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UniProtKB - Q96JB1 (DYH8_HUMAN)

Entry version 146 (25 May 2022)
Sequence version 2 (23 Jan 2007)
Previous versions | rss
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Protein

Dynein axonemal heavy chain 8

Gene

DNAH8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Force generating protein component of the outer dynein arms (ODAs) in the sperm flagellum. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly.

1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1846 – 1853ATPSequence analysis8
Nucleotide bindingi2128 – 2135ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96JB1

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q96JB1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynein axonemal heavy chain 8Curated
Alternative name(s):
Axonemal beta dynein heavy chain 8
Ciliary dynein heavy chain 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DNAH8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2952, DNAH8

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603337, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96JB1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000124721

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Flagellum, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spermatogenic failure 46 (SPGF46)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive infertility disorder caused by spermatogenesis defects resulting in asthenoteratozoospermia. SPGF46 is characterized by multiple morphologic abnormalities of sperm flagella with disorganization of axonemal and periaxonemal structures. Flagella are absent, short, coiled, angulated, and/or of irregular caliber.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0851882013K → R in SPGF46; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1563044711Ensembl.1
Natural variantiVAR_0851892926R → C in SPGF46; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs151313083Ensembl.1
Natural variantiVAR_0851914024A → T in SPGF46; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs369473998Ensembl.1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		1769

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		DNAH8

MalaCards human disease database

More...MalaCardsi		DNAH8
MIMi619095, phenotype

Open Targets

More...OpenTargetsi		ENSG00000124721

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27405

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96JB1, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DNAH8

Domain mapping of disease mutations (DMDM)

More...DMDMi		124007137

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002740441 – 4490Dynein axonemal heavy chain 8Add BLAST4490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei674PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96JB1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96JB1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96JB1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96JB1

PeptideAtlas

More...PeptideAtlasi		Q96JB1

PRoteomics IDEntifications database

More...PRIDEi		Q96JB1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		76924 [Q96JB1-1]
76925 [Q96JB1-2]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		Q96JB1

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q96JB1, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96JB1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96JB1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in spermatozoa (at protein level). Not detected in airway epithelial cells (at protein level).1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression is detected in the germ cells from the early spermatocyte to late spermatid stages but not in the somatic cells (Leydig, Sertoli cells).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000124721, Expressed in testis and 53 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96JB1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96JB1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000124721, Tissue enhanced (epididymis, prostate, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Consists of at least two heavy chains and a number of intermediate and light chains.

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108108, 10 interactors

Protein interaction database and analysis system

More...IntActi		Q96JB1, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000333363

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96JB1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96JB1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1808 – 2030AAA 1By similarityAdd BLAST223
Regioni2090 – 2309AAA 2By similarityAdd BLAST220
Regioni2416 – 2669AAA 3By similarityAdd BLAST254
Regioni2780 – 3034AAA 4By similarityAdd BLAST255
Regioni3049 – 3346StalkBy similarityAdd BLAST298
Regioni3432 – 3662AAA 5By similarityAdd BLAST231
Regioni3877 – 4091AAA 6By similarityAdd BLAST215

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3072 – 3164Sequence analysisAdd BLAST93
Coiled coili3290 – 3354Sequence analysisAdd BLAST65
Coiled coili3594 – 3630Sequence analysisAdd BLAST37

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3595, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158992

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000038_9_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96JB1

Database of Orthologous Groups

More...OrthoDBi		6295at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96JB1

TreeFam database of animal gene trees

More...TreeFami		TF316836

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.8.710, 1 hit
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.10.490.20, 1 hit
3.20.180.20, 1 hit
3.40.50.300, 5 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003593, AAA+_ATPase
IPR035699, AAA_6
IPR035706, AAA_9
IPR041658, AAA_lid_11
IPR042219, AAA_lid_11_sf
IPR026983, DHC_fam
IPR041589, DNAH3_AAA_lid_1
IPR042222, Dynein_2_N
IPR043157, Dynein_AAA1S
IPR041466, Dynein_AAA5_ext
IPR041228, Dynein_C
IPR043160, Dynein_C_barrel
IPR024743, Dynein_HC_stalk
IPR024317, Dynein_heavy_chain_D4_dom
IPR004273, Dynein_heavy_D6_P-loop
IPR013602, Dynein_heavy_linker
IPR013594, Dynein_heavy_tail
IPR042228, Dynein_linker_3
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...PANTHERi		PTHR10676, PTHR10676, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12774, AAA_6, 1 hit
PF12780, AAA_8, 1 hit
PF12781, AAA_9, 1 hit
PF17857, AAA_lid_1, 1 hit
PF18198, AAA_lid_11, 1 hit
PF08385, DHC_N1, 1 hit
PF08393, DHC_N2, 1 hit
PF17852, Dynein_AAA_lid, 1 hit
PF18199, Dynein_C, 1 hit
PF03028, Dynein_heavy, 1 hit
PF12777, MT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00382, AAA, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96JB1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMKLYIDNAA PDKLKGLCIF FVRCRNDVAI NVKTIQEEAL FTVLDASKGL 
        60         70         80         90        100
LNGIRDMLAN IFLPAVLATN NWGALNQSKQ GESEKHIFTE TINRYLSFLD 
       110        120        130        140        150
GARISIEGTV KLKTIDNVNF SKLHTFEEVT AAASNSETVH QLEEVLMVWY 
       160        170        180        190        200
KQIEQVLIES EQMRKEAGDS GPLTELEHWK RMSAKFNYII EQIKGPSCKA 
       210        220        230        240        250
VINVLNVAHS KLLKNWRDLD ARITDTANES KDNVRYLYTL EKVCQPLYNH 
       260        270        280        290        300
DLVSMAHGIQ NLINAIRMIH GVSRYYNTSE RMTSLFIKVT NQMVTACKAY 
       310        320        330        340        350
ITDGGLNHVW DQETPVVLKK IQDCIFLFKE YQASFHKTRK LISESSGEKS 
       360        370        380        390        400
FEVSEMYIFG KFEAFCKRLE KITEMITVVQ TYSTLSNSTI EGIDIMAIKF 
       410        420        430        440        450
RNIYQGVKKK QYDILDPRRT EFDTDFLDFM TKINGLEVQI QAFMNSSFGK 
       460        470        480        490        500
ILSSQQALQL LQRFQKLNIP CLGLEINHTI ERILQYYVAE LDATKKLYHS 
       510        520        530        540        550
QKDDPPLARN MPPIAGKILW VRQLYRRISE PINYFFKNSD ILSSPDGKAV 
       560        570        580        590        600
IRQYNKISYV LVEFEVVYHT AWIREISQLH YALQATLFVR HPETGKLLVN 
       610        620        630        640        650
FDPKILEVVR ETKCMIKMKL DVPEQAKRLL KLESKLKADK LYLQGLLQYY 
       660        670        680        690        700
DELCQEVPSV FVNLMTPKMK KVESVLRQGL TVLTWSSLTL ESFFQEVELV 
       710        720        730        740        750
LDMFNQLLKK ISDLCEMHID TVLKEIAKTV LISLPESGAT KVEDMLTLNE 
       760        770        780        790        800
TYTKEWADIL NHKSKHVEEA VRELISIFEQ IYEVKYTGKV GKQSEQRKHV 
       810        820        830        840        850
VFGSETGEGE NNDYEANIVN EFDTHDKEDE FKKECKEVFA FFSHQLLDSL 
       860        870        880        890        900
QKATRLSLDT MKRRIFVASL YGRKQSEDII SFIKSEVHLA IPNVVMIPSL 
       910        920        930        940        950
DDIQQAINRM IQLTLEVSRG VAHWGQQQIR PIKSVIPSPT TTDVTHQNTG 
       960        970        980        990       1000
KLLKKEERSF EEAIPARKLK NFYPGVAEHK DISKLVLLLS SSVNSLRKAA 
      1010       1020       1030       1040       1050
HEALQDFQKY KTLWTEDRDV KVKEFLANNP SLTEIRSEIL HYATFEQEID 
      1060       1070       1080       1090       1100
ELKPIIVVGA LELHTEPMKL ALSIEAKAWK MLLCRYLNEE YKKKMSYMIA 
      1110       1120       1130       1140       1150
FINEYLKKLS RPIRDLDDVR FAMEALSCIR DNEIQMDMTL GPIEEAYAIL 
      1160       1170       1180       1190       1200
NRFEVEVTKE ESEAVDTLRY SFNKLQSKAV SVQEDLVQVQ PKFKSNLLES 
      1210       1220       1230       1240       1250
VEVFREDVIN FAEAYELEGP MVPNIPPQEA SNRLQIFQAS FDDLWRKFVT 
      1260       1270       1280       1290       1300
YSSGEQLFGL PVTDYEVLHK TRKELNLLQK LYGLYDTVMS SISGYYEILW 
      1310       1320       1330       1340       1350
GDVDIEKINA ELLEFQNRCR KLPKGLKDWQ AFLDLKKRID DFSESCPLLE 
      1360       1370       1380       1390       1400
MMTNKAMKQR HWDRISELTG TPFDVESDSF CLRNIMEAPL LKHKDDIEDI 
      1410       1420       1430       1440       1450
CISAIKEKDI EAKLTQVIEN WTNQNLSFAA FKGKGELLLK GTESGEIITL 
      1460       1470       1480       1490       1500
MEDSLMVLGS LLSNRYNAPF KKNIQNWVYK LSTSSDIIEE WLVVQNLWVY 
      1510       1520       1530       1540       1550
LEAVFVGGDI AKQLPQEAKR FQNIDKSWIK IMQRAHENPN VINCCVGDET 
      1560       1570       1580       1590       1600
MGQLLPHLHE QLEVCQKSLT GYLEKKRLLF PRFFFVSDPV LLEILGQASD 
      1610       1620       1630       1640       1650
SHTIQPHLPA VSDNINEVTF HAKDYDRIMA VISREGEKIV LDNSVMAKGP 
      1660       1670       1680       1690       1700
VEIWLLDLLK MQMSSLHNII RSAFYQISDS GFQLLPFLSH FPAQVGLLGI 
      1710       1720       1730       1740       1750
QMLWTHDSEE ALRNAKDDRK IMQVTNQKFL DILNTLISQT THDLSKFDRV 
      1760       1770       1780       1790       1800
KFETLITIHV HQRDIFDDLV KMHIKSPTDF EWLKQSRFYF KEDLDQTVVS 
      1810       1820       1830       1840       1850
ITDVDFIYQN EFLGCTDRLV ITPLTDRCYI TLAQALGMNM GGAPAGPAGT 
      1860       1870       1880       1890       1900
GKTETTKDMG RCLGKYVVVF NCSDQMDFRG LGRIFKGLAQ SGSWGCFDEF 
      1910       1920       1930       1940       1950
NRIELPVLSV AAQQIYIVLT ARKERKKQFI FSDGDCVDLN PEFGIFLTMN 
      1960       1970       1980       1990       2000
PGYAGRQELP ENLKIQFRTV AMMVPDRQII MRVKLASCGF LENVILAQKF 
      2010       2020       2030       2040       2050
YVLYKLCEEQ LTKQVHYDFG LRNILSVLRT LGSQKRARPE DSELSIVMRG 
      2060       2070       2080       2090       2100
LRDMNLSKLV DEDEPLFLSL INDLFPGLQL DSNTYAELQN AVAHQVQIEG 
      2110       2120       2130       2140       2150
LINHPPWNLK LVQLYETSLV RHGLMTLGPS GSGKTTVITI LMKAQTECGR 
      2160       2170       2180       2190       2200
PHREMRMNPK AITAPQMFGR LDTATNDWTD GIFSTLWRKT LKAKKGENIF 
      2210       2220       2230       2240       2250
LILDGPVDAI WIENLNSVLD DNKTLTLANG DRIPMAPSCK LLFEVHNIEN 
      2260       2270       2280       2290       2300
ASPATVSRMG MVYISSSALS WRPILQAWLK KRTAQEAAVF LTLYEKVFED 
      2310       2320       2330       2340       2350
TYTYMKLNLN PKMQLLECNY IVQSLNLLEG LIPSKEEGGV SCVEHLHKLF 
      2360       2370       2380       2390       2400
VFGLMWSLGA LLELESREKL EAFLRQHESK LDLPEIPKGS NQTMYEFYVT 
      2410       2420       2430       2440       2450
DYGDWEHWNK KLQPYYYPTD SIPEYSSILV PNVDNIRTNF LIDTIAKQHK 
      2460       2470       2480       2490       2500
AVLLTGEQGT AKTVMVKAYL KKYDPEVQLS KSLNFSSATE PMMFQRTIES 
      2510       2520       2530       2540       2550
YVDKRIGSTY GPPGGRKMTV FIDDINMPVI NEWGDQITNE IVRQMMEMEG 
      2560       2570       2580       2590       2600
MYSLDKPGDF TTIVDVQLIA AMIHPGGGRN DIPQRLKRQF TVFNCTLPSN 
      2610       2620       2630       2640       2650
ASIDKIFGII GCGYFDPCRS FKPQICEMIV NLVSVGRVLW QWTKVKMLPT 
      2660       2670       2680       2690       2700
PSKFHYIFNL RDLSRIWQGM LTIKAEECAS IPTLLSLFKH ECSRVIADRF 
      2710       2720       2730       2740       2750
ITPEDEQWFN AHLTRAVEEN IGSDAASCIL PEPYFVDFLR EMPEPTGDEP 
      2760       2770       2780       2790       2800
EDSVFEVPKI YELMPSFDFL AEKLQFYQRQ FNEIIRGTSL DLVFFKDAMT 
      2810       2820       2830       2840       2850
HLIKISRIIR TSCGNALLVG VGGSGKQSLS RLASFIAGYQ IFQITLTRSY 
      2860       2870       2880       2890       2900
NVTNLTDDLK ALYKVAGADG KGITFIFTDS EIKDEAFLEY LNNLLSSGEI 
      2910       2920       2930       2940       2950
SNLFARDEMD EITQGLISVM KRELPRHPPT FDNLYEYFIS RSRKNLHVVL 
      2960       2970       2980       2990       3000
CFSPVGEKFR ARSLKFPGLI SGCTMDWFSR WPREALIAVA SYFLSDYNIV 
      3010       3020       3030       3040       3050
CSSEIKRQVV ETMGLFHDMV SESCESYFQR YRRRAHVTPK SYLSFINGYK 
      3060       3070       3080       3090       3100
NIYAEKVKFI NEQAERMNIG LDKLMEASES VAKLSQDLAV KEKELAVASI 
      3110       3120       3130       3140       3150
KADEVLAEVT VSAQASAKIK NEVQEVKDKA QKIVDEIDSE KVKAESKLEA 
      3160       3170       3180       3190       3200
AKPALEEAEA ALNTIKPNDI ATVRKLAKPP HLIMRIMDCV LLLFQKKIDP 
      3210       3220       3230       3240       3250
VTMDPEKSCC KPSWGESLKL MSATGFLWSL QQFPKDTINE ETVELLQPYF 
      3260       3270       3280       3290       3300
NMDDYTFESA KKVCGNVAGL LSWTLAMAIF YGINREVLPL KANLAKQEGR 
      3310       3320       3330       3340       3350
LAVANAELGK AQALLDEKQA ELDKVQAKFD AAMNEKMDLL NDADTCRKKM 
      3360       3370       3380       3390       3400
QAASTLIDGL SGEKIRWTQQ SKEFKAQINR LVGDILLCTG FLSYLGPFNQ 
      3410       3420       3430       3440       3450
IFRNYLLKDQ WEMELRARKI PFTENLNLIS MLVDPPTIGE WGLQGLPGDD 
      3460       3470       3480       3490       3500
LSIQNGIIVT KATRYPLLID PQTQGKTWIK SKEKENDLQV TSLNHKYFRT 
      3510       3520       3530       3540       3550
HLEDSLSLGR PLLIEDIHEE LDPALDNVLE KNFIKSGTTF KVKVGDKECD 
      3560       3570       3580       3590       3600
IMDTFKLYIT TKLPNPAFTP EINAKTSVID FTVTMKGLEN QLLRRVILTE 
      3610       3620       3630       3640       3650
KQELEAERVK LLEDVTFNKR KMKELEDNLL YKLSATKGSL VDDESLIGVL 
      3660       3670       3680       3690       3700
RTTKQTAAEV SEKLHVAAET EIKINAAQEE FRPAATRGSI LYFLITEMSM 
      3710       3720       3730       3740       3750
VNIMYQTSLA QFLKLFDQSM ARSEKSPLPQ KRITNIIEYL TYEVFTYSVR 
      3760       3770       3780       3790       3800
GLYENHKFLF VLLMTLKIDL QRGTVKHREF QALIKGGAAL DLKACPPKPY 
      3810       3820       3830       3840       3850
RWILDMTWLN LVELSKLPQF AEIMNQISRN EKGWKSWFDK DAPEEEIIPD 
      3860       3870       3880       3890       3900
GYNDSLDTCH KLLLIRSWCP DRTVFQARKY IADSLEEKYT EPVILNLEKT 
      3910       3920       3930       3940       3950
WEESDTRTPL ICFLSMGSDP TNQIDALAKK LKLECRTISM GQGQEVHARK 
      3960       3970       3980       3990       4000
LIQMSMQQGG WVLLQNCHLG LEFMEELLET LITTEASDDS FRVWITTEPH 
      4010       4020       4030       4040       4050
DRFPITLLQT SLKFTNEPPQ GVRAGLKRTF AGINQDLLDI SNLPMWKPML 
      4060       4070       4080       4090       4100
YTVAFLHSTV QERRKFGPLG WNIPYEFNSA DFSASVQFIQ NHLDECDIKK 
      4110       4120       4130       4140       4150
GVSWNTVRYM IGEVQYGGRV TDDFDKRLLN CFARVWFSEK MFEPSFCFYT 
      4160       4170       4180       4190       4200
GYKIPLCKTL DQYFEYIQSL PSLDNPEVFG LHPNADITYQ SNTASAVLET 
      4210       4220       4230       4240       4250
ITNIQPKESG GGVGETREAI VYRLSEDMLS KLPPDYIPHE VKSRLIKMGH 
      4260       4270       4280       4290       4300
LNSMNIFLRQ EIDRMQRVIS ILRSSLSDLK LAIEGTIIMS ENLRDALDNM 
      4310       4320       4330       4340       4350
YDARIPQLWK RVSWDSSTLG FWFTELLERN AQFSTWIFEG RPNVFWMTGF 
      4360       4370       4380       4390       4400
FNPQGFLTAM RQEVTRAHKG WALDTVTIHN EVLRQTKEEI TSPPGEGVYI 
      4410       4420       4430       4440       4450
YGLYMDGAAW DRRNGKLMES TPKVLFTQLP VLHIFAINST APKDPKLYVC 
      4460       4470       4480       4490
PIYKKPRRTD LTFITVVYLR TVLSPDHWIL RGVALLCDIK
Length:4,490
Mass (Da):514,664
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE5809E32FF08199B
GO
Isoform 2 (identifier: Q96JB1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1978-2013: Missing.

Show »
Length:4,454
Mass (Da):510,448
Checksum:i99F3877237ACCF7A
GO
Isoform 3 (identifier: Q96JB1-3)
Sequence is not available
Length:–
Mass (Da):–
Isoform 4 (identifier: Q96JB1-4)
Sequence is not available
Length:–
Mass (Da):–

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A075B6F3A0A075B6F3_HUMAN
Dynein axonemal heavy chain 8
DNAH8
4,707Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y7V4H0Y7V4_HUMAN
Dynein axonemal heavy chain 8
DNAH8
4,188Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BLZ4H3BLZ4_HUMAN
Dynein axonemal heavy chain 8
DNAH8
135Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8IU65Q8IU65_HUMAN
Axonemal dynein heavy chain 8 isofo...
DNAH8
217Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1622A → T in AAK60620 (PubMed:12297094).Curated1
Sequence conflicti1945 – 1947IFL → VFI in CAB06060 (PubMed:9373155).Curated3
Sequence conflicti3495H → R in AAK60620 (PubMed:12297094).Curated1
Sequence conflicti4118G → D in AAK60620 (PubMed:12297094).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03017171N → S. Corresponds to variant dbSNP:rs6935293Ensembl.1
Natural variantiVAR_030172473G → R. Corresponds to variant dbSNP:rs1738254Ensembl.1
Natural variantiVAR_030173573I → V1 PublicationCorresponds to variant dbSNP:rs3823430Ensembl.1
Natural variantiVAR_085187590 – 4490Missing Found in a patient with primary ciliary dyskinesia; unknown pathological significance. 1 PublicationAdd BLAST3901
Natural variantiVAR_030174727A → T. Corresponds to variant dbSNP:rs1678674Ensembl.1
Natural variantiVAR_030175807G → E1 PublicationCorresponds to variant dbSNP:rs874808Ensembl.1
Natural variantiVAR_0301761202E → K1 PublicationCorresponds to variant dbSNP:rs9357283Ensembl.1
Natural variantiVAR_0851882013K → R in SPGF46; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1563044711Ensembl.1
Natural variantiVAR_0362132226T → M in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0301772444T → N. Corresponds to variant dbSNP:rs862432Ensembl.1
Natural variantiVAR_0851892926R → C in SPGF46; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs151313083Ensembl.1
Natural variantiVAR_0851903707T → M1 PublicationCorresponds to variant dbSNP:rs61757218Ensembl.1
Natural variantiVAR_0851914024A → T in SPGF46; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs369473998Ensembl.1
Natural variantiVAR_0301784106T → M. Corresponds to variant dbSNP:rs1537232Ensembl.1
Natural variantiVAR_0301794271I → V1 PublicationCorresponds to variant dbSNP:rs10484847Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0226141978 – 2013Missing in isoform 2. CuratedAdd BLAST36

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF356519 mRNA Translation: AAK60620.1
AL034345 Genomic DNA No translation available.
AL035555 Genomic DNA No translation available.
AL035690 Genomic DNA No translation available.
AL353700 Genomic DNA No translation available.
AL391415 Genomic DNA No translation available.
Z83806 mRNA Translation: CAB06060.1
AJ132091 mRNA Translation: CAA10564.1

NCBI Reference Sequences

More...RefSeqi		NP_001193856.1, NM_001206927.1
XP_011512623.1, XM_011514321.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000359357.7; ENSP00000352312.3; ENSG00000124721.18

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1769

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1769

UCSC genome browser

More...UCSCi		uc003ooe.3, human [Q96JB1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF356519 mRNA Translation: AAK60620.1
AL034345 Genomic DNA No translation available.
AL035555 Genomic DNA No translation available.
AL035690 Genomic DNA No translation available.
AL353700 Genomic DNA No translation available.
AL391415 Genomic DNA No translation available.
Z83806 mRNA Translation: CAB06060.1
AJ132091 mRNA Translation: CAA10564.1
RefSeqiNP_001193856.1, NM_001206927.1
XP_011512623.1, XM_011514321.1

3D structure databases

SMRiQ96JB1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi108108, 10 interactors
IntActiQ96JB1, 3 interactors
STRINGi9606.ENSP00000333363

PTM databases

CarbonylDBiQ96JB1
GlyGeniQ96JB1, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ96JB1
PhosphoSitePlusiQ96JB1

Genetic variation databases

BioMutaiDNAH8
DMDMi124007137

Proteomic databases

EPDiQ96JB1
MassIVEiQ96JB1
MaxQBiQ96JB1
PaxDbiQ96JB1
PeptideAtlasiQ96JB1
PRIDEiQ96JB1
ProteomicsDBi76924 [Q96JB1-1]
76925 [Q96JB1-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		29878, 52 antibodies from 16 providers

The DNASU plasmid repository

More...DNASUi		1769

Genome annotation databases

EnsembliENST00000359357.7; ENSP00000352312.3; ENSG00000124721.18
GeneIDi1769
KEGGihsa:1769
UCSCiuc003ooe.3, human [Q96JB1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1769
DisGeNETi1769

GeneCards: human genes, protein and diseases

More...GeneCardsi		DNAH8
GeneReviewsiDNAH8
HGNCiHGNC:2952, DNAH8
HPAiENSG00000124721, Tissue enhanced (epididymis, prostate, testis)
MalaCardsiDNAH8
MIMi603337, gene
619095, phenotype
neXtProtiNX_Q96JB1
OpenTargetsiENSG00000124721
PharmGKBiPA27405
VEuPathDBiHostDB:ENSG00000124721

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3595, Eukaryota
GeneTreeiENSGT00940000158992
HOGENOMiCLU_000038_9_1_1
InParanoidiQ96JB1
OrthoDBi6295at2759
PhylomeDBiQ96JB1
TreeFamiTF316836

Enzyme and pathway databases

PathwayCommonsiQ96JB1
SignaLinkiQ96JB1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1769, 7 hits in 318 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DNAH8, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1769
PharosiQ96JB1, Tbio

Protein Ontology

More...PROi		PR:Q96JB1
RNActiQ96JB1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000124721, Expressed in testis and 53 other tissues
ExpressionAtlasiQ96JB1, baseline and differential
GenevisibleiQ96JB1, HS

Family and domain databases

Gene3Di1.10.8.710, 1 hit
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.10.490.20, 1 hit
3.20.180.20, 1 hit
3.40.50.300, 5 hits
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR035699, AAA_6
IPR035706, AAA_9
IPR041658, AAA_lid_11
IPR042219, AAA_lid_11_sf
IPR026983, DHC_fam
IPR041589, DNAH3_AAA_lid_1
IPR042222, Dynein_2_N
IPR043157, Dynein_AAA1S
IPR041466, Dynein_AAA5_ext
IPR041228, Dynein_C
IPR043160, Dynein_C_barrel
IPR024743, Dynein_HC_stalk
IPR024317, Dynein_heavy_chain_D4_dom
IPR004273, Dynein_heavy_D6_P-loop
IPR013602, Dynein_heavy_linker
IPR013594, Dynein_heavy_tail
IPR042228, Dynein_linker_3
IPR027417, P-loop_NTPase
PANTHERiPTHR10676, PTHR10676, 1 hit
PfamiView protein in Pfam
PF12774, AAA_6, 1 hit
PF12780, AAA_8, 1 hit
PF12781, AAA_9, 1 hit
PF17857, AAA_lid_1, 1 hit
PF18198, AAA_lid_11, 1 hit
PF08385, DHC_N1, 1 hit
PF08393, DHC_N2, 1 hit
PF17852, Dynein_AAA_lid, 1 hit
PF18199, Dynein_C, 1 hit
PF03028, Dynein_heavy, 1 hit
PF12777, MT, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 3 hits
SUPFAMiSSF52540, SSF52540, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDYH8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96JB1
Secondary accession number(s): O00438
, Q5JYI2, Q5T2M3, Q5T2M4, Q5TG00, Q9UEM4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: May 25, 2022
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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