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UniProtKB - Q96IZ5 (RBM41_HUMAN)

Protein

RNA-binding protein 41

Gene

RBM41

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May bind RNA.Curated

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 41
Alternative name(s):
RNA-binding motif protein 41
Gene namesi
Name:RBM41
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000089682.16
HGNCiHGNC:25617 RBM41
neXtProtiNX_Q96IZ5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000089682
PharmGKBiPA145148155

Polymorphism and mutation databases

BioMutaiRBM41
DMDMi117949772

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002562671 – 413RNA-binding protein 41Add BLAST413

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei232PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96IZ5
MaxQBiQ96IZ5
PaxDbiQ96IZ5
PeptideAtlasiQ96IZ5
PRIDEiQ96IZ5
ProteomicsDBi76874
76875 [Q96IZ5-2]
76876 [Q96IZ5-3]

PTM databases

iPTMnetiQ96IZ5
PhosphoSitePlusiQ96IZ5

Expressioni

Gene expression databases

BgeeiENSG00000089682 Expressed in 210 organ(s), highest expression level in cauda epididymis
CleanExiHS_RBM41
ExpressionAtlasiQ96IZ5 baseline and differential
GenevisibleiQ96IZ5 HS

Organism-specific databases

HPAiHPA042881

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi120573, 18 interactors
IntActiQ96IZ5, 33 interactors
MINTiQ96IZ5
STRINGi9606.ENSP00000361557

Structurei

Secondary structure

1413
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ96IZ5
SMRiQ96IZ5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96IZ5

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini309 – 387RRMPROSITE-ProRule annotationAdd BLAST79

Phylogenomic databases

eggNOGiENOG410IH35 Eukaryota
ENOG4111F4W LUCA
GeneTreeiENSGT00530000063786
HOGENOMiHOG000231401
HOVERGENiHBG057264
InParanoidiQ96IZ5
OMAiDNSPEQC
OrthoDBiEOG091G0OCH
PhylomeDBiQ96IZ5
TreeFamiTF324298

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96IZ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKRVNSCVKS DEHVLEELET EGERQLKSLL QHQLDTSVSI EECMSKKESF 
        60         70         80         90        100
APGTMYKPFG KEAAGTMTLS QFQTLHEKDQ ETASLRELGL NETEILIWKS 
       110        120        130        140        150
HVSGEKKTKL RATPEAIQNR LQDIEERISE RQRILCLPQR FAKSKQLTRR 
       160        170        180        190        200
EMEIEKSLFQ GADRHSFLKA LYYQDEPQKK NKGDPMNNLE SFYQEMIMKK 
       210        220        230        240        250
RLEEFQLMRG EPFASHSLVS ATSVGDSGTA ESPSLLQDKG KQAAQGKGPS 
       260        270        280        290        300
LHVANVIDFS PEQCWTGPKK LTQPIEFVPE DEIQRNRLSE EEIRKIPMFS 
       310        320        330        340        350
SYNPGEPNKV LYLKNLSPRV TERDLVSLFA RFQEKKGPPI QFRMMTGRMR 
       360        370        380        390        400
GQAFITFPNK EIAWQALHLV NGYKLHGKIL VIEFGKNKKQ RSNLQATSLI 
       410 
SCATGSTTEI SGS
Length:413
Mass (Da):47,100
Last modified:October 31, 2006 - v2
Checksum:i759B1BFF358943A8
GO
Isoform 2 (identifier: Q96IZ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     406-413: Missing.

Show »
Length:405
Mass (Da):46,337
Checksum:i703AF52FBC9CC486
GO
Isoform 3 (identifier: Q96IZ5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     174-174: Q → QAYHKKTSADKYMTSMKRKIKLGTK
     211-287: EPFASHSLVS...VPEDEIQRNR → LTSFPREDFQ...TRIGKLSFTP
     288-413: Missing.

Show »
Length:311
Mass (Da):35,962
Checksum:i5E5699E9D3352E2D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y6F9H0Y6F9_HUMAN
RNA-binding protein 41
RBM41
203Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61K → E in BAB14660 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028897376H → Y1 PublicationCorresponds to variant dbSNP:rs17850127Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021346174Q → QAYHKKTSADKYMTSMKRKI KLGTK in isoform 3. 1 Publication1
Alternative sequenceiVSP_021347211 – 287EPFAS…IQRNR → LTSFPREDFQNLSYEGTTSV LGAKWQKRTGRTSTFSILLV SLLSETVFTSSAMYGIPHLL TMSLKFSTRIGKLSFTP in isoform 3. 1 PublicationAdd BLAST77
Alternative sequenceiVSP_021348288 – 413Missing in isoform 3. 1 PublicationAdd BLAST126
Alternative sequenceiVSP_021349406 – 413Missing in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001878 mRNA Translation: BAA91957.1
AK023732 mRNA Translation: BAB14660.1
AL390039 Genomic DNA No translation available.
BC006986 mRNA Translation: AAH06986.1
CCDSiCCDS14526.1 [Q96IZ5-1]
CCDS55472.1 [Q96IZ5-2]
RefSeqiNP_001164551.1, NM_001171080.1 [Q96IZ5-2]
NP_060771.3, NM_018301.4 [Q96IZ5-1]
UniGeneiHs.139053

Genome annotation databases

EnsembliENST00000372479; ENSP00000361557; ENSG00000089682 [Q96IZ5-1]
ENST00000372487; ENSP00000361565; ENSG00000089682 [Q96IZ5-2]
ENST00000495517; ENSP00000433251; ENSG00000089682 [Q96IZ5-3]
GeneIDi55285
KEGGihsa:55285
UCSCiuc004emy.3 human [Q96IZ5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001878 mRNA Translation: BAA91957.1
AK023732 mRNA Translation: BAB14660.1
AL390039 Genomic DNA No translation available.
BC006986 mRNA Translation: AAH06986.1
CCDSiCCDS14526.1 [Q96IZ5-1]
CCDS55472.1 [Q96IZ5-2]
RefSeqiNP_001164551.1, NM_001171080.1 [Q96IZ5-2]
NP_060771.3, NM_018301.4 [Q96IZ5-1]
UniGeneiHs.139053

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CPXNMR-A291-392[»]
ProteinModelPortaliQ96IZ5
SMRiQ96IZ5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120573, 18 interactors
IntActiQ96IZ5, 33 interactors
MINTiQ96IZ5
STRINGi9606.ENSP00000361557

PTM databases

iPTMnetiQ96IZ5
PhosphoSitePlusiQ96IZ5

Polymorphism and mutation databases

BioMutaiRBM41
DMDMi117949772

Proteomic databases

EPDiQ96IZ5
MaxQBiQ96IZ5
PaxDbiQ96IZ5
PeptideAtlasiQ96IZ5
PRIDEiQ96IZ5
ProteomicsDBi76874
76875 [Q96IZ5-2]
76876 [Q96IZ5-3]

Protocols and materials databases

DNASUi55285
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372479; ENSP00000361557; ENSG00000089682 [Q96IZ5-1]
ENST00000372487; ENSP00000361565; ENSG00000089682 [Q96IZ5-2]
ENST00000495517; ENSP00000433251; ENSG00000089682 [Q96IZ5-3]
GeneIDi55285
KEGGihsa:55285
UCSCiuc004emy.3 human [Q96IZ5-1]

Organism-specific databases

CTDi55285
EuPathDBiHostDB:ENSG00000089682.16
GeneCardsiRBM41
H-InvDBiHIX0020243
HGNCiHGNC:25617 RBM41
HPAiHPA042881
neXtProtiNX_Q96IZ5
OpenTargetsiENSG00000089682
PharmGKBiPA145148155
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH35 Eukaryota
ENOG4111F4W LUCA
GeneTreeiENSGT00530000063786
HOGENOMiHOG000231401
HOVERGENiHBG057264
InParanoidiQ96IZ5
OMAiDNSPEQC
OrthoDBiEOG091G0OCH
PhylomeDBiQ96IZ5
TreeFamiTF324298

Miscellaneous databases

EvolutionaryTraceiQ96IZ5
GenomeRNAii55285
PROiPR:Q96IZ5

Gene expression databases

BgeeiENSG00000089682 Expressed in 210 organ(s), highest expression level in cauda epididymis
CleanExiHS_RBM41
ExpressionAtlasiQ96IZ5 baseline and differential
GenevisibleiQ96IZ5 HS

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRBM41_HUMAN
AccessioniPrimary (citable) accession number: Q96IZ5
Secondary accession number(s): Q5JSN7
, Q5JSN8, Q9H8F7, Q9NV04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: September 12, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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