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Protein

Zinc finger protein 479

Gene

ZNF479

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri185 – 212C2H2-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri213 – 235C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri241 – 263C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri269 – 291C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri297 – 319C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri325 – 347C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri353 – 375C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri381 – 403C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri409 – 431C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri437 – 459C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri465 – 487C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri493 – 515C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 479
Alternative name(s):
Zinc finger protein Kr19
Short name:
HKr19
Gene namesi
Name:ZNF479
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000185177.12
HGNCiHGNC:23258 ZNF479
MIMi617444 gene
neXtProtiNX_Q96JC4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134903704

Polymorphism and mutation databases

BioMutaiZNF479
DMDMi38258829

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476061 – 524Zinc finger protein 479Add BLAST524

Proteomic databases

EPDiQ96JC4
MaxQBiQ96JC4
PaxDbiQ96JC4
PeptideAtlasiQ96JC4
PRIDEiQ96JC4
ProteomicsDBi76941

PTM databases

iPTMnetiQ96JC4
PhosphoSitePlusiQ96JC4

Expressioni

Tissue specificityi

Expressed primarily in testis and fetal tissues.1 Publication

Gene expression databases

BgeeiENSG00000185177 Expressed in 4 organ(s), highest expression level in testis
CleanExiHS_ZNF479
ExpressionAtlasiQ96JC4 baseline and differential
GenevisibleiQ96JC4 HS

Interactioni

Protein-protein interaction databases

BioGridi124767, 2 interactors
IntActiQ96JC4, 6 interactors
STRINGi9606.ENSP00000333776

Structurei

3D structure databases

ProteinModelPortaliQ96JC4
SMRiQ96JC4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 87KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri185 – 212C2H2-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri213 – 235C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri241 – 263C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri269 – 291C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri297 – 319C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri325 – 347C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri353 – 375C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri381 – 403C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri409 – 431C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri437 – 459C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri465 – 487C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri493 – 515C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144042
HOVERGENiHBG018163
InParanoidiQ96JC4
KOiK09228
OMAiYSEVNQC
OrthoDBiEOG091G02KC
PhylomeDBiQ96JC4
TreeFamiTF342117

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 9 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 11 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q96JC4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKRPGPPGS REMGLLTFRD IAIEFSLEEW QCLDCAQRNL YRDVMLENYR
60 70 80 90 100
NLVSLGIAVS KPDLITCLEQ NKESQNIKRN EMVAKHPVTR SHFTQDLQPE
110 120 130 140 150
QGIKDSLQKV IPRTYGKCGH EKLQFKKCCK SVGEYEVHKG GYSEVNQCLS
160 170 180 190 200
TTQNKIFQTH KYVKVFGKFS NSNRDKTRYT GNKHFKCNKY GKSFCMLSHL
210 220 230 240 250
NQHQVIHTRE KSYKCKECGK SFNCSSNHTT HKIIHTGEKP YRCEECGKAF
260 270 280 290 300
SWSANLTRHK RTHTGEKPYT CEECGQAFRR SSALTNHKRI HTGERPYKCE
310 320 330 340 350
ECGKAFSVSS TLTDHKRIHT GEKPCRCEEC GKAFSWSSNL TRHKRIHTRE
360 370 380 390 400
KPYACEECGQ AFSLSSNLMR HRRIHTGEKP YTCEECGQDF RRSSALTIHK
410 420 430 440 450
RIHTGERPYK CEECGKVFSL SSTLTDHKRI HTGERPYKCE ECGKAFSLSS
460 470 480 490 500
TLTDHKRIHT GERPYTCEEC GKAFNCSSTL MQHKRIHTGE KPYKCEECEQ
510 520
AFKWHSSLAK HKIIHTGEKP YKCE
Length:524
Mass (Da):60,598
Last modified:December 1, 2001 - v1
Checksum:iF1AD4929DC67D105
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WTN2A0A087WTN2_HUMAN
Zinc finger protein 479
ZNF479
412Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF277624 mRNA Translation: AAK61307.1
CCDSiCCDS43590.1
RefSeqiNP_150376.1, NM_033273.2
XP_011513906.1, XM_011515604.2
XP_011513910.1, XM_011515608.2
XP_016868266.1, XM_017012777.1
UniGeneiHs.616660

Genome annotation databases

EnsembliENST00000319636; ENSP00000324518; ENSG00000185177
ENST00000331162; ENSP00000333776; ENSG00000185177
GeneIDi90827
KEGGihsa:90827
UCSCiuc010kzo.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF277624 mRNA Translation: AAK61307.1
CCDSiCCDS43590.1
RefSeqiNP_150376.1, NM_033273.2
XP_011513906.1, XM_011515604.2
XP_011513910.1, XM_011515608.2
XP_016868266.1, XM_017012777.1
UniGeneiHs.616660

3D structure databases

ProteinModelPortaliQ96JC4
SMRiQ96JC4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124767, 2 interactors
IntActiQ96JC4, 6 interactors
STRINGi9606.ENSP00000333776

PTM databases

iPTMnetiQ96JC4
PhosphoSitePlusiQ96JC4

Polymorphism and mutation databases

BioMutaiZNF479
DMDMi38258829

Proteomic databases

EPDiQ96JC4
MaxQBiQ96JC4
PaxDbiQ96JC4
PeptideAtlasiQ96JC4
PRIDEiQ96JC4
ProteomicsDBi76941

Protocols and materials databases

DNASUi90827
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319636; ENSP00000324518; ENSG00000185177
ENST00000331162; ENSP00000333776; ENSG00000185177
GeneIDi90827
KEGGihsa:90827
UCSCiuc010kzo.4 human

Organism-specific databases

CTDi90827
EuPathDBiHostDB:ENSG00000185177.12
GeneCardsiZNF479
HGNCiHGNC:23258 ZNF479
MIMi617444 gene
neXtProtiNX_Q96JC4
PharmGKBiPA134903704
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144042
HOVERGENiHBG018163
InParanoidiQ96JC4
KOiK09228
OMAiYSEVNQC
OrthoDBiEOG091G02KC
PhylomeDBiQ96JC4
TreeFamiTF342117

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSiZNF479 human
GenomeRNAii90827
PROiPR:Q96JC4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185177 Expressed in 4 organ(s), highest expression level in testis
CleanExiHS_ZNF479
ExpressionAtlasiQ96JC4 baseline and differential
GenevisibleiQ96JC4 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 9 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 11 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN479_HUMAN
AccessioniPrimary (citable) accession number: Q96JC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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