UniProtKB - Q96JB3 (HIC2_HUMAN)
Protein
Hypermethylated in cancer 2 protein
Gene
HIC2
Organism
Homo sapiens (Human)
Status
Functioni
Transcriptional repressor.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 442 – 469 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 505 – 532 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 533 – 560 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 561 – 588 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 589 – 615 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 27 |
GO - Molecular functioni
- DNA binding Source: UniProtKB
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- protein C-terminus binding Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q96JB3 |
Names & Taxonomyi
Protein namesi | Recommended name: Hypermethylated in cancer 2 proteinShort name: Hic-2 Alternative name(s): HIC1-related gene on chromosome 22 protein Hic-3 Zinc finger and BTB domain-containing protein 30 |
Gene namesi | Name:HIC2 Synonyms:HRG22, KIAA1020, ZBTB30 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000169635.9 |
HGNCi | HGNC:18595, HIC2 |
MIMi | 607712, gene |
neXtProti | NX_Q96JB3 |
Subcellular locationi
Nucleus
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 23119 |
OpenTargetsi | ENSG00000169635 |
PharmGKBi | PA38357 |
Miscellaneous databases
Pharosi | Q96JB3, Tbio |
Polymorphism and mutation databases
BioMutai | HIC2 |
DMDMi | 20454983 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046945 | 1 – 615 | Hypermethylated in cancer 2 proteinAdd BLAST | 615 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 166 | PhosphoserineCombined sources | 1 | |
Modified residuei | 169 | PhosphoserineCombined sources | 1 | |
Modified residuei | 197 | PhosphoserineCombined sources | 1 | |
Modified residuei | 348 | PhosphoserineCombined sources | 1 | |
Modified residuei | 412 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q96JB3 |
jPOSTi | Q96JB3 |
MassIVEi | Q96JB3 |
MaxQBi | Q96JB3 |
PaxDbi | Q96JB3 |
PeptideAtlasi | Q96JB3 |
PRIDEi | Q96JB3 |
ProteomicsDBi | 76928 [Q96JB3-1] 76929 [Q96JB3-2] |
PTM databases
iPTMneti | Q96JB3 |
PhosphoSitePlusi | Q96JB3 |
SwissPalmi | Q96JB3 |
Expressioni
Tissue specificityi
Highest levels in cerebellum.
Gene expression databases
Bgeei | ENSG00000169635, Expressed in secondary oocyte and 232 other tissues |
Genevisiblei | Q96JB3, HS |
Organism-specific databases
HPAi | ENSG00000169635, Low tissue specificity |
Interactioni
Subunit structurei
Self-associates.
Interacts with HIC1.
1 PublicationBinary interactionsi
Hide detailsQ96JB3
With | #Exp. | IntAct |
---|---|---|
CEP70 [Q8NHQ1] | 3 | EBI-726282,EBI-739624 |
EHMT2 [Q96KQ7] | 3 | EBI-726282,EBI-744366 |
ZBTB8A [Q96BR9] | 5 | EBI-726282,EBI-742740 |
GO - Molecular functioni
- protein C-terminus binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 116741, 32 interactors |
IntActi | Q96JB3, 24 interactors |
MINTi | Q96JB3 |
STRINGi | 9606.ENSP00000387757 |
Miscellaneous databases
RNActi | Q96JB3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 46 – 109 | BTBPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 246 – 250 | Binding to CtBP | 5 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 442 – 469 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 505 – 532 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 533 – 560 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 561 – 588 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 589 – 615 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 27 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159978 |
HOGENOMi | CLU_015352_1_0_1 |
InParanoidi | Q96JB3 |
OMAi | DQSFQCK |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q96JB3 |
TreeFami | TF333488 |
Family and domain databases
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q96JB3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVSGPLALRW CAWAGRGDMG PDMELPSHSK QLLLQLNQQR TKGFLCDVII
60 70 80 90 100
MVENSIFRAH KNVLAASSIY FKSLVLHDNL INLDTDMVSS TVFQQILDFI
110 120 130 140 150
YTGKLLPSDQ PAEPNFSTLL TAASYLQLPE LAALCRRKLK RAGKPFGSGR
160 170 180 190 200
AGSTGMGRPP RSQRLSTASV IQARYQGLVD GRKGAHAPQE LPQAKGSDDE
210 220 230 240 250
LFLGGSNQDS VQGLGRAVCP AGGEAGLGGC SSSTNGSSGG CEQELGLDLS
260 270 280 290 300
KKSPPLPPAT PGPHLTPDDA AQLSDSQHGS PPAASAPPVA NSASYSELGG
310 320 330 340 350
TPDEPMDLEG AEDNHLSLLE APGGQPRKSL RHSTRKKEWG KKEPVAGSPF
360 370 380 390 400
ERREAGPKGP CPGEEGEGVG DRVPNGILAS GAGPSGPYGE PPYPCKEEEE
410 420 430 440 450
NGKDASEDSA QSGSEGGSGH ASAHYMYRQE GYETVSYGDN LYVCIPCAKG
460 470 480 490 500
FPSSEQLNAH VETHTEEELF IKEEGAYETG SGGAEEEAED LSAPSAAYTA
510 520 530 540 550
EPRPFKCSVC EKTYKDPATL RQHEKTHWLT RPFPCNICGK MFTQRGTMTR
560 570 580 590 600
HMRSHLGLKP FACDECGMRF TRQYRLTEHM RVHSGEKPYE CQLCGGKFTQ
610
QRNLISHLRM HTSPS
Sequence cautioni
The sequence BAA82972 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 49 – 51 | IIM → TIR in CAC70715 (PubMed:11554746).Curated | 3 | |
Sequence conflicti | 176 | Q → R in BAA82972 (PubMed:10470851).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006829 | 1 – 18 | Missing in isoform 2. 1 PublicationAdd BLAST | 18 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ313204 mRNA Translation: CAC70715.1 AF349035 mRNA Translation: AAK72951.1 AB028943 mRNA Translation: BAA82972.2 Different initiation. CR456377 mRNA Translation: CAG30263.1 AP000557 Genomic DNA No translation available. BC094787 mRNA Translation: AAH94787.1 AL162003 mRNA Translation: CAB82344.1 |
CCDSi | CCDS13789.1 [Q96JB3-1] |
PIRi | T47181 |
RefSeqi | NP_055909.2, NM_015094.2 [Q96JB3-1] XP_011528309.1, XM_011530007.2 [Q96JB3-1] XP_011528310.1, XM_011530008.2 [Q96JB3-1] XP_011528311.1, XM_011530009.2 [Q96JB3-1] XP_011528312.1, XM_011530010.2 [Q96JB3-1] XP_016884158.1, XM_017028669.1 [Q96JB3-2] |
Genome annotation databases
Ensembli | ENST00000407464; ENSP00000385319; ENSG00000169635 [Q96JB3-1] ENST00000407598; ENSP00000384889; ENSG00000169635 [Q96JB3-1] ENST00000443632; ENSP00000387757; ENSG00000169635 [Q96JB3-1] |
GeneIDi | 23119 |
KEGGi | hsa:23119 |
UCSCi | uc002zur.5, human [Q96JB3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ313204 mRNA Translation: CAC70715.1 AF349035 mRNA Translation: AAK72951.1 AB028943 mRNA Translation: BAA82972.2 Different initiation. CR456377 mRNA Translation: CAG30263.1 AP000557 Genomic DNA No translation available. BC094787 mRNA Translation: AAH94787.1 AL162003 mRNA Translation: CAB82344.1 |
CCDSi | CCDS13789.1 [Q96JB3-1] |
PIRi | T47181 |
RefSeqi | NP_055909.2, NM_015094.2 [Q96JB3-1] XP_011528309.1, XM_011530007.2 [Q96JB3-1] XP_011528310.1, XM_011530008.2 [Q96JB3-1] XP_011528311.1, XM_011530009.2 [Q96JB3-1] XP_011528312.1, XM_011530010.2 [Q96JB3-1] XP_016884158.1, XM_017028669.1 [Q96JB3-2] |
3D structure databases
SMRi | Q96JB3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116741, 32 interactors |
IntActi | Q96JB3, 24 interactors |
MINTi | Q96JB3 |
STRINGi | 9606.ENSP00000387757 |
PTM databases
iPTMneti | Q96JB3 |
PhosphoSitePlusi | Q96JB3 |
SwissPalmi | Q96JB3 |
Polymorphism and mutation databases
BioMutai | HIC2 |
DMDMi | 20454983 |
Proteomic databases
EPDi | Q96JB3 |
jPOSTi | Q96JB3 |
MassIVEi | Q96JB3 |
MaxQBi | Q96JB3 |
PaxDbi | Q96JB3 |
PeptideAtlasi | Q96JB3 |
PRIDEi | Q96JB3 |
ProteomicsDBi | 76928 [Q96JB3-1] 76929 [Q96JB3-2] |
Protocols and materials databases
Antibodypediai | 8461, 238 antibodies |
DNASUi | 23119 |
Genome annotation databases
Ensembli | ENST00000407464; ENSP00000385319; ENSG00000169635 [Q96JB3-1] ENST00000407598; ENSP00000384889; ENSG00000169635 [Q96JB3-1] ENST00000443632; ENSP00000387757; ENSG00000169635 [Q96JB3-1] |
GeneIDi | 23119 |
KEGGi | hsa:23119 |
UCSCi | uc002zur.5, human [Q96JB3-1] |
Organism-specific databases
CTDi | 23119 |
DisGeNETi | 23119 |
EuPathDBi | HostDB:ENSG00000169635.9 |
GeneCardsi | HIC2 |
HGNCi | HGNC:18595, HIC2 |
HPAi | ENSG00000169635, Low tissue specificity |
MIMi | 607712, gene |
neXtProti | NX_Q96JB3 |
OpenTargetsi | ENSG00000169635 |
PharmGKBi | PA38357 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159978 |
HOGENOMi | CLU_015352_1_0_1 |
InParanoidi | Q96JB3 |
OMAi | DQSFQCK |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q96JB3 |
TreeFami | TF333488 |
Enzyme and pathway databases
PathwayCommonsi | Q96JB3 |
Miscellaneous databases
BioGRID-ORCSi | 23119, 15 hits in 863 CRISPR screens |
ChiTaRSi | HIC2, human |
GeneWikii | HIC2 |
GenomeRNAii | 23119 |
Pharosi | Q96JB3, Tbio |
PROi | PR:Q96JB3 |
RNActi | Q96JB3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000169635, Expressed in secondary oocyte and 232 other tissues |
Genevisiblei | Q96JB3, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HIC2_HUMAN | |
Accessioni | Q96JB3Primary (citable) accession number: Q96JB3 Secondary accession number(s): Q504T6 Q9UPX9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2002 |
Last sequence update: | May 2, 2002 | |
Last modified: | December 2, 2020 | |
This is version 183 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM