PAWR

Functionⁱ

Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.1 Publication

GO - Molecular functionⁱ

actin binding Source: UniProtKB
enzyme binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15671026
leucine zipper domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 14627703
transcription corepressor activity
Source: ProtInc
Traceable author statementⁱ
- 8943350

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin filament bundle assembly Source: UniProtKB
apoptotic process Source: UniProtKB
apoptotic signaling pathway Source: Ensembl
interleukin-2 biosynthetic process Source: Ensembl
negative regulation of B cell proliferation Source: Ensembl
negative regulation of fibroblast proliferation Source: Ensembl
negative regulation of T cell proliferation Source: Ensembl
negative regulation of T cell receptor signaling pathway Source: Ensembl
negative regulation of transcription by RNA polymerase II
Source: ProtInc
Traceable author statementⁱ
- 8943350
positive regulation of amyloid precursor protein biosynthetic process Source: Ensembl
positive regulation of apoptotic process Source: GO_Central
positive regulation of cellular senescence Source: Ensembl
positive regulation of gene expression Source: Ensembl
positive regulation of hydrogen peroxide-mediated programmed cell death Source: Ensembl
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Apoptosis, Transcription, Transcription regulation

Biological process

Apoptosis, Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORⁱ	Q96IZ0

SIGNORⁱ

Q96IZ0

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: PRKC apoptosis WT1 regulator protein Alternative name(s): Prostate apoptosis response 4 protein Short name: Par-4
Gene namesⁱ	Name:PAWR Synonyms:PAR4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000177425.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8614 PAWR
MIMⁱ	601936 gene
neXtProtⁱ	NX_Q96IZ0

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	66	A → D: No loss of interaction with SPSB1, SPSB2 and SPSB4. 1 Publication	1
Mutagenesisⁱ	68	E → D: Increased interaction with SPSB2. Increased only sligthly interaction with SPSB4. Increased interaction with SPSB1, SPSB2 and SPSB4; when associated with A-69. 1 Publication	1
Mutagenesisⁱ	69	L → I: Increased only sligthly interaction with SPSB2. Increased only sligthly interaction with SPSB4. Increased interaction with SPSB1, SPSB2 and SPSB4; when associated with A-68. 1 Publication	1
Mutagenesisⁱ	71	N → A: Loss of interaction with SPSB1, SPSB2 and SPSB4. 1 Publication	1
Mutagenesisⁱ	72	N → A: Loss of interaction with SPSB1-Elongin BC complex and SPSB2 and SPSB4. 2 Publications	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5074
Open Targets More...OpenTargetsⁱ	ENSG00000177425
PharmGKBⁱ	PA32954

Polymorphism and mutation databases

BioMutaⁱ	PAWR
DMDMⁱ	66773935

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000058236	1 – 340	PRKC apoptosis WT1 regulator proteinAdd BLAST		340

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	108	PhosphoserineCombined sources	1
Modified residueⁱ	163	Phosphothreonine; by PKABy similarity	1
Modified residueⁱ	231	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Preferentially phosphorylated at the Thr-163 by PKC in cancer cells.By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q96IZ0
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96IZ0
PaxDbⁱ	Q96IZ0
PeptideAtlas More...PeptideAtlasⁱ	Q96IZ0
PRIDEⁱ	Q96IZ0
ProteomicsDBⁱ	76870
TopDownProteomicsⁱ	Q96IZ0

PTM databases

iPTMnetⁱ	Q96IZ0
PhosphoSitePlusⁱ	Q96IZ0

Expressionⁱ

Tissue specificityⁱ

Widely expressed. Expression is elevated in various neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer, Parkinson and Huntington diseases and stroke. Down-regulated in several cancers.1 Publication

Inductionⁱ

By apoptosis.

Gene expression databases

Bgeeⁱ	ENSG00000177425
CleanExⁱ	HS_PAWR
ExpressionAtlasⁱ	Q96IZ0 baseline and differential
Genevisibleⁱ	Q96IZ0 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB020779 HPA012640

HPAⁱ

CAB020779
HPA012640

Interactionⁱ

Subunit structureⁱ

Homooligomer. Interacts (via the C-terminal region) with WT1 (PubMed:8943350). Interacts with THAP1 (PubMed:12717420). Interacts with AATF (PubMed:14627703). Interacts with BACE1 (PubMed:15671026). Interacts with SPSB1 (via B30.2/SPRY domain); this interaction is direct and occurs in association with the Elongin BC complex (PubMed:17189197, PubMed:20561531). Interacts with SPSB2 (via B30.2/SPRY domain); this interaction occurs in association with the Elongin BC complex (PubMed:17189197, PubMed:20561531). Interacts with SPSB4 (via B30.2/SPRY domain) (PubMed:20561531); this interaction occurs in association with the Elongin BC complex (PubMed:20561531). Component of a ternary complex composed of SQSTM1 and PRKCZ (PubMed:11755531). Interacts with actin (By similarity).By similarity7 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
HSPA5	P11021	8	EBI-595869,EBI-354921
SPSB1	Q96BD6	2	EBI-595869,EBI-2659201
Spsb1	Q9D5L7	2	EBI-595869,EBI-8821912	From Mus musculus.
Spsb2	O88838	6	EBI-595869,EBI-8820410	From Mus musculus.
Spsb4	Q8R5B6	3	EBI-595869,EBI-8821982	From Mus musculus.
VIM	P08670	2	EBI-595869,EBI-353844

Show more details

GO - Molecular functionⁱ

actin binding Source: UniProtKB
enzyme binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15671026
leucine zipper domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 14627703

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111108, 50 interactors
CORUMⁱ	Q96IZ0
Database of interacting proteins More...DIPⁱ	DIP-29003N
ELMⁱ	Q96IZ0
IntActⁱ	Q96IZ0, 20 interactors
STRINGⁱ	9606.ENSP00000328088

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96IZ0
SMRⁱ	Q96IZ0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q96IZ0

EvolutionaryTraceⁱ

Q96IZ0

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	145 – 203	Selective for apoptosis induction in cancer cells (SAC)Add BLAST		59
Regionⁱ	300 – 340	Leucine-zipperAdd BLAST		41

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	186 – 206	Sequence analysisAdd BLAST		21

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	68 – 72	B30.2/SPRY domain-binding motif1 Publication		5
Motifⁱ	145 – 161	Nuclear localization signalBy similarityAdd BLAST		17

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	49 – 120	Ala-richAdd BLAST		72

Domainⁱ

The leucine-zipper domain is not essential for apoptosis, but is required for sensitization of cells to exogenous apoptotic insults and for interaction with its partners.By similarity

The SAC domain is a death-inducing domain selective for apoptosis induction in cancer cells. This domain is essential for nuclear entry, Fas activation, inhibition of NF-kappa-B activity and induction of apoptosis in cancer cells (By similarity).By similarity

The B30.2/SPRY domain-binding motif mediates recognition by proteins containing a B30.2/SPRY domain.1 Publication

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IFBP Eukaryota ENOG4111M3H LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000406
HOGENOMⁱ	HOG000115462
HOVERGENⁱ	HBG058812
InParanoidⁱ	Q96IZ0
OMAⁱ	NCAVGPA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0JYK
PhylomeDBⁱ	Q96IZ0
TreeFamⁱ	TF332824

Family and domain databases

InterProⁱ	View protein in InterPro IPR026117 Par-4
PANTHERⁱ	PTHR15093 PTHR15093, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q96IZ0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MATGGYRTSS GLGGSTTDFL EEWKAKREKM RAKQNPPGPA PPGGGSSDAA 
        60         70         80         90        100
GKPPAGALGT PAAAAANELN NNLPGGAPAA PAVPGPGGVN CAVGSAMLTR 
       110        120        130        140        150
AAPGPRRSED EPPAASASAA PPPQRDEEEP DGVPEKGKSS GPSARKGKGQ 
       160        170        180        190        200
IEKRKLREKR RSTGVVNIPA AECLDEYEDD EAGQKERKRE DAITQQNTIQ 
       210        220        230        240        250
NEAVNLLDPG SSYLLQEPPR TVSGRYKSTT SVSEEDVSSR YSRTDRSGFP 
       260        270        280        290        300
RYNRDANVSG TLVSSSTLEK KIEDLEKEVV RERQENLRLV RLMQDKEEMI 
       310        320        330        340
GKLKEEIDLL NRDLDDIEDE NEQLKQENKT LLKVVGQLTR

Length:340

Mass (Da):36,568

Last modified:December 1, 2001 - v1

Checksum:ⁱ7E7515455402DBF8

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	102 – 103	AP → PPAR in AAC24947 (PubMed:8943350).Curated	2
Sequence conflictⁱ	199	I → M in CAG38786 (Ref. 2) Curated	1
Sequence conflictⁱ	281	R → T in AAC24947 (PubMed:8943350).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_022465	42	P → L1 PublicationCorresponds to variant dbSNP:rs8176804Ensembl.	1
Natural variantⁱVAR_022466	78	P → R2 PublicationsCorresponds to variant dbSNP:rs8176805Ensembl.	1
Natural variantⁱVAR_022467	137	G → A1 PublicationCorresponds to variant dbSNP:rs8176806Ensembl.	1
Natural variantⁱVAR_022468	202	E → A1 PublicationCorresponds to variant dbSNP:rs8176870Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U63809 mRNA Translation: AAC24947.1 CR536549 mRNA Translation: CAG38786.1 AY300794 Genomic DNA Translation: AAP43693.1 BC007018 mRNA Translation: AAH07018.1 AF503628 Genomic DNA Translation: AAM27453.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31863.1
NCBI Reference Sequences More...RefSeqⁱ	NP_002574.2, NM_002583.2 XP_006719498.1, XM_006719435.2 XP_016874866.1, XM_017019377.1
UniGeneⁱ	Hs.643130 Hs.662065

Genome annotation databases

Ensemblⁱ	ENST00000328827; ENSP00000328088; ENSG00000177425
GeneIDⁱ	5074
KEGGⁱ	hsa:5074
UCSC genome browser More...UCSCⁱ	uc001syx.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q96IZ0	UPI0007DC605C		HUMAN		216
PRKC, apoptosis, WT1, regulator		PANTR		354
Pro-apoptotic WT1 regulator		MACFA		342
Pro-apoptotic WT1 regulator		PAPAN		342
Pro-apoptotic WT1 regulator		MACNE		342
+33

Protein	Similar proteins		Species	Score	Length
Q96IZ0	UPI0007DC605C		HUMAN		216
PRKC, apoptosis, WT1, regulator		PANTR		354
Pro-apoptotic WT1 regulator		PAPAN		342
Pro-apoptotic WT1 regulator		MACFA		342
Pro-apoptotic WT1 regulator		MACNE		342
+59

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U63809 mRNA Translation: AAC24947.1 CR536549 mRNA Translation: CAG38786.1 AY300794 Genomic DNA Translation: AAP43693.1 BC007018 mRNA Translation: AAH07018.1 AF503628 Genomic DNA Translation: AAM27453.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31863.1
NCBI Reference Sequences More...RefSeqⁱ	NP_002574.2, NM_002583.2 XP_006719498.1, XM_006719435.2 XP_016874866.1, XM_017019377.1
UniGeneⁱ	Hs.643130 Hs.662065

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2JK9	X-ray	1.79	B	67-81	[»]
ProteinModelPortalⁱ	Q96IZ0
SMRⁱ	Q96IZ0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111108, 50 interactors
CORUMⁱ	Q96IZ0
Database of interacting proteins More...DIPⁱ	DIP-29003N
ELMⁱ	Q96IZ0
IntActⁱ	Q96IZ0, 20 interactors
STRINGⁱ	9606.ENSP00000328088

PTM databases

iPTMnetⁱ	Q96IZ0
PhosphoSitePlusⁱ	Q96IZ0

Polymorphism and mutation databases

BioMutaⁱ	PAWR
DMDMⁱ	66773935

Proteomic databases

EPDⁱ	Q96IZ0
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96IZ0
PaxDbⁱ	Q96IZ0
PeptideAtlas More...PeptideAtlasⁱ	Q96IZ0
PRIDEⁱ	Q96IZ0
ProteomicsDBⁱ	76870
TopDownProteomicsⁱ	Q96IZ0

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5074
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000328827; ENSP00000328088; ENSG00000177425
GeneIDⁱ	5074
KEGGⁱ	hsa:5074
UCSC genome browser More...UCSCⁱ	uc001syx.4 human

Organism-specific databases

CTDⁱ	5074
DisGeNET More...DisGeNETⁱ	5074
EuPathDBⁱ	HostDB:ENSG00000177425.10
GeneCardsⁱ	PAWR
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8614 PAWR
Human Protein Atlas More...HPAⁱ	CAB020779 HPA012640
MIMⁱ	601936 gene
neXtProtⁱ	NX_Q96IZ0
Open Targets More...OpenTargetsⁱ	ENSG00000177425
PharmGKBⁱ	PA32954
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IFBP Eukaryota ENOG4111M3H LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000406
HOGENOMⁱ	HOG000115462
HOVERGENⁱ	HBG058812
InParanoidⁱ	Q96IZ0
OMAⁱ	NCAVGPA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0JYK
PhylomeDBⁱ	Q96IZ0
TreeFamⁱ	TF332824

Enzyme and pathway databases

SIGNORⁱ	Q96IZ0

SIGNORⁱ

Q96IZ0

Miscellaneous databases

ChiTaRSⁱ	PAWR human
EvolutionaryTraceⁱ	Q96IZ0
GeneWikiⁱ	PAWR
GenomeRNAiⁱ	5074
Protein Ontology More...PROⁱ	PR:Q96IZ0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000177425
CleanExⁱ	HS_PAWR
ExpressionAtlasⁱ	Q96IZ0 baseline and differential
Genevisibleⁱ	Q96IZ0 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR026117 Par-4
PANTHERⁱ	PTHR15093 PTHR15093, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PAWR_HUMAN
Accessionⁱ	Q96IZ0Primary (citable) accession number: Q96IZ0 Secondary accession number(s): O75796, Q6FHY9, Q8N700
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 24, 2005
	Last sequence update:	December 1, 2001
	Last modified:	June 20, 2018
	This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q96IZ0 (PAWR_HUMAN)

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PRKC apoptosis WT1 regulator protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytoskeleton

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Coiled coil

Motif

Compositional bias

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ