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Entry version 144 (26 Feb 2020)
Sequence version 2 (04 Dec 2007)
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Protein

Multidrug resistance-associated protein 9

Gene

ABCC12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable transporter.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi513 – 520ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1154 – 1161ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.208.29 the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Multidrug resistance-associated protein 9
Alternative name(s):
ATP-binding cassette sub-family C member 12
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABCC12
Synonyms:MRP9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14640 ABCC12

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607041 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96J65

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei125 – 145HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei159 – 179HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei231 – 251HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei256 – 276HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei348 – 368HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei376 – 396HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei791 – 811HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei853 – 873HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei934 – 954HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1031 – 1051HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
94160

Open Targets

More...
OpenTargetsi
ENSG00000140798

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24394

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96J65 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ABCC12

Domain mapping of disease mutations (DMDM)

More...
DMDMi
161788999

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002535781 – 1359Multidrug resistance-associated protein 9Add BLAST1359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi405N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi438N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi540N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi981N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96J65

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96J65

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96J65

PeptideAtlas

More...
PeptideAtlasi
Q96J65

PRoteomics IDEntifications database

More...
PRIDEi
Q96J65

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76886 [Q96J65-1]
76887 [Q96J65-2]
76888 [Q96J65-3]
76889 [Q96J65-4]
76890 [Q96J65-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96J65

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96J65

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in testis (at protein level). Widely expressed at low level. Isoform 5 is specifically expressed in brain, testis and breast cancer cells.3 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in fetal tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000140798 Expressed in testis and 45 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96J65 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96J65 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043100

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125142, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q96J65, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000311030

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96J65 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96J65

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini123 – 403ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST281
Domaini467 – 701ABC transporter 1PROSITE-ProRule annotationAdd BLAST235
Domaini795 – 1082ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST288
Domaini1120 – 1354ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0054 Eukaryota
COG1132 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159578

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000604_27_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96J65

KEGG Orthology (KO)

More...
KOi
K05672

Identification of Orthologs from Complete Genome Data

More...
OMAi
ANTVVLW

Database of Orthologous Groups

More...
OrthoDBi
138195at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96J65

TreeFam database of animal gene trees

More...
TreeFami
TF105202

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030250 MRP9
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR24223:SF10 PTHR24223:SF10, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96J65-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVGEGPYLIS DLDQRGRRRS FAERYDPSLK TMIPVRPCAR LAPNPVDDAG
60 70 80 90 100
LLSFATFSWL TPVMVKGYRQ RLTVDTLPPL STYDSSDTNA KRFRVLWDEE
110 120 130 140 150
VARVGPEKAS LSHVVWKFQR TRVLMDIVAN ILCIIMAAIG PVILIHQILQ
160 170 180 190 200
QTERTSGKVW VGIGLCIALF ATEFTKVFFW ALAWAINYRT AIRLKVALST
210 220 230 240 250
LVFENLVSFK TLTHISVGEV LNILSSDSYS LFEAALFCPL PATIPILMVF
260 270 280 290 300
CAAYAFFILG PTALIGISVY VIFIPVQMFM AKLNSAFRRS AILVTDKRVQ
310 320 330 340 350
TMNEFLTCIR LIKMYAWEKS FTNTIQDIRR RERKLLEKAG FVQSGNSALA
360 370 380 390 400
PIVSTIAIVL TLSCHILLRR KLTAPVAFSV IAMFNVMKFS IAILPFSIKA
410 420 430 440 450
MAEANVSLRR MKKILIDKSP PSYITQPEDP DTVLLLANAT LTWEHEASRK
460 470 480 490 500
STPKKLQNQK RHLCKKQRSE AYSERSPPAK GATGPEEQSD SLKSVLHSIS
510 520 530 540 550
FVVRKGKILG ICGNVGSGKS SLLAALLGQM QLQKGVVAVN GTLAYVSQQA
560 570 580 590 600
WIFHGNVREN ILFGEKYDHQ RYQHTVRVCG LQKDLSNLPY GDLTEIGERG
610 620 630 640 650
LNLSGGQRQR ISLARAVYSD RQLYLLDDPL SAVDAHVGKH VFEECIKKTL
660 670 680 690 700
RGKTVVLVTH QLQFLESCDE VILLEDGEIC EKGTHKELME ERGRYAKLIH
710 720 730 740 750
NLRGLQFKDP EHLYNAAMVE AFKESPAERE EDAGIIVLAP GNEKDEGKES
760 770 780 790 800
ETGSEFVDTK VPEHQLIQTE SPQEGTVTWK TYHTYIKASG GYLLSLFTVF
810 820 830 840 850
LFLLMIGSAA FSNWWLGLWL DKGSRMTCGP QGNRTMCEVG AVLADIGQHV
860 870 880 890 900
YQWVYTASMV FMLVFGVTKG FVFTKTTLMA SSSLHDTVFD KILKSPMSFF
910 920 930 940 950
DTTPTGRLMN RFSKDMDELD VRLPFHAENF LQQFFMVVFI LVILAAVFPA
960 970 980 990 1000
VLLVVASLAV GFFILLRIFH RGVQELKKVE NVSRSPWFTH ITSSMQGLGI
1010 1020 1030 1040 1050
IHAYGKKESC ITYHLLYFNC ALRWFALRMD VLMNILTFTV ALLVTLSFSS
1060 1070 1080 1090 1100
ISTSSKGLSL SYIIQLSGLL QVCVRTGTET QAKFTSVELL REYISTCVPE
1110 1120 1130 1140 1150
CTHPLKVGTC PKDWPSRGEI TFRDYQMRYR DNTPLVLDSL NLNIQSGQTV
1160 1170 1180 1190 1200
GIVGRTGSGK SSLGMALFRL VEPASGTIFI DEVDICILSL EDLRTKLTVI
1210 1220 1230 1240 1250
PQDPVLFVGT VRYNLDPFES HTDEMLWQVL ERTFMRDTIM KLPEKLQAEV
1260 1270 1280 1290 1300
TENGENFSVG ERQLLCVARA LLRNSKIILL DEATASMDSK TDTLVQNTIK
1310 1320 1330 1340 1350
DAFKGCTVLT IAHRLNTVLN CDHVLVMENG KVIEFDKPEV LAEKPDSAFA

MLLAAEVRL
Length:1,359
Mass (Da):152,297
Last modified:December 4, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDA8AF5A3EE9B10E8
GO
Isoform 2 (identifier: Q96J65-2) [UniParc]FASTAAdd to basket
Also known as: A, C, D

The sequence of this isoform differs from the canonical sequence as follows:
     142-143: VI → TV
     734-736: Missing.
     1013-1359: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:1,009
Mass (Da):113,163
Checksum:i6491AA00FBC280E5
GO
Isoform 3 (identifier: Q96J65-3) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     142-143: VI → TV
     734-736: Missing.
     892-938: ILKSPMSFFD...NFLQQFFMVV → HFPQRSPGAQ...WQEGELHHLV
     939-1359: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:935
Mass (Da):104,651
Checksum:iAD0715883A3971E2
GO
Isoform 4 (identifier: Q96J65-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-143: VI → TV
     572-633: YQHTVRVCGL...YLLDDPLSAV → LGSGASTSLG...RRSGERQSSW
     634-1359: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:633
Mass (Da):70,399
Checksum:i66DEE4BFA9C4D7E4
GO
Isoform 5 (identifier: Q96J65-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-143: VI → TV
     220-277: Missing.
     737-760: Missing.
     1013-1359: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:930
Mass (Da):104,660
Checksum:i22A26E88E51CE234
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DYN2B4DYN2_HUMAN
Multidrug resistance-associated pro...
ABCC12
285Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ITL4A0A3B3ITL4_HUMAN
Multidrug resistance-associated pro...
ABCC12
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PHY2E9PHY2_HUMAN
Multidrug resistance-associated pro...
ABCC12
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti73T → A in BC036378 (PubMed:15489334).Curated1
Sequence conflicti448 – 450SRK → RQE in AAL79528 (PubMed:11688999).Curated3
Sequence conflicti448 – 450SRK → RQE in AAL79529 (PubMed:11688999).Curated3
Sequence conflicti448 – 450SRK → RQE in AAL99900 (PubMed:11688999).Curated3
Sequence conflicti448 – 450SRK → RQE in AAL99901 (PubMed:11688999).Curated3
Sequence conflicti853W → R in AAL79528 (PubMed:11688999).Curated1
Sequence conflicti853W → R in AAL79529 (PubMed:11688999).Curated1
Sequence conflicti853W → R in AAL99900 (PubMed:11688999).Curated1
Sequence conflicti853W → R in AAL99901 (PubMed:11688999).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0283929I → L. Corresponds to variant dbSNP:rs16945901Ensembl.1
Natural variantiVAR_028393102A → E. Corresponds to variant dbSNP:rs16945874Ensembl.1
Natural variantiVAR_028394587N → Y. Corresponds to variant dbSNP:rs16945816Ensembl.1
Natural variantiVAR_048139690E → V. Corresponds to variant dbSNP:rs34135219Ensembl.1
Natural variantiVAR_028395894K → M. Corresponds to variant dbSNP:rs8057474Ensembl.1
Natural variantiVAR_028396989T → S. Corresponds to variant dbSNP:rs6500305Ensembl.1
Natural variantiVAR_0283971013Y → H. Corresponds to variant dbSNP:rs6500304Ensembl.1
Natural variantiVAR_0283981117R → C1 PublicationCorresponds to variant dbSNP:rs7193955Ensembl.1
Natural variantiVAR_0481401187I → T. Corresponds to variant dbSNP:rs34106426Ensembl.1
Natural variantiVAR_0283991191E → A. Corresponds to variant dbSNP:rs16945787Ensembl.1
Natural variantiVAR_0284001349F → L. Corresponds to variant dbSNP:rs12373105Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_021084142 – 143VI → TV in isoform 2, isoform 3, isoform 4 and isoform 5. 3 Publications2
Alternative sequenceiVSP_021085220 – 277Missing in isoform 5. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_021086572 – 633YQHTV…PLSAV → LGSGASTSLGGRGRGLAWPA LSTPTVSSTCWTTPCRPWTP TWGSTSLRSALRRRSGERQS SW in isoform 4. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_021087634 – 1359Missing in isoform 4. 1 PublicationAdd BLAST726
Alternative sequenceiVSP_021088734 – 736Missing in isoform 2 and isoform 3. 1 Publication3
Alternative sequenceiVSP_021089737 – 760Missing in isoform 5. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_021090892 – 938ILKSP…FFMVV → HFPQRSPGAQEGGECQPVTL VHPHHLLHAGPGHHSRLWQE GELHHLV in isoform 3. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_021091939 – 1359Missing in isoform 3. 1 PublicationAdd BLAST421
Alternative sequenceiVSP_0210921013 – 1359Missing in isoform 2 and isoform 5. 2 PublicationsAdd BLAST347

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF395908 mRNA Translation: AAL79528.1
AF395909 mRNA Translation: AAL79529.1
AF411577 mRNA Translation: AAL99900.1
AF411578 mRNA Translation: AAL99901.1
AY040220 mRNA Translation: AAK76740.1
AY196326 mRNA Translation: AAO40749.1
AC096996 Genomic DNA No translation available.
BC036378 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10730.1 [Q96J65-1]

NCBI Reference Sequences

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RefSeqi
NP_150229.2, NM_033226.2 [Q96J65-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000311303; ENSP00000311030; ENSG00000140798 [Q96J65-1]
ENST00000497206; ENSP00000431232; ENSG00000140798 [Q96J65-2]
ENST00000529084; ENSP00000434510; ENSG00000140798 [Q96J65-4]
ENST00000529504; ENSP00000433333; ENSG00000140798 [Q96J65-3]
ENST00000532494; ENSP00000437047; ENSG00000140798 [Q96J65-2]
ENST00000534418; ENSP00000431354; ENSG00000140798 [Q96J65-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
94160

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:94160

UCSC genome browser

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UCSCi
uc002efc.1 human [Q96J65-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395908 mRNA Translation: AAL79528.1
AF395909 mRNA Translation: AAL79529.1
AF411577 mRNA Translation: AAL99900.1
AF411578 mRNA Translation: AAL99901.1
AY040220 mRNA Translation: AAK76740.1
AY196326 mRNA Translation: AAO40749.1
AC096996 Genomic DNA No translation available.
BC036378 mRNA No translation available.
CCDSiCCDS10730.1 [Q96J65-1]
RefSeqiNP_150229.2, NM_033226.2 [Q96J65-1]

3D structure databases

SMRiQ96J65
ModBaseiSearch...

Protein-protein interaction databases

BioGridi125142, 1 interactor
IntActiQ96J65, 3 interactors
STRINGi9606.ENSP00000311030

Protein family/group databases

TCDBi3.A.1.208.29 the atp-binding cassette (abc) superfamily

PTM databases

iPTMnetiQ96J65
PhosphoSitePlusiQ96J65

Polymorphism and mutation databases

BioMutaiABCC12
DMDMi161788999

Proteomic databases

jPOSTiQ96J65
MassIVEiQ96J65
PaxDbiQ96J65
PeptideAtlasiQ96J65
PRIDEiQ96J65
ProteomicsDBi76886 [Q96J65-1]
76887 [Q96J65-2]
76888 [Q96J65-3]
76889 [Q96J65-4]
76890 [Q96J65-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
94160

Genome annotation databases

EnsembliENST00000311303; ENSP00000311030; ENSG00000140798 [Q96J65-1]
ENST00000497206; ENSP00000431232; ENSG00000140798 [Q96J65-2]
ENST00000529084; ENSP00000434510; ENSG00000140798 [Q96J65-4]
ENST00000529504; ENSP00000433333; ENSG00000140798 [Q96J65-3]
ENST00000532494; ENSP00000437047; ENSG00000140798 [Q96J65-2]
ENST00000534418; ENSP00000431354; ENSG00000140798 [Q96J65-5]
GeneIDi94160
KEGGihsa:94160
UCSCiuc002efc.1 human [Q96J65-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
94160
DisGeNETi94160

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ABCC12
HGNCiHGNC:14640 ABCC12
HPAiHPA043100
MIMi607041 gene
neXtProtiNX_Q96J65
OpenTargetsiENSG00000140798
PharmGKBiPA24394

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00940000159578
HOGENOMiCLU_000604_27_1_1
InParanoidiQ96J65
KOiK05672
OMAiANTVVLW
OrthoDBi138195at2759
PhylomeDBiQ96J65
TreeFamiTF105202

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ABCC12

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
94160
PharosiQ96J65 Tbio

Protein Ontology

More...
PROi
PR:Q96J65
RNActiQ96J65 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000140798 Expressed in testis and 45 other tissues
ExpressionAtlasiQ96J65 baseline and differential
GenevisibleiQ96J65 HS

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030250 MRP9
IPR027417 P-loop_NTPase
PANTHERiPTHR24223:SF10 PTHR24223:SF10, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMRP9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96J65
Secondary accession number(s): Q49AL2, Q8TAF0, Q8TEY2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: December 4, 2007
Last modified: February 26, 2020
This is version 144 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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