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Protein

Thioredoxin domain-containing protein 15

Gene

TXNDC15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

It is uncertain whether Met-1 or Met-13 is the initiator.Curated

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin domain-containing protein 15
Gene namesi
Name:TXNDC15
Synonyms:C5orf14
ORF Names:UNQ335/PRO534
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113621.14
HGNCiHGNC:20652 TXNDC15
MIMi617778 gene
neXtProtiNX_Q96J42

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 321ExtracellularSequence analysisAdd BLAST289
Transmembranei322 – 342HelicalSequence analysisAdd BLAST21
Topological domaini343 – 360CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79770
OpenTargetsiENSG00000113621
PharmGKBiPA162407473

Polymorphism and mutation databases

BioMutaiTXNDC15
DMDMi74732127

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000029609433 – 360Thioredoxin domain-containing protein 15Add BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi194N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi293N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ96J42
MaxQBiQ96J42
PaxDbiQ96J42
PeptideAtlasiQ96J42
PRIDEiQ96J42
ProteomicsDBi76884
76885 [Q96J42-2]
TopDownProteomicsiQ96J42-1 [Q96J42-1]

PTM databases

iPTMnetiQ96J42
PhosphoSitePlusiQ96J42

Expressioni

Gene expression databases

BgeeiENSG00000113621
CleanExiHS_TXNDC15
ExpressionAtlasiQ96J42 baseline and differential
GenevisibleiQ96J42 HS

Organism-specific databases

HPAiHPA015483

Interactioni

Protein-protein interaction databases

BioGridi122874, 48 interactors
IntActiQ96J42, 3 interactors

Structurei

3D structure databases

ProteinModelPortaliQ96J42
SMRiQ96J42
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini153 – 296ThioredoxinPROSITE-ProRule annotationAdd BLAST144

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2640 Eukaryota
ENOG4111M6Z LUCA
GeneTreeiENSGT00390000002845
HOGENOMiHOG000154718
HOVERGENiHBG054981
InParanoidiQ96J42
OMAiWWQVLLW
OrthoDBiEOG091G0YYA
PhylomeDBiQ96J42
TreeFamiTF323528

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS51352 THIOREDOXIN_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96J42-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVPAAGRRPP RVMRLLGWWQ VLLWVLGLPV RGVEVAEESG RLWSEEQPAH
60 70 80 90 100
PLQVGAVYLG EEELLHDPMG QDRAAEEANA VLGLDTQGDH MVMLSVIPGE
110 120 130 140 150
AEDKVSSEPS GVTCGAGGAE DSRCNVRESL FSLDGAGAHF PDREEEYYTE
160 170 180 190 200
PEVAESDAAP TEDSNNTESL KSPKVNCEER NITGLENFTL KILNMSQDLM
210 220 230 240 250
DFLNPNGSDC TLVLFYTPWC RFSASLAPHF NSLPRAFPAL HFLALDASQH
260 270 280 290 300
SSLSTRFGTV AVPNILLFQG AKPMARFNHT DRTLETLKIF IFNQTGIEAK
310 320 330 340 350
KNVVVTQADQ IGPLPSTLIK SVDWLLVFSL FFLISFIMYA TIRTESIRWL
360
IPGQEQEHVE
Length:360
Mass (Da):39,885
Last modified:December 1, 2001 - v1
Checksum:i708473B7238FCCF6
GO
Isoform 2 (identifier: Q96J42-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     45-61: Missing.

Note: No experimental confirmation available.
Show »
Length:343
Mass (Da):38,066
Checksum:iA9FC7A48F76C877F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71Q → R in BAB15427 (PubMed:14702039).Curated1
Sequence conflicti85D → G in BAB71199 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036172248S → P in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02712945 – 61Missing in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358649 mRNA Translation: AAQ89012.1
AK026278 mRNA Translation: BAB15427.1
AK056512 mRNA Translation: BAB71199.1
CH471062 Genomic DNA Translation: EAW62231.1
CH471062 Genomic DNA Translation: EAW62233.1
BC001615 mRNA Translation: AAH01615.1
BC032568 mRNA Translation: AAH32568.1
CCDSiCCDS4180.1 [Q96J42-1]
RefSeqiNP_078991.3, NM_024715.3 [Q96J42-1]
UniGeneiHs.741304

Genome annotation databases

EnsembliENST00000358387; ENSP00000351157; ENSG00000113621 [Q96J42-1]
GeneIDi79770
KEGGihsa:79770
UCSCiuc003lac.2 human [Q96J42-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTXD15_HUMAN
AccessioniPrimary (citable) accession number: Q96J42
Secondary accession number(s): D3DQA9, Q96MT2, Q9H639
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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