UniProtKB - Q96IZ2 (ADTRP_HUMAN)
Androgen-dependent TFPI-regulating protein
ADTRP
Functioni
Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (PubMed:27018888).
Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (PubMed:27018888).
Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro) (PubMed:21868574).
2 PublicationsCatalytic activityi
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- 9-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 12-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 12-hydroxyoctadecanoate + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 13-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 13-hydroxy-octadecanoate + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- 9-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 9-hydroxy-octadecanoate + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 12-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 12-hydroxyoctadecanoate + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 13-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 13-hydroxy-octadecanoate + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 5-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 5-hydroxy-octadecanoate + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 47 | Important for catalytic activity1 Publication | 1 | |
Sitei | 131 | Important for catalytic activity1 Publication | 1 |
GO - Molecular functioni
- hydrolase activity Source: UniProtKB
GO - Biological processi
- cell migration involved in sprouting angiogenesis Source: BHF-UCL
- cellular response to oxidised low-density lipoprotein particle stimulus Source: BHF-UCL
- cellular response to steroid hormone stimulus Source: UniProtKB
- long-chain fatty acid catabolic process Source: UniProtKB
- negative regulation of blood coagulation Source: UniProtKB
- negative regulation of extracellular matrix constituent secretion Source: BHF-UCL
- negative regulation of leukocyte cell-cell adhesion Source: BHF-UCL
- negative regulation of leukocyte migration Source: BHF-UCL
- negative regulation of lymphocyte migration Source: BHF-UCL
- negative regulation of protein secretion Source: BHF-UCL
- positive regulation of gene expression Source: UniProtKB
- positive regulation of protein phosphorylation Source: BHF-UCL
- protein kinase B signaling Source: BHF-UCL
Keywordsi
Molecular function | Hydrolase |
Biological process | Lipid metabolism |
Enzyme and pathway databases
PathwayCommonsi | Q96IZ2 |
SignaLinki | Q96IZ2 |
Chemistry databases
SwissLipidsi | SLP:000001683 |
Names & Taxonomyi
Protein namesi | Recommended name: Androgen-dependent TFPI-regulating proteinAlternative name(s): Fatty acid esters of hydroxy fatty acids hydrolase ADTRP1 Publication (EC:3.1.-.-1 Publication) Short name: FAHFA hydrolase ADTRP1 Publication |
Gene namesi | Name:ADTRP Synonyms:C6orf105 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21214, ADTRP |
MIMi | 614348, gene |
neXtProti | NX_Q96IZ2 |
VEuPathDBi | HostDB:ENSG00000111863 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Multi-pass membrane protein Sequence analysis
Note: Colocalized with TFPI and CAV1 in lipid rafts.1 Publication
Plasma Membrane
- caveola Source: UniProtKB
Other locations
- cell surface Source: UniProtKB
- endomembrane system Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 3 | Cytoplasmic1 Publication | 3 | |
Transmembranei | 4 – 24 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 25 – 46 | Extracellular1 PublicationAdd BLAST | 22 | |
Transmembranei | 47 – 67 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 68 – 85 | Cytoplasmic1 PublicationAdd BLAST | 18 | |
Transmembranei | 86 – 106 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 107 – 119 | Extracellular1 PublicationAdd BLAST | 13 | |
Transmembranei | 120 – 140 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 141 – 154 | Cytoplasmic1 PublicationAdd BLAST | 14 | |
Transmembranei | 155 – 175 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 176 – 189 | Extracellular1 PublicationAdd BLAST | 14 | |
Transmembranei | 190 – 210 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 211 – 230 | Cytoplasmic1 PublicationAdd BLAST | 20 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 47 | T → A: Loss of hydrolase activity. 1 Publication | 1 | |
Mutagenesisi | 131 | H → A: Loss of hydrolase activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 84830 |
OpenTargetsi | ENSG00000111863 |
PharmGKBi | PA134981312 |
Miscellaneous databases
Pharosi | Q96IZ2, Tbio |
Genetic variation databases
BioMutai | ADTRP |
DMDMi | 83286865 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000190100 | 1 – 230 | Androgen-dependent TFPI-regulating proteinAdd BLAST | 230 |
Proteomic databases
MassIVEi | Q96IZ2 |
PeptideAtlasi | Q96IZ2 |
PRIDEi | Q96IZ2 |
ProteomicsDBi | 76871 [Q96IZ2-1] 76872 [Q96IZ2-2] 76873 [Q96IZ2-3] |
PTM databases
iPTMneti | Q96IZ2 |
PhosphoSitePlusi | Q96IZ2 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000111863, Expressed in pigmented layer of retina and 174 other tissues |
ExpressionAtlasi | Q96IZ2, baseline and differential |
Genevisiblei | Q96IZ2, HS |
Organism-specific databases
HPAi | ENSG00000111863, Tissue enhanced (intestine, parathyroid gland) |
Interactioni
Binary interactionsi
Protein-protein interaction databases
BioGRIDi | 124285, 5 interactors |
IntActi | Q96IZ2, 5 interactors |
MINTi | Q96IZ2 |
STRINGi | 9606.ENSP00000229583 |
Chemistry databases
BindingDBi | Q96IZ2 |
Miscellaneous databases
RNActi | Q96IZ2, protein |
Structurei
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3989, Eukaryota |
GeneTreei | ENSGT00940000158284 |
HOGENOMi | CLU_073346_2_0_1 |
InParanoidi | Q96IZ2 |
OMAi | FFPPWIN |
OrthoDBi | 1482757at2759 |
PhylomeDBi | Q96IZ2 |
TreeFami | TF318170 |
Family and domain databases
InterProi | View protein in InterPro IPR006838, Far-17a_AIG1 |
PANTHERi | PTHR10989, PTHR10989, 1 hit |
Pfami | View protein in Pfam PF04750, Far-17a_AIG1, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTKTSTCIYH FLVLSWYTFL NYYISQEGKD EVKPKILANG ARWKYMTLLN
60 70 80 90 100
LLLQTIFYGV TCLDDVLKRT KGGKDIKFLT AFRDLLFTTL AFPVSTFVFL
110 120 130 140 150
AFWILFLYNR DLIYPKVLDT VIPVWLNHAM HTFIFPITLA EVVLRPHSYP
160 170 180 190 200
SKKTGLTLLA AASIAYISRI LWLYFETGTW VYPVFAKLSL LGLAAFFSLS
210 220 230
YVFIASIYLL GEKLNHWKWG DMRQPRKKRK
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y9P4 | H0Y9P4_HUMAN | Androgen-dependent TFPI-regulating ... | ADTRP | 120 | Annotation score: | ||
H0YAA5 | H0YAA5_HUMAN | Androgen-dependent TFPI-regulating ... | ADTRP | 116 | Annotation score: | ||
D6R9A9 | D6R9A9_HUMAN | Androgen-dependent TFPI-regulating ... | ADTRP | 168 | Annotation score: | ||
D6RDG9 | D6RDG9_HUMAN | Androgen-dependent TFPI-regulating ... | ADTRP | 86 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024365 | 202 | V → I. Corresponds to variant dbSNP:rs2076185Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041965 | 52 | L → LKNRTAGFDIYQPGSFRQL in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_042868 | 220 – 230 | GDMRQPRKKRK → VSVQILQRWRLESVGICFQW PDWKSPAKHQLVKNIR in isoform 3. CuratedAdd BLAST | 11 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK313114 mRNA Translation: BAG35936.1 AK300919 mRNA Translation: BAG62551.1 AL022724 Genomic DNA No translation available. CH471087 Genomic DNA Translation: EAW55304.1 CH471087 Genomic DNA Translation: EAW55306.1 BC007011 mRNA Translation: AAH07011.1 |
CCDSi | CCDS4521.1 [Q96IZ2-1] CCDS47374.1 [Q96IZ2-2] |
RefSeqi | NP_001137420.1, NM_001143948.1 [Q96IZ2-2] NP_116133.1, NM_032744.3 [Q96IZ2-1] XP_005249511.1, XM_005249454.3 [Q96IZ2-1] XP_011513258.1, XM_011514956.1 [Q96IZ2-3] |
Genome annotation databases
Ensembli | ENST00000229583; ENSP00000229583; ENSG00000111863 [Q96IZ2-2] ENST00000414691; ENSP00000404416; ENSG00000111863 |
GeneIDi | 84830 |
KEGGi | hsa:84830 |
MANE-Selecti | ENST00000414691.8; ENSP00000404416.2; NM_032744.4; NP_116133.1 |
UCSCi | uc003nab.4, human [Q96IZ2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK313114 mRNA Translation: BAG35936.1 AK300919 mRNA Translation: BAG62551.1 AL022724 Genomic DNA No translation available. CH471087 Genomic DNA Translation: EAW55304.1 CH471087 Genomic DNA Translation: EAW55306.1 BC007011 mRNA Translation: AAH07011.1 |
CCDSi | CCDS4521.1 [Q96IZ2-1] CCDS47374.1 [Q96IZ2-2] |
RefSeqi | NP_001137420.1, NM_001143948.1 [Q96IZ2-2] NP_116133.1, NM_032744.3 [Q96IZ2-1] XP_005249511.1, XM_005249454.3 [Q96IZ2-1] XP_011513258.1, XM_011514956.1 [Q96IZ2-3] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 124285, 5 interactors |
IntActi | Q96IZ2, 5 interactors |
MINTi | Q96IZ2 |
STRINGi | 9606.ENSP00000229583 |
Chemistry databases
BindingDBi | Q96IZ2 |
SwissLipidsi | SLP:000001683 |
PTM databases
iPTMneti | Q96IZ2 |
PhosphoSitePlusi | Q96IZ2 |
Genetic variation databases
BioMutai | ADTRP |
DMDMi | 83286865 |
Proteomic databases
MassIVEi | Q96IZ2 |
PeptideAtlasi | Q96IZ2 |
PRIDEi | Q96IZ2 |
ProteomicsDBi | 76871 [Q96IZ2-1] 76872 [Q96IZ2-2] 76873 [Q96IZ2-3] |
Protocols and materials databases
Antibodypediai | 63585, 4 antibodies from 4 providers |
DNASUi | 84830 |
Genome annotation databases
Ensembli | ENST00000229583; ENSP00000229583; ENSG00000111863 [Q96IZ2-2] ENST00000414691; ENSP00000404416; ENSG00000111863 |
GeneIDi | 84830 |
KEGGi | hsa:84830 |
MANE-Selecti | ENST00000414691.8; ENSP00000404416.2; NM_032744.4; NP_116133.1 |
UCSCi | uc003nab.4, human [Q96IZ2-1] |
Organism-specific databases
CTDi | 84830 |
DisGeNETi | 84830 |
GeneCardsi | ADTRP |
HGNCi | HGNC:21214, ADTRP |
HPAi | ENSG00000111863, Tissue enhanced (intestine, parathyroid gland) |
MIMi | 614348, gene |
neXtProti | NX_Q96IZ2 |
OpenTargetsi | ENSG00000111863 |
PharmGKBi | PA134981312 |
VEuPathDBi | HostDB:ENSG00000111863 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3989, Eukaryota |
GeneTreei | ENSGT00940000158284 |
HOGENOMi | CLU_073346_2_0_1 |
InParanoidi | Q96IZ2 |
OMAi | FFPPWIN |
OrthoDBi | 1482757at2759 |
PhylomeDBi | Q96IZ2 |
TreeFami | TF318170 |
Enzyme and pathway databases
PathwayCommonsi | Q96IZ2 |
SignaLinki | Q96IZ2 |
Miscellaneous databases
BioGRID-ORCSi | 84830, 5 hits in 1045 CRISPR screens |
ChiTaRSi | ADTRP, human |
GenomeRNAii | 84830 |
Pharosi | Q96IZ2, Tbio |
PROi | PR:Q96IZ2 |
RNActi | Q96IZ2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000111863, Expressed in pigmented layer of retina and 174 other tissues |
ExpressionAtlasi | Q96IZ2, baseline and differential |
Genevisiblei | Q96IZ2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR006838, Far-17a_AIG1 |
PANTHERi | PTHR10989, PTHR10989, 1 hit |
Pfami | View protein in Pfam PF04750, Far-17a_AIG1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ADTRP_HUMAN | |
Accessioni | Q96IZ2Primary (citable) accession number: Q96IZ2 Secondary accession number(s): B2R7T9, B4DV39, Q5THW1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2005 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families