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Protein

Cysteine and tyrosine-rich protein 1

Gene

CYYR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine and tyrosine-rich protein 1
Alternative name(s):
Proline-rich domain-containing protein
Gene namesi
Name:CYYR1
Synonyms:C21orf95
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000166265.11
HGNCiHGNC:16274 CYYR1
MIMi616020 gene
neXtProtiNX_Q96J86

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 61ExtracellularSequence analysisAdd BLAST32
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 154CytoplasmicSequence analysisAdd BLAST72

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi116159
OpenTargetsiENSG00000166265
PharmGKBiPA27127

Polymorphism and mutation databases

BioMutaiCYYR1
DMDMi27151488

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000002105430 – 154Cysteine and tyrosine-rich protein 1Add BLAST125

Proteomic databases

PaxDbiQ96J86
PeptideAtlasiQ96J86
PRIDEiQ96J86
ProteomicsDBi76900
76901 [Q96J86-2]

PTM databases

PhosphoSitePlusiQ96J86

Expressioni

Tissue specificityi

Widely expressed.2 Publications

Gene expression databases

BgeeiENSG00000166265 Expressed in 195 organ(s), highest expression level in visceral pleura
CleanExiHS_CYYR1
GenevisibleiQ96J86 HS

Organism-specific databases

HPAiCAB034921
HPA067685

Interactioni

Protein-protein interaction databases

BioGridi125484, 3 interactors
IntActiQ96J86, 1 interactor
STRINGi9606.ENSP00000299340

Structurei

3D structure databases

ProteinModelPortaliQ96J86
SMRiQ96J86
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi144 – 149Poly-Pro6

Sequence similaritiesi

Belongs to the CYYR1 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWAY Eukaryota
ENOG4111TRP LUCA
GeneTreeiENSGT00500000044986
HOGENOMiHOG000015276
HOVERGENiHBG051282
InParanoidiQ96J86
OMAiCMCMKNN
OrthoDBiEOG091G15ZN
PhylomeDBiQ96J86
TreeFamiTF332064

Family and domain databases

InterProiView protein in InterPro
IPR022640 CYYR1
PANTHERiPTHR38490 PTHR38490, 1 hit
PfamiView protein in Pfam
PF10873 CYYR1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD588499 PD588499, 1 hit

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96J86-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDAPRLPVRP GVLLPKLVLL FVYADDCLAQ CGKDCKSYCC DGTTPYCCSY
60 70 80 90 100
YAYIGNILSG TAIAGIVFGI VFIMGVIAGI AICICMCMKN HRATRVGILR
110 120 130 140 150
TTHINTVSSY PGPPPYGHDH EMEYCADLPP PYSPTPQGPA QRSPPPPYPG

NARK
Length:154
Mass (Da):16,626
Last modified:December 1, 2001 - v1
Checksum:i0B0E5BD3FEC65F7D
GO
Isoform 2 (identifier: Q96J86-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-111: P → PA

Show »
Length:155
Mass (Da):16,698
Checksum:i77B16E1075F55585
GO
Isoform 3 (identifier: Q96J86-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-132: GPPPYGHDHEMEYCADLPPPY → EYELHEAEILVYFVQHSIPSM
     133-154: Missing.

Show »
Length:132
Mass (Da):14,493
Checksum:i05053883B967D234
GO
Isoform 4 (identifier: Q96J86-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-112: GTAIAGIVFG...HINTVSSYPG → RTTTLRSRPR...IIYLPEQNMC
     113-154: Missing.

Show »
Length:112
Mass (Da):12,459
Checksum:i88278552F8F48CCA
GO
Isoform 5 (identifier: Q96J86-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-75: GTAIAGIVFGIVFIMG → REFKDHQTFEENIKYE
     76-154: Missing.

Show »
Length:75
Mass (Da):8,597
Checksum:i338BED9D4EDB6B28
GO
Isoform 6 (identifier: Q96J86-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-64: GTAIA → CCCPR
     65-154: Missing.

Show »
Length:64
Mass (Da):7,064
Checksum:i209D8C4D7CAF7D60
GO

Sequence cautioni

The sequence BAB70764 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04404295R → H. Corresponds to variant dbSNP:rs35253087Ensembl.1
Natural variantiVAR_044043111P → S1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05714360 – 112GTAIA…SSYPG → RTTTLRSRPRDGILCRLASS ILPHPTGSSTAFSTPSLSWK RKEIIYLPEQNMC in isoform 4. Add BLAST53
Alternative sequenceiVSP_05714460 – 75GTAIA…VFIMG → REFKDHQTFEENIKYE in isoform 5. Add BLAST16
Alternative sequenceiVSP_05714560 – 64GTAIA → CCCPR in isoform 6. 5
Alternative sequenceiVSP_05714665 – 154Missing in isoform 6. Add BLAST90
Alternative sequenceiVSP_05714776 – 154Missing in isoform 5. Add BLAST79
Alternative sequenceiVSP_034245111P → PA in isoform 2. 1 Publication1
Alternative sequenceiVSP_057148112 – 132GPPPY…LPPPY → EYELHEAEILVYFVQHSIPS M in isoform 3. Add BLAST21
Alternative sequenceiVSP_057149113 – 154Missing in isoform 4. Add BLAST42
Alternative sequenceiVSP_057150133 – 154Missing in isoform 3. Add BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF401639 mRNA Translation: AAK84158.1
AY061853 mRNA Translation: AAL35737.1
AK054581 mRNA Translation: BAB70764.1 Different initiation.
AK313231 mRNA Translation: BAG36042.1
AK223576 mRNA Translation: BAD97296.1
AL833200 mRNA Translation: CAI46188.1
JF693912 mRNA Translation: AFC01211.1
JF693913 mRNA Translation: AFC01212.1
KC843341 mRNA Translation: AGM21753.1
KF154022 mRNA Translation: AHY03237.1
AP001596 Genomic DNA No translation available.
AP001597 Genomic DNA No translation available.
BC036761 mRNA Translation: AAH36761.1
RefSeqiNP_001307697.1, NM_001320768.1
NP_443186.2, NM_052954.3 [Q96J86-1]
UniGeneiHs.37445

Genome annotation databases

EnsembliENST00000299340; ENSP00000299340; ENSG00000166265 [Q96J86-1]
ENST00000400043; ENSP00000382918; ENSG00000166265 [Q96J86-3]
GeneIDi116159
KEGGihsa:116159
UCSCiuc002ymd.4 human [Q96J86-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF401639 mRNA Translation: AAK84158.1
AY061853 mRNA Translation: AAL35737.1
AK054581 mRNA Translation: BAB70764.1 Different initiation.
AK313231 mRNA Translation: BAG36042.1
AK223576 mRNA Translation: BAD97296.1
AL833200 mRNA Translation: CAI46188.1
JF693912 mRNA Translation: AFC01211.1
JF693913 mRNA Translation: AFC01212.1
KC843341 mRNA Translation: AGM21753.1
KF154022 mRNA Translation: AHY03237.1
AP001596 Genomic DNA No translation available.
AP001597 Genomic DNA No translation available.
BC036761 mRNA Translation: AAH36761.1
RefSeqiNP_001307697.1, NM_001320768.1
NP_443186.2, NM_052954.3 [Q96J86-1]
UniGeneiHs.37445

3D structure databases

ProteinModelPortaliQ96J86
SMRiQ96J86
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125484, 3 interactors
IntActiQ96J86, 1 interactor
STRINGi9606.ENSP00000299340

PTM databases

PhosphoSitePlusiQ96J86

Polymorphism and mutation databases

BioMutaiCYYR1
DMDMi27151488

Proteomic databases

PaxDbiQ96J86
PeptideAtlasiQ96J86
PRIDEiQ96J86
ProteomicsDBi76900
76901 [Q96J86-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299340; ENSP00000299340; ENSG00000166265 [Q96J86-1]
ENST00000400043; ENSP00000382918; ENSG00000166265 [Q96J86-3]
GeneIDi116159
KEGGihsa:116159
UCSCiuc002ymd.4 human [Q96J86-1]

Organism-specific databases

CTDi116159
DisGeNETi116159
EuPathDBiHostDB:ENSG00000166265.11
GeneCardsiCYYR1
HGNCiHGNC:16274 CYYR1
HPAiCAB034921
HPA067685
MIMi616020 gene
neXtProtiNX_Q96J86
OpenTargetsiENSG00000166265
PharmGKBiPA27127
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWAY Eukaryota
ENOG4111TRP LUCA
GeneTreeiENSGT00500000044986
HOGENOMiHOG000015276
HOVERGENiHBG051282
InParanoidiQ96J86
OMAiCMCMKNN
OrthoDBiEOG091G15ZN
PhylomeDBiQ96J86
TreeFamiTF332064

Miscellaneous databases

ChiTaRSiCYYR1 human
GeneWikiiCYYR1
GenomeRNAii116159
PROiPR:Q96J86
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166265 Expressed in 195 organ(s), highest expression level in visceral pleura
CleanExiHS_CYYR1
GenevisibleiQ96J86 HS

Family and domain databases

InterProiView protein in InterPro
IPR022640 CYYR1
PANTHERiPTHR38490 PTHR38490, 1 hit
PfamiView protein in Pfam
PF10873 CYYR1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD588499 PD588499, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCYYR1_HUMAN
AccessioniPrimary (citable) accession number: Q96J86
Secondary accession number(s): A0A059TD09
, A8MTU9, B2R845, Q53ER3, Q5JPD0, Q96NV7, R9QAJ4, W8CQB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
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