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Protein

CDK5 regulatory subunit-associated protein 3

Gene

CDK5RAP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629).10 Publications
(Microbial infection) May be negatively regulated by hepatitis B virus large envelope protein mutant pre-s2 to promote mitotic entry.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cyclin binding Source: UniProtKB
  • MDM2/MDM4 family protein binding Source: UniProtKB
  • mitogen-activated protein kinase binding Source: UniProtKB
  • NF-kappaB binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • ubiquitin-like protein ligase binding Source: MGI

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CDK5 regulatory subunit-associated protein 3Imported
Alternative name(s):
CDK5 activator-binding protein C531 Publication
LXXLL/leucine-zipper-containing ARF-binding protein1 Publication
Protein HSF-27Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDK5RAP3Imported
Synonyms:IC531 Publication, LZAP1 Publication
ORF Names:MSTP016, OK/SW-cl.114, PP1553
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000108465.14

Human Gene Nomenclature Database

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HGNCi
HGNC:18673 CDK5RAP3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
608202 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q96JB5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi268D → E: Alters cleavage by CASP3 in vitro. Prevents apoptosis-induced cleavage in vivo; when associated with E-282 and E-311. 1 Publication1
Mutagenesisi282D → E: Alters cleavage by CASP3 in vitro. Prevents apoptosis-induced cleavage in vivo; when associated with E-268 and E-311. 1 Publication1
Mutagenesisi311D → E: Alters cleavage by CASP3 in vitro. Prevents apoptosis-induced cleavage in vivo; when associated with E-268 and E-282. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
80279

Open Targets

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OpenTargetsi
ENSG00000108465

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA38633

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

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DMDMi
32129444

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002205161 – 506CDK5 regulatory subunit-associated protein 3Add BLAST506

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki450Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

May be phosphorylated by CDK5.By similarity
Ubiquitinated. Probably triggers proteasomal degradation and is negatively regulated by UFL1.1 Publication
May be ufmylated.By similarity
Cleaved by caspases early during apoptosis, the resulting peptides may play a role in rupture of the nuclear envelope.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96JB5

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96JB5

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96JB5

PeptideAtlas

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PeptideAtlasi
Q96JB5

PRoteomics IDEntifications database

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PRIDEi
Q96JB5

ProteomicsDB human proteome resource

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ProteomicsDBi
76930
76931 [Q96JB5-2]
76932 [Q96JB5-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q96JB5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96JB5

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q96JB5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed (PubMed:12054757, PubMed:10721722). Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform 3 is expressed in kidney, liver, skeletal muscle and placenta (PubMed:12737517).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000108465 Expressed in 226 organ(s), highest expression level in pituitary gland

CleanEx database of gene expression profiles

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CleanExi
HS_CDK5RAP3

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96JB5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96JB5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA022141
HPA022882
HPA027883

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CDK5R1; competes with CDK5RAP1 and CDK5RAP2 (PubMed:12737517). Interacts with RELA (PubMed:17785205). Interacts with CHEK1; may negatively regulate CHEK1 and thereby stimulate entry into mitosis (PubMed:19223857). Interacts with CDKN2A/ARF and MDM2; forms a ternary complex involved in regulation of p53/TP53 (PubMed:16173922). Interacts with UFL1; the interaction is direct (PubMed:20164180, PubMed:20228063). Interacts with DDRGK1 (PubMed:20228063). Interacts with MAPK14 (PubMed:21283629). Interacts with CCNB1 (PubMed:15790566). Interacts with TUBG1; may regulate CDK5RAP3 in mitotic G2/M transition checkpoint (PubMed:21465471).9 Publications
(Microbial infection) Interacts with hepatitis B virus large envelope protein mutant pre-s2; promotes mitotic entry.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
123213, 54 interactors

Protein interaction database and analysis system

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IntActi
Q96JB5, 27 interactors

Molecular INTeraction database

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MINTi
Q96JB5

STRING: functional protein association networks

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STRINGi
9606.ENSP00000344683

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q96JB5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96JB5

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni269 – 506Required for interaction with UFL1 and mediates interaction with CHEK12 PublicationsAdd BLAST238

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CDK5RAP3 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2607 Eukaryota
ENOG410XSWB LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000000713

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231047

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG050978

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96JB5

Identification of Orthologs from Complete Genome Data

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OMAi
PGVRKQM

Database of Orthologous Groups

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OrthoDBi
EOG091G11PB

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96JB5

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR008491 CDK5RAP3

The PANTHER Classification System

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PANTHERi
PTHR14894 PTHR14894, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05600 DUF773, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96JB5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEDHQHVPID IQTSKLLDWL VDRRHCSLKW QSLVLTIREK INAAIQDMPE
60 70 80 90 100
SEEIAQLLSG SYIHYFHCLR ILDLLKGTEA STKNIFGRYS SQRMKDWQEI
110 120 130 140 150
IALYEKDNTY LVELSSLLVR NVNYEIPSLK KQIAKCQQLQ QEYSRKEEEC
160 170 180 190 200
QAGAAEMREQ FYHSCKQYGI TGENVRGELL ALVKDLPSQL AEIGAAAQQS
210 220 230 240 250
LGEAIDVYQA SVGFVCESPT EQVLPMLRFV QKRGNSTVYE WRTGTEPSVV
260 270 280 290 300
ERPHLEELPE QVAEDAIDWG DFGVEAVSEG TDSGISAEAA GIDWGIFPES
310 320 330 340 350
DSKDPGGDGI DWGDDAVALQ ITVLEAGTQA PEGVARGPDA LTLLEYTETR
360 370 380 390 400
NQFLDELMEL EIFLAQRAVE LSEEADVLSV SQFQLAPAIL QGQTKEKMVT
410 420 430 440 450
MVSVLEDLIG KLTSLQLQHL FMILASPRYV DRVTEFLQQK LKQSQLLALK
460 470 480 490 500
KELMVQKQQE ALEEQAALEP KLDLLLEKTK ELQKLIEADI SKRYSGRPVN

LMGTSL
Length:506
Mass (Da):56,921
Last modified:June 16, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA21E59A79E1F87E0
GO
Isoform 2 (identifier: Q96JB5-2) [UniParc]FASTAAdd to basket
Also known as: IC53

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.
     88-111: RYSSQRMKDWQEIIALYEKDNTYL → MCVHPGACLPHVGVSWAEFPGHFS

Note: Due to an intron retention.
Show »
Length:419
Mass (Da):46,351
Checksum:iDA15DED087A5A795
GO
Isoform 3 (identifier: Q96JB5-3) [UniParc]FASTAAdd to basket
Also known as: IC53-2

The sequence of this isoform differs from the canonical sequence as follows:
     1-225: Missing.

Note: Due to intron retention. No experimental confirmation available.
Show »
Length:281
Mass (Da):31,200
Checksum:iBDC6C94A65DF078C
GO
Isoform 4 (identifier: Q96JB5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: ME → MRRQSMTSATRDLHTALDGKATQGGKK

Note: No experimental confirmation available.
Show »
Length:531
Mass (Da):59,589
Checksum:iAE71C7A39A36A358
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QRM1J3QRM1_HUMAN
CDK5 regulatory subunit-associated ...
CDK5RAP3
272Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QS62J3QS62_HUMAN
CDK5 regulatory subunit-associated ...
CDK5RAP3
196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QL86J3QL86_HUMAN
CDK5 regulatory subunit-associated ...
CDK5RAP3
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QQY1J3QQY1_HUMAN
CDK5 regulatory subunit-associated ...
CDK5RAP3
281Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRK4J3KRK4_HUMAN
CDK5 regulatory subunit-associated ...
CDK5RAP3
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KS63J3KS63_HUMAN
CDK5 regulatory subunit-associated ...
CDK5RAP3
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRI2J3KRI2_HUMAN
CDK5 regulatory subunit-associated ...
CDK5RAP3
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QL95J3QL95_HUMAN
CDK5 regulatory subunit-associated ...
CDK5RAP3
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QQS7J3QQS7_HUMAN
CDK5 regulatory subunit-associated ...
CDK5RAP3
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KTA5J3KTA5_HUMAN
CDK5 regulatory subunit-associated ...
CDK5RAP3
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK69655 differs from that shown. Reason: Frameshift at position 410.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti98Q → R in BAH13320 (PubMed:14702039).Curated1
Sequence conflicti113E → V in BAD97107 (Ref. 6) Curated1
Sequence conflicti406E → K in AAK69655 (Ref. 3) Curated1
Sequence conflicti443Q → E in BAD97107 (Ref. 6) Curated1
Sequence conflicti479T → A in BAH13320 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048688324L → V. Corresponds to variant dbSNP:rs35054799Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0075681 – 225Missing in isoform 3. 1 PublicationAdd BLAST225
Alternative sequenceiVSP_0075661 – 87Missing in isoform 2. 1 PublicationAdd BLAST87
Alternative sequenceiVSP_0556461 – 2ME → MRRQSMTSATRDLHTALDGK ATQGGKK in isoform 4. 1 Publication2
Alternative sequenceiVSP_00756788 – 111RYSSQ…DNTYL → MCVHPGACLPHVGVSWAEFP GHFS in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF110322 mRNA Translation: AAG39277.1
AF217982 mRNA Translation: AAG17225.1
AF343090 mRNA Translation: AAK69655.1 Frameshift.
AB062433 mRNA Translation: BAB93496.1
AK023722 mRNA Translation: BAB14657.1
AK300643 mRNA Translation: BAH13320.1
AK223387 mRNA Translation: BAD97107.1
AC018521 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94772.1
CH471109 Genomic DNA Translation: EAW94774.1
CH471109 Genomic DNA Translation: EAW94775.1
CH471109 Genomic DNA Translation: EAW94778.1
BC009957 mRNA Translation: AAH09957.1
BC072435 mRNA Translation: AAH72435.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS42356.1 [Q96JB5-1]
CCDS62232.1 [Q96JB5-4]

Protein sequence database of the Protein Information Resource

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PIRi
JC7863

NCBI Reference Sequences

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RefSeqi
NP_001265126.1, NM_001278197.1 [Q96JB5-4]
NP_001265127.1, NM_001278198.1
NP_001265145.1, NM_001278216.1 [Q96JB5-3]
NP_001265146.1, NM_001278217.1 [Q96JB5-2]
NP_788276.1, NM_176096.2 [Q96JB5-1]
XP_011523599.1, XM_011525297.1 [Q96JB5-4]
XP_016880653.1, XM_017025164.1 [Q96JB5-2]
XP_016880654.1, XM_017025165.1 [Q96JB5-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.20157

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000338399; ENSP00000344683; ENSG00000108465 [Q96JB5-1]
ENST00000536708; ENSP00000438886; ENSG00000108465 [Q96JB5-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
80279

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:80279

UCSC genome browser

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UCSCi
uc002imr.5 human [Q96JB5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110322 mRNA Translation: AAG39277.1
AF217982 mRNA Translation: AAG17225.1
AF343090 mRNA Translation: AAK69655.1 Frameshift.
AB062433 mRNA Translation: BAB93496.1
AK023722 mRNA Translation: BAB14657.1
AK300643 mRNA Translation: BAH13320.1
AK223387 mRNA Translation: BAD97107.1
AC018521 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94772.1
CH471109 Genomic DNA Translation: EAW94774.1
CH471109 Genomic DNA Translation: EAW94775.1
CH471109 Genomic DNA Translation: EAW94778.1
BC009957 mRNA Translation: AAH09957.1
BC072435 mRNA Translation: AAH72435.1
CCDSiCCDS42356.1 [Q96JB5-1]
CCDS62232.1 [Q96JB5-4]
PIRiJC7863
RefSeqiNP_001265126.1, NM_001278197.1 [Q96JB5-4]
NP_001265127.1, NM_001278198.1
NP_001265145.1, NM_001278216.1 [Q96JB5-3]
NP_001265146.1, NM_001278217.1 [Q96JB5-2]
NP_788276.1, NM_176096.2 [Q96JB5-1]
XP_011523599.1, XM_011525297.1 [Q96JB5-4]
XP_016880653.1, XM_017025164.1 [Q96JB5-2]
XP_016880654.1, XM_017025165.1 [Q96JB5-2]
UniGeneiHs.20157

3D structure databases

ProteinModelPortaliQ96JB5
SMRiQ96JB5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123213, 54 interactors
IntActiQ96JB5, 27 interactors
MINTiQ96JB5
STRINGi9606.ENSP00000344683

PTM databases

iPTMnetiQ96JB5
PhosphoSitePlusiQ96JB5
SwissPalmiQ96JB5

Polymorphism and mutation databases

DMDMi32129444

Proteomic databases

EPDiQ96JB5
MaxQBiQ96JB5
PaxDbiQ96JB5
PeptideAtlasiQ96JB5
PRIDEiQ96JB5
ProteomicsDBi76930
76931 [Q96JB5-2]
76932 [Q96JB5-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
80279
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338399; ENSP00000344683; ENSG00000108465 [Q96JB5-1]
ENST00000536708; ENSP00000438886; ENSG00000108465 [Q96JB5-4]
GeneIDi80279
KEGGihsa:80279
UCSCiuc002imr.5 human [Q96JB5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80279
DisGeNETi80279
EuPathDBiHostDB:ENSG00000108465.14

GeneCards: human genes, protein and diseases

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GeneCardsi
CDK5RAP3

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0013932
HGNCiHGNC:18673 CDK5RAP3
HPAiHPA022141
HPA022882
HPA027883
MIMi608202 gene
neXtProtiNX_Q96JB5
OpenTargetsiENSG00000108465
PharmGKBiPA38633

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2607 Eukaryota
ENOG410XSWB LUCA
GeneTreeiENSGT00390000000713
HOGENOMiHOG000231047
HOVERGENiHBG050978
InParanoidiQ96JB5
OMAiPGVRKQM
OrthoDBiEOG091G11PB
PhylomeDBiQ96JB5

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CDK5RAP3 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CDK5RAP3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
80279

Protein Ontology

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PROi
PR:Q96JB5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000108465 Expressed in 226 organ(s), highest expression level in pituitary gland
CleanExiHS_CDK5RAP3
ExpressionAtlasiQ96JB5 baseline and differential
GenevisibleiQ96JB5 HS

Family and domain databases

InterProiView protein in InterPro
IPR008491 CDK5RAP3
PANTHERiPTHR14894 PTHR14894, 1 hit
PfamiView protein in Pfam
PF05600 DUF773, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCK5P3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96JB5
Secondary accession number(s): B7Z6N4
, D3DTU1, D3DTU2, F5H3I5, Q53FA2, Q9H3F8, Q9H8G0, Q9HBR9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 16, 2003
Last modified: December 5, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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