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Protein

ATP-binding cassette sub-family C member 11

Gene

ABCC11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides (PubMed:12764137, PubMed:15537867). Enhances the cellular extrusion of cAMP and cGMP (PubMed:12764137, PubMed:15537867). Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E217betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate (PubMed:15537867, PubMed:25896536). Probably functions to secrete earwax (PubMed:16444273, PubMed:19383836). Required for the secretion of components contributing to axillary odor formation (PubMed:19710689).6 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi544 – 551ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1175 – 1182ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-382556 ABC-family proteins mediated transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.208.13 the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-binding cassette sub-family C member 11
Alternative name(s):
Multidrug resistance-associated protein 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABCC11
Synonyms:MRP8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000121270.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14639 ABCC11

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607040 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96J66

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 163CytoplasmicSequence analysisAdd BLAST163
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei164 – 184HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei195 – 215HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei271 – 291HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei297 – 317HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei384 – 404HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei418 – 438HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini439 – 806CytoplasmicSequence analysisAdd BLAST368
Transmembranei807 – 827HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei864 – 884HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei931 – 951HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1050 – 1070HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini1071 – 1382CytoplasmicSequence analysisAdd BLAST312

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane, Vacuole

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi180G → A or P: Does not affect N-glycosylation. 1 Publication1
Mutagenesisi180G → L, H, D or E: Loss of N-glycosylation. 1 Publication1
Mutagenesisi838N → Q: Loss of N-glycosylation. 1 Publication1
Mutagenesisi844N → Q: Loss of N-glycosylation. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
85320

MalaCards human disease database

More...
MalaCardsi
ABCC11
MIMi117800 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000121270

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24393

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2073702

Drug and drug target database

More...
DrugBanki
DB00286 Conjugated Equine Estrogens
DB02527 Cyclic Adenosine Monophosphate
DB00158 Folic Acid
DB00328 Indomethacin
DB00563 Methotrexate
DB01032 Probenecid
DB04348 Taurocholic Acid

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ABCC11

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762666

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002255941 – 1382ATP-binding cassette sub-family C member 11Add BLAST1382

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi838N-linked (GlcNAc...) asparagineSequence analysis1 Publication1
Glycosylationi844N-linked (GlcNAc...) asparagineSequence analysis1 Publication1
Glycosylationi992N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96J66

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96J66

PeptideAtlas

More...
PeptideAtlasi
Q96J66

PRoteomics IDEntifications database

More...
PRIDEi
Q96J66

ProteomicsDB human proteome resource

More...
ProteomicsDBi
76891
76892 [Q96J66-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96J66

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96J66

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in ceruminous apocrine gland (at protein level) (PubMed:19383836, PubMed:19710689). Expressed in many tissues. Not expressed in kidney, spleen and colon. Highly expressed in breast cancer. Expressed at moderate levels in normal breast and testis and at very low levels in liver, brain and placenta.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000121270 Expressed in 66 organ(s), highest expression level in right lobe of liver

CleanEx database of gene expression profiles

More...
CleanExi
HS_ABCC11

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96J66 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96J66 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB032513
HPA031980
HPA031981
HPA031982

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124474, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000349017

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q96J66

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96J66

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini163 – 443ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST281
Domaini508 – 732ABC transporter 1PROSITE-ProRule annotationAdd BLAST225
Domaini806 – 1105ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST300
Domaini1141 – 1375ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0054 Eukaryota
COG1132 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162968

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG108314

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96J66

KEGG Orthology (KO)

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KOi
K05671

Identification of Orthologs from Complete Genome Data

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OMAi
FEGVYYG

Database of Orthologous Groups

More...
OrthoDBi
EOG091G01TC

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96J66

TreeFam database of animal gene trees

More...
TreeFami
TF352085

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030251 ABCC11
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR24223:SF168 PTHR24223:SF168, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96J66-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTRKRTYWVP NSSGGLVNRG IDIGDDMVSG LIYKTYTLQD GPWSQQERNP
60 70 80 90 100
EAPGRAAVPP WGKYDAALRT MIPFRPKPRF PAPQPLDNAG LFSYLTVSWL
110 120 130 140 150
TPLMIQSLRS RLDENTIPPL SVHDASDKNV QRLHRLWEEE VSRRGIEKAS
160 170 180 190 200
VLLVMLRFQR TRLIFDALLG ICFCIASVLG PILIIPKILE YSEEQLGNVV
210 220 230 240 250
HGVGLCFALF LSECVKSLSF SSSWIINQRT AIRFRAAVSS FAFEKLIQFK
260 270 280 290 300
SVIHITSGEA ISFFTGDVNY LFEGVCYGPL VLITCASLVI CSISSYFIIG
310 320 330 340 350
YTAFIAILCY LLVFPLAVFM TRMAVKAQHH TSEVSDQRIR VTSEVLTCIK
360 370 380 390 400
LIKMYTWEKP FAKIIEDLRR KERKLLEKCG LVQSLTSITL FIIPTVATAV
410 420 430 440 450
WVLIHTSLKL KLTASMAFSM LASLNLLRLS VFFVPIAVKG LTNSKSAVMR
460 470 480 490 500
FKKFFLQESP VFYVQTLQDP SKALVFEEAT LSWQQTCPGI VNGALELERN
510 520 530 540 550
GHASEGMTRP RDALGPEEEG NSLGPELHKI NLVVSKGMML GVCGNTGSGK
560 570 580 590 600
SSLLSAILEE MHLLEGSVGV QGSLAYVPQQ AWIVSGNIRE NILMGGAYDK
610 620 630 640 650
ARYLQVLHCC SLNRDLELLP FGDMTEIGER GLNLSGGQKQ RISLARAVYS
660 670 680 690 700
DRQIYLLDDP LSAVDAHVGK HIFEECIKKT LRGKTVVLVT HQLQYLEFCG
710 720 730 740 750
QIILLENGKI CENGTHSELM QKKGKYAQLI QKMHKEATSD MLQDTAKIAE
760 770 780 790 800
KPKVESQALA TSLEESLNGN AVPEHQLTQE EEMEEGSLSW RVYHHYIQAA
810 820 830 840 850
GGYMVSCIIF FFVVLIVFLT IFSFWWLSYW LEQGSGTNSS RESNGTMADL
860 870 880 890 900
GNIADNPQLS FYQLVYGLNA LLLICVGVCS SGIFTKVTRK ASTALHNKLF
910 920 930 940 950
NKVFRCPMSF FDTIPIGRLL NCFAGDLEQL DQLLPIFSEQ FLVLSLMVIA
960 970 980 990 1000
VLLIVSVLSP YILLMGAIIM VICFIYYMMF KKAIGVFKRL ENYSRSPLFS
1010 1020 1030 1040 1050
HILNSLQGLS SIHVYGKTED FISQFKRLTD AQNNYLLLFL SSTRWMALRL
1060 1070 1080 1090 1100
EIMTNLVTLA VALFVAFGIS STPYSFKVMA VNIVLQLASS FQATARIGLE
1110 1120 1130 1140 1150
TEAQFTAVER ILQYMKMCVS EAPLHMEGTS CPQGWPQHGE IIFQDYHMKY
1160 1170 1180 1190 1200
RDNTPTVLHG INLTIRGHEV VGIVGRTGSG KSSLGMALFR LVEPMAGRIL
1210 1220 1230 1240 1250
IDGVDICSIG LEDLRSKLSV IPQDPVLLSG TIRFNLDPFD RHTDQQIWDA
1260 1270 1280 1290 1300
LERTFLTKAI SKFPKKLHTD VVENGGNFSV GERQLLCIAR AVLRNSKIIL
1310 1320 1330 1340 1350
IDEATASIDM ETDTLIQRTI REAFQGCTVL VIAHRVTTVL NCDHILVMGN
1360 1370 1380
GKVVEFDRPE VLRKKPGSLF AALMATATSS LR
Length:1,382
Mass (Da):154,301
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0F3C17DC69AE97F4
GO
Isoform 2 (identifier: Q96J66-2) [UniParc]FASTAAdd to basket
Also known as: Isoform A

The sequence of this isoform differs from the canonical sequence as follows:
     1261-1298: Missing.

Show »
Length:1,344
Mass (Da):150,093
Checksum:i4859DCC95569B2C7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BRJ2H3BRJ2_HUMAN
ATP-binding cassette sub-family C m...
ABCC11
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti199V → A in AAK58869 (PubMed:11688999).Curated1
Sequence conflicti199V → A in AAL99902 (PubMed:11688999).Curated1
Sequence conflicti311L → P in AAK19755 (PubMed:11591886).Curated1
Sequence conflicti363K → E in AAK58869 (PubMed:11688999).Curated1
Sequence conflicti363K → E in AAL99902 (PubMed:11688999).Curated1
Sequence conflicti395T → A in AAK19755 (PubMed:11591886).Curated1
Sequence conflicti632L → P in AAK19755 (PubMed:11591886).Curated1
Sequence conflicti688L → Q in AAK19755 (PubMed:11591886).Curated1
Sequence conflicti702I → V in AAK19755 (PubMed:11591886).Curated1
Sequence conflicti982K → E in AAK19755 (PubMed:11591886).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Polymorphism in ABCC11 is associated with variation in apocrine gland secretion [MIMi:117800]. This determines different ear wax phenotypes, presence or absence of axillary odor, and variation in colostrum secretion. Characteristic of earwax and strength of axillary odor are most likely interconnected. Human earwax is a Mendelian trait consisting of wet and dry types. The wet earwax is brownish and sticky, whereas the dry type lacks cerumen. The wet cerumen phenotype is completely dominant. The dry type is seen frequently (80-95%) among East Asians, but uncommon (0-3%) in populations of European and African origins. Intermediate frequencies (30-50%) of the dry type are seen in populations of Southern Asia, the Pacific Islands, Central Asia and Asia Minor, as well as among the Native North American and Inuit of Asian ancestry. The allele with Arg-180 is responsible for the dry earwax phenotype and lack of axillary odor.3 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02543719R → H No effect on glycosylation; no effect on transport activity; no effect on plasma membrane localization. 2 PublicationsCorresponds to variant dbSNP:rs16945988Ensembl.1
Natural variantiVAR_025438180G → R in dry earwax and lack of axillary odor phenotype; loss of N-glycosylation; strongly reduced plasma membrane localization; reduced transport activity; decreased protein concentration in axillary sweat. 4 PublicationsCorresponds to variant dbSNP:rs17822931EnsemblClinVar.1
Natural variantiVAR_048144317A → E No effect on glycoslylation; no effect on transport activity; no effect on plasma membrane localization. 3 PublicationsCorresponds to variant dbSNP:rs11863236Ensembl.1
Natural variantiVAR_048145546T → M Reduced transport activity; no effect on glycoslylation; no effect on plasma membrane localization. 2 PublicationsCorresponds to variant dbSNP:rs17822471Ensembl.1
Natural variantiVAR_077575630R → W No effect on glycoslylation. 1 PublicationCorresponds to variant dbSNP:rs41282045Ensembl.1
Natural variantiVAR_048146648V → I No effect on glycoslylation; no effect on transport activity; no effect on plasma membrane localization. 2 PublicationsCorresponds to variant dbSNP:rs16945930Ensembl.1
Natural variantiVAR_048147687V → I No effect on glycoslylation. 1 PublicationCorresponds to variant dbSNP:rs16945928Ensembl.1
Natural variantiVAR_048148735K → R No effect on glycoslylation. 1 PublicationCorresponds to variant dbSNP:rs16945926Ensembl.1
Natural variantiVAR_077576970M → V No effect on glycoslylation. 1 PublicationCorresponds to variant dbSNP:rs41280943Ensembl.1
Natural variantiVAR_0481491344H → R No effect on glycoslylation; no effect on transport activity; no effect on plasma membrane localization. 3 PublicationsCorresponds to variant dbSNP:rs16945916Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0173511261 – 1298Missing in isoform 2. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY040219 mRNA Translation: AAK76739.1
AF367202 mRNA Translation: AAK58869.1
AF411579 mRNA Translation: AAL99902.1
AF352582 mRNA Translation: AAK19755.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS10732.1 [Q96J66-1]
CCDS10733.1 [Q96J66-2]

NCBI Reference Sequences

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RefSeqi
NP_115972.2, NM_032583.3 [Q96J66-1]
NP_149163.2, NM_033151.3 [Q96J66-1]
NP_660187.1, NM_145186.2 [Q96J66-2]
XP_016879284.1, XM_017023795.1 [Q96J66-1]
XP_016879285.1, XM_017023796.1 [Q96J66-1]
XP_016879286.1, XM_017023797.1 [Q96J66-1]
XP_016879287.1, XM_017023798.1 [Q96J66-1]
XP_016879288.1, XM_017023799.1 [Q96J66-1]
XP_016879289.1, XM_017023800.1 [Q96J66-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.652267

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000353782; ENSP00000311326; ENSG00000121270 [Q96J66-2]
ENST00000356608; ENSP00000349017; ENSG00000121270 [Q96J66-1]
ENST00000394747; ENSP00000378230; ENSG00000121270 [Q96J66-1]
ENST00000394748; ENSP00000378231; ENSG00000121270 [Q96J66-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
85320

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:85320

UCSC genome browser

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UCSCi
uc002eff.1 human [Q96J66-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

Of earwax and migration - Issue 67 of February 2006

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY040219 mRNA Translation: AAK76739.1
AF367202 mRNA Translation: AAK58869.1
AF411579 mRNA Translation: AAL99902.1
AF352582 mRNA Translation: AAK19755.1
CCDSiCCDS10732.1 [Q96J66-1]
CCDS10733.1 [Q96J66-2]
RefSeqiNP_115972.2, NM_032583.3 [Q96J66-1]
NP_149163.2, NM_033151.3 [Q96J66-1]
NP_660187.1, NM_145186.2 [Q96J66-2]
XP_016879284.1, XM_017023795.1 [Q96J66-1]
XP_016879285.1, XM_017023796.1 [Q96J66-1]
XP_016879286.1, XM_017023797.1 [Q96J66-1]
XP_016879287.1, XM_017023798.1 [Q96J66-1]
XP_016879288.1, XM_017023799.1 [Q96J66-1]
XP_016879289.1, XM_017023800.1 [Q96J66-1]
UniGeneiHs.652267

3D structure databases

ProteinModelPortaliQ96J66
SMRiQ96J66
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124474, 1 interactor
STRINGi9606.ENSP00000349017

Chemistry databases

ChEMBLiCHEMBL2073702
DrugBankiDB00286 Conjugated Equine Estrogens
DB02527 Cyclic Adenosine Monophosphate
DB00158 Folic Acid
DB00328 Indomethacin
DB00563 Methotrexate
DB01032 Probenecid
DB04348 Taurocholic Acid

Protein family/group databases

TCDBi3.A.1.208.13 the atp-binding cassette (abc) superfamily

PTM databases

iPTMnetiQ96J66
PhosphoSitePlusiQ96J66

Polymorphism and mutation databases

BioMutaiABCC11
DMDMi74762666

Proteomic databases

MaxQBiQ96J66
PaxDbiQ96J66
PeptideAtlasiQ96J66
PRIDEiQ96J66
ProteomicsDBi76891
76892 [Q96J66-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
85320
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000353782; ENSP00000311326; ENSG00000121270 [Q96J66-2]
ENST00000356608; ENSP00000349017; ENSG00000121270 [Q96J66-1]
ENST00000394747; ENSP00000378230; ENSG00000121270 [Q96J66-1]
ENST00000394748; ENSP00000378231; ENSG00000121270 [Q96J66-1]
GeneIDi85320
KEGGihsa:85320
UCSCiuc002eff.1 human [Q96J66-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
85320
DisGeNETi85320
EuPathDBiHostDB:ENSG00000121270.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ABCC11
HGNCiHGNC:14639 ABCC11
HPAiCAB032513
HPA031980
HPA031981
HPA031982
MalaCardsiABCC11
MIMi117800 phenotype
607040 gene
neXtProtiNX_Q96J66
OpenTargetsiENSG00000121270
PharmGKBiPA24393

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00940000162968
HOVERGENiHBG108314
InParanoidiQ96J66
KOiK05671
OMAiFEGVYYG
OrthoDBiEOG091G01TC
PhylomeDBiQ96J66
TreeFamiTF352085

Enzyme and pathway databases

ReactomeiR-HSA-382556 ABC-family proteins mediated transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ABCC11 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ABCC11

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
85320

Protein Ontology

More...
PROi
PR:Q96J66

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000121270 Expressed in 66 organ(s), highest expression level in right lobe of liver
CleanExiHS_ABCC11
ExpressionAtlasiQ96J66 baseline and differential
GenevisibleiQ96J66 HS

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030251 ABCC11
IPR027417 P-loop_NTPase
PANTHERiPTHR24223:SF168 PTHR24223:SF168, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABCCB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96J66
Secondary accession number(s): Q8TDJ0, Q96JA6, Q9BX80
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: December 1, 2001
Last modified: December 5, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
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