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Entry version 169 (12 Aug 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Lysyl oxidase homolog 4

Gene

LOXL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May modulate the formation of a collagenous extracellular matrix.

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi611CopperSequence analysis1
Metal bindingi613CopperSequence analysis1
Metal bindingi615CopperSequence analysis1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandCopper, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q96JB6

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1566948, Elastic fibre formation
R-HSA-2243919, Crosslinking of collagen fibrils

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lysyl oxidase homolog 4 (EC:1.4.3.-)
Alternative name(s):
Lysyl oxidase-like protein 4
Lysyl oxidase-related protein C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOXL4
Synonyms:LOXC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000138131.3

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17171, LOXL4

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607318, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q96JB6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84171

Open Targets

More...
OpenTargetsi
ENSG00000138131

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30431

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96JB6, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4295926

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LOXL4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20177960

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001853525 – 756Lysyl oxidase homolog 4Add BLAST732

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi58 ↔ 122PROSITE-ProRule annotation
Disulfide bondi71 ↔ 132PROSITE-ProRule annotation
Disulfide bondi102 ↔ 112PROSITE-ProRule annotation
Disulfide bondi191 ↔ 276PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi204 ↔ 286PROSITE-ProRule annotation
Disulfide bondi251 ↔ 261PROSITE-ProRule annotation
Disulfide bondi336 ↔ 400PROSITE-ProRule annotation
Disulfide bondi349 ↔ 410PROSITE-ProRule annotation
Disulfide bondi380 ↔ 390PROSITE-ProRule annotation
Disulfide bondi450 ↔ 515PROSITE-ProRule annotation
Disulfide bondi463 ↔ 528PROSITE-ProRule annotation
Disulfide bondi497 ↔ 507PROSITE-ProRule annotation
Disulfide bondi558 ↔ 564PROSITE-ProRule annotation
Disulfide bondi610 ↔ 658PROSITE-ProRule annotation
Glycosylationi629N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki638 ↔ 674Lysine tyrosylquinone (Lys-Tyr)By similarity
Disulfide bondi642 ↔ 648PROSITE-ProRule annotation
Disulfide bondi670 ↔ 680PROSITE-ProRule annotation
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei6742',4',5'-topaquinoneBy similarity1
Disulfide bondi717 ↔ 731PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, LTQ, TPQ

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96JB6

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96JB6

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96JB6

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96JB6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96JB6

PeptideAtlas

More...
PeptideAtlasi
Q96JB6

PRoteomics IDEntifications database

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PRIDEi
Q96JB6

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
76933

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1482, 1 N-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
Q96JB6, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q96JB6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96JB6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in many tissues, the highest levels among the tissues studied being in the skeletal muscle, testis and pancreas. Expressed in cartilage.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000138131, Expressed in tendon of biceps brachii and 159 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96JB6, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000138131, Tissue enhanced (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
123925, 18 interactors

Protein interaction database and analysis system

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IntActi
Q96JB6, 16 interactors

Molecular INTeraction database

More...
MINTi
Q96JB6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000260702

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96JB6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96JB6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini32 – 133SRCR 1PROSITE-ProRule annotationAdd BLAST102
Domaini159 – 287SRCR 2PROSITE-ProRule annotationAdd BLAST129
Domaini311 – 411SRCR 3PROSITE-ProRule annotationAdd BLAST101
Domaini421 – 529SRCR 4PROSITE-ProRule annotationAdd BLAST109

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni533 – 736Lysyl-oxidase likeAdd BLAST204

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the lysyl oxidase family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502QSX8, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000157042

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002555_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96JB6

KEGG Orthology (KO)

More...
KOi
K00280

Identification of Orthologs from Complete Genome Data

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OMAi
EDLFDHQ

Database of Orthologous Groups

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OrthoDBi
815466at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96JB6

TreeFam database of animal gene trees

More...
TreeFami
TF326061

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.250.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001695, Lysyl_oxidase
IPR019828, Lysyl_oxidase_CS
IPR001190, SRCR
IPR017448, SRCR-like_dom
IPR036772, SRCR-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01186, Lysyl_oxidase, 1 hit
PF00530, SRCR, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00074, LYSYLOXIDASE
PR00258, SPERACTRCPTR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00202, SR, 4 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF56487, SSF56487, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00926, LYSYL_OXIDASE, 1 hit
PS00420, SRCR_1, 1 hit
PS50287, SRCR_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q96JB6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAWSPPATLF LFLLLLGQPP PSRPQSLGTT KLRLVGPESK PEEGRLEVLH
60 70 80 90 100
QGQWGTVCDD NFAIQEATVA CRQLGFEAAL TWAHSAKYGQ GEGPIWLDNV
110 120 130 140 150
RCVGTESSLD QCGSNGWGVS DCSHSEDVGV ICHPRRHRGY LSETVSNALG
160 170 180 190 200
PQGRRLEEVR LKPILASAKQ HSPVTEGAVE VKYEGHWRQV CDQGWTMNNS
210 220 230 240 250
RVVCGMLGFP SEVPVDSHYY RKVWDLKMRD PKSRLKSLTN KNSFWIHQVT
260 270 280 290 300
CLGTEPHMAN CQVQVAPARG KLRPACPGGM HAVVSCVAGP HFRPPKTKPQ
310 320 330 340 350
RKGSWAEEPR VRLRSGAQVG EGRVEVLMNR QWGTVCDHRW NLISASVVCR
360 370 380 390 400
QLGFGSAREA LFGARLGQGL GPIHLSEVRC RGYERTLSDC PALEGSQNGC
410 420 430 440 450
QHENDAAVRC NVPNMGFQNQ VRLAGGRIPE EGLLEVQVEV NGVPRWGSVC
460 470 480 490 500
SENWGLTEAM VACRQLGLGF AIHAYKETWF WSGTPRAQEV VMSGVRCSGT
510 520 530 540 550
ELALQQCQRH GPVHCSHGGG RFLAGVSCMD SAPDLVMNAQ LVQETAYLED
560 570 580 590 600
RPLSQLYCAH EENCLSKSAD HMDWPYGYRR LLRFSTQIYN LGRTDFRPKT
610 620 630 640 650
GRDSWVWHQC HRHYHSIEVF THYDLLTLNG SKVAEGHKAS FCLEDTNCPT
660 670 680 690 700
GLQRRYACAN FGEQGVTVGC WDTYRHDIDC QWVDITDVGP GNYIFQVIVN
710 720 730 740 750
PHYEVAESDF SNNMLQCRCK YDGHRVWLHN CHTGNSYPAN AELSLEQEQR

LRNNLI
Length:756
Mass (Da):84,483
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i13051ACADB922BBC
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH07522 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3W → R in AAH13153 (PubMed:15489334).Curated1
Sequence conflicti101R → Q in AAH13153 (PubMed:15489334).Curated1
Sequence conflicti493S → G in AAL27543 (PubMed:11691588).Curated1
Sequence conflicti539A → T in AAL27543 (PubMed:11691588).Curated1
Sequence conflicti542V → A in AAL27543 (PubMed:11691588).Curated1
Sequence conflicti703Y → H in AAL27543 (PubMed:11691588).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050012154R → Q. Corresponds to variant dbSNP:rs33995374Ensembl.1
Natural variantiVAR_059431372P → T. Corresponds to variant dbSNP:rs11189525Ensembl.1
Natural variantiVAR_050013405D → A1 PublicationCorresponds to variant dbSNP:rs1983864Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF338441 mRNA Translation: AAK71934.1
AY036093 mRNA Translation: AAK64186.1
AF395336 mRNA Translation: AAL27543.1
AK025542 mRNA Translation: BAB15167.1
AK172781 mRNA Translation: BAD18762.1
AL139241 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49886.1
BC007522 mRNA Translation: AAH07522.1 Different initiation.
BC013153 mRNA Translation: AAH13153.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7473.1

NCBI Reference Sequences

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RefSeqi
NP_115587.6, NM_032211.6

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000260702; ENSP00000260702; ENSG00000138131

Database of genes from NCBI RefSeq genomes

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GeneIDi
84171

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84171

UCSC genome browser

More...
UCSCi
uc001kpa.2, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF338441 mRNA Translation: AAK71934.1
AY036093 mRNA Translation: AAK64186.1
AF395336 mRNA Translation: AAL27543.1
AK025542 mRNA Translation: BAB15167.1
AK172781 mRNA Translation: BAD18762.1
AL139241 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49886.1
BC007522 mRNA Translation: AAH07522.1 Different initiation.
BC013153 mRNA Translation: AAH13153.1
CCDSiCCDS7473.1
RefSeqiNP_115587.6, NM_032211.6

3D structure databases

SMRiQ96JB6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123925, 18 interactors
IntActiQ96JB6, 16 interactors
MINTiQ96JB6
STRINGi9606.ENSP00000260702

Chemistry databases

ChEMBLiCHEMBL4295926

PTM databases

GlyConnecti1482, 1 N-Linked glycan (1 site)
GlyGeniQ96JB6, 2 sites
iPTMnetiQ96JB6
PhosphoSitePlusiQ96JB6

Polymorphism and mutation databases

BioMutaiLOXL4
DMDMi20177960

Proteomic databases

EPDiQ96JB6
jPOSTiQ96JB6
MassIVEiQ96JB6
MaxQBiQ96JB6
PaxDbiQ96JB6
PeptideAtlasiQ96JB6
PRIDEiQ96JB6
ProteomicsDBi76933

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
31028, 214 antibodies

The DNASU plasmid repository

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DNASUi
84171

Genome annotation databases

EnsembliENST00000260702; ENSP00000260702; ENSG00000138131
GeneIDi84171
KEGGihsa:84171
UCSCiuc001kpa.2, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84171
DisGeNETi84171
EuPathDBiHostDB:ENSG00000138131.3

GeneCards: human genes, protein and diseases

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GeneCardsi
LOXL4
HGNCiHGNC:17171, LOXL4
HPAiENSG00000138131, Tissue enhanced (liver)
MIMi607318, gene
neXtProtiNX_Q96JB6
OpenTargetsiENSG00000138131
PharmGKBiPA30431

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502QSX8, Eukaryota
GeneTreeiENSGT00940000157042
HOGENOMiCLU_002555_3_0_1
InParanoidiQ96JB6
KOiK00280
OMAiEDLFDHQ
OrthoDBi815466at2759
PhylomeDBiQ96JB6
TreeFamiTF326061

Enzyme and pathway databases

PathwayCommonsiQ96JB6
ReactomeiR-HSA-1566948, Elastic fibre formation
R-HSA-2243919, Crosslinking of collagen fibrils

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
84171, 1 hit in 868 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LOXL4, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
LOXL4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84171
PharosiQ96JB6, Tbio

Protein Ontology

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PROi
PR:Q96JB6
RNActiQ96JB6, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000138131, Expressed in tendon of biceps brachii and 159 other tissues
GenevisibleiQ96JB6, HS

Family and domain databases

Gene3Di3.10.250.10, 4 hits
InterProiView protein in InterPro
IPR001695, Lysyl_oxidase
IPR019828, Lysyl_oxidase_CS
IPR001190, SRCR
IPR017448, SRCR-like_dom
IPR036772, SRCR-like_dom_sf
PfamiView protein in Pfam
PF01186, Lysyl_oxidase, 1 hit
PF00530, SRCR, 4 hits
PRINTSiPR00074, LYSYLOXIDASE
PR00258, SPERACTRCPTR
SMARTiView protein in SMART
SM00202, SR, 4 hits
SUPFAMiSSF56487, SSF56487, 4 hits
PROSITEiView protein in PROSITE
PS00926, LYSYL_OXIDASE, 1 hit
PS00420, SRCR_1, 1 hit
PS50287, SRCR_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLOXL4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96JB6
Secondary accession number(s): Q5W0B3
, Q96DY1, Q96PC0, Q9H6T5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: December 1, 2001
Last modified: August 12, 2020
This is version 169 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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