UniProtKB - Q96JA1 (LRIG1_HUMAN)
Leucine-rich repeats and immunoglobulin-like domains protein 1
LRIG1
Functioni
GO - Biological processi
- hair cycle process Source: Ensembl
- innervation Source: Ensembl
- otolith morphogenesis Source: Ensembl
- sensory perception of sound Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | Q96JA1 |
Reactomei | R-HSA-177929, Signaling by EGFR R-HSA-6807004, Negative regulation of MET activity |
SignaLinki | Q96JA1 |
SIGNORi | Q96JA1 |
Protein family/group databases
TCDBi | 8.A.43.1.21, the neat-domain containing methaemoglobin heme sequestration (n-mhs) family |
Names & Taxonomyi
Protein namesi | Recommended name: Leucine-rich repeats and immunoglobulin-like domains protein 1Short name: LIG-11 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000144749.13 |
HGNCi | HGNC:17360, LRIG1 |
MIMi | 608868, gene |
neXtProti | NX_Q96JA1 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Extracellular region or secreted
- extracellular matrix Source: GO_Central
- extracellular space Source: GO_Central
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 35 – 794 | ExtracellularSequence analysisAdd BLAST | 760 | |
Transmembranei | 795 – 815 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 816 – 1093 | CytoplasmicSequence analysisAdd BLAST | 278 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 26018 |
OpenTargetsi | ENSG00000144749 |
PharmGKBi | PA38450 |
Miscellaneous databases
Pharosi | Q96JA1, Tbio |
Polymorphism and mutation databases
BioMutai | LRIG1 |
DMDMi | 143811415 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 34 | Sequence analysisAdd BLAST | 34 | |
ChainiPRO_0000014827 | 35 – 1093 | Leucine-rich repeats and immunoglobulin-like domains protein 1Add BLAST | 1059 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 45 ↔ 54 | Combined sources1 Publication | ||
Glycosylationi | 74 | N-linked (GlcNAc...) asparagineSequence analysisCombined sources1 Publication | 1 | |
Glycosylationi | 150 | N-linked (GlcNAc...) asparagineSequence analysisCombined sources1 Publication | 1 | |
Glycosylationi | 246 | N-linked (GlcNAc...) asparagineSequence analysisCombined sources1 Publication | 1 | |
Glycosylationi | 292 | N-linked (GlcNAc...) asparagineSequence analysisCombined sources1 Publication | 1 | |
Glycosylationi | 318 | N-linked (GlcNAc...) asparagineSequence analysisCombined sources1 Publication | 1 | |
Disulfide bondi | 444 ↔ 468 | Combined sources1 Publication | ||
Disulfide bondi | 446 ↔ 489 | Combined sources1 Publication | ||
Disulfide bondi | 516 ↔ 577 | PROSITE-ProRule annotationCombined sources1 Publication | ||
Disulfide bondi | 620 ↔ 672 | PROSITE-ProRule annotationCombined sources1 Publication | ||
Glycosylationi | 684 | N-linked (GlcNAc...) asparagineSequence analysisCombined sources1 Publication | 1 | |
Disulfide bondi | 714 ↔ 763 | PROSITE-ProRule annotationCombined sources1 Publication |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
CPTACi | CPTAC-1495 |
EPDi | Q96JA1 |
jPOSTi | Q96JA1 |
MassIVEi | Q96JA1 |
MaxQBi | Q96JA1 |
PaxDbi | Q96JA1 |
PeptideAtlasi | Q96JA1 |
PRIDEi | Q96JA1 |
ProteomicsDBi | 76916 [Q96JA1-1] 76917 [Q96JA1-2] |
PTM databases
GlyGeni | Q96JA1, 9 sites |
iPTMneti | Q96JA1 |
PhosphoSitePlusi | Q96JA1 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000144749, Expressed in pancreas and 243 other tissues |
Genevisiblei | Q96JA1, HS |
Organism-specific databases
HPAi | ENSG00000144749, Tissue enhanced (pancreas) |
Interactioni
Subunit structurei
Interacts (via extracellular LRR and Ig-like domains) with EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 (via extracellular domain) (PubMed:15282549). The physiological relevance of the interaction is controversial; LRIG1 may have low affinity for EGFR, and interaction may occur only when high levels of both proteins are present (PubMed:25765764).
2 PublicationsBinary interactionsi
Hide detailsQ96JA1
Isoform 2 [Q96JA1-2]
With | #Exp. | IntAct |
---|---|---|
NBL1 - isoform 2 [P41271-2] | 3 | EBI-13067910,EBI-12135485 |
Protein-protein interaction databases
BioGRIDi | 117489, 42 interactors |
IntActi | Q96JA1, 32 interactors |
STRINGi | 9606.ENSP00000273261 |
Miscellaneous databases
RNActi | Q96JA1, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q96JA1 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 68 | LRRNTAdd BLAST | 34 | |
Repeati | 69 – 90 | LRR 1Add BLAST | 22 | |
Repeati | 93 – 114 | LRR 2Add BLAST | 22 | |
Repeati | 116 – 137 | LRR 3Add BLAST | 22 | |
Repeati | 140 – 161 | LRR 4Add BLAST | 22 | |
Repeati | 164 – 185 | LRR 5Add BLAST | 22 | |
Repeati | 189 – 210 | LRR 6Add BLAST | 22 | |
Repeati | 212 – 233 | LRR 7Add BLAST | 22 | |
Repeati | 236 – 257 | LRR 8Add BLAST | 22 | |
Repeati | 260 – 281 | LRR 9Add BLAST | 22 | |
Repeati | 284 – 305 | LRR 10Add BLAST | 22 | |
Repeati | 308 – 329 | LRR 11Add BLAST | 22 | |
Repeati | 332 – 353 | LRR 12Add BLAST | 22 | |
Repeati | 356 – 378 | LRR 13Add BLAST | 23 | |
Repeati | 383 – 404 | LRR 14Add BLAST | 22 | |
Repeati | 407 – 428 | LRR 15Add BLAST | 22 | |
Domaini | 440 – 491 | LRRCTAdd BLAST | 52 | |
Domaini | 495 – 594 | Ig-like C2-type 1Add BLAST | 100 | |
Domaini | 599 – 688 | Ig-like C2-type 2Add BLAST | 90 | |
Domaini | 693 – 779 | Ig-like C2-type 3Add BLAST | 87 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 520 – 524 | Poly-Ser | 5 |
Domaini
Keywords - Domaini
Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4194, Eukaryota |
GeneTreei | ENSGT00940000158502 |
HOGENOMi | CLU_000288_18_24_1 |
InParanoidi | Q96JA1 |
OMAi | WIIEDQS |
OrthoDBi | 161719at2759 |
PhylomeDBi | Q96JA1 |
TreeFami | TF325380 |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR000372, LRRNT |
Pfami | View protein in Pfam PF07679, I-set, 2 hits PF13855, LRR_8, 5 hits PF01463, LRRCT, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 3 hits SM00408, IGc2, 3 hits SM00369, LRR_TYP, 14 hits SM00082, LRRCT, 1 hit SM00013, LRRNT, 1 hit |
SUPFAMi | SSF48726, SSF48726, 3 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits PS51450, LRR, 14 hits |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MARPVRGGLG APRRSPCLLL LWLLLLRLEP VTAAAGPRAP CAAACTCAGD
60 70 80 90 100
SLDCGGRGLA ALPGDLPSWT RSLNLSYNKL SEIDPAGFED LPNLQEVYLN
110 120 130 140 150
NNELTAVPSL GAASSHVVSL FLQHNKIRSV EGSQLKAYLS LEVLDLSLNN
160 170 180 190 200
ITEVRNTCFP HGPPIKELNL AGNRIGTLEL GAFDGLSRSL LTLRLSKNRI
210 220 230 240 250
TQLPVRAFKL PRLTQLDLNR NRIRLIEGLT FQGLNSLEVL KLQRNNISKL
260 270 280 290 300
TDGAFWGLSK MHVLHLEYNS LVEVNSGSLY GLTALHQLHL SNNSIARIHR
310 320 330 340 350
KGWSFCQKLH ELVLSFNNLT RLDEESLAEL SSLSVLRLSH NSISHIAEGA
360 370 380 390 400
FKGLRSLRVL DLDHNEISGT IEDTSGAFSG LDSLSKLTLF GNKIKSVAKR
410 420 430 440 450
AFSGLEGLEH LNLGGNAIRS VQFDAFVKMK NLKELHISSD SFLCDCQLKW
460 470 480 490 500
LPPWLIGRML QAFVTATCAH PESLKGQSIF SVPPESFVCD DFLKPQIITQ
510 520 530 540 550
PETTMAMVGK DIRFTCSAAS SSSSPMTFAW KKDNEVLTNA DMENFVHVHA
560 570 580 590 600
QDGEVMEYTT ILHLRQVTFG HEGRYQCVIT NHFGSTYSHK ARLTVNVLPS
610 620 630 640 650
FTKTPHDITI RTTTMARLEC AATGHPNPQI AWQKDGGTDF PAARERRMHV
660 670 680 690 700
MPDDDVFFIT DVKIDDAGVY SCTAQNSAGS ISANATLTVL ETPSLVVPLE
710 720 730 740 750
DRVVSVGETV ALQCKATGNP PPRITWFKGD RPLSLTERHH LTPDNQLLVV
760 770 780 790 800
QNVVAEDAGR YTCEMSNTLG TERAHSQLSV LPAAGCRKDG TTVGIFTIAV
810 820 830 840 850
VSSIVLTSLV WVCIIYQTRK KSEEYSVTNT DETVVPPDVP SYLSSQGTLS
860 870 880 890 900
DRQETVVRTE GGPQANGHIE SNGVCPRDAS HFPEPDTHSV ACRQPKLCAG
910 920 930 940 950
SAYHKEPWKA MEKAEGTPGP HKMEHGGRVV CSDCNTEVDC YSRGQAFHPQ
960 970 980 990 1000
PVSRDSAQPS APNGPEPGGS DQEHSPHHQC SRTAAGSCPE CQGSLYPSNH
1010 1020 1030 1040 1050
DRMLTAVKKK PMASLDGKGD SSWTLARLYH PDSTELQPAS SLTSGSPERA
1060 1070 1080 1090
EAQYLLVSNG HLPKACDASP ESTPLTGQLP GKQRVPLLLA PKS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 24 – 26 | LLL → VLV in AAK62357 (PubMed:11414704).Curated | 3 | |
Sequence conflicti | 24 – 26 | LLL → VLV in AAH71561 (PubMed:15489334).Curated | 3 | |
Sequence conflicti | 80 | L → F in AAH71561 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 612 – 613 | TT → VR in CAB56036 (PubMed:17974005).Curated | 2 | |
Sequence conflicti | 861 | G → GA in BAB40659 (Ref. 2) Curated | 1 | |
Sequence conflicti | 911 | M → I in BAB40659 (Ref. 2) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049889 | 24 | L → V. Corresponds to variant dbSNP:rs1403626EnsemblClinVar. | 1 | |
Natural variantiVAR_031581 | 615 | M → V2 PublicationsCorresponds to variant dbSNP:rs2306272EnsemblClinVar. | 1 | |
Natural variantiVAR_031582 | 926 | G → S. Corresponds to variant dbSNP:rs9877201Ensembl. | 1 | |
Natural variantiVAR_031583 | 957 | A → T. Corresponds to variant dbSNP:rs332373Ensembl. | 1 | |
Natural variantiVAR_049890 | 993 | G → A. Corresponds to variant dbSNP:rs2279289Ensembl. | 1 | |
Natural variantiVAR_031584 | 1031 | P → R. Corresponds to variant dbSNP:rs332374Ensembl. | 1 | |
Natural variantiVAR_031585 | 1053 | Q → P. Corresponds to variant dbSNP:rs2279290EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_011730 | 387 | L → LLLLEPSQSAGCSSPSQPHM SAGGR in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_011731 | 644 – 691 | RERRM…LTVLE → Q in isoform 2. 1 PublicationAdd BLAST | 48 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF381545 mRNA Translation: AAK62357.1 AB050468 mRNA Translation: BAB40659.1 BC071561 mRNA Translation: AAH71561.1 BC014276 mRNA Translation: AAH14276.2 AL117666 mRNA Translation: CAB56036.1 |
CCDSi | CCDS33783.1 [Q96JA1-1] |
PIRi | T17346 |
RefSeqi | NP_056356.2, NM_015541.2 [Q96JA1-1] |
Genome annotation databases
Ensembli | ENST00000273261; ENSP00000273261; ENSG00000144749 [Q96JA1-1] ENST00000383703; ENSP00000373208; ENSG00000144749 [Q96JA1-2] |
GeneIDi | 26018 |
KEGGi | hsa:26018 |
UCSCi | uc003dmx.4, human [Q96JA1-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF381545 mRNA Translation: AAK62357.1 AB050468 mRNA Translation: BAB40659.1 BC071561 mRNA Translation: AAH71561.1 BC014276 mRNA Translation: AAH14276.2 AL117666 mRNA Translation: CAB56036.1 |
CCDSi | CCDS33783.1 [Q96JA1-1] |
PIRi | T17346 |
RefSeqi | NP_056356.2, NM_015541.2 [Q96JA1-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4U7L | X-ray | 2.30 | A | 42-494 | [»] | |
4U7M | X-ray | 2.76 | A | 494-781 | [»] | |
SMRi | Q96JA1 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 117489, 42 interactors |
IntActi | Q96JA1, 32 interactors |
STRINGi | 9606.ENSP00000273261 |
Protein family/group databases
TCDBi | 8.A.43.1.21, the neat-domain containing methaemoglobin heme sequestration (n-mhs) family |
PTM databases
GlyGeni | Q96JA1, 9 sites |
iPTMneti | Q96JA1 |
PhosphoSitePlusi | Q96JA1 |
Polymorphism and mutation databases
BioMutai | LRIG1 |
DMDMi | 143811415 |
Proteomic databases
CPTACi | CPTAC-1495 |
EPDi | Q96JA1 |
jPOSTi | Q96JA1 |
MassIVEi | Q96JA1 |
MaxQBi | Q96JA1 |
PaxDbi | Q96JA1 |
PeptideAtlasi | Q96JA1 |
PRIDEi | Q96JA1 |
ProteomicsDBi | 76916 [Q96JA1-1] 76917 [Q96JA1-2] |
Protocols and materials databases
Antibodypediai | 55087, 221 antibodies |
Genome annotation databases
Ensembli | ENST00000273261; ENSP00000273261; ENSG00000144749 [Q96JA1-1] ENST00000383703; ENSP00000373208; ENSG00000144749 [Q96JA1-2] |
GeneIDi | 26018 |
KEGGi | hsa:26018 |
UCSCi | uc003dmx.4, human [Q96JA1-1] |
Organism-specific databases
CTDi | 26018 |
DisGeNETi | 26018 |
EuPathDBi | HostDB:ENSG00000144749.13 |
GeneCardsi | LRIG1 |
HGNCi | HGNC:17360, LRIG1 |
HPAi | ENSG00000144749, Tissue enhanced (pancreas) |
MIMi | 608868, gene |
neXtProti | NX_Q96JA1 |
OpenTargetsi | ENSG00000144749 |
PharmGKBi | PA38450 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4194, Eukaryota |
GeneTreei | ENSGT00940000158502 |
HOGENOMi | CLU_000288_18_24_1 |
InParanoidi | Q96JA1 |
OMAi | WIIEDQS |
OrthoDBi | 161719at2759 |
PhylomeDBi | Q96JA1 |
TreeFami | TF325380 |
Enzyme and pathway databases
PathwayCommonsi | Q96JA1 |
Reactomei | R-HSA-177929, Signaling by EGFR R-HSA-6807004, Negative regulation of MET activity |
SignaLinki | Q96JA1 |
SIGNORi | Q96JA1 |
Miscellaneous databases
BioGRID-ORCSi | 26018, 9 hits in 841 CRISPR screens |
ChiTaRSi | LRIG1, human |
GeneWikii | LRIG1 |
GenomeRNAii | 26018 |
Pharosi | Q96JA1, Tbio |
PROi | PR:Q96JA1 |
RNActi | Q96JA1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000144749, Expressed in pancreas and 243 other tissues |
Genevisiblei | Q96JA1, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR000372, LRRNT |
Pfami | View protein in Pfam PF07679, I-set, 2 hits PF13855, LRR_8, 5 hits PF01463, LRRCT, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 3 hits SM00408, IGc2, 3 hits SM00369, LRR_TYP, 14 hits SM00082, LRRCT, 1 hit SM00013, LRRNT, 1 hit |
SUPFAMi | SSF48726, SSF48726, 3 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits PS51450, LRR, 14 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LRIG1_HUMAN | |
Accessioni | Q96JA1Primary (citable) accession number: Q96JA1 Secondary accession number(s): Q6IQ51 Q9UFI4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2004 |
Last sequence update: | April 3, 2007 | |
Last modified: | December 2, 2020 | |
This is version 158 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations