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Entry version 132 (02 Jun 2021)
Sequence version 2 (22 Jul 2008)
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Protein

Microtubule-associated protein 6

Gene

MAP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in microtubule stabilization in many cell types, including neuronal cells (By similarity).

Specifically has microtubule cold stabilizing activity (By similarity).

Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (PubMed:24357581).

Regulates KIF5A-mediated axonal cargo transport (By similarity).

Regulates axonal growth during neuron polarization (By similarity).

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding
Biological processTransport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96JE9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Microtubule-associated protein 6
Short name:
MAP-6
Alternative name(s):
Stable tubule-only polypeptide
Short name:
STOP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAP6
Synonyms:KIAA1878
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6868, MAP6

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601783, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96JE9

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000171533.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Golgi apparatus, Membrane, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi71P → A: Inhibits interaction with ZDHHC13 and ZDHHC17. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
4135

Open Targets

More...
OpenTargetsi
ENSG00000171533

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30614

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96JE9, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MAP6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
205830862

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003440441 – 813Microtubule-associated protein 6Add BLAST813

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi5S-palmitoyl cysteineBy similarity1
Lipidationi10S-palmitoyl cysteineBy similarity1
Lipidationi11S-palmitoyl cysteineBy similarity1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei102PhosphoserineBy similarity1
Modified residuei143PhosphotyrosineBy similarity1
Modified residuei187PhosphoserineBy similarity1
Modified residuei812PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Palmitoylated. Probably depalmitoylated by ABHD17A, ABHD17B and ABHD17C. During neuronal polarization, palmitoylation and depalmitoylation cycles regulate MAP6 shuttling between secretory vesicles and microtubules, and its polarized distribution in the axon.By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96JE9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96JE9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96JE9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96JE9

PeptideAtlas

More...
PeptideAtlasi
Q96JE9

PRoteomics IDEntifications database

More...
PRIDEi
Q96JE9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
68473
76951 [Q96JE9-1]
76952 [Q96JE9-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96JE9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96JE9

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q96JE9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain (at protein level). Expressed in spinal cord. Isoform 2 expression is up-regulated in the prefrontal cortex (Brodmann's area 46) of patients with schizophrenia (postmortem brain study).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000171533, Expressed in cortical plate and 186 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96JE9, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000171533, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with calmodulin (via C-terminus); the interaction is dependent on Ca2+ (By similarity).

Interacts with TMEM106B (PubMed:24357581).

Interacts with ZDHHC17 (via ANK repeats) (PubMed:26198635).

Interacts with ZDHHC13 (via ANK repeats) (PubMed:26198635).

By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
110307, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q96JE9, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000307093

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96JE9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni36 – 283DisorderedSequence analysisAdd BLAST248
Regioni118 – 141Mn 1By similarityAdd BLAST24
Regioni126 – 140Calmodulin-bindingBy similarityAdd BLAST15
Regioni153 – 176Mn 2By similarityAdd BLAST24
Regioni162 – 176Calmodulin-bindingBy similarityAdd BLAST15
Regioni189 – 203Calmodulin-bindingBy similarityAdd BLAST15
Regioni298 – 321Mn 3By similarityAdd BLAST24
Regioni306 – 320Calmodulin-bindingBy similarityAdd BLAST15
Regioni314 – 651DisorderedSequence analysisAdd BLAST338
Regioni357 – 371Calmodulin-bindingBy similarityAdd BLAST15
Regioni384 – 398Calmodulin-bindingBy similarityAdd BLAST15
Regioni756 – 813DisorderedSequence analysisAdd BLAST58

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi40 – 55Pro residuesSequence analysisAdd BLAST16
Compositional biasi152 – 166Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi232 – 246Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi350 – 373Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi415 – 435Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi442 – 458Polar residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the STOP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QS1F, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063947

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_018049_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96JE9

Identification of Orthologs from Complete Genome Data

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OMAi
KKPGPAW

Database of Orthologous Groups

More...
OrthoDBi
577082at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96JE9

TreeFam database of animal gene trees

More...
TreeFami
TF338320

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007882, MAP6

The PANTHER Classification System

More...
PANTHERi
PTHR14759, PTHR14759, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96JE9-1) [UniParc]FASTAAdd to basket
Also known as: N-STOP, Neuronal-STOP

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAWPCITRAC CIARFWNQLD KADIAVPLVF TKYSEATEHP GAPPQPPPPQ
60 70 80 90 100
QQAQPALAPP SARAVAIETQ PAQGELDAVA RATGPAPGPT GEREPAAGPG
110 120 130 140 150
RSGPGPGLGS GSTSGPADSV MRQDYRAWKV QRPEPSCRPR SEYQPSDAPF
160 170 180 190 200
ERETQYQKDF RAWPLPRRGD HPWIPKPVQI SAASQASAPI LGAPKRRPQS
210 220 230 240 250
QERWPVQAAA EAREQEAAPG GAGGLAAGKA SGADERDTRR KAGPAWIVRR
260 270 280 290 300
AEGLGHEQTP LPAAQAQVQA TGPEAGRGRA AADALNRQIR EEVASAVSSS
310 320 330 340 350
YRNEFRAWTD IKPVKPIKAK PQYKPPDDKM VHETSYSAQF KGEASKPTTA
360 370 380 390 400
DNKVIDRRRI RSLYSEPFKE PPKVEKPSVQ SSKPKKTSAS HKPTRKAKDK
410 420 430 440 450
QAVSGQAAKK KSAEGPSTTK PDDKEQSKEM NNKLAEAKES LAQPVSDSSK
460 470 480 490 500
TQGPVATEPD KDQGSVVPGL LKGQGPMVQE PLKKQGSVVP GPPKDLGPMI
510 520 530 540 550
PLPVKDQDHT VPEPLKNESP VISAPVKDQG PSVPVPPKNQ SPMVPAKVKD
560 570 580 590 600
QGSVVPESLK DQGPRIPEPV KNQAPMVPAP VKDEGPMVSA SVKDQGPMVS
610 620 630 640 650
APVKDQGPIV PAPVKGEGPI VPAPVKDEGP MVSAPIKDQD PMVPEHPKDE
660 670 680 690 700
SAMATAPIKN QGSMVSEPVK NQGLVVSGPV KDQDVVVPEH AKVHDSAVVA
710 720 730 740 750
PVKNQGPVVP ESVKNQDPIL PVLVKDQGPT VLQPPKNQGR IVPEPLKNQV
760 770 780 790 800
PIVPVPLKDQ DPLVPVPAKD QGPAVPEPLK TQGPRDPQLP TVSPLPRVMI
810
PTAPHTEYIE SSP
Length:813
Mass (Da):86,505
Last modified:July 22, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9680ACAFDB5694D1
GO
Isoform 2 (identifier: Q96JE9-2) [UniParc]FASTAAdd to basket
Also known as: E-STOP, Early-STOP

The sequence of this isoform differs from the canonical sequence as follows:
     440-813: Missing.

Show »
Length:439
Mass (Da):47,376
Checksum:i3FBA4647C7906F89
GO
Isoform 3 (identifier: Q96JE9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-329: Missing.

Show »
Length:484
Mass (Da):51,329
Checksum:iF49849A9813B336C
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH63860 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_044542247I → M1 PublicationCorresponds to variant dbSNP:rs12225010Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0541511 – 329Missing in isoform 3. 2 PublicationsAdd BLAST329
Alternative sequenceiVSP_034723440 – 813Missing in isoform 2. 1 PublicationAdd BLAST374

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK123340 mRNA Translation: BAC85586.1
AP001922 Genomic DNA No translation available.
BC063860 mRNA Translation: AAH63860.1 Different initiation.
BC139780 mRNA Translation: AAI39781.1
BC150254 mRNA Translation: AAI50255.1
AB058781 mRNA Translation: BAB47507.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31641.1 [Q96JE9-1]
CCDS44686.1 [Q96JE9-2]

NCBI Reference Sequences

More...
RefSeqi
NP_149052.1, NM_033063.1 [Q96JE9-1]
NP_997460.1, NM_207577.1 [Q96JE9-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000304771; ENSP00000307093; ENSG00000171533 [Q96JE9-1]
ENST00000434603; ENSP00000415108; ENSG00000171533 [Q96JE9-2]
ENST00000526740; ENSP00000434278; ENSG00000171533 [Q96JE9-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
4135

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4135

UCSC genome browser

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UCSCi
uc001owu.4, human [Q96JE9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123340 mRNA Translation: BAC85586.1
AP001922 Genomic DNA No translation available.
BC063860 mRNA Translation: AAH63860.1 Different initiation.
BC139780 mRNA Translation: AAI39781.1
BC150254 mRNA Translation: AAI50255.1
AB058781 mRNA Translation: BAB47507.1
CCDSiCCDS31641.1 [Q96JE9-1]
CCDS44686.1 [Q96JE9-2]
RefSeqiNP_149052.1, NM_033063.1 [Q96JE9-1]
NP_997460.1, NM_207577.1 [Q96JE9-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi110307, 4 interactors
IntActiQ96JE9, 2 interactors
STRINGi9606.ENSP00000307093

PTM databases

iPTMnetiQ96JE9
PhosphoSitePlusiQ96JE9
SwissPalmiQ96JE9

Genetic variation databases

BioMutaiMAP6
DMDMi205830862

Proteomic databases

EPDiQ96JE9
jPOSTiQ96JE9
MassIVEiQ96JE9
PaxDbiQ96JE9
PeptideAtlasiQ96JE9
PRIDEiQ96JE9
ProteomicsDBi68473
76951 [Q96JE9-1]
76952 [Q96JE9-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
17382, 59 antibodies

The DNASU plasmid repository

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DNASUi
4135

Genome annotation databases

EnsembliENST00000304771; ENSP00000307093; ENSG00000171533 [Q96JE9-1]
ENST00000434603; ENSP00000415108; ENSG00000171533 [Q96JE9-2]
ENST00000526740; ENSP00000434278; ENSG00000171533 [Q96JE9-3]
GeneIDi4135
KEGGihsa:4135
UCSCiuc001owu.4, human [Q96JE9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4135
DisGeNETi4135

GeneCards: human genes, protein and diseases

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GeneCardsi
MAP6
HGNCiHGNC:6868, MAP6
HPAiENSG00000171533, Tissue enhanced (brain)
MIMi601783, gene
neXtProtiNX_Q96JE9
OpenTargetsiENSG00000171533
PharmGKBiPA30614
VEuPathDBiHostDB:ENSG00000171533.11

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502QS1F, Eukaryota
GeneTreeiENSGT00530000063947
HOGENOMiCLU_018049_1_0_1
InParanoidiQ96JE9
OMAiKKPGPAW
OrthoDBi577082at2759
PhylomeDBiQ96JE9
TreeFamiTF338320

Enzyme and pathway databases

PathwayCommonsiQ96JE9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
4135, 9 hits in 993 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MAP6, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MAP6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4135
PharosiQ96JE9, Tbio

Protein Ontology

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PROi
PR:Q96JE9
RNActiQ96JE9, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000171533, Expressed in cortical plate and 186 other tissues
GenevisibleiQ96JE9, HS

Family and domain databases

InterProiView protein in InterPro
IPR007882, MAP6
PANTHERiPTHR14759, PTHR14759, 3 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAP6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96JE9
Secondary accession number(s): A7E2A1, Q6P3T0, Q6ZWB8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: June 2, 2021
This is version 132 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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