UniProtKB - Q96IZ5 (RBM41_HUMAN)
Protein
RNA-binding protein 41
Gene
RBM41
Organism
Homo sapiens (Human)
Status
Functioni
May bind RNA.Curated
GO - Molecular functioni
- pre-mRNA intronic binding Source: GO_Central
- U12 snRNA binding Source: GO_Central
GO - Biological processi
- mRNA splicing, via spliceosome Source: GO_Central
Keywordsi
Molecular function | RNA-binding |
Enzyme and pathway databases
PathwayCommonsi | Q96IZ5 |
Names & Taxonomyi
Protein namesi | Recommended name: RNA-binding protein 41Alternative name(s): RNA-binding motif protein 41 |
Gene namesi | Name:RBM41 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25617, RBM41 |
neXtProti | NX_Q96IZ5 |
VEuPathDBi | HostDB:ENSG00000089682.16 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000089682 |
PharmGKBi | PA145148155 |
Miscellaneous databases
Pharosi | Q96IZ5, Tdark |
Genetic variation databases
BioMutai | RBM41 |
DMDMi | 117949772 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000256267 | 1 – 413 | RNA-binding protein 41Add BLAST | 413 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 232 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q96IZ5 |
jPOSTi | Q96IZ5 |
MassIVEi | Q96IZ5 |
MaxQBi | Q96IZ5 |
PaxDbi | Q96IZ5 |
PeptideAtlasi | Q96IZ5 |
PRIDEi | Q96IZ5 |
ProteomicsDBi | 76874 [Q96IZ5-1] 76875 [Q96IZ5-2] 76876 [Q96IZ5-3] |
PTM databases
iPTMneti | Q96IZ5 |
PhosphoSitePlusi | Q96IZ5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000089682, Expressed in cauda epididymis and 224 other tissues |
ExpressionAtlasi | Q96IZ5, baseline and differential |
Genevisiblei | Q96IZ5, HS |
Organism-specific databases
HPAi | ENSG00000089682, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ96IZ5
Protein-protein interaction databases
BioGRIDi | 120573, 39 interactors |
IntActi | Q96IZ5, 35 interactors |
MINTi | Q96IZ5 |
STRINGi | 9606.ENSP00000361557 |
Miscellaneous databases
RNActi | Q96IZ5, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q96IZ5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q96IZ5 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 309 – 387 | RRMPROSITE-ProRule annotationAdd BLAST | 79 |
Phylogenomic databases
eggNOGi | ENOG502RIV3, Eukaryota |
GeneTreei | ENSGT00530000063786 |
HOGENOMi | CLU_054957_0_0_1 |
InParanoidi | Q96IZ5 |
OMAi | ALYHQDD |
OrthoDBi | 1080666at2759 |
PhylomeDBi | Q96IZ5 |
TreeFami | TF324298 |
Family and domain databases
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96IZ5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKRVNSCVKS DEHVLEELET EGERQLKSLL QHQLDTSVSI EECMSKKESF
60 70 80 90 100
APGTMYKPFG KEAAGTMTLS QFQTLHEKDQ ETASLRELGL NETEILIWKS
110 120 130 140 150
HVSGEKKTKL RATPEAIQNR LQDIEERISE RQRILCLPQR FAKSKQLTRR
160 170 180 190 200
EMEIEKSLFQ GADRHSFLKA LYYQDEPQKK NKGDPMNNLE SFYQEMIMKK
210 220 230 240 250
RLEEFQLMRG EPFASHSLVS ATSVGDSGTA ESPSLLQDKG KQAAQGKGPS
260 270 280 290 300
LHVANVIDFS PEQCWTGPKK LTQPIEFVPE DEIQRNRLSE EEIRKIPMFS
310 320 330 340 350
SYNPGEPNKV LYLKNLSPRV TERDLVSLFA RFQEKKGPPI QFRMMTGRMR
360 370 380 390 400
GQAFITFPNK EIAWQALHLV NGYKLHGKIL VIEFGKNKKQ RSNLQATSLI
410
SCATGSTTEI SGS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0Y6F9 | H0Y6F9_HUMAN | RNA-binding protein 41 | RBM41 | 203 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 61 | K → E in BAB14660 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_028897 | 376 | H → Y1 PublicationCorresponds to variant dbSNP:rs17850127Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_021346 | 174 | Q → QAYHKKTSADKYMTSMKRKI KLGTK in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_021347 | 211 – 287 | EPFAS…IQRNR → LTSFPREDFQNLSYEGTTSV LGAKWQKRTGRTSTFSILLV SLLSETVFTSSAMYGIPHLL TMSLKFSTRIGKLSFTP in isoform 3. 1 PublicationAdd BLAST | 77 | |
Alternative sequenceiVSP_021348 | 288 – 413 | Missing in isoform 3. 1 PublicationAdd BLAST | 126 | |
Alternative sequenceiVSP_021349 | 406 – 413 | Missing in isoform 2. 1 Publication | 8 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK001878 mRNA Translation: BAA91957.1 AK023732 mRNA Translation: BAB14660.1 AL390039 Genomic DNA No translation available. BC006986 mRNA Translation: AAH06986.1 |
CCDSi | CCDS14526.1 [Q96IZ5-1] CCDS55472.1 [Q96IZ5-2] |
RefSeqi | NP_001164551.1, NM_001171080.1 [Q96IZ5-2] NP_060771.3, NM_018301.4 [Q96IZ5-1] |
Genome annotation databases
Ensembli | ENST00000372479; ENSP00000361557; ENSG00000089682 [Q96IZ5-1] ENST00000372487; ENSP00000361565; ENSG00000089682 [Q96IZ5-2] ENST00000495517; ENSP00000433251; ENSG00000089682 [Q96IZ5-3] |
GeneIDi | 55285 |
KEGGi | hsa:55285 |
UCSCi | uc004emy.3, human [Q96IZ5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK001878 mRNA Translation: BAA91957.1 AK023732 mRNA Translation: BAB14660.1 AL390039 Genomic DNA No translation available. BC006986 mRNA Translation: AAH06986.1 |
CCDSi | CCDS14526.1 [Q96IZ5-1] CCDS55472.1 [Q96IZ5-2] |
RefSeqi | NP_001164551.1, NM_001171080.1 [Q96IZ5-2] NP_060771.3, NM_018301.4 [Q96IZ5-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CPX | NMR | - | A | 291-392 | [»] | |
SMRi | Q96IZ5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120573, 39 interactors |
IntActi | Q96IZ5, 35 interactors |
MINTi | Q96IZ5 |
STRINGi | 9606.ENSP00000361557 |
PTM databases
iPTMneti | Q96IZ5 |
PhosphoSitePlusi | Q96IZ5 |
Genetic variation databases
BioMutai | RBM41 |
DMDMi | 117949772 |
Proteomic databases
EPDi | Q96IZ5 |
jPOSTi | Q96IZ5 |
MassIVEi | Q96IZ5 |
MaxQBi | Q96IZ5 |
PaxDbi | Q96IZ5 |
PeptideAtlasi | Q96IZ5 |
PRIDEi | Q96IZ5 |
ProteomicsDBi | 76874 [Q96IZ5-1] 76875 [Q96IZ5-2] 76876 [Q96IZ5-3] |
Protocols and materials databases
Antibodypediai | 29287, 131 antibodies |
DNASUi | 55285 |
Genome annotation databases
Ensembli | ENST00000372479; ENSP00000361557; ENSG00000089682 [Q96IZ5-1] ENST00000372487; ENSP00000361565; ENSG00000089682 [Q96IZ5-2] ENST00000495517; ENSP00000433251; ENSG00000089682 [Q96IZ5-3] |
GeneIDi | 55285 |
KEGGi | hsa:55285 |
UCSCi | uc004emy.3, human [Q96IZ5-1] |
Organism-specific databases
CTDi | 55285 |
GeneCardsi | RBM41 |
HGNCi | HGNC:25617, RBM41 |
HPAi | ENSG00000089682, Low tissue specificity |
neXtProti | NX_Q96IZ5 |
OpenTargetsi | ENSG00000089682 |
PharmGKBi | PA145148155 |
VEuPathDBi | HostDB:ENSG00000089682.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RIV3, Eukaryota |
GeneTreei | ENSGT00530000063786 |
HOGENOMi | CLU_054957_0_0_1 |
InParanoidi | Q96IZ5 |
OMAi | ALYHQDD |
OrthoDBi | 1080666at2759 |
PhylomeDBi | Q96IZ5 |
TreeFami | TF324298 |
Enzyme and pathway databases
PathwayCommonsi | Q96IZ5 |
Miscellaneous databases
BioGRID-ORCSi | 55285, 4 hits in 628 CRISPR screens |
ChiTaRSi | RBM41, human |
EvolutionaryTracei | Q96IZ5 |
GenomeRNAii | 55285 |
Pharosi | Q96IZ5, Tdark |
PROi | PR:Q96IZ5 |
RNActi | Q96IZ5, protein |
Gene expression databases
Bgeei | ENSG00000089682, Expressed in cauda epididymis and 224 other tissues |
ExpressionAtlasi | Q96IZ5, baseline and differential |
Genevisiblei | Q96IZ5, HS |
Family and domain databases
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RBM41_HUMAN | |
Accessioni | Q96IZ5Primary (citable) accession number: Q96IZ5 Secondary accession number(s): Q5JSN7 Q9NV04 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | October 31, 2006 | |
Last modified: | April 7, 2021 | |
This is version 151 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - PDB cross-references
Index of Protein Data Bank (PDB) cross-references