UniProtKB - Q96J77 (TPD55_HUMAN)
Protein
Tumor protein D55
Gene
TPD52L3
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Tumor protein D55Short name: hD55 Alternative name(s): Testis development protein NYD-SP25 Tumor protein D52-like 3 |
Gene namesi | Name:TPD52L3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000170777.10 |
HGNCi | HGNC:23382, TPD52L3 |
MIMi | 617567, gene |
neXtProti | NX_Q96J77 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 89882 |
OpenTargetsi | ENSG00000170777 |
PharmGKBi | PA142670712 |
Miscellaneous databases
Pharosi | Q96J77, Tdark |
Polymorphism and mutation databases
BioMutai | TPD52L3 |
DMDMi | 313104031 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000295856 | 1 – 140 | Tumor protein D55Add BLAST | 140 |
Proteomic databases
jPOSTi | Q96J77 |
MassIVEi | Q96J77 |
PaxDbi | Q96J77 |
PeptideAtlasi | Q96J77 |
PRIDEi | Q96J77 |
ProteomicsDBi | 76893 [Q96J77-1] 76894 [Q96J77-2] 76895 [Q96J77-3] |
PTM databases
iPTMneti | Q96J77 |
PhosphoSitePlusi | Q96J77 |
Expressioni
Tissue specificityi
Specifically expressed in testis. Expressed at 5.6-fold higher levels in adult testis than in fetal testis.1 Publication
Gene expression databases
Bgeei | ENSG00000170777, Expressed in testis and 100 other tissues |
Genevisiblei | Q96J77, HS |
Organism-specific databases
HPAi | ENSG00000170777, Tissue enriched (testis) |
Interactioni
Subunit structurei
Interacts with TPD52L2.
1 PublicationBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 124633, 4 interactors |
IntActi | Q96J77, 11 interactors |
STRINGi | 9606.ENSP00000341677 |
Miscellaneous databases
RNActi | Q96J77, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 28 – 57 | Sequence analysisAdd BLAST | 30 |
Sequence similaritiesi
Belongs to the TPD52 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG4010, Eukaryota |
GeneTreei | ENSGT00940000163110 |
HOGENOMi | CLU_080743_1_1_1 |
InParanoidi | Q96J77 |
OMAi | EGIFNKH |
OrthoDBi | 1225782at2759 |
PhylomeDBi | Q96J77 |
TreeFami | TF317562 |
Family and domain databases
InterProi | View protein in InterPro IPR007327, TPD52 |
PANTHERi | PTHR19307, PTHR19307, 1 hit |
Pfami | View protein in Pfam PF04201, TPD52, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q96J77-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPHARTETSV GTYESHSTSE LEDLTEPEQR ELKTKLTKLE AEIVTLRHVL
60 70 80 90 100
AAKERRCGEL KRKLGLTALV GLRQNLSKSW LDVQVSNTYV KQKTSAALST
110 120 130 140
MGTLICRKLG GVKKSATFRS FEGLMGTIKS KVSGGKRAWP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 109 | L → P in BAB71505 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033372 | 118 | F → L3 PublicationsCorresponds to variant dbSNP:rs3847262Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027113 | 124 – 140 | LMGTI…KRAWP → NPKGEGSRI in isoform 3. 1 PublicationAdd BLAST | 17 | |
Alternative sequenceiVSP_027114 | 125 – 140 | MGTIK…KRAWP → IFNKYTLNQGRN in isoform 2. 1 PublicationAdd BLAST | 16 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY032877 mRNA Translation: AAK66820.1 AK057479 mRNA Translation: BAB71505.1 AL133480 Genomic DNA No translation available. BC017589 mRNA Translation: AAH17589.1 BC033792 mRNA Translation: AAH33792.1 BC042113 mRNA Translation: AAH42113.1 |
CCDSi | CCDS34984.1 [Q96J77-2] CCDS34985.1 [Q96J77-3] CCDS34986.1 [Q96J77-1] |
RefSeqi | NP_001001874.1, NM_001001874.2 [Q96J77-2] NP_001001875.1, NM_001001875.3 [Q96J77-3] NP_277051.3, NM_033516.5 [Q96J77-1] XP_016870769.1, XM_017015280.1 [Q96J77-3] |
Genome annotation databases
Ensembli | ENST00000314556; ENSP00000318665; ENSG00000170777 [Q96J77-2] ENST00000344545; ENSP00000341677; ENSG00000170777 [Q96J77-1] ENST00000381428; ENSP00000370836; ENSG00000170777 [Q96J77-3] |
GeneIDi | 89882 |
KEGGi | hsa:89882 |
UCSCi | uc003zjv.4, human [Q96J77-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY032877 mRNA Translation: AAK66820.1 AK057479 mRNA Translation: BAB71505.1 AL133480 Genomic DNA No translation available. BC017589 mRNA Translation: AAH17589.1 BC033792 mRNA Translation: AAH33792.1 BC042113 mRNA Translation: AAH42113.1 |
CCDSi | CCDS34984.1 [Q96J77-2] CCDS34985.1 [Q96J77-3] CCDS34986.1 [Q96J77-1] |
RefSeqi | NP_001001874.1, NM_001001874.2 [Q96J77-2] NP_001001875.1, NM_001001875.3 [Q96J77-3] NP_277051.3, NM_033516.5 [Q96J77-1] XP_016870769.1, XM_017015280.1 [Q96J77-3] |
3D structure databases
SMRi | Q96J77 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124633, 4 interactors |
IntActi | Q96J77, 11 interactors |
STRINGi | 9606.ENSP00000341677 |
PTM databases
iPTMneti | Q96J77 |
PhosphoSitePlusi | Q96J77 |
Polymorphism and mutation databases
BioMutai | TPD52L3 |
DMDMi | 313104031 |
Proteomic databases
jPOSTi | Q96J77 |
MassIVEi | Q96J77 |
PaxDbi | Q96J77 |
PeptideAtlasi | Q96J77 |
PRIDEi | Q96J77 |
ProteomicsDBi | 76893 [Q96J77-1] 76894 [Q96J77-2] 76895 [Q96J77-3] |
Protocols and materials databases
Antibodypediai | 9681, 269 antibodies |
DNASUi | 89882 |
Genome annotation databases
Ensembli | ENST00000314556; ENSP00000318665; ENSG00000170777 [Q96J77-2] ENST00000344545; ENSP00000341677; ENSG00000170777 [Q96J77-1] ENST00000381428; ENSP00000370836; ENSG00000170777 [Q96J77-3] |
GeneIDi | 89882 |
KEGGi | hsa:89882 |
UCSCi | uc003zjv.4, human [Q96J77-1] |
Organism-specific databases
CTDi | 89882 |
DisGeNETi | 89882 |
EuPathDBi | HostDB:ENSG00000170777.10 |
GeneCardsi | TPD52L3 |
HGNCi | HGNC:23382, TPD52L3 |
HPAi | ENSG00000170777, Tissue enriched (testis) |
MIMi | 617567, gene |
neXtProti | NX_Q96J77 |
OpenTargetsi | ENSG00000170777 |
PharmGKBi | PA142670712 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4010, Eukaryota |
GeneTreei | ENSGT00940000163110 |
HOGENOMi | CLU_080743_1_1_1 |
InParanoidi | Q96J77 |
OMAi | EGIFNKH |
OrthoDBi | 1225782at2759 |
PhylomeDBi | Q96J77 |
TreeFami | TF317562 |
Enzyme and pathway databases
PathwayCommonsi | Q96J77 |
Miscellaneous databases
BioGRID-ORCSi | 89882, 5 hits in 840 CRISPR screens |
GenomeRNAii | 89882 |
Pharosi | Q96J77, Tdark |
PROi | PR:Q96J77 |
RNActi | Q96J77, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000170777, Expressed in testis and 100 other tissues |
Genevisiblei | Q96J77, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007327, TPD52 |
PANTHERi | PTHR19307, PTHR19307, 1 hit |
Pfami | View protein in Pfam PF04201, TPD52, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TPD55_HUMAN | |
Accessioni | Q96J77Primary (citable) accession number: Q96J77 Secondary accession number(s): Q5TCR3 Q96M09 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 24, 2007 |
Last sequence update: | November 30, 2010 | |
Last modified: | December 2, 2020 | |
This is version 106 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations