [Q96JF0-2]
    RefSeqiNP_001135823.1, NM_001142351.1 [Q96JF0-1]
    NP_001135824.1, NM_001142352.1 [Q96JF0-2]
    NP_001309291.1, NM_001322362.1 [Q96JF0-1]
    NP_115917.1, NM_032528.2 [Q96JF0-1]
    XP_006712865.1, XM_006712802.1 [Q96JF0-1]
    XP_011510301.1, XM_011511999.2 [Q96JF0-1]
    XP_011510303.1, XM_011512001.2 [Q96JF0-2]

    3D structure databases

    SMRiQ96JF0
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi124151, 1 interactor
    IntActiQ96JF0, 14 interactors
    STRINGi9606.ENSP00000386942

    Protein family/group databases

    CAZyiGT29 Glycosyltransferase Family 29

    PTM databases

    iPTMnetiQ96JF0
    PhosphoSitePlusiQ96JF0

    Polymorphism and mutation databases

    BioMutaiST6GAL2
    DMDMi166219772

    Proteomic databases

    PaxDbiQ96JF0
    PeptideAtlasiQ96JF0
    PRIDEiQ96JF0
    ProteomicsDBi76953
    76954 [Q96JF0-2]

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    84620
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000361686; ENSP00000355273; ENSG00000144057 [Q96JF0-1]
    ENST00000409087; ENSP00000387332; ENSG00000144057 [Q96JF0-2]
    ENST00000409382; ENSP00000386942; ENSG00000144057 [Q96JF0-1]
    GeneIDi84620
    KEGGihsa:84620
    UCSCiuc002tdq.4 human [Q96JF0-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    84620
    DisGeNETi84620

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    ST6GAL2

    H-Invitational Database, human transcriptome db

    More...
    H-InvDBi
    HIX0161642
    HGNCiHGNC:10861 ST6GAL2
    HPAiHPA014459
    MIMi608472 gene
    neXtProtiNX_Q96JF0
    OpenTargetsiENSG00000144057
    PharmGKBiPA35763

    Human Unidentified Gene-Encoded large proteins database

    More...
    HUGEi
    Search...

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG2692 Eukaryota
    ENOG410XT8P LUCA
    GeneTreeiENSGT00940000158714
    HOGENOMiHOG000013206
    InParanoidiQ96JF0
    KOiK00779
    OMAiHSHTQGT
    OrthoDBi494294at2759
    PhylomeDBiQ96JF0
    TreeFamiTF323961

    Enzyme and pathway databases

    BRENDAi2.4.99.1 2681
    ReactomeiR-HSA-4085001 Sialic acid metabolism

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    ST6GAL2 human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    84620

    Protein Ontology

    More...
    PROi
    PR:Q96JF0

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000144057 Expressed in 129 organ(s), highest expression level in neocortex
    ExpressionAtlasiQ96JF0 baseline and differential
    GenevisibleiQ96JF0 HS

    Family and domain databases

    Gene3Di3.90.1480.20, 1 hit
    InterProiView protein in InterPro
    IPR011330 Glyco_hydro/deAcase_b/a-brl
    IPR001675 Glyco_trans_29
    IPR038578 GT29-like_sf
    PfamiView protein in Pfam
    PF00777 Glyco_transf_29, 1 hit
    SUPFAMiSSF88713 SSF88713, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSIAT2_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96JF0
    Secondary accession number(s): D3DVK3
    , Q53QP4, Q86Y44, Q8IUG7, Q96HE4
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 15, 2008
    Last modified: May 8, 2019
    This is version 125 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again