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Protein

Conserved oligomeric Golgi complex subunit 3

Gene

COG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in ER-Golgi transport.1 Publication

GO - Molecular functioni

  • protein transporter activity Source: UniProtKB

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: UniProtKB
  • Golgi organization Source: UniProtKB
  • intracellular protein transport Source: InterPro
  • intra-Golgi vesicle-mediated transport Source: UniProtKB
  • protein glycosylation Source: UniProtKB
  • protein localization to organelle Source: UniProtKB
  • protein stabilization Source: UniProtKB
  • retrograde vesicle-mediated transport, Golgi to ER Source: UniProtKB

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811438 Intra-Golgi traffic
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

Names & Taxonomyi

Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 3
Short name:
COG complex subunit 3
Alternative name(s):
Component of oligomeric Golgi complex 3
Vesicle-docking protein SEC34 homolog
p94
Gene namesi
Name:COG3
Synonyms:SEC34
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000136152.14
HGNCiHGNC:18619 COG3
MIMi606975 gene
neXtProtiNX_Q96JB2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi83548
OpenTargetsiENSG00000136152
PharmGKBiPA38602

Polymorphism and mutation databases

BioMutaiCOG3
DMDMi85701302

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002135002 – 828Conserved oligomeric Golgi complex subunit 3Add BLAST827

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei663PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96JB2
MaxQBiQ96JB2
PaxDbiQ96JB2
PeptideAtlasiQ96JB2
PRIDEiQ96JB2
ProteomicsDBi76926
76927 [Q96JB2-2]

PTM databases

iPTMnetiQ96JB2
PhosphoSitePlusiQ96JB2

Expressioni

Tissue specificityi

Widely expressed with highest levels in pancreas and testis and lowest levels in lung.1 Publication

Gene expression databases

BgeeiENSG00000136152
CleanExiHS_COG3
ExpressionAtlasiQ96JB2 baseline and differential
GenevisibleiQ96JB2 HS

Organism-specific databases

HPAiHPA040353
HPA054470

Interactioni

Subunit structurei

Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Interacts with TMEM115.By similarity1 Publication

Protein-protein interaction databases

BioGridi123680, 48 interactors
CORUMiQ96JB2
IntActiQ96JB2, 20 interactors
MINTiQ96JB2
STRINGi9606.ENSP00000258654

Structurei

3D structure databases

ProteinModelPortaliQ96JB2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COG3 family.Curated

Phylogenomic databases

eggNOGiKOG2604 Eukaryota
ENOG410XNXH LUCA
GeneTreeiENSGT00390000015682
HOGENOMiHOG000264596
HOVERGENiHBG051062
InParanoidiQ96JB2
KOiK20290
OMAiKIPEYQQ
OrthoDBiEOG091G03O0
PhylomeDBiQ96JB2
TreeFamiTF314200

Family and domain databases

InterProiView protein in InterPro
IPR007265 COG_su3
PANTHERiPTHR13302 PTHR13302, 1 hit
PfamiView protein in Pfam
PF04136 Sec34, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96JB2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEAALLLLP EAAAERDARE KLALWDRRPD TTAPLTDRQT DSVLELKAAA
60 70 80 90 100
ENLPVPAELP IEDLCSLTSQ SLPIELTSVV PESTEDILLK GFTSLGMEEE
110 120 130 140 150
RIETAQQFFS WFAKLQTQMD QDEGTKYRQM RDYLSGFQEQ CDAILNDVNS
160 170 180 190 200
ALQHLESLQK QYLFVSNKTG TLHEACEQLL KEQSELVDLA ENIQQKLSYF
210 220 230 240 250
NELETINTKL NSPTLSVNSD GFIPMLAKLD DCITYISSHP NFKDYPIYLL
260 270 280 290 300
KFKQCLSKAL HLMKTYTVNT LQTLTSQLLK RDPSSVPNAD NAFTLFYVKF
310 320 330 340 350
RAAAPKVRTL IEQIELRSEK IPEYQQLLND IHQCYLDQRE LLLGPSIACT
360 370 380 390 400
VAELTSQNNR DHCALVRSGC AFMVHVCQDE HQLYNEFFTK PTSKLDELLE
410 420 430 440 450
KLCVSLYDVF RPLIIHVIHL ETLSELCGIL KNEVLEDHVQ NNAEQLGAFA
460 470 480 490 500
AGVKQMLEDV QERLVYRTHI YIQTDITGYK PAPGDLAYPD KLVMMEQIAQ
510 520 530 540 550
SLKDEQKKVP SEASFSDVHL EEGESNSLTK SGSTESLNPR PQTTISPADL
560 570 580 590 600
HGMWYPTVRR TLVCLSKLYR CIDRAVFQGL SQEALSACIQ SLLGASESIS
610 620 630 640 650
KNKTQIDGQL FLIKHLLILR EQIAPFHTEF TIKEISLDLK KTRDAAFKIL
660 670 680 690 700
NPMTVPRFFR LNSNNALIEF LLEGTPEIRE HYLDSKKDVD RHLKSACEQF
710 720 730 740 750
IQQQTKLFVE QLEEFMTKVS ALKTMASQGG PKYTLSQQPW AQPAKVNDLA
760 770 780 790 800
ATAYKTIKTK LPVTLRSMSL YLSNKDTEFI LFKPVRNNIQ QVFQKFHALL
810 820
KEEFSPEDIQ IIACPSMEQL SLLLLVSK
Length:828
Mass (Da):94,096
Last modified:January 23, 2007 - v3
Checksum:iB3DCF03FD4DC6A60
GO
Isoform 2 (identifier: Q96JB2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     443-444: AE → GK
     445-828: Missing.

Note: No experimental confirmation available.
Show »
Length:444
Mass (Da):50,540
Checksum:i55874C370679512F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti106 – 107QQ → HE in AAK66974 (PubMed:11292827).Curated2
Sequence conflicti825L → S in AAK66974 (PubMed:11292827).Curated1
Sequence conflicti825L → S in AAK06848 (PubMed:11929878).Curated1
Sequence conflicti825L → S in BAG37012 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036454620R → C in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs747042102Ensembl.1
Natural variantiVAR_055663747N → S1 PublicationCorresponds to variant dbSNP:rs2274285Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013652443 – 444AE → GK in isoform 2. 1 Publication2
Alternative sequenceiVSP_013653445 – 828Missing in isoform 2. 1 PublicationAdd BLAST384

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF349676 mRNA Translation: AAK66974.1
AF332595 mRNA Translation: AAK06848.1
AK314387 mRNA Translation: BAG37012.1
AL139326 Genomic DNA No translation available.
AL606514 Genomic DNA No translation available.
BC038953 mRNA Translation: AAH38953.1
CCDSiCCDS9398.1 [Q96JB2-1]
RefSeqiNP_113619.2, NM_031431.3
UniGeneiHs.507948

Genome annotation databases

EnsembliENST00000349995; ENSP00000258654; ENSG00000136152 [Q96JB2-1]
ENST00000617493; ENSP00000481332; ENSG00000136152 [Q96JB2-2]
GeneIDi83548
KEGGihsa:83548
UCSCiuc001vai.4 human [Q96JB2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCOG3_HUMAN
AccessioniPrimary (citable) accession number: Q96JB2
Secondary accession number(s): B2RAW5
, Q5VT70, Q8IXX4, Q9BZ92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 139 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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