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Entry version 109 (02 Jun 2021)
Sequence version 2 (30 Nov 2010)
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Protein

Tumor protein D55

Gene

TPD52L3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96J77

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tumor protein D55
Short name:
hD55
Alternative name(s):
Testis development protein NYD-SP25
Tumor protein D52-like 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TPD52L3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23382, TPD52L3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617567, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96J77

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000170777.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
89882

Open Targets

More...
OpenTargetsi
ENSG00000170777

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670712

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96J77, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TPD52L3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104031

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002958561 – 140Tumor protein D55Add BLAST140

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96J77

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96J77

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96J77

PeptideAtlas

More...
PeptideAtlasi
Q96J77

PRoteomics IDEntifications database

More...
PRIDEi
Q96J77

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76893 [Q96J77-1]
76894 [Q96J77-2]
76895 [Q96J77-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96J77

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96J77

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Specifically expressed in testis. Expressed at 5.6-fold higher levels in adult testis than in fetal testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000170777, Expressed in testis and 100 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96J77, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000170777, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TPD52L2.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124633, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q96J77, 11 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000341677

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96J77, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96J77

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 28DisorderedSequence analysisAdd BLAST28

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili28 – 57Sequence analysisAdd BLAST30

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TPD52 family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4010, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163110

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_080743_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96J77

Identification of Orthologs from Complete Genome Data

More...
OMAi
EGIFNKH

Database of Orthologous Groups

More...
OrthoDBi
1225782at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96J77

TreeFam database of animal gene trees

More...
TreeFami
TF317562

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007327, TPD52

The PANTHER Classification System

More...
PANTHERi
PTHR19307, PTHR19307, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04201, TPD52, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96J77-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPHARTETSV GTYESHSTSE LEDLTEPEQR ELKTKLTKLE AEIVTLRHVL
60 70 80 90 100
AAKERRCGEL KRKLGLTALV GLRQNLSKSW LDVQVSNTYV KQKTSAALST
110 120 130 140
MGTLICRKLG GVKKSATFRS FEGLMGTIKS KVSGGKRAWP
Length:140
Mass (Da):15,503
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i759F26E983B1EFAD
GO
Isoform 2 (identifier: Q96J77-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-140: MGTIKSKVSGGKRAWP → IFNKYTLNQGRN

Show »
Length:136
Mass (Da):15,268
Checksum:iFC4B6CEE61A9C324
GO
Isoform 3 (identifier: Q96J77-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-140: LMGTIKSKVSGGKRAWP → NPKGEGSRI

Show »
Length:132
Mass (Da):14,644
Checksum:i8A20E727D9FC7432
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti109L → P in BAB71505 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033372118F → L3 PublicationsCorresponds to variant dbSNP:rs3847262Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_027113124 – 140LMGTI…KRAWP → NPKGEGSRI in isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_027114125 – 140MGTIK…KRAWP → IFNKYTLNQGRN in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY032877 mRNA Translation: AAK66820.1
AK057479 mRNA Translation: BAB71505.1
AL133480 Genomic DNA No translation available.
BC017589 mRNA Translation: AAH17589.1
BC033792 mRNA Translation: AAH33792.1
BC042113 mRNA Translation: AAH42113.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34984.1 [Q96J77-2]
CCDS34985.1 [Q96J77-3]
CCDS34986.1 [Q96J77-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001001874.1, NM_001001874.2 [Q96J77-2]
NP_001001875.1, NM_001001875.3 [Q96J77-3]
NP_277051.3, NM_033516.5 [Q96J77-1]
XP_016870769.1, XM_017015280.1 [Q96J77-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000314556; ENSP00000318665; ENSG00000170777 [Q96J77-2]
ENST00000344545; ENSP00000341677; ENSG00000170777 [Q96J77-1]
ENST00000381428; ENSP00000370836; ENSG00000170777 [Q96J77-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
89882

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:89882

UCSC genome browser

More...
UCSCi
uc003zjv.4, human [Q96J77-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032877 mRNA Translation: AAK66820.1
AK057479 mRNA Translation: BAB71505.1
AL133480 Genomic DNA No translation available.
BC017589 mRNA Translation: AAH17589.1
BC033792 mRNA Translation: AAH33792.1
BC042113 mRNA Translation: AAH42113.1
CCDSiCCDS34984.1 [Q96J77-2]
CCDS34985.1 [Q96J77-3]
CCDS34986.1 [Q96J77-1]
RefSeqiNP_001001874.1, NM_001001874.2 [Q96J77-2]
NP_001001875.1, NM_001001875.3 [Q96J77-3]
NP_277051.3, NM_033516.5 [Q96J77-1]
XP_016870769.1, XM_017015280.1 [Q96J77-3]

3D structure databases

SMRiQ96J77
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124633, 9 interactors
IntActiQ96J77, 11 interactors
STRINGi9606.ENSP00000341677

PTM databases

iPTMnetiQ96J77
PhosphoSitePlusiQ96J77

Genetic variation databases

BioMutaiTPD52L3
DMDMi313104031

Proteomic databases

jPOSTiQ96J77
MassIVEiQ96J77
PaxDbiQ96J77
PeptideAtlasiQ96J77
PRIDEiQ96J77
ProteomicsDBi76893 [Q96J77-1]
76894 [Q96J77-2]
76895 [Q96J77-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
9681, 275 antibodies

The DNASU plasmid repository

More...
DNASUi
89882

Genome annotation databases

EnsembliENST00000314556; ENSP00000318665; ENSG00000170777 [Q96J77-2]
ENST00000344545; ENSP00000341677; ENSG00000170777 [Q96J77-1]
ENST00000381428; ENSP00000370836; ENSG00000170777 [Q96J77-3]
GeneIDi89882
KEGGihsa:89882
UCSCiuc003zjv.4, human [Q96J77-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
89882
DisGeNETi89882

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TPD52L3
HGNCiHGNC:23382, TPD52L3
HPAiENSG00000170777, Tissue enriched (testis)
MIMi617567, gene
neXtProtiNX_Q96J77
OpenTargetsiENSG00000170777
PharmGKBiPA142670712
VEuPathDBiHostDB:ENSG00000170777.10

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4010, Eukaryota
GeneTreeiENSGT00940000163110
HOGENOMiCLU_080743_1_1_1
InParanoidiQ96J77
OMAiEGIFNKH
OrthoDBi1225782at2759
PhylomeDBiQ96J77
TreeFamiTF317562

Enzyme and pathway databases

PathwayCommonsiQ96J77

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
89882, 6 hits in 984 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
89882
PharosiQ96J77, Tdark

Protein Ontology

More...
PROi
PR:Q96J77
RNActiQ96J77, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000170777, Expressed in testis and 100 other tissues
GenevisibleiQ96J77, HS

Family and domain databases

InterProiView protein in InterPro
IPR007327, TPD52
PANTHERiPTHR19307, PTHR19307, 1 hit
PfamiView protein in Pfam
PF04201, TPD52, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPD55_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96J77
Secondary accession number(s): Q5TCR3
, Q5TCR4, Q5TCR5, Q8N4P5, Q8WWF7, Q96M09
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: November 30, 2010
Last modified: June 2, 2021
This is version 109 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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